Northeast biodefense center

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Project Title: Northeast biodefense center
Project Number: 5U54AI057158-09
Project web address: Follow on NIH
Project Description:
The Northeast Biodefense Center (NBC) is a consortium of >350 investigators in 28 academic and research institutions (many of them in close proximity to one another in the greater NYC metro area), and 13 US based governmental and international organizations. Over the past 5 years, NBC investigators have demonstrated their commitment to working together across disciplines and institutional boundaries in research and training programs focused on biodefense and emerging infectious diseases as well as emergency preparedness. Evidence of productivity includes >160 publications, 15 invention disclosures, 13 patent applications and 5 licenses for product development. This renewal will comprise 42 investigators and 32 research projects organized into 6 scientific theme areas: Passive Immunotherapeutics (chair: Arturo Casadevall, Einstein); Vaccines (chair: John Rose, Yale); Diagnostics and Pathogen Discovery (chair: Ian Lipkin, Columbia); Therapeutics (chairs: Charles Rice, Rockefeller and Howard Shuman, Columbia,); Innate Immunity (chairs: David Levy, NYU, and Adolfo Garcia-Sastre, Sinai), and Microbial Pathogenesis (chairs: Jorge E. Galan, Yale, and Jorge Benach, Stony Book). Biotechnology and pharmaceutical collaborators are represented in the Diagnostics and Pathogen Discovery (Agilent, Akonni, Cepheid, Xynostics, 454 Life Sciences), Therapeutics (Prosetta, Snowdon), and Passive Immunotherapeutics (Regeneron) themes. These industrial links provide not only intellectual capital and resources but also a path for moving discoveries from NBC laboratories to a larger arena where they can contribute to human health and welfare. Additional strength derives from relationships with national and international public health agencies that provide unique access to insights and clinical materials (such as diagnostic samples and PBMC) that enable work that could not otherwise be pursuec. Core facilities will include Protein Expression, Animal Models, and Proteomics. We will also invest in Developmental Projects (innovative pilot projects) and in Career Development and Training Programs that include individual and group career development awards. As a Center based in a School of Public Health and a State Department of Health, the NBC has a firm commitment to and practical understanding of Emergency Preparedness.
Project Terms:
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Project Title: Northeast biodefense center
Project Number: 5U54AI057158-09
Project web address: Follow on NIH
Organization: Columbia University Health Sciences, United States, New York, NEW YORK
Principal Investigators (PI): Lipkin W Ian, US
Other Information:
Fiscal Year: 2003
Project Start Date: 4 September 2003
Project End Date: 28 February 2014
Project program: Specialized Center--Cooperative Agreements
Project Funding Information:
Funding Mechanism: Research Centers
Year Funding Organization Total Funding, $
2012 NIH - National Institute Of Allergy And Infectious Diseases $9,384,103
Project Title: Northeast biodefense center
Project Number: 5U54AI057158-09
Project web address: Follow on NIH
Title FY Funding
Pathogenic mechanisms of coxiella burnetti 2012 $363642
Development of new passive immunization strategies for anthrax 2012 $983096
Career development and training program 2012 $677179
Optimization of mabs to staphylococcal enterotoxin b for treatment 2012 $440345
Development of mab immunotherapy for genetically modified plague 2012 $290065
Mechanism and inhibition of dengue and chikungunya virus fusion protiens 2012 $366839
Filovirus inhibitors of interferon signaling: virulence factors and drug targets 2012 $374578
Development of mab therapeutics against biothreat and emerging diease agents 2012 $402448
Identification of interferon effectors that inhibit rna virus replication 2012 $352031
A novel antiviral platform: untimely activation of viral fusion mechanisms will 2012 $302923
Molecular biomarkers for identification of disease stage in lyme borreliosis 2012 $154986
Administrative core 2012 $1596852
Pathogen discovery in emerging infectious diseases 2012 $832044
Animal core 2012 $676051
Protein expression core 2012 $454164
Live, recombinant newcastle disease virus-based vaccine against high pri pathoge 2012 $374462
A genomics based strategy for the discovery and study of new signaling systems... 2012 $349457
