Igf::ot::igf high-plex pharmacodynamic biomarker assay

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Project Title: Igf::ot::igf high-plex pharmacodynamic biomarker assay
Project Number: 261201500003I-0-26100055-1
Project web address: Follow on NIH
 
Project Description:
Pharmacodynamics is the drug-induced response of a biological system and it can be assessed and quantitated using molecular, physiological and medical imaging techniques. As part of DCTD?s support for targeted cancer therapies, it is necessary to develop useful and reliable assays that can guide drug development and be used to understand the biochemical changes that are part of the evaluation of drug response in clinical trial patients. This project supports the design, development, validation and demonstration of fitness-for-purpose of a new multiplex assay for the analysis and quantitation of important biological markers of tumor cell death or survival. These robust assays will be created to support testing of humor tumor biopsies collected during the conduct of human clinical trials and will investigate the linkage between ER stress, oxidative DNA damage and repair, and tumor cell death.
 
Project Terms:
affect algorithmic analysis antibodies apoptosis biochemical biological assay biological markers biological systems biological tumor markers biopsy cancer cell cell death cell survival clinical clinical trials complex design detection development dna repair drug development drug evaluation endoplasmic reticulum stress epithelial fitness functional imaging histology human humor image analysis imaging techniques laboratories link measures medical imaging meiosis membrane mesenchymal mismatch repair modeling molecular imaging necrosis needles neoplastic cell oxidases oxidative dna damage patients pharmaceutical preparations pharmacodynamic biomarker pharmacodynamics repaired reproducibility response sampling stemness stress system targeted cancer therapy technology technology transfer testing tumor tumor immunity united states national institutes of health validation
Project Title: Igf::ot::igf high-plex pharmacodynamic biomarker assay
Project Number: 261201500003I-0-26100055-1
Project web address: Follow on NIH
Organization: Leidos Biomedical Research, Inc., United States, Maryland, FREDERICK
Principal Investigators (PI): Parchment Ralph, US
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2017
Project Start Date: 21 September 2017
Project End Date: 20 September 2022
 
Project Funding Information:
Funding Mechanism: Non SBIR/STTR Contracts
Year Funding Organization Total Funding, $
2017 NIH - National Cancer Institute $25,266,647
Project Title: Igf::ot::igf high-plex pharmacodynamic biomarker assay
Project Number: 261201500003I-0-26100055-1
Project web address: Follow on NIH
 
Title FY Funding
There are no results for this project in database.
Project Title: Igf::ot::igf high-plex pharmacodynamic biomarker assay
Project Number: 261201500003I-0-26100055-1
Project web address: Follow on NIH
 
Project Title Organization FY Funding
Igf::Ot::Igf High-Plex Pharmacodynamic Biomarker AssayLeidos Biomedical Research, Inc.2017$25,266,647
Canine Immuno-OncologyLeidos Biomedical Research, Inc.2017$18,408,319
Igf::Ot::Igf Discovery Of Novel Drug Combinations For Clinical DevelopmentLeidos Biomedical Research, Inc.2016$2,700,568
Igf::Ot::Igf Dctd Tumor Tissue AcquisitionLeidos Biomedical Research, Inc.2016$2,582,405
Project Title: Igf::ot::igf high-plex pharmacodynamic biomarker assay
Project Number: 261201500003I-0-26100055-1
Project web address: Follow on NIH
 
Title Journal Year Country Rel
Project Title: Igf::ot::igf high-plex pharmacodynamic biomarker assay
Project Number: 261201500003I-0-26100055-1
Project web address: Follow on NIH
 
Title Year
Project Title: Igf::ot::igf high-plex pharmacodynamic biomarker assay
Project Number: 261201500003I-0-26100055-1
Project web address: Follow on NIH
 
Title Phase Year