National biomedical information services

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Project Title: National biomedical information services
Project Number: 1ZIHLM200888-05
Project web address: Follow on NIH
Project Description:
Delivering Biomedical Information Services In FY13, NLM expanded the quantity and range of high quality information available to researchers, health professionals, and the public. Among the NLM's intramural programs that contribute to its national biomedical information services are the following examples: PubMed/MEDLINE: PubMed, which incorporates MEDLINE, is NLM's premier bibliographic database with over 23 million references to biomedical journal articles. MEDLINE articles are indexed by experts using the Medical Subject Headings (MeSH) controlled vocabulary, updated annually. In FY13, more than 700,000 new indexed citations were added. Also in FY13, NLM expanded the use of automated indexing technology to increase efficiency. PubMed Central: The PubMed Central archive of over 2.8 million full-text journal articles is central to the NIH effort to make accessible the published results of research it supports. In FY13, NLM introduced PubReader, an innovative interface designed to enhance readability and navigation of articles in PMC, particularly on tablet and other small screen devices. MedlinePlus and MedlinePlus en espanol: These consumer health information resources cover more than 900 topics, in more than 40 languages. MedlinePlus Connect, linking electronic health records to MedlinePlus drug information and health topics by leveraging standardized codes and vocabularies required for meaningful use, was expanded in FY13. Clinical Trials: covers more than 150,000 clinical research studies in nearly 180 countries, with hundreds added weekly. It also contains summary information about trial results, including adverse effects, in accordance with the FDA Amendments Act of 2007 (PL 110-85). In FY13, more than 18,500 new trials were registered. Summary results, including adverse event information, of more than 2000 trials were also added, bringing the total summary results to more than 10,000. Toxicology and Environmental Health: Toxicology Data Network (TOXNET) is a primary reference for toxicologists, poison control centers, public health administrators, physicians and other environmental health professionals, and includes databases such as TOXLINE, GENE-TOX, Toxic Release Inventory, Hazardous Substances Data Bank (HSDB), and LiverTox, produced with NIDDK. In FY13, NLM continued efforts to expand information about the effects of nanomaterials. Drug Information Resources: Drug information resources include DailyMed and Pillbox. DailyMed provides medication content and labeling information from medical package inserts for more than 55,000 marketed drugs. Pillbox enables rapid identification of unknown solid-dosage medications based on physical characteristics and high-resolution images. Both are linked to NLM's RxNorm standard drug names. Disaster Preparedness and Response: NLM's Disaster Information Management Research Center facilitates access to disaster information, promotes effective use of libraries and disaster information specialists for disaster management, and supports initiatives to ensure uninterrupted access to critical health information resources when disasters occur. A continuing collaboration with the Bethesda Hospital Emergency Preparedness Partnership (BHEPP) provides backup communication systems and tools for patient tracking, information access, and responder training. DIMRC produces WISER, CHEMM, and REMM, emergency responder tools for hazardous materials (Hazmat) and chemical, biological, radiological, and nuclear (CBRN) incidents. Molecular Biology, Bioinformatics, and Human Genome Resources: NCBI resources include more than 40 integrated molecular biology databases and bioinformatics software tools such as GenBank, Entrez, BLAST, RefSeq, dbGAP, Genomes, Genetic Testing Registry, the NCBI software toolkit, and MedGen released in FY13. NCBI also provides access to PubMed, PubMed Central, and the Books database. Continuing areas of emphasis in FY13 included addressing the impact of enormous quantities of data emanating from high throughput sequencing and microarrays; improving methodology for representing mammalian genome assemblies; organizing data from genome-wide association studies; and enhancing the interfaces to journal literature retrieval to facilitate search and discovery. NCBI also began pilot projects with CDC and FDA to apply whole genome sequencing for real-time monitoring and investigation of outbreaks of food borne illness. Outreach: Promoting Public Awareness and Access Consumer health websites and the NIH MedlinePlus Magazine, in English and Spanish, transmit the latest useful research findings in lay language. NLM outreach programs enhance awareness of its information services, with emphasis on underserved populations, including African American, Hispanic, and Native American communities, as well as health professionals serving minority populations and practicing in rural and inner city communities. In FY13, dozens of community-based projects were funded. Health Services Research NICHSR promotes access to public health and health services research through such information systems as: HSRProj, a database of more than 9000 health services research projects from more than 110 funding organizations; HSRR, a database of research datasets, instruments and software relevant to health services research; and HSTAT, a full-text database of high quality evidence reports, guidelines, technology assessments, consensus statements, and treatment protocols. Structured search queries are developed to aid in searching PubMed,, and HSRProj for information on health services research, comparative effectiveness, health