Glycemic load &obesity effects on cancer biomarkers

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Project Title: Glycemic load &obesity effects on cancer biomarkers
Project Number: 5U54CA116847-05-0003
Project web address: Follow on NIH
Parent Project: 5U54CA116847-05
 
Project Description:
Nearly two-thirds of the adult population of the United States is overweight or obese. One of the serious consequences of this obesity epidemic is the growing evidence that obesity increases risk for several common cancers. Hyperinsulinemia, and altered levels of adipocyte hormones, insulin-like growth factors and markers of inflammation often accompany obesity and may provide the mechanistic explanation for these observed associations of obesity with cancer. IGF-1 inhibits apoptosis and stimulates proliferation and both insulin leptin are mitogenic. On the other hand, obesity inhibits adiponectin, which has been associated with both the inflammatory response and carcinogenesis. Dietary patterns are related to the synthesis, metabolism and distribution of these biomarkers. For example, diets can be characterized relative to their influence on the postprandial glucose response;e.g., diets rich in simple sugars and refined carbohydrates have a high glycemic index because they produce a rapid rise in blood glucose. Foods such as meats, legumes, and high-fiber fruits and vegetables produce a low rise in blood glucose and have a low glycemic index. Despite the plethora of scientific papers suggesting that high-glycemic-index foods increase cancer risk, very few intervention studies in humans have evaluated the action of low and high glycemic foods on biomarkers of cancer risk. We propose a randomized, controlled cross-over feeding trial in 88 lean (BMI<25) and obese men and women (BMI>30). Participants will be randomized to consume either a low- or highglycemic- load diet for four weeks, followed by a four week wash-out period, then cross-over to the other arm. Blood samples will be collected at the beginning and end of each diet period and assayed for insulin, glucose, IGF-1, IGFBP3, leptin, adiponectin, C-reactive protein, serum amyloid A, and interleukin-6. This study will provide a rigorous test of common dietary patterns in humans that will allow us to directly test dietrelated mechanisms of obesity and biomarkers of carcinogenesis. Importantly, by recruiting both lean and obese persons, we will be able to examine whether there is a differential response to the high- and lowglycemic load diets for lean vs. obese individuals. This study will provide data of immediate clinical and public-health benefit.
 
Project Terms:
accounting address adipocytes adiponectin adult animal model apoptosis base beverages biological biological assay biological markers blood glucose blood specimen body mass index body weight changes body weight decreased bread breast carcinoma c-reactive protein cancer initiation cancer prevention cancer risk carbohydrates carcinogenesis characteristics clinical collaborations colon carcinoma crossover design cytokine data design diet diet habits dietary carbohydrates dietary factors dietary intervention dietary practices discipline dose eating effective intervention energy balance energy intake epidemic equation event exercise experience fabaceae feeding fiber food fruits and vegetables genetic crossing over glucose glycemic index goals growth factor hand health health benefit hormones human hyperglycemia hyperinsulinism igf1 gene igfbp3 gene improved individual inflammation inflammatory marker inflammatory response ingestion insight insulin insulin-like growth factor i interest interleukin-6 intervention intervention studies investigation laboratories leptin life macronutrients nutrition malignant breast neoplasm malignant neoplasms measures meat mediating men metabolic metabolism minor modeling motivation new technology nutrition obesity obesity associated cancer outcome overweight paper participant pathway interactions pattern peptides phase physical activity physicians physiological plasma population postmenopause pre-clinical process production protein expression protein structure proteomics public health medicine (field) randomized rattus recipe recruitment activity relative (related person) research research design research personnel research proposals resources response risk risk factors serum amyloid a protein services signal transduction signaling molecule somatomedins staging sugar t-cell receptor-rearrangement excision dna circles testing time tumor growth united states upper arm variant vitamins weight woman work breast cancer diabetes prevention aging digestive diseases cancer
Project Title: Glycemic load &obesity effects on cancer biomarkers
Project Number: 5U54CA116847-05-0003
Project web address: Follow on NIH
Parent Project: 5U54CA116847-05
Organization: Fred Hutchinson Cancer Research Center, United States, Washington, SEATTLE
Principal Investigators (PI): Neuhouser Marian L, US
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2009
Project Start Date: 1 September 2009
Project End Date: 31 August 2010
Project program: Specialized Center--Cooperative Agreements
 
Project Funding Information:
Funding Mechanism: Research Centers
Year Funding Organization Total Funding, $
2009 NIH - National Cancer Institute $103,375
Project Title: Glycemic load &obesity effects on cancer biomarkers
Project Number: 5U54CA116847-05-0003
Project web address: Follow on NIH
Parent Project: 5U54CA116847-05
 
Title FY Funding
There are no results for this project in database.
Project Title: Glycemic load &obesity effects on cancer biomarkers
Project Number: 5U54CA116847-05-0003
Project web address: Follow on NIH
Parent Project: 5U54CA116847-05
 
Project Title Organization FY Funding
Project Title: Glycemic load &obesity effects on cancer biomarkers
Project Number: 5U54CA116847-05-0003
Project web address: Follow on NIH
Parent Project: 5U54CA116847-05
 
Title Journal Year Country Rel
Project Title: Glycemic load &obesity effects on cancer biomarkers
Project Number: 5U54CA116847-05-0003
Project web address: Follow on NIH
Parent Project: 5U54CA116847-05
 
Title Year
Project Title: Glycemic load &obesity effects on cancer biomarkers
Project Number: 5U54CA116847-05-0003
Project web address: Follow on NIH
Parent Project: 5U54CA116847-05
 
Title Phase Year