Development of novel vaccines for high priority pathogens 2012 $410626
Developmental research program 2012 $606710
A chikungunya viral replicon as a platform for antiviral therapeutics 2012 $327642
Inhibition of innate immunity by hemorrhagic fever arboviruses 2012 $370730
Proteomics core 2012 $137155
Project Title: Northeast biodefense center
Project Number: 5U54AI057158-09
Project web address: Follow on NIH
Title Journal Year Country Rel
A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions. ACS Infect Dis 2017 united states
Ricin uses arginine 235 as an anchor residue to bind to P-proteins of the ribosomal stalk. Sci Rep 2017 england
Parameters of Mosquito-Enhanced West Nile Virus Infection. J Virol 2016 united states
Epitope-Specific Evolution of Human B Cell Responses to Borrelia burgdorferi VlsE Protein from Early to Late Stages of Lyme Disease. J Immunol 2016 united states
Expression of C-Reactive Protein and Serum Amyloid A in Early to Late Manifestations of Lyme Disease. Clin Infect Dis 2016 united states
Narrowing of the Diagnostic Gap of Acute Gastroenteritis in Children 0-6 Years of Age Using a Combination of Classical and Molecular Techniques, Delivers Challenges in Syndromic Approach Diagnostics. Pediatr Infect Dis J 2016 united states
Conserved Arginines at the P-Protein Stalk Binding Site and the Active Site Are Critical for Ribosome Interactions of Shiga Toxins but Do Not Contribute to Differences in the Affinity of the A1 Subunits for the Ribosome. Infect Immun 2016 united states
Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion. J Exp Med 2016 united states
Absence of TLR11 in Mice Does Not Confer Susceptibility to Salmonella Typhi. Cell 2016 united states
PKR Transduces MDA5-Dependent Signals for Type I IFN Induction. PLoS Pathog 2016 united states
Merida virus, a putative novel rhabdovirus discovered in Culex and Ochlerotatus spp. mosquitoes in the Yucatan Peninsula of Mexico. J Gen Virol 2016 england
Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia. Am J Trop Med Hyg 2016 united states
Production of immunogenic West Nile virus-like particles using a herpes simplex virus 1 recombinant vector. Virology 2016 united states
Monoclonal antibodies protect from Staphylococcal Enterotoxin K (SEK) induced toxic shock and sepsis by USA300 Staphylococcus aureus. Virulence 2016 united states
Unity in diversity: shared mechanism of entry among paramyxoviruses. Prog Mol Biol Transl Sci 2015 netherlands
Hypercholesterolemia and ApoE deficiency result in severe infection with Lyme disease and relapsing-fever Borrelia. Proc Natl Acad Sci U S A 2015 united states
Optimization of experimental conditions for functional in vitro characterization of humanized antibodies specific for staphylococcal enterotoxin B. Int Immunopharmacol 2015 netherlands
A serpin shapes the extracellular environment to prevent influenza A virus maturation. Cell 2015 united states
Preexisting human antibodies neutralize recently emerged H7N9 influenza strains. J Clin Invest 2015 united states
To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. Trends Cell Biol 2015 england
Mapping of the interaction domains of the Crimean-Congo hemorrhagic fever virus nucleocapsid protein. J Gen Virol 2015 england
Distinct plasma immune signatures in ME/CFS are present early in the course of illness. Sci Adv 2015
Characterization of the Punta Toro species complex (genus Phlebovirus, family Bunyaviridae). J Gen Virol 2015 england
Dengue Virus NS Proteins Inhibit RIG-I/MAVS Signaling by Blocking TBK1/IRF3 Phosphorylation: Dengue Virus Serotype 1 NS4A Is a Unique Interferon-Regulating Virulence Determinant. MBio 2015 united states
High preexisting serological antibody levels correlate with diversification of the influenza vaccine response. J Virol 2015 united states
Host Langerin (CD207) is a receptor for Yersinia pestis phagocytosis and promotes dissemination. Immunol Cell Biol 2015 england
High Affinity Antibodies against Influenza Characterize the Plasmablast Response in SLE Patients After Vaccination. PLoS One 2015 united states
Mechanisms mediating enhanced neutralization efficacy of staphylococcal enterotoxin B by combinations of monoclonal antibodies. J Biol Chem 2015 united states
Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents. Cell Cycle 2015 united states
A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3. Mol Cell Biol 2015 united states
Characterization of the Sandfly fever Naples species complex and description of a new Karimabad species complex (genus Phlebovirus, family Bunyaviridae). J Gen Virol 2014 england