disparities, and HealthyPeople 2020 objectives. Advanced Information Systems and Research Tools In FY13, LHC and NCBI continued to conduct research in biomedical informatics and computational biology, tested the effectiveness of medical informatics interventions, and developed new scientific computing tools. To cite a few examples, intramural researchers developed tools that support standards-based personal health records; released a new set of high resolution pill-images for use in advanced imaging research; applied natural language processing methods to extract information from biomedical literature and to triage and answer certain types of inquiries from the general public; designed improved methods for integrated search and discovery across multiple databases; and provided expertise for the trans-NIH Big Data to Knowledge (BD2K) initiative to increase data sharing make research data more broadly available, useful, discoverable, and linked to the scientific literature. Health Data Standards: As the central coordinating body for clinical terminology standards within HHS, NLM supports nationwide implementation of an interoperable health information technology infrastructure and provides essential tools for meaningful use of electronic health records (EHRs). NLM develops, supports, or licenses for free US-wide use the key clinical terminologies designated as standards for U.S. health information exchange. The Unified Medical Language System Metathesaurus, with more than 11 million concept names from more than 160 vocabularies, is a distribution mechanism for standard code sets and vocabularies used in health data systems. NLM also produces RxNorm, a standard clinical drug vocabulary; supports the LOINC nomenclature for laboratory tests and patient observations; and promotes international adoption of the SNOMED CT clinical terminology. In FY13, In FY13, NLM released a new Value Set Authority Center that to provide ready access to vocabulary value sets for CMS-required clinical quality measures, expanded drug class information released with RxNorm, released a new US edition of SNOMED CT that combines the international
Project Terms:
address administrator adoption adverse effects adverse event african american amendment archives area authority automated indexing awareness base bibliographic databases bioinformatics biological biomedical informatics biomedical information system biotechnology books centers for disease control and prevention (u.s.) characteristics chemicals clinical clinical practice guideline clinical research clinical trials code collaborations collection communication communities comparative effectiveness computational biology computer software consensus controlled vocabulary country data data set databases design development devices disasters disease outbreaks dosage drug market drug standard effectiveness electronic health record emergency situation ensure environmental health family foodborne illness fostering funding genbank general population genetic screening method genome genome sequencing genome wide association study genomics goals guidelines hazardous substances health health disparity health information technology health literacy health policy health professional health sciences health services research health technology healthcare hispanics hospitals human genome image imagery improve access improved indexing information centers information dissemination information management information resources information services information specialists information systems inner city innovation instrument international intervention intramural research program investigation journal article journals knowledge knowledge base label laboratories language language processing libraries licensing link literature logical observation identifiers names and codes mammalian genome measures medical medical informatics medline medlineplus mesh thesaurus metathesaurus methodology methods minority molecular biology monitor names nanomaterials national institute of diabetes and digestive and kidney diseases native americans natural language processing nomenclature nuclear outreach outreach program package insert patient observation patients personal health records pharmaceutical preparations physicians pill pilot projects play poison control centers policy maker population practice guidelines process public health publishing pubmed readability readiness registries reporting research research and development research infrastructure research personnel research project grants research study resolution resources response retrieval role rural scientific computing sharing data snomed clinical terms software tools solid speed structure system systems research tablets technology technology assessment terminology testing text time tool toxicology toxicology data network toxics release inventory training treatment protocols triage underserved population unified medical language system united states national institutes of health united states national library of medicine update vocabulary web site bioengineering genetics health services prevention
Project Title: National biomedical information services
Project Number: 1ZIHLM200888-05
Project web address: Follow on NIH
Organization: National Library Of Medicine, United States, Maryland, BETHESDA
Principal Investigators (PI): Humphreys Betsy, US
Project Categories:
Natural Sciences
Other Information:
Fiscal Year: 2013
Project Start Date: 1 January 2013
Project End Date: 31 December 2014
Project Funding Information:
Funding Mechanism: Intramural Research
Year Funding Organization Total Funding, $
2013 NIH - National Library Of Medicine $263,817,945
Project Title: National biomedical information services
Project Number: 1ZIHLM200888-05
Project web address: Follow on NIH
Title FY Funding
There are no results for this project in database.
