Small-molecule inhibitor leads versus emerging and neglected rna viruses

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Project Title: Small-molecule inhibitor leads versus emerging and neglected rna viruses
Project Number: CORDIS-96747
Project web address: Follow on CORDIS
Organization: Universite D'Aix Marseille, France, Marseille
Collaborators: Katholieke Universiteit Leuven, BE
Freie Universität Berlin, DE
Centre National De La Recherche Scientifique, FR
Università Degli Studi Di Milano, IT
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
Universitaet Hamburg, DE
University Of Luebeck, DE
Univ Innsbruck, AT
Universität Leipzig, DE
Universiteit Utrecht, NL
Universitaetsklinikum Heidelberg, DE
Global Phasing Limited, GB
Agencia Estatal Consejo Superior De Investigaciones Cientificas, ES
Erasmus Universitair Medisch Centrum Rotterdam, NL
Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, CN
Academisch Ziekenhuis Leiden - Leids Universitair Medisch Centrum, NL
Institute Pasteur, FR
Stichting Katholieke Universiteit / Radboud University Medical Center, NL
Pike Pharma Gmbh, CH
Korea Research Institute Of Chemical Technology, KR
Centrum Voor Innovatie En Stimulatievan Medicijnontwikkeling Leuven Vzw, BE
National Central University,
Riboxx Gmbh, DE
Principal Investigators (PI): Gérard Bricogne, GB
Kurt Habitzel, AT
Linda Polik, GB
Thorsten Brietz, DE
Elke Lammertyn, BE
Jocelyn Mere, FR
Eusebio Jimenez Arroyo, ES
Nadia Khelef, