Whole genome sequencing in ethnically diverse cohorts for the adsp follow-up study (fus)

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Project Title: Whole genome sequencing in ethnically diverse cohorts for the adsp follow-up study (fus)
Project Number: 1U01AG057659-01
Project web address: Follow on NIH
 
Project Description:
PROJECT SUMMARY The Alzheimer?s Disease Sequencing Project (ADSP) is a national sequencing initiative focused on identifying genetic risk and protective factors for Alzheimer?s Disease (AD) in an effort to identify new pathways for prevention and new targets for drug development. The projects? discovery phase included whole exome sequencing (WES) of 10,914 unrelated cases (N=5,778) and controls (N=5,136) and whole genome sequencing (WGS) of 1,019 familial samples. A majority of these samples are non-Hispanic white (NHW) in origin, making the addition of ethnically diverse samples to the study critical to identification of both shared and novel genetic risk factors for AD between populations. This ethnic diversity was emphasized in the ?ADSP Follow-Up Study (FUS) Phase? planning stage with a directive that additional existing cohorts with unrelated AD cases that ?encompass the richest possible ethnic diversity? be given the highest priority for inclusion. To fulfill the goals of this RFA and this FUS Phase Mandate, this proposal identifies seven existing elderly cohorts of African-American (AA) and pan-HI ancestry with a total of 10,430 samples (N=2,322 AA AD cases and 1,843 AA controls and 2,928 Hispanic AD cases and 2,875 Hispanic controls) for WGS and processing in collaboration with existing NIH-funded AD infrastructure. Combining these cohorts with existing African America (AA) and Hispanic (HI) sequencing from the Washington Heights-Hamilton Heights-Inwood Community Aging Project (WHICAP), the Alzheimer?s Disease Genetics Consortium (ADGC) and the ADSP will provide large ethnically diverse datasets for both validation of ADSP discovery phase findings and discovery of novel risk and/or protective variants for AD. Importantly, these data will allow for admixture mapping, a powerful method of gene mapping for diseases that show differential risk by ancestry, by comparing allele frequency differences between populations. They will also become an invaluable resource for the AD research community at-large, and will help to address the health disparities that contribute to AA and HI populations having higher rates of AD than NHW. Thus, we will address these important issues by creating a large dataset of AA and pan-HI AD cases and controls for study. Specifically we propose to: 1) increase the ethnic diversity of the ADSP by assembling samples from existing cohorts with AA and HI AD cases and controls; 2) collaborate with the National Cell Repository for Alzheimer?s Disease (NCRAD) in assemblage, storage, and distribution of DNA on these cohorts; 3) generating genome-wide SNP array data and WGS for all collected samples; and 4) collaborate with the NIA Genetics of Alzheimer?s Disease Data Storage Site (NIAGADS) and The Genome Center for Alzheimer?s Disease (GCAD) in processing, quality controls, storage and distribution of the final datasets. Our overall goal is to enhance the discovery of AD risk factors by facilitating research on AD in ethnically diverse datasets.
 
Project Terms:
address adjudicate admixture mapping african african american aging alzheimer's disease alzheimer's disease risk americas case control case-control studies cells chromosome mapping clinical data cohort collaborations communities data data set data storage and retrieval database of genotypes and phenotypes disease dna drug development elderly ethnic diversity exome sequencing follow-up studies funding gene frequency genetic genetic risk genetic risk factor genetic variant genome genome sequencing genome-wide genotype goals health health disparity hereditary disease hispanics human genomics individual institutes late onset alzheimer disease methods mexican multi-ethnic study of atherosclerosis national institute on aging new therapeutic target new york not hispanic or latino novel participant pathway interactions phase phenotype population prevention production puerto rican quality control reasons for geographic and racial differences in stroke repository research research infrastructure resources risk risk factors sampling screening site snp array technology united states national institutes of health universities validation variant washington whole genome working group
Project Title: Whole genome sequencing in ethnically diverse cohorts for the adsp follow-up study (fus)
Project Number: 1U01AG057659-01
Project web address: Follow on NIH
Organization: University Of Miami School Of Medicine, United States, Florida, MIAMI
Principal Investigators (PI): Pericak-Vance Margaret A, US
Mayeux Richard P, US
Vardarajan Badri N, US
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology
 
Other Information:
Fiscal Year: 2017
Project Start Date: 30 September 2017
Project End Date: 31 August 2022
Project program: Research Project--Cooperative Agreements
 
Project Funding Information:
Funding Mechanism: Non-SBIR/STTR RPGs
Year Funding Organization Total Funding, $
2017 NIH - National Institute On Aging $11,819,206
Project Title: Whole genome sequencing in ethnically diverse cohorts for the adsp follow-up study (fus)
Project Number: 1U01AG057659-01
Project web address: Follow on NIH
 
Title FY Funding
There are no results for this project in database.
Project Title: Whole genome sequencing in ethnically diverse cohorts for the adsp follow-up study (fus)
Project Number: 1U01AG057659-01
Project web address: Follow on NIH
 
Project Title Organization FY Funding
Whole Genome Sequencing In Ethnically Diverse Cohorts For The Adsp Follow-Up Study (Fus)University Of Miami School Of Medicine2017$11,819,206
Project Title: Whole genome sequencing in ethnically diverse cohorts for the adsp follow-up study (fus)
Project Number: 1U01AG057659-01
Project web address: Follow on NIH
 
Title Journal Year Country Rel
Project Title: Whole genome sequencing in ethnically diverse cohorts for the adsp follow-up study (fus)
Project Number: 1U01AG057659-01
Project web address: Follow on NIH
 
Title Year
Project Title: Whole genome sequencing in ethnically diverse cohorts for the adsp follow-up study (fus)
Project Number: 1U01AG057659-01
Project web address: Follow on NIH
 
Title Phase Year