Project Title: National biomedical information services
Project Number: 1ZIHLM200888-05
Project web address: Follow on NIH
Title Journal Year Country Rel
Update on Trial Registration 11 Years after the ICMJE Policy Was Established. N Engl J Med 2017 united states
Assigning factuality values to semantic relations extracted from biomedical research literature. PLoS One 2017 united states
Data Sharing Statements for Clinical Trials: A Requirement of the International Committee of Medical Journal Editors. JAMA 2017 united states
A curated catalog of canine and equine keratin genes. PLoS One 2017 united states
Comparing High Definition Live Interactive and Store-and-Forward Consultations to In-Person Examinations. Telemed J E Health 2017 united states
Concern noted: A descriptive study of editorial expressions of concern in PubMed and PubMed Central. Res Integr Peer Rev 2017 england
Progress in promoting data sharing in public health emergencies. Bull World Health Organ 2017 switzerland
Patient and Provider Satisfaction with Teledermatology. Telemed J E Health 2017 united states
Analyzing structural changes in SNOMED CT's Bacterial infectious diseases using a visual semantic delta. J Biomed Inform 2017 united states
DangerTrack: A scoring system to detect difficult-to-assess regions. F1000Res 2017 england
Quickly identifying identical and closely related subjects in large databases using genotype data. PLoS One 2017 united states
Teaching and Researching the History of Medicine in the Era of (Big) Data: Introduction. Med Hist 2017 england
A systematic approach for studying the signs and symptoms of fever in adult patients: the fever assessment tool (FAST). Health Qual Life Outcomes 2017 england
Improving precision medicine using individual patient data from trials. CMAJ 2017 canada
The dbGaP data browser: a new tool for browsing dbGaP controlled-access genomic data. Nucleic Acids Res 2017 england
Assessing the usability by clinicians of VISION: A hierarchical display of patient-collected physiological information to clinicians. BMC Med Inform Decis Mak 2017 england
Harnessing scientific literature reports for pharmacovigilance. Prototype software analytical tool development and usability testing. Appl Clin Inform 2017 germany
Extending TCGA queries to automatically identify analogous genomic data from dbGaP. F1000Res 2017 england
Rational confederation of genes and diseases: NGS interpretation via GeneCards, MalaCards and VarElect. Biomed Eng Online 2017 england
Big Data Science: Opportunities and Challenges to Address Minority Health and Health Disparities in the 21st Century. Ethn Dis 2017 united states
Biomedical informatics advancing the national health agenda: the AMIA 2015 year-in-review in clinical and consumer informatics. J Am Med Inform Assoc 2017 england
Meta-analysis on the effect of text message reminders for HIV-related compliance. AIDS Care 2017 england
Managing Sequence Data. Methods Mol Biol 2017 united states
GenBank. Nucleic Acids Res 2017 england
Whole Genome Sequencing of the Braconid Parasitoid Wasp Fopius arisanus, an Important Biocontrol Agent of Pest Tepritid Fruit Flies. G3 (Bethesda) 2017 united states
Evaluation of Android Smartphones for Telepathology. J Pathol Inform 2017 india
Principles and Recommendations for Standardizing the Use of the Next-Generation Sequencing Variant File in Clinical Settings. J Mol Diagn 2017 united states
Atlas-based rib-bone detection in chest X-rays. Comput Med Imaging Graph 2016 united states
Using ClinVar as a Resource to Support Variant Interpretation. Curr Protoc Hum Genet 2016 united states
GenBank. Nucleic Acids Res 2016 england
The International Nucleotide Sequence Database Collaboration. Nucleic Acids Res 2016 england
Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation. Nucleic Acids Res 2016 england
ClinVar: public archive of interpretations of clinically relevant variants. Nucleic Acids Res 2016 england
Assembly: a resource for assembled genomes at NCBI. Nucleic Acids Res 2016 england
Database resources of the National Center for Biotechnology Information. Nucleic Acids Res 2016 england
Preparing for the ICD-10-CM Transition: Automated Methods for Translating ICD Codes in Clinical Phenotype Definitions. EGEMS (Wash DC) 2016 united states
The Drug Data to Knowledge Pipeline: Large-Scale Claims Data Classification for Pharmacologic Insight. AMIA Jt Summits Transl Sci Proc 2016 united states
Interoperability between phenotypes in research and healthcare terminologies--Investigating partial mappings between HPO and SNOMED CT. J Biomed Semantics 2016 england
ClinGen--the Clinical Genome Resource. N Engl J Med 2015 united states
Evaluation of a smartphone for telepathology: Lessons learned. J Pathol Inform 2015 india
Sizing the Problem of Improving Discovery and Access to NIH-Funded Data: A Preliminary Study. PLoS One 2015 united states
NCBI viral genomes resource. Nucleic Acids Res 2015 england
Gene: a gene-centered information resource at NCBI. Nucleic Acids Res 2015 england
CDD: NCBI's conserved domain database. Nucleic Acids Res 2015 england
RefSeq microbial genomes database: new representation and annotation strategy. Nucleic Acids Res 2015 england
Ebola outbreak response: the role of information resources and the National Library of Medicine. Disaster Med Public Health Prep 2015 england
An update on the use of health information technology in newborn screening. Semin Perinatol 2015 united states
RefSeq curation and annotation of antizyme and antizyme inhibitor genes in vertebrates. Nucleic Acids Res 2015 england
GenBank. Nucleic Acids Res 2015 england
Transforming consumer health informatics: connecting CHI applications to the health-IT ecosystem. J Am Med Inform Assoc 2015 england
cddApp: a Cytoscape app for accessing the NCBI conserved domain database. Bioinformatics 2015 england
Type material in the NCBI Taxonomy Database. Nucleic Acids Res 2015 england
Update on RefSeq microbial genomes resources. Nucleic Acids Res 2015 england
An exploration of the properties of the CORE problem list subset and how it facilitates the implementation of SNOMED CT. J Am Med Inform Assoc 2015 england
Extending the coverage of phenotypes in SNOMED CT through post-coordination. Stud Health Technol Inform 2015 netherlands
The 2015 Nucleic Acids Research Database Issue and molecular biology database collection. Nucleic Acids Res 2015 england
Feature engineering for MEDLINE citation categorization with MeSH. BMC Bioinformatics 2015 england
Mouse genome annotation by the RefSeq project. Mamm Genome 2015
Supporting interoperability of genetic data with LOINC. J Am Med Inform Assoc 2015 england
RefSeq: an update on mammalian reference sequences. Nucleic Acids Res 2014 england
LabeledIn: cataloging labeled indications for human drugs. J Biomed Inform 2014 united states
Current status and new features of the Consensus Coding Sequence database. Nucleic Acids Res 2014 england
GenBank. Nucleic Acids Res 2014 england
Locus Reference Genomic: reference sequences for the reporting of clinically relevant sequence variants. Nucleic Acids Res 2014 england
PubChem applications in drug discovery: a bibliometric analysis. Drug Discov Today 2014 england
RefSeq microbial genomes database: new representation and annotation strategy. Nucleic Acids Res 2014 england
Toward richer metadata for microbial sequences: replacing strain-level NCBI taxonomy taxids with BioProject, BioSample and Assembly records. Stand Genomic Sci 2014 england
Virus Variation Resource--recent updates and future directions. Nucleic Acids Res 2014 england
