Loc: hiv prevention trials network

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Project Title: Loc: hiv prevention trials network
Project Number: 5UM1AI068619-11
Project web address: Follow on NIH
 
Project Description:
The mission of the HIV Prevention Trials Network (HPTN) is to conduct research designed to identify the best combinations of HIV prevention interventions to prevent HIV infection in populations at the highest risk for this infection. The HPTN will be led by Drs. Wafaa EI-Sadr, Columbia University, and Myron S. Cohen, University of North Carolina at Chapel Hill, and supported by experienced operations, laboratory and statistical and data centers. The HPTN will address and support the two research Priority Areas in order to achieve the following eight Specific Aims: Specific Aims for Priority Area 1: Integrate Strategies to Prevent HIV Infection: Aim 1: To develop an integrated strategy to prevent HIV infection in young women in Southern Africa; Aim 2: To develop integrated strategies to prevent HIV infection in men who have sex with men (MSM); Sub-aim 2a: To identify an integrated strategy to prevent HIV acquisition in HIV-uninfected MSM and transgender women in the Americas; Sub-aim 2b: To identify an integrated strategy to prevent HIV transmission from HIV-infected MSM in the United States (U.S.); Aim 3: To develop an integrated strategy to prevent HIV infection in injection drug users (IDUs) in Eastern Europe and Asia; Aim 4: To implement an integrated strategy to virtually eliminate (<1%) HIV transmission in discordant couples in sub-Saharan Africa {SSA}; Aim 5: To develop methods to engage MSM in SSA in prevention research, paving the way for development of an integrated strategy to prevent HIV infection in this population Specific Aims for Priority Area 2: Pre-exposure Prophylaxis {PrEP}: Aim 6: To evaluate the efficacy of an ARV regimen containing maraviroc (MVC) for PrEP; Aim 7: To develop new agents for PrEP with favorable profiles, including long lasting agents; Aim 8: To develop pharmacostatistical models to define the role of new agents for PrEP.
 
Project Terms:
address africa south of the sahara aids prevention americas area couples data development eastern europe epidemic experience far east goals health policy health practice high risk hiv hiv infections hiv prevention trials network infection injecting drug user intervention laboratories men who have sex with men methods mission modeling myron new agents north carolina operation population pre-exposure prophylaxis prevent prevention research preventive intervention public health regimen research research design research priority role southern africa transgender women transmission process united states universities virtual young woman
Project Title: Loc: hiv prevention trials network
Project Number: 5UM1AI068619-11
Project web address: Follow on NIH
Organization: Family Health International, United States, North Carolina, RESEARCH TRIANGLE PARK
Principal Investigators (PI): El-Sadr Wafaa M, US
Cohen Myron S, US
 
Project Categories:
Behavioral and Social Sciences > Population studies
Natural Sciences
 
Other Information:
Fiscal Year: 2006
Project Start Date: 1 June 2006
Project End Date: 30 November 2020
Project program: Research Project with Complex Structure Cooperative Agreement
 
Project Funding Information:
Funding Mechanism: Non-SBIR/STTR RPGs
Year Funding Organization Total Funding, $
2017 NIH - National Institute Of Allergy And Infectious Diseases $39,184,529
Project Title: Loc: hiv prevention trials network
Project Number: 5UM1AI068619-11
Project web address: Follow on NIH
 
Title FY Funding
There are no results for this project in database.
Project Title: Loc: hiv prevention trials network
Project Number: 5UM1AI068619-11
Project web address: Follow on NIH
 
