Prospective study of breast cancer survivorship

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Project Title: Prospective study of breast cancer survivorship
Project Number: 1R01CA105274-01A1
Project web address: Follow on NIH
 
Project Description:
Despite substantial lifestyle changes such as in diet or use of complementary and alternative medicine (CAM) among women with breast cancer, few studies have examined whether such factors improve prognosis. These factors may also influence quality of life, which may in turn influence prognosis. How these factors influence prognosis may depend in part on molecular characteristics such as genetic polymorphisms that influence oxidative damage or DNA repair, or aberrant DNA methylation which influences gene expression. These markers may themselves influence prognosis or interact with conventional therapies. We propose to address these gaps in knowledge by establishing the largest prospective cohort study of women with breast cancer to date. We will enroll at least 5,021 women with breast cancer from Kaiser Permanente of Northern California (KPNC). With extremely rapid case ascertainment through computerized pathology reports, we can identify cases of breast cancer as they are confirmed histologically, minimizing survival bias. We will interview and send questionnaires to participants, and extract data from medical charts and KPNC databases. Blood samples will be collected prior to treatment to characterize genetic polymorphisms, and tumor specimens will be obtained to examine aberrant DNA methylation. Blood samples and breast tumor DNAs will also be banked for future use. This resource will enable study of the effects on recurrence and survival of: 1) lifestyle factors, including diet, physical activity, use of CAM, and quality of life; and, 2) host and tumor molecular characteristics, including genetic polymorphisms (e.g., those involved in: cyclophosphamide (CYP3A4, GSTP1, GSTA1) or tamoxifen metabolism (SULTIA1); protection against oxidative damage (MnSOD, CAT, GPX1, GSTM1, GSTT1); and DNA repair (XRCC1, LIG4, XRCC3, XPD, ERCC1, APE1)), and aberrant DNA methylation of genes in breast tumors (BRCA1, P161NK4a, E-Cadherin, glypican3, DUTT1, HIC1, TSLC1, DAP-kinase, GSTP1). Using proportional hazards regression, we will examine associations of lifestyle factors and molecular markers on risk of recurrence and mortality; we estimate at least 599 recurrences and 331 deaths during the 5-year funding period. For survival, we will have power to detect a relative hazard of 1.64 comparing upper to lower quartiles of continuous exposures such as nutrient intake, and a relative hazard of 159 for an exposure with prevalence of 0.10. This study will provide some of the first information on these risk factors and breast cancer prognosis.
 
Project Terms:
long term survivor lifestyle neoplasm /cancer epidemiology neoplasm /cancer relapse /recurrence breast neoplasms nutrition aspect of cancer biomarker prognosis neoplasm /cancer genetics genetic susceptibility nucleic acid methylation longitudinal human study oxidative stress genetic polymorphism alternative medicine cancer registry /resource outcomes research nutrition related tag female human subject human genetic material tag clinical research women's health
Project Title: Prospective study of breast cancer survivorship
Project Number: 1R01CA105274-01A1
Project web address: Follow on NIH
Organization: Kaiser Foundation Research Institute, United States, California, LOS ANGELES
Principal Investigators (PI): Kushi Lawrence H, US
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology > Cancer & related diseases > Malignant neoplasms (including in situ) > Breast Cancer > Breast cancer, biomarkers
 
Other Information:
Fiscal Year: 2004
Project Start Date: 20 September 2004
Project End Date: 31 August 2009
Project program: Research Project
 
Project Funding Information:
Funding Mechanism: Research project grants
Year Funding Organization Total Funding, $
2004 NIH - National Cancer Institute $1,487,114
Project Title: Prospective study of breast cancer survivorship
Project Number: 1R01CA105274-01A1
Project web address: Follow on NIH
 
Title FY Funding
There are no results for this project in database.
Project Title: Prospective study of breast cancer survivorship
Project Number: 1R01CA105274-01A1
Project web address: Follow on NIH
 