Standardized metadata for human pathogen/vector genomic sequences. PLoS One 2014 united states
A framework for assessing the consistency of drug classes across sources. J Biomed Semantics 2014 england
Feature engineering and a proposed decision-support system for systematic reviewers of medical evidence. PLoS One 2014 united states
Analyzing U.S. prescription lists with RxNorm and the ATC/DDD Index. AMIA Annu Symp Proc 2014 united states
QNOTE: an instrument for measuring the quality of EHR clinical notes. J Am Med Inform Assoc 2014 united states
NCBI's Database of Genotypes and Phenotypes: dbGaP. Nucleic Acids Res 2014 england
Finding needles in haystacks: linking scientific names, reference specimens and molecular data for Fungi. Database (Oxford) 2014 england
ClinVar: public archive of relationships among sequence variation and human phenotype. Nucleic Acids Res 2014 england
Privacy protection during internet search for health-related information. JAMA Intern Med 2014 united states
Using semantic predications to uncover drug-drug interactions in clinical data. J Biomed Inform 2014 united states
Improvements to pairwise sequence comparison (PASC): a genome-based web tool for virus classification. Arch Virol 2014
Phenotype-Genotype Integrator (PheGenI): synthesizing genome-wide association study (GWAS) data with existing genomic resources. Eur J Hum Genet 2014 england
Genomic standards consortium projects. Stand Genomic Sci 2014 england
BLAST: a more efficient report with usability improvements. Nucleic Acids Res 2013 england
Medical concept representation: the years beyond 2000. Stud Health Technol Inform 2013 netherlands
Comparison and combination of several MeSH indexing approaches. AMIA Annu Symp Proc 2013 united states
Database resources of the National Center for Biotechnology Information. Nucleic Acids Res 2013 england
Automatic screening for tuberculosis in chest radiographs: a survey. Quant Imaging Med Surg 2013 china
IgBLAST: an immunoglobulin variable domain sequence analysis tool. Nucleic Acids Res 2013 england
Comparison of RefSeq protein-coding regions in human and vertebrate genomes. BMC Genomics 2013 england
A methodology for extending domain coverage in SemRep. J Biomed Inform 2013 united states
The NIH genetic testing registry: a new, centralized database of genetic tests to enable access to comprehensive information and improve transparency. Nucleic Acids Res 2013 england
Metrics for assessing the quality of value sets in clinical quality measures. AMIA Annu Symp Proc 2013 united states
Information-seeking trends of medical professionals and students from middle-income countries: a focus on the Philippines. Health Info Libr J 2013 england
Optimizing the txt2MEDLINE search portal for low-resource clinical decision support. AMIA Annu Symp Proc 2013 united states
GenBank. Nucleic Acids Res 2013 england
From concept representations to ontologies: a paradigm shift in health informatics? Healthc Inform Res 2013 korea (south)
Mobile app versus Web app: a comparison using 2008-2012 PubMed for Handhelds server data. AMIA Annu Symp Proc 2013 united states
NCBI Epigenomics: what's new for 2013. Nucleic Acids Res 2013 england
Mining MEDLINE for problems associated with vitamin D. AMIA Annu Symp Proc 2013 united states
The National Library of Medicine's Disaster Information Management Research Center. Front Public Health 2013 switzerland
Finding biomedical categories in Medline®. J Biomed Semantics 2012 england
Project Title: National biomedical information services
Project Number: 1ZIHLM200888-05
Project web address: Follow on NIH
Title Year
Project Title: National biomedical information services
Project Number: 1ZIHLM200888-05
Project web address: Follow on NIH
Title Phase Year