Prevention of alzheimer's disease in women: risks and benefits of hormone therapy

  • Description
  • Details
  • Subprojects
  • History
  • Publications
  • Patents
  • Trials
Project Title: Prevention of alzheimer's disease in women: risks and benefits of hormone therapy
Project Number: 1RF1AG057547-01
Project web address: Follow on NIH
 
Project Description:
PROJECT SUMMARY / ABSTRACT With the growing social and economic impact of dementia on the society, the emphasis is shifting from early diagnosis and treatment to the prevention of cognitive impairment and dementia. The social and economic implications of this epidemic will be greatest in women because of their longer life expectancy and elevated risk for dementia compared to men. Neuroprotective effects of estrogens offer the possibility of preventing or delaying mild cognitive impairment and dementia in postmenopausal women. However, oral conjugated equine estrogen treatment in older women who were more than a decade past their menopause did not prevent dementia, and there is controversy as to whether or not estrogen can preserve neurological function and decrease the risk of dementia when administered early in menopause defined as the ?critical window?. This project is proposed as a continuation to the Kronos Early Estrogen Prevention Study (KEEPS), a nationwide, multi-center, randomized blinded study of menopausal hormone therapy in newly postmenopausal women. Our objective is to assess the long-term risks and benefits of menopausal hormone therapy on Alzheimer's disease pathophysiology, cerebrovascular lesion load, cognitive and mood health in women who were treated with transdermal 17?-estradiol and oral conjugated equine estrogen compared to placebo within 36 months of their last menses; hypothesized as the ?critical window? for menopausal hormone therapy. Furthermore, we will investigate whether the Alzheimer's disease risk allele APOE ?4 and vascular risk factors influence the differences in A? deposition, brain structure, and cognition between each of the menopausal hormone therapy formulations and placebo, in order to provide insight into the mechanisms of cognitive and imaging biomarker changes associated with early menopausal hormone therapy. This project addresses an important and controversial problem regarding whether two commonly-used formulations of menopausal hormone therapy, administered during immediate postmenopausal years preserves cognition, neuronal integrity, and protects against cerebrovascular and Alzheimer's disease-related pathology. It is expected that the findings will hold the premise to significantly advance scientific knowledge and clinical practice by providing insight into the effects of early menopausal hormone therapy on long-term cognitive health.
 
Project Terms:
abeta deposition address age alzheimer disease prevention alzheimer's disease alzheimer's disease risk amyloid beta-protein attention auditory benefits and risks biological biological markers blinded blood vessels brain brain volume cerebrovascular cerebrovascular disorders cerebrovascular lesion clinical practice clinical trials cognition cognitive cognitive change cognitive performance conjugated equine estrogens data decision making dementia disorder prevention doctor of philosophy early diagnosis early treatment economic impact economic implication elderly enrollment epidemic estradiol estrogen therapy estrogens exposure to flexibility follow-up formulation functional disorder funding funding opportunities genotype health hormone therapy hormone use image imaging biomarker impaired cognition insight knowledge language life expectancy long-term effects magnetic resonance imaging measures memory men menopausal symptom menopause menstruation middle age mild cognitive impairment modeling moods nerve degeneration nervous system physiology neurons non-invasive imaging older women oral outcome participant pathology pharmaceutical preparations placebos population study positioning attribute positron-emission tomography postmenopause premature menopause prevent prevention prevention strategy preventive intervention primary outcome publishing randomized rate of change research risk risk factors risk variant safety scientific advances and accomplishments short-term memory site social impacts social implication societies speed structure time tnfrsf5 gene united states national institutes of health verbal learning visual attention white matter disease white matter hyperintensity woman women's health
Project Title: Prevention of alzheimer's disease in women: risks and benefits of hormone therapy
Project Number: 1RF1AG057547-01
Project web address: Follow on NIH
Organization: Mayo Clinic Rochester, United States, New York, Rochester
Principal Investigators (PI): Kantarci Kejal, US
Gleason Carey E, US
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology > Neurodegenerative diseases > Alzheimer's disease
 
Other Information:
Fiscal Year: 2017
Project Start Date: 15 September 2017
Project End Date: 30 June 2022
Project program: Multi-Year Funded Research Project Grant
 
Project Funding Information:
Funding Mechanism: Non-SBIR/STTR RPGs
Year Funding Organization Total Funding, $
2017 NIH - National Institute On Aging $10,638,873
Project Title: Prevention of alzheimer's disease in women: risks and benefits of hormone therapy
Project Number: 1RF1AG057547-01
Project web address: Follow on NIH
 
Title FY Funding
There are no results for this project in database.
Project Title: Prevention of alzheimer's disease in women: risks and benefits of hormone therapy
Project Number: 1RF1AG057547-01
Project web address: Follow on NIH
 
Project Title Organization FY Funding
Prevention Of Alzheimer'S Disease In Women: Risks And Benefits Of Hormone TherapyMayo Clinic Rochester2017$10,638,873
Project Title: Prevention of alzheimer's disease in women: risks and benefits of hormone therapy
Project Number: 1RF1AG057547-01
Project web address: Follow on NIH
 
Title Journal Year Country Rel
Project Title: Prevention of alzheimer's disease in women: risks and benefits of hormone therapy
Project Number: 1RF1AG057547-01
Project web address: Follow on NIH
 
Title Year
Project Title: Prevention of alzheimer's disease in women: risks and benefits of hormone therapy
Project Number: 1RF1AG057547-01
Project web address: Follow on NIH
 
Title Phase Year