Title Journal Year Country Rel
Basis and Statistical Design of the Passive HIV-1 Antibody Mediated Prevention (AMP) Test-of-Concept Efficacy Trials. Stat Commun Infect Dis 2017 united states
A health intervention or a kitchen appliance? Household costs and benefits of a cleaner burning biomass-fuelled cookstove in Malawi. Soc Sci Med 2017 england
Substance Use and HIV Risk Among Men Who Have Sex With Men in Africa: A Systematic Review. J Acquir Immune Defic Syndr 2017 united states
Segmented polynomials for incidence rate estimation from prevalence data. Stat Med 2017 england
A Randomized-Controlled Trial of Computer-based Prevention Counseling for HIV-Positive Persons (HPTN 065). J AIDS Clin Res 2017
Cash transfers for HIV prevention: what do young women spend it on? Mixed methods findings from HPTN 068. BMC Public Health 2017 england
Comparison of Hepatitis B Virus Infection in HIV-Infected and HIV-Uninfected Participants Enrolled in a Multinational Clinical Trial: HPTN 052. J Acquir Immune Defic Syndr 2017 united states
Design of the HPTN 065 (TLC-Plus) study: A study to evaluate the feasibility of an enhanced test, link-to-care, plus treat approach for HIV prevention in the United States. Clin Trials 2017 england
The effect of school attendance and school dropout on incident HIV and HSV-2 among young women in rural South Africa enrolled in HPTN 068. AIDS 2017 england
Brief Report: Recovery of Bone Mineral Density After Discontinuation of Tenofovir-Based HIV Pre-exposure Prophylaxis. J Acquir Immune Defic Syndr 2017 united states
Community intervention improves knowledge of HIV status of adolescents in Zambia: findings from HPTN 071-PopART for youth study. AIDS 2017 england
Phylogenetic Tools for Generalized HIV-1 Epidemics: Findings from the PANGEA-HIV Methods Comparison. Mol Biol Evol 2017 united states
Recruitment of Female Sex Workers in HIV Prevention Trials: Can Efficacy Endpoints Be Reached More Efficiently? J Acquir Immune Defic Syndr 2017 united states
Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial. J Acquir Immune Defic Syndr 2017 united states
Virologic outcomes in early antiretroviral treatment: HPTN 052. HIV Clin Trials 2017 england
Hiv Drug Resistance in Adults Receiving Early Versus Delayed Antiretroviral Therapy: Hptn 052. J Acquir Immune Defic Syndr 2017 united states
Effect of Schooling on Age-Disparate Relationships and Number of Sexual Partners Among Young Women in Rural South Africa Enrolled in HPTN 068. J Acquir Immune Defic Syndr 2017 united states
Evaluation of a Multidrug Assay for Monitoring Adherence to a Regimen for HIV Preexposure Prophylaxis in a Clinical Study, HIV Prevention Trials Network 073. Antimicrob Agents Chemother 2017 united states
Brief Report: Impact of Early Antiretroviral Therapy on the Performance of HIV Rapid Tests and HIV Incidence Assays. J Acquir Immune Defic Syndr 2017 united states
Trends in Responses to DHS Questions Should Not Be Interpreted as Reflecting an Increase in "Anticipated Stigma" in Africa. J Acquir Immune Defic Syndr 2017 united states
Safety and Tolerability of Maraviroc-Containing Regimens to Prevent HIV Infection in Women: A Phase 2 Randomized Trial. Ann Intern Med 2017 united states
Age-Related Differences in Socio-demographic and Behavioral Determinants of HIV Testing and Counseling in HPTN 043/NIMH Project Accept. AIDS Behav 2017 united states
Characterization of HIV Seroconverters in a TDF/FTC PrEP Study: HPTN 067/ADAPT. J Acquir Immune Defic Syndr 2017 united states
Venues for Meeting Sex Partners and Partner HIV Risk Characteristics: HIV Prevention Trials Network (HPTN064) Women's HIV Seroincidence Study (ISIS). AIDS Behav 2016 united states
Antiretroviral Medication Adherence and Amplified HIV Transmission Risk Among Sexually Active HIV-Infected Individuals in Three Diverse International Settings. AIDS Behav 2016 united states
Brief Report: HIV Drug Resistance in Adults Failing Early Antiretroviral Treatment: Results From the HIV Prevention Trials Network 052 Trial. J Acquir Immune Defic Syndr 2016 united states
Socioecological factors influencing women's HIV risk in the United States: qualitative findings from the women's HIV SeroIncidence study (HPTN 064). BMC Public Health 2016 england
Using Cognitive Interviews to Enhance Measurement in Empirical Bioethics: Developing a Measure of the Preventive Misconception in Biomedical HIV Prevention Trials. AJOB Empir Bioeth 2016 united states
Transgender Women in Clinical Trials of Pre-Exposure Prophylaxis. J Acquir Immune Defic Syndr 2016 united states
HPTN 068: A Randomized Control Trial of a Conditional Cash Transfer to Reduce HIV Infection in Young Women in South Africa-Study Design and Baseline Results. AIDS Behav 2016 united states
Costs of Expanded Rapid HIV Testing in Four Emergency Departments. Public Health Rep 2016 united states
Frequency and predictors of estimated HIV transmissions and bacterial STI acquisition among HIV-positive patients in HIV care across three continents. J Int AIDS Soc 2016 switzerland
Transgender People and HIV Prevention: What We Know and What We Need to Know, a Call to Action. J Acquir Immune Defic Syndr 2016 united states
Engaging Transgender People in NIH-Funded HIV/AIDS Clinical Trials Research. J Acquir Immune Defic Syndr 2016 united states
Symptoms, Side Effects and Adherence in the iPrEx Open-Label Extension. Clin Infect Dis 2016 united states
The promise and pitfalls of long-acting injectable agents for HIV prevention. Curr Opin HIV AIDS 2016 united states
Economic, Legal, and Social Hardships Associated with HIV Risk among Black Men who have Sex with Men in Six US Cities. J Urban Health 2016 united states
Pharmacology supports on-demand PrEP. Lancet HIV 2016 netherlands
Population health and individualized care in the global AIDS response: synergy or conflict? AIDS 2016 england
Antiretroviral Therapy for the Prevention of HIV-1 Transmission. N Engl J Med 2016 united states
Post-traumatic Stress Disorder Symptoms and Mental Health over Time among Low-Income Women at Increased Risk of HIV in the U.S. J Health Care Poor Underserved 2016 united states
Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study. Lancet HIV 2016 netherlands
Economic Resources and HIV Preventive Behaviors Among School-Enrolled Young Women in Rural South Africa (HPTN 068). AIDS Behav 2016 united states
Antiretroviral drug use in a cross-sectional population survey in Africa: NIMH Project Accept (HPTN 043). J Acquir Immune Defic Syndr 2016 united states
Hope Matters: Developing and Validating a Measure of Future Expectations Among Young Women in a High HIV Prevalence Setting in Rural South Africa (HPTN 068). AIDS Behav 2016 united states
Social Network Factors as Correlates and Predictors of High Depressive Symptoms Among Black Men Who Have Sex with Men in HPTN 061. AIDS Behav 2016 united states
International perspectives on the collection, storage, and testing of human biospecimens in HIV research. IRB 2008 united states
Partnering for Care in HIV Prevention Trials. J Empir Res Hum Res Ethics 2008 united states
Project Title: Loc: hiv prevention trials network
Project Number: 5UM1AI068619-11
Project web address: Follow on NIH
 
Title Year