Immune monitoring and analysis of cancer at stanford (imacs)

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Project Title: Immune monitoring and analysis of cancer at stanford (imacs)
Project Number: 1U24CA224309-01
Project web address: Follow on NIH
 
Project Description:
IMMUNE MONITORING AND ANALYSIS OF CANCER AT STANFORD (IMACS) Abstract The Center for Immune Monitoring and Analysis of Cancer at Stanford (IMACS) will perform highly comprehensive assays of immune phenotype and function for NCI-­identified clinical trials. These will include standardized assays already developed on CyTOF, high-­dimensional flow cytometry, Luminex, TCRseq, and RNAseq platforms. As part of the program we will also standardize and offer as assays Stanford-­invented technologies under development, including Multiplexed Ion Beam Imaging (MIBI) and Assays of Transposon-­ Accessible Chromatin (ATAC-­seq). We have designed our center structure to work with investigators to define the assays best suited to the immunological questions being posed, and match these with the required sample types. We will perform quality control measures on all assays, as well as generate a standard report for each assay and project. Data will be organized via our online database, Stanford Data Miner, to ensure data longevity and transferability, as well as access to both raw data files and analyzed results. Finally, we will work with investigators on novel bioinformatics approaches to mining these high-­dimensional data sets. These will include approaches designed for a single data type (e.g., viSNE and Citrus for CyTOF and flow cytometry data), as well as approaches for integrating data across assays, using appropriate machine learning algorithms to aid NCI researchers in identifying immune hallmarks central to their trials. Relevance: The IMACS center will provide access to a suite of state-­of-­the-­art immune assays, many of them developed or refined at Stanford. This unmatched set of technologies will facilitate the discovery of new biomarkers for predicting cancer outcome or therapeutic response, as well as defining potential new mechanisms of immune control of cancer.
 
Project Terms:
adaptive immune system algorithms alpha cell archives bioinformatics biological assay cancer clinical trial cancer control cells chromatin citrus clinical clinical trials complex custom cytokine data data files data set databases design development disease ensure epigenetic process experience flow cytometry genomics health high dimensionality human image image reconstruction immune immunologic monitoring immunologics immunology procedure informatics innovation interest longevity machine learning malignant neoplasms measures methods mining multiplexed ion beam imaging nature network-based new technology next generation novel operation outcome phenotype population predictive marker programs quality control reporting research research personnel response sampling specimen standardization structure technology tissues transcriptome sequencing treatment response work
Project Title: Immune monitoring and analysis of cancer at stanford (imacs)
Project Number: 1U24CA224309-01
Project web address: Follow on NIH
Organization: Stanford University, United States, California, STANFORD
Principal Investigators (PI): Maecker Holden T, US
Bendall Sean Curtis, US
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2017
Project Start Date: 30 September 2017
Project End Date: 31 August 2022
Project program: Resource-Related Research Projects--Cooperative Agreements
 
Project Funding Information:
Funding Mechanism: OTHER RESEARCH-RELATED
Year Funding Organization Total Funding, $
2017 NIH - National Cancer Institute $12,560,000
Project Title: Immune monitoring and analysis of cancer at stanford (imacs)
Project Number: 1U24CA224309-01
Project web address: Follow on NIH
 
Title FY Funding
There are no results for this project in database.
Project Title: Immune monitoring and analysis of cancer at stanford (imacs)
Project Number: 1U24CA224309-01
Project web address: Follow on NIH
 
Project Title Organization FY Funding
Immune Monitoring And Analysis Of Cancer At Stanford (Imacs)Stanford University2017$12,560,000
Project Title: Immune monitoring and analysis of cancer at stanford (imacs)
Project Number: 1U24CA224309-01
Project web address: Follow on NIH
 
Title Journal Year Country Rel
Project Title: Immune monitoring and analysis of cancer at stanford (imacs)
Project Number: 1U24CA224309-01
Project web address: Follow on NIH
 
Title Year
Project Title: Immune monitoring and analysis of cancer at stanford (imacs)
Project Number: 1U24CA224309-01
Project web address: Follow on NIH
 
Title Phase Year