Epidemiology of age-related dementia, mild cognitive impairment and brain pathology in a multiethnic cohort of oldest-old

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Project Title: Epidemiology of age-related dementia, mild cognitive impairment and brain pathology in a multiethnic cohort of oldest-old
Project Number: 1RF1AG056519-01
Project web address: Follow on NIH
 
Project Description:
Abstract Though life expectancy in the US has steadily increased and many people live to age 90 and beyond, health and quality of life is extremely poor for most. While Alzheimer's disease and related dementias (ADRD) affect 15% of those age 65+, by age 90+, this number increases to a startling 40-50%. The oldest-old (OO), people aged 90+, are the fastest growing segment of the elderly population in the US, currently comprising 4.7% and expected to increase to 11.5% by 2060. Yet there's an enormous dearth of information on the epidemiology of mild cognitive impairment (MCI) and ADRD in the OO, particularly in non-whites and those from lower socioeconomic classes. This is highly problematic as the proportion of non-white minorities is rapidly increasing and by 2060 will represent 36% of the OO. Dementia and MCI rates highly vary between ethnic groups at younger ages yet it is completely unknown if patterns are the same in the OO. Brain imaging and neuropathology studies so far in OO suggest that vascular pathologies, rather than AD, play a larger role in dementia, yet this hasn't been examined in non-Whites. Beyond the lack of demographic diversity in 90+ studies of OO, there is a paucity of information on early and midlife risk and protective factors for ADRD and brain pathology in OO. Lifecourse studies in the OO are imperative; yet very costly and logistically challenging since studies encompassing multiple decades are needed. Thus, careful investigation of lifecourse health and protective mechanisms is strongly needed in this high risk population to tease apart which factors, at what point in time, may protect an individual. We propose an unprecedented epidemiologic study of MCI and Dementia in the OO whom we have 30-50 years of prospectively collected life history and health data. Kaiser Permanente has an unparalleled cohort of almost 7121 individuals currently aged 90+ (36% Non-White) who participated in the Multiphasic Health Study (MHC) with baseline exams from 1964-1973, and follow-ups to 1991. These data, joined with granular electronic medical records from 1996?present provide an exceptional and comprehensive resource. Eight hundred MHC members aged 90+ (300 Black, 300 Asian, and 200 White) without dementia will enroll in a study of incident dementia and MCI. Structural MRI and Amyloid PET will be obtained on a random subsample of 200 individuals (75 Black, 75 Asian, 50 White) to characterize cerebral amyloid burden, vascular lesions, and atrophy. Brain donation for postmortem pathology will be sought from all 800 participants. Our overall objectives are to estimate incidence of dementia/MCI in a diverse cohort of OO, identify midlife and late-life risk and protective factors, and understand the pattern of cerebral and brain pathologies in this diverse OO population.
 
Project Terms:
ad pathology affect age age related aged aging brain alpha synuclein alzheimer disease prevention alzheimer's disease amyloid amyloid deposition asians atrophic autopsy blood vessels brain brain imaging brain pathology cerebrum clinical cohort computerized medical record cost data dementia education elderly enrollment epidemiology epidemiology study ethnic diversity ethnic group ethnic minority population etiology future health health data heterogeneity high risk population hippocampal sclerosis impaired cognition incidence individual infarction injury insight investigation knowledge lesion life life expectancy life history logistics magnetic resonance imaging mediating member middle age mild cognitive impairment minority neuropathology participant pathology pattern play population positron-emission tomography prevention prospective psychosocial factor quality of life race racial difference racial diversity resources risk risk factors role socioeconomics time tissues vascular factor white matter
Project Title: Epidemiology of age-related dementia, mild cognitive impairment and brain pathology in a multiethnic cohort of oldest-old
Project Number: 1RF1AG056519-01
Project web address: Follow on NIH
Organization: Kaiser Foundation Research Institute, United States, California, LOS ANGELES
Principal Investigators (PI): Whitmer Rachel A, US
Corrada Maria, US
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology > Neurodegenerative diseases > Alzheimer's disease
 
Other Information:
Fiscal Year: 2017
Project Start Date: 15 September 2017
Project End Date: 30 June 2022
Project program: Multi-Year Funded Research Project Grant
 
Project Funding Information:
Funding Mechanism: Non-SBIR/STTR RPGs
Year Funding Organization Total Funding, $
2017 NIH - National Institute On Aging $13,075,100
Project Title: Epidemiology of age-related dementia, mild cognitive impairment and brain pathology in a multiethnic cohort of oldest-old
Project Number: 1RF1AG056519-01
Project web address: Follow on NIH
 
Title FY Funding
There are no results for this project in database.
Project Title: Epidemiology of age-related dementia, mild cognitive impairment and brain pathology in a multiethnic cohort of oldest-old
Project Number: 1RF1AG056519-01
Project web address: Follow on NIH
 
Project Title Organization FY Funding
Epidemiology Of Age-Related Dementia, Mild Cognitive Impairment And Brain Pathology In A Multiethnic Cohort Of Oldest-OldKaiser Foundation Research Institute2017$13,075,100
Project Title: Epidemiology of age-related dementia, mild cognitive impairment and brain pathology in a multiethnic cohort of oldest-old
Project Number: 1RF1AG056519-01
Project web address: Follow on NIH
 
Title Journal Year Country Rel
Project Title: Epidemiology of age-related dementia, mild cognitive impairment and brain pathology in a multiethnic cohort of oldest-old
Project Number: 1RF1AG056519-01
Project web address: Follow on NIH
 
Title Year
Project Title: Epidemiology of age-related dementia, mild cognitive impairment and brain pathology in a multiethnic cohort of oldest-old
Project Number: 1RF1AG056519-01
Project web address: Follow on NIH
 
Title Phase Year