Isotype switching increases efficacy of antibody protection against staphylococcal enterotoxin B-induced lethal shock and Staphylococcus aureus sepsis in mice. MBio 2014 united states
Broadly neutralizing hemagglutinin stalk-specific antibodies require Fc?R interactions for protection against influenza virus in vivo. Nat Med 2014 united states
The GAP activity of type III effector YopE triggers killing of Yersinia in macrophages. PLoS Pathog 2014 united states
Virus interactions with endothelial cell receptors: implications for viral pathogenesis. Curr Opin Virol 2014 netherlands
IQGAP1 is important for activation of caspase-1 in macrophages and is targeted by Yersinia pestis type III effector YopM. MBio 2014 united states
The RimL transacetylase provides resistance to translation inhibitor microcin C. J Bacteriol 2014 united states
Molecular determinants for a cardiovascular collapse in anthrax. Front Biosci (Elite Ed) 2014 united states
Carbapenem-resistant Klebsiella pneumoniae exhibit variability in capsular polysaccharide and capsule associated virulence traits. J Infect Dis 2014 united states
Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through whole-genome analysis and virus cultured from dromedary camels in Saudi Arabia. MBio 2014 united states
TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity. J Mol Biol 2014 england
Direct neutralization of type III effector translocation by the variable region of a monoclonal antibody to Yersinia pestis LcrV. Clin Vaccine Immunol 2014 united states
Novel coronavirus and astrovirus in Delaware Bay shorebirds. PLoS One 2014 united states
Genetics of follicular lymphoma transformation. Cell Rep 2014 united states
Microbicidal power of alpha radiation in sterilizing germinating Bacillus anthracis spores. Antimicrob Agents Chemother 2014 united states
Genome characterization of Long Island tick rhabdovirus, a new virus identified in Amblyomma americanum ticks. Virol J 2014 england
Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia. MBio 2014 united states
Genomic and phylogenetic characterization of viruses included in the Manzanilla and Oropouche species complexes of the genus Orthobunyavirus, family Bunyaviridae. J Gen Virol 2014 england
Pyridinyl imidazole inhibitors of p38 MAP kinase impair viral entry and reduce cytokine induction by Zaire ebolavirus in human dendritic cells. Antiviral Res 2014 netherlands
The interferon signaling antagonist function of yellow fever virus NS5 protein is activated by type I interferon. Cell Host Microbe 2014 united states
A screen of Coxiella burnetii mutants reveals important roles for Dot/Icm effectors and host autophagy in vacuole biogenesis. PLoS Pathog 2014 united states
Identification of a novel polyomavirus in a pancreatic transplant recipient with retinal blindness and vasculitic myopathy. J Infect Dis 2014 united states
A toggle switch controls the low pH-triggered rearrangement and maturation of the dengue virus envelope proteins. Nat Commun 2014 england
Staphylococcus aureus infection induces protein A-mediated immune evasion in humans. J Exp Med 2014 united states
Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian hamsters. Antiviral Res 2014 netherlands
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature 2014 england
STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation. Blood 2014 united states
Humanized staphylococcal enterotoxin B (SEB)-specific monoclonal antibodies protect from SEB intoxication and Staphylococcus aureus infections alone or as adjunctive therapy with vancomycin. J Infect Dis 2014 united states
Detection and measurement of staphylococcal enterotoxin-like K (SEl-K) secretion by Staphylococcus aureus clinical isolates. J Clin Microbiol 2014 united states
Effector CD8+ T cells are generated in response to an immunodominant epitope in type III effector YopE during primary Yersinia pseudotuberculosis infection. Infect Immun 2014 united states
TNF? and IFN? but not perforin are critical for CD8 T cell-mediated protection against pulmonary Yersinia pestis infection. PLoS Pathog 2014 united states
Human IgG Fc domain engineering enhances antitoxin neutralizing antibody activity. J Clin Invest 2014 united states
Upolu virus and Aransas Bay virus, two presumptive bunyaviruses, are novel members of the family Orthomyxoviridae. J Virol 2014 united states
Selective association of outer surface lipoproteins with the lipid rafts of Borrelia burgdorferi. MBio 2014 united states