Title Journal Year Country Rel
Association of Serum Level of Vitamin D at Diagnosis With Breast Cancer Survival: A Case-Cohort Analysis in the Pathways Study. JAMA Oncol 2017 united states
Body mass index, PAM50 subtype, recurrence, and survival among patients with nonmetastatic breast cancer. Cancer 2017 united states
Adiposity, post-diagnosis weight change, and risk of cardiovascular events among early-stage breast cancer survivors. Breast Cancer Res Treat 2017 netherlands
Impact of Social and Built Environment Factors on Body Size among Breast Cancer Survivors: The Pathways Study. Cancer Epidemiol Biomarkers Prev 2017 united states
BMI, Lifestyle Factors and Taxane-Induced Neuropathy in Breast Cancer Patients: The Pathways Study. J Natl Cancer Inst 2017 united states
Patterns and reasons for switching classes of hormonal therapy among women with early-stage breast cancer. Cancer Causes Control 2017 netherlands
Genetic Ancestry Is not Associated with Breast Cancer Recurrence or Survival in U.S. Latina Women Enrolled in the Kaiser Permanente Pathways Study. Cancer Epidemiol Biomarkers Prev 2017 united states
Oncologist and organizational factors associated with variation in breast cancer multigene testing. Breast Cancer Res Treat 2017 netherlands
Race/ethnicity, genetic ancestry, and breast cancer-related lymphedema in the Pathways Study. Breast Cancer Res Treat 2016 netherlands
Exercise and Prognosis on the Basis of Clinicopathologic and Molecular Features in Early-Stage Breast Cancer: The LACE and Pathways Studies. Cancer Res 2016 united states
Exercise and Risk of Cardiovascular Events in Women With Nonmetastatic Breast Cancer. J Clin Oncol 2016 united states
Breast cancer multigene testing trends and impact on chemotherapy use. Am J Manag Care 2016 united states
The impact of DNA input amount and DNA source on the performance of whole-exome sequencing in cancer epidemiology. Cancer Epidemiol Biomarkers Prev 2015 united states
Association of high obesity with PAM50 breast cancer intrinsic subtypes and gene expression. BMC Cancer 2015 england
Representativeness of breast cancer cases in an integrated health care delivery system. BMC Cancer 2015 england
Breastfeeding, PAM50 tumor subtype, and breast cancer prognosis and survival. J Natl Cancer Inst 2015 united states
Non-initiation and early discontinuation of adjuvant trastuzumab in women with localized HER2-positive breast cancer. Breast Cancer 2014 japan
Changes in vitamin and mineral supplement use after breast cancer diagnosis in the Pathways Study: a prospective cohort study. BMC Cancer 2014 england
Intrinsic subtypes from the PAM50 gene expression assay in a population-based breast cancer survivor cohort: prognostication of short- and long-term outcomes. Cancer Epidemiol Biomarkers Prev 2014 united states
Race and breast cancer survival by intrinsic subtype based on PAM50 gene expression. Breast Cancer Res Treat 2014 netherlands
Intrinsic subtypes from PAM50 gene expression assay in a population-based breast cancer cohort: differences by age, race, and tumor characteristics. Cancer Epidemiol Biomarkers Prev 2014 united states
Bone health history in breast cancer patients on aromatase inhibitors. PLoS One 2014 united states
Racial disparities in posttraumatic stress after diagnosis of localized breast cancer: the BQUAL study. J Natl Cancer Inst 2013 united states
Patient-physician interaction and quality of life in recently diagnosed breast cancer patients. Breast Cancer Res Treat 2013 netherlands
Interpersonal influences and attitudes about adjuvant therapy treatment decisions among non-metastatic breast cancer patients: an examination of differences by age and race/ethnicity in the BQUAL study. Breast Cancer Res Treat 2013 netherlands
A survey of breast cancer physicians regarding patient involvement in breast cancer treatment decisions. Breast 2013 netherlands
The Breast Cancer Quality of Care Study (BQUAL): a multi-center study to determine causes for noncompliance with breast cancer adjuvant therapy. Breast J 2012 united states
Racial/ethnic differences in initiation of adjuvant hormonal therapy among women with hormone receptor-positive breast cancer. Breast Cancer Res Treat 2012 netherlands
Change in physical activity during active treatment in a prospective study of breast cancer survivors. Breast Cancer Res Treat 2012 netherlands
Non-initiation of adjuvant hormonal therapy in women with hormone receptor-positive breast cancer: The Breast Cancer Quality of Care Study (BQUAL). Breast Cancer Res Treat 2012 netherlands
Noninitiation of adjuvant chemotherapy in women with localized breast cancer: the breast cancer quality of care study. J Clin Oncol 2012 united states
Associations of physical activity with quality of life and functional ability in breast cancer patients during active adjuvant treatment: the Pathways Study. Breast Cancer Res Treat 2011 netherlands
Parity and lactation in relation to estrogen receptor negative breast cancer in African American women. Cancer Epidemiol Biomarkers Prev 2011 united states
Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer. Breast Cancer Res Treat 2011 netherlands
Risk factors for lymphedema in a prospective breast cancer survivorship study: the Pathways Study. Arch Surg 2010 united states
Early discontinuation and nonadherence to adjuvant hormonal therapy in a cohort of 8,769 early-stage breast cancer patients. J Clin Oncol 2010 united states
Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake. PLoS Genet 2010 united states
A practical method for collecting food record data in a prospective cohort study of breast cancer survivors. Am J Epidemiol 2010 united states
Quality of life among women recently diagnosed with invasive breast cancer: the Pathways Study. Breast Cancer Res Treat 2010 netherlands
Complementary and alternative therapy use before and after breast cancer diagnosis: the Pathways Study. Breast Cancer Res Treat 2009 netherlands
Epidemiology of breast cancer subtypes in two prospective cohort studies of breast cancer survivors. Breast Cancer Res 2009 england
Differentiation of lung adenocarcinoma, pleural mesothelioma, and nonmalignant pulmonary tissues using DNA methylation profiles. Cancer Res 2009 united states
The Pathways Study: a prospective study of breast cancer survivorship within Kaiser Permanente Northern California. Cancer Causes Control 2008 netherlands
Lifestyle factors and survival in women with breast cancer. J Nutr 2007 united states
Project Title: Prospective study of breast cancer survivorship
Project Number: 1R01CA105274-01A1
Project web address: Follow on NIH
 
Title Year
Project Title: Prospective study of breast cancer survivorship
Project Number: 1R01CA105274-01A1
Project web address: Follow on NIH
 
Title Phase Year