Mechanisms of energy balance and cancer prevention

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Project Title: Mechanisms of energy balance and cancer prevention
Project Number: 5U54CA116847-05
Project web address: Follow on NIH
Project Description:
We propose in the Seattle TREC Center to elucidate the pathways linking components of energy balance to the cancer process using several different study designs, with the transdisciplinary contributions of scientists from medicine, cell biology, animal models, epidemiology, nutrition, gastroenterology, molecular biology, obesity, endocrinology, obesity, cardiology, immunology, biostatistics, mathematics, exercise physiology, and behavioral science. The overarching theme of the Seattle TREC Center will be determining the mechanisms by which energy balance modifies and influences the process of carcinogenesis across the lifespan in a broad range of settings including cell culture, animal models, small-scale human experimental studies, and population-level experimental work. In Project 1 we will bring together basic research efforts underway in our laboratories in an innovative approach to analyzing the cellular effects of hyperglycemia, hyperinsulinemia, and inflammation on growth, proliferation and survival pathways relevant to oncogenesis. In Project 2 we will determine, in an animal model, the effects of caloric restriction and exercise, alone and in combination, on the carcinogenic response in the mammary gland and on the mechanisms by which changes in energy balance modulate the development of cancer. In Project 3 we will investigate the metabolic and cancer biomarker response to experimental high and low glycemic load diets in lean and obese teenagers and young adults in a crossover clinical trial design. Within a randomized controlled trial in Project 4, we will investigate the effects of dietary weight loss and exercise, alone and together, on biomarkers of inflammation, and DNA damage and repair, and the influences of genetic polymorphisms on these associations. In Project 5 we will test a worksite obesity prevention intervention in a geographic area with large representation of low income and minority individuals on body mass index and markers of insulin resistance and inflammation. Our novel laboratory work will include testing intervention effects on serum proteomics and, in a developmental project, on metabolomics, in order to identify biological signals of dietary, exercise, and adiposity. Our investigators have a wealth of expertise in the components of the energy balance and cancer equation, and will provide important scientific leadership, training, and contributions to the overall TREC program.
Project Terms:
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Project Title: Mechanisms of energy balance and cancer prevention
Project Number: 5U54CA116847-05
Project web address: Follow on NIH
Organization: Fred Hutchinson Cancer Research Center, United States, Washington, SEATTLE
Principal Investigators (PI): Mctiernan Anne M, US
Project Categories:
Natural Sciences
Other Information:
Fiscal Year: 2005
Project Start Date: 23 September 2005
Project End Date: 31 August 2011
Project program: Specialized Center--Cooperative Agreements
Project Funding Information:
Funding Mechanism: Research Centers
Year Funding Organization Total Funding, $
2009 NIH - National Cancer Institute $2,461,328
Project Title: Mechanisms of energy balance and cancer prevention
Project Number: 5U54CA116847-05
Project web address: Follow on NIH
Title Journal Year Country Rel
Genetic variation in TNF?, PPAR?, and IRS-1 genes, and their association with breast-cancer survival in the HEAL cohort. Breast Cancer Res Treat 2017 netherlands
Diet and Exercise and Serum Markers of Oxidative Stress-Response. Cancer Prev Res (Phila) 2017 united states
Long-Term Effects of Weight Loss and Exercise on Biomarkers Associated with Angiogenesis. Cancer Epidemiol Biomarkers Prev 2017 united states
Plasma metabolite abundances are associated with urinary enterolactone excretion in healthy participants on controlled diets. Food Funct 2017 england
Prospective Study of Insufficient Sleep and Neurobehavioral Functioning Among School-Age Children. Acad Pediatr 2017 united states
Methods to adjust for misclassification in the quantiles for the generalized linear model with measurement error in continuous exposures. Stat Med 2016 england
Measurement of Circulating Phospholipid Fatty Acids: Association between Relative Weight Percentage and Absolute Concentrations. J Am Coll Nutr 2016 united states
Associations of sex steroid hormones with mortality in women with breast cancer. Breast Cancer Res Treat 2016 netherlands
Dietary Weight Loss and Exercise Effects on Serum Biomarkers of Angiogenesis in Overweight Postmenopausal Women: A Randomized Controlled Trial. Cancer Res 2016 united states
Subjective mood and energy levels of healthy weight and overweight/obese healthy adults on high-and low-glycemic load experimental diets. Appetite 2016 england
Dietary Weight Loss, Exercise, and Oxidative Stress in Postmenopausal Women: A Randomized Controlled Trial. Cancer Prev Res (Phila) 2016 united states
Long-term changes in sleep duration, energy balance and risk of type 2 diabetes. Diabetologia 2016 germany
Chronic insufficient sleep and diet quality: Contributors to childhood obesity. Obesity (Silver Spring) 2016 united states