Multiplex PCR analysis of clusters of unexplained viral respiratory tract infection in Cambodia. Virol J 2014 england
Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity. Cell 2014 united states
Hantavirus interferon regulation and virulence determinants. Virus Res 2014 netherlands
Viral surveillance and discovery. Curr Opin Virol 2013 netherlands
Modulation of innate immune responses by Yersinia type III secretion system translocators and effectors. Cell Microbiol 2013 england
Combinations of monoclonal antibodies to anthrax toxin manifest new properties in neutralization assays. Infect Immun 2013 united states
Asparagine substitution at PB2 residue 701 enhances the replication, pathogenicity, and transmission of the 2009 pandemic H1N1 influenza A virus. PLoS One 2013 united states
Bats are a major natural reservoir for hepaciviruses and pegiviruses. Proc Natl Acad Sci U S A 2013 united states
SAVI: a statistical algorithm for variant frequency identification. BMC Syst Biol 2013 england
Characterization of the Uukuniemi virus group (Phlebovirus: Bunyaviridae): evidence for seven distinct species. J Virol 2013 united states
Identification of a region in the stalk domain of the nipah virus receptor binding protein that is critical for fusion activation. J Virol 2013 united states
A mutation in the Ebola virus envelope glycoprotein restricts viral entry in a host species- and cell-type-specific manner. J Virol 2013 united states
An upstream open reading frame modulates ebola virus polymerase translation and virus replication. PLoS Pathog 2013 united states
Slit2-Robo4 receptor responses inhibit ANDV directed permeability of human lung microvascular endothelial cells. Antiviral Res 2013 netherlands
A prospective study of agents associated with acute respiratory infection among young American Indian children. Pediatr Infect Dis J 2013 united states
Genomic analysis of coxsackieviruses A1, A19, A22, enteroviruses 113 and 104: viruses representing two clades with distinct tropism within enterovirus C. J Gen Virol 2013 england
Autophagy and bacterial infection: an evolving arms race. Trends Microbiol 2013 england
MX2 is an interferon-induced inhibitor of HIV-1 infection. Nature 2013 england
The pvc operon regulates the expression of the Pseudomonas aeruginosa fimbrial chaperone/usher pathway (cup) genes. PLoS One 2013 united states
Use of staged molecular analysis to determine causes of unexplained central nervous system infections. Emerg Infect Dis 2013 united states
Genomic analysis of two novel human enterovirus C genotypes found in respiratory samples from Peru. J Gen Virol 2013 england
Discovery of a unique novel clade of mosquito-associated bunyaviruses. J Virol 2013 united states
Bacterial Toxins-Staphylococcal Enterotoxin B. Microbiol Spectr 2013 united states
Staphylococcal Enterotoxin B-specific monoclonal antibody 20B1 successfully treats diverse Staphylococcus aureus infections. J Infect Dis 2013 united states
A chimeric vesiculo/alphavirus is an effective alphavirus vaccine. J Virol 2013 united states
Flaviviruses: braking the entering. Curr Opin Virol 2013 netherlands
Identification of rodent homologs of hepatitis C virus and pegiviruses. MBio 2013 united states
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways. Trends Microbiol 2013 england
Role of vascular and lymphatic endothelial cells in hantavirus pulmonary syndrome suggests targeted therapeutic approaches. Lymphat Res Biol 2013 united states
Serotype analysis of Streptococcus pneumoniae in lung and nasopharyngeal aspirates from children in the Gambia by MassTag PCR. J Clin Microbiol 2013 united states
Intranasal prophylaxis with CpG oligodeoxynucleotide can protect against Yersinia pestis infection. Infect Immun 2013 united states
The HtrA protease of Borrelia burgdorferi degrades outer membrane protein BmpD and chemotaxis phosphatase CheX. Mol Microbiol 2013 england
Identification of a pegivirus (GB virus-like virus) that infects horses. J Virol 2013 united states
Hypoxia induces permeability and giant cell responses of Andes virus-infected pulmonary endothelial cells by activating the mTOR-S6K signaling pathway. J Virol 2013 united states
Coronaviruses in bats from Mexico. J Gen Virol 2013 england
Induction of cross-reactive antibodies to novel H7N9 influenza virus by recombinant Newcastle disease virus expressing a North American lineage H7 subtype hemagglutinin. J Virol 2013 united states
Project Title: Northeast biodefense center
Project Number: 5U54AI057158-09
Project web address: Follow on NIH
Title Phase Year