Validating c. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies.

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Project Title: Validating c. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies.
Project Number: CORDIS-193245
Project web address: Follow on CORDIS
 
Project Description:
Healthspan (the life period when one is generally healthy and free from serious disease) depends on nature (genetic make-up) and nurture (environmental influences, from the earliest stages of development throughout life). Genetic studies increasingly reveal mutations and polymorphisms that may affect healthspan. Similarly, claims abound about lifestyle modifications or treatments improving healthspan. In both cases, rigorous testing is hampered by the long lifespan of model organisms like mice (let alone humans) and the difficulty of introducing genetic changes to examine the phenotype of the altered genome. We will develop C. elegans as a healthspan model. Already validated extensively as an ageing model, this organism can be readily modified genetically, and effects of environmental manipulations on healthspan can be measured in days or weeks. Once validated as a healthspan model, it can be used for an initial assessment of preventive and therapeutic measures for humans, as well as for risk identification and the initial evaluation of potential biomarkers. It will also prove useful to study interactions between genetic and various environmental factors.
 
Project Terms:
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Project Title: Validating c. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies.
Project Number: CORDIS-193245
Project web address: Follow on CORDIS
Organization: Katholieke Universiteit Leuven, Belgium, Leuven
Collaborators: Istituto Superiore Di Sanita, IT
National Institute For Health & Welfare, FI
Karolinska Institutet, SE
Universiteit Gent, BE
Imperial College Of Science, Technology And Medicine, GB
Aarhus Universitet, DK
Tsinghua University, CN
Eidgenoessische Technische Hochschule Zuerich, CH
Tartu Ulikool, EE
Biopolis Sl, ES
Analyticon Discovery Gmbh, DE
The Trustees Of The University Of Pennsylvania Corp, US
Universitatsmedizin Rostock, DE
Cartagenia Nv, BE
Abiomics Europe Kft, HU
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology
 
Other Information:
Fiscal Year: 2015
Project Start Date: 1 May 2015
Project End Date: 30 April 2020
Project program: H2020-EU.3.1.1.
 
Project Funding Information:
Funding Mechanism: RIA - Research and Innovation action
Year Funding Organization Total Funding, $
2015 European Research Council $8,035,661
Project Title: Validating c. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies.
Project Number: CORDIS-193245
Project web address: Follow on CORDIS
 
Title FY Funding
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Project Title: Validating c. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies.
Project Number: CORDIS-193245
Project web address: Follow on CORDIS
 
Project Title Organization FY Funding
Project Title: Validating c. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies.
Project Number: CORDIS-193245
Project web address: Follow on CORDIS
 
Title Journal Year Country Rel
Project Title: Validating c. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies.
Project Number: CORDIS-193245
Project web address: Follow on CORDIS
 
Title Year
Project Title: Validating c. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies.
Project Number: CORDIS-193245
Project web address: Follow on CORDIS
 
Title Phase Year