Enterolignan-producing phenotypes are associated with increased gut microbial diversity and altered composition in premenopausal women in the United States. Cancer Epidemiol Biomarkers Prev 2015 united states
Targeted plasma metabolome response to variations in dietary glycemic load in a randomized, controlled, crossover feeding trial in healthy adults. Food Funct 2015 england
The effects of separate and combined dietary weight loss and exercise on fasting ghrelin concentrations in overweight and obese women: a randomized controlled trial. Clin Endocrinol (Oxf) 2015 england
No effect of caloric restriction or exercise on radiation repair capacity. Med Sci Sports Exerc 2015 united states
Longitudinal associations of sleep curtailment with metabolic risk in mid-childhood. Obesity (Silver Spring) 2014 united states
Aspirin and serum estrogens in postmenopausal women: a randomized controlled clinical trial. Cancer Prev Res (Phila) 2014 united states
Change in peripheral blood leukocyte telomere length and mortality in breast cancer survivors. J Natl Cancer Inst 2014 united states
Attitudes, beliefs, and perceptions of caregivers and rehabilitation providers about disabled children's sleep health: a qualitative study. BMC Pediatr 2014 england
No effect of weight loss on LINE-1 methylation levels in peripheral blood leukocytes from postmenopausal overweight women. Obesity (Silver Spring) 2014 united states
Chronic sleep curtailment and adiposity. Pediatrics 2014 united states
Effects of physical activity on melatonin levels in previously sedentary men and women. Cancer Epidemiol Biomarkers Prev 2014 united states
Associations of serum 25-hydroxyvitamin D with overall and breast cancer-specific mortality in a multiethnic cohort of breast cancer survivors. Cancer Causes Control 2013 netherlands
Associations of insulin-like growth factor and insulin-like growth factor binding protein-3 with mortality in women with breast cancer. Int J Cancer 2013 united states
Exercise adherence, cardiopulmonary fitness and anthropometric changes improve exercise self-efficacy and health-related quality of life. J Phys Act Health 2013 united states
Independent and combined effects of dietary weight loss and exercise on leukocyte telomere length in postmenopausal women. Obesity (Silver Spring) 2013 united states
Comparison and validation of 2 analytical methods for measurement of urinary sucrose and fructose excretion. Nutr Res 2013 united states
Influence of diet, exercise, and serum vitamin d on sarcopenia in postmenopausal women. Med Sci Sports Exerc 2013 united states
Gene expression changes in adipose tissue with diet- and/or exercise-induced weight loss. Cancer Prev Res (Phila) 2013 united states
Predictors of adherence to a 26-week viniyoga intervention among post-treatment breast cancer survivors. J Altern Complement Med 2013 united states
Weight and metabolic effects of dietary weight loss and exercise interventions in postmenopausal antidepressant medication users and non-users: a randomized controlled trial. Prev Med 2013 united states
History of weight cycling does not impede future weight loss or metabolic improvements in postmenopausal women. Metabolism 2013 united states
Effect of low- and high-glycemic load on circulating incretins in a randomized clinical trial. Metabolism 2013 united states
Effects of dietary weight loss and exercise on insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in postmenopausal women: a randomized controlled trial. Cancer Epidemiol Biomarkers Prev 2013 united states
Recruiting underrepresented groups into the Carbohydrates and Related Biomarkers (CARB) cancer prevention feeding study. Contemp Clin Trials 2012 united states
A low-glycemic load diet reduces serum C-reactive protein and modestly increases adiponectin in overweight and obese adults. J Nutr 2012 united states
Adoption of diet-related self-monitoring behaviors varies by race/ethnicity, education, and baseline binge eating score among overweight-to-obese postmenopausal women in a 12-month dietary weight loss intervention. Nutr Res 2012 united states
DEXA measures of body fat percentage and acute phase proteins among breast cancer survivors: a cross-sectional analysis. BMC Cancer 2012 england
Self-monitoring and eating-related behaviors are associated with 12-month weight loss in postmenopausal overweight-to-obese women. J Acad Nutr Diet 2012 united states
Glycemic load effect on fasting and post-prandial serum glucose, insulin, IGF-1 and IGFBP-3 in a randomized, controlled feeding study. Eur J Clin Nutr 2012 england
Effect of diet and exercise, alone or combined, on weight and body composition in overweight-to-obese postmenopausal women. Obesity (Silver Spring) 2012 united states
Randomized controlled pilot trial of yoga in overweight and obese breast cancer survivors: effects on quality of life and anthropometric measures. Support Care Cancer 2012 germany
Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trial. Cancer Res 2012 united states
Dietary and physical activity behaviours related to obesity-specific quality of life and work productivity: baseline results from a worksite trial. Br J Nutr 2012 england
Low glycemic load experimental diet more satiating than high glycemic load diet. Nutr Cancer 2012 united states
Prevalence and prognostic effect of sarcopenia in breast cancer survivors: the HEAL Study. J Cancer Surviv 2012 united states
Effects of weight loss on serum vitamin D in postmenopausal women. Am J Clin Nutr 2011 united states
Dietary weight loss and exercise effects on insulin resistance in postmenopausal women. Am J Prev Med 2011 netherlands
Fine particulate matter (PM₂.₅) air pollution and immune status among women in the Seattle area. Arch Environ Occup Health 2011 united states
Dietary fiber is associated with circulating concentrations of C-reactive protein in breast cancer survivors: the HEAL study. Breast Cancer Res Treat 2011 netherlands
Associations between snacking and weight loss and nutrient intake among postmenopausal overweight to obese women in a dietary weight-loss intervention. J Am Diet Assoc 2011 united states
Associations of insulin resistance and adiponectin with mortality in women with breast cancer. J Clin Oncol 2011 united states
Effects of 12-month exercise on health-related quality of life: a randomized controlled trial. Prev Med 2011 united states
Physical inactivity, but not sedentary behavior or energy intake, is associated with higher fat mass in Latina and African American girls. Ethn Dis 2011 united states
Case-control study of overweight, obesity, and colorectal cancer risk, overall and by tumor microsatellite instability status. J Natl Cancer Inst 2010 united states
Wheel running, skeletal muscle aerobic capacity and 1-methyl-1-nitrosourea induced mammary carcinogenesis in the rat. Carcinogenesis 2010 england
Frequent intentional weight loss is associated with higher ghrelin and lower glucose and androgen levels in postmenopausal women. Nutr Res 2010 united states
Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells. Proc Natl Acad Sci U S A 2010 united states
Wheel running-induced changes in plasma biomarkers and carcinogenic response in the 1-methyl-1-nitrosourea-induced rat model for breast cancer. Cancer Prev Res (Phila) 2010 united states
Effect of exercise on oxidative stress: a 12-month randomized, controlled trial. Med Sci Sports Exerc 2010 united states
Weight, physical activity, diet, and prognosis in breast and gynecologic cancers. J Clin Oncol 2010 united states
Characterization of low molecular weight chemical fractions of dry bean (Phaseolus vulgaris) for bioactivity using Caenorhabditis elegans longevity and metabolite fingerprinting. J Agric Food Chem 2010 united states
A yearlong exercise intervention decreases CRP among obese postmenopausal women. Med Sci Sports Exerc 2009 united states
Mismatch repair polymorphisms and risk of colon cancer, tumour microsatellite instability and interactions with lifestyle factors. Gut 2009 england
Correlates of circulating C-reactive protein and serum amyloid A concentrations in breast cancer survivors. Breast Cancer Res Treat 2009 netherlands
Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation. Arterioscler Thromb Vasc Biol 2009 united states
Candidate mechanisms accounting for effects of physical activity on breast carcinogenesis. IUBMB Life 2009 england
A transfer-less, multi-well liquid culture feeding system for screening small molecules that affect the longevity of Caenorhabditis elegans. Biotechniques 2009 england
Higher habitual intake of dietary fat and carbohydrates are associated with lower leptin and higher ghrelin concentrations in overweight and obese postmenopausal women with elevated insulin levels. Nutr Res 2009 united states
Energetics and mammary carcinogenesis: effects of moderate-intensity running and energy intake on cellular processes and molecular mechanisms in rats. J Appl Physiol 2009 united states
A pilot study of sampling subcutaneous adipose tissue to examine biomarkers of cancer risk. Cancer Prev Res (Phila Pa) 2009 united states
Endothelial inflammation induced by excess glucose is associated with cytosolic glucose 6-phosphate but not increased mitochondrial respiration. Diabetologia 2009 germany
Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients. J Clin Oncol 2009 united states
The use of pre-hospital mild hypothermia after resuscitation from out-of-hospital cardiac arrest. J Neurotrauma 2009 united states
No reduction in C-reactive protein following a 12-month randomized controlled trial of exercise in men and women. Cancer Epidemiol Biomarkers Prev 2008 united states
Effect of exercise on serum sex hormones in men: a 12-month randomized clinical trial. Med Sci Sports Exerc 2008 united states
The collaboration readiness of transdisciplinary research teams and centers findings from the National Cancer Institute's TREC Year-One evaluation study. Am J Prev Med 2008 netherlands
Exercise effect on weight and body fat in men and women. Obesity (Silver Spring) 2007 united states
Effect of a 12-month exercise intervention on patterns of cellular proliferation in colonic crypts: a randomized controlled trial. Cancer Epidemiol Biomarkers Prev 2006 united states
Project Title: Mechanisms of energy balance and cancer prevention
Project Number: 5U54CA116847-05
Project web address: Follow on NIH
Title Year
Project Title: Mechanisms of energy balance and cancer prevention
Project Number: 5U54CA116847-05
Project web address: Follow on NIH
Title Phase Year
Move and Moderate in Balance N/A 2005
Yoga Study in Breast Cancer Patients N/A 2005
Effect of a Low-Calorie Diet and/or Exercise Program on Risk Factors for Developing Breast Cancer in Overweight or Obese Postmenopausal Women N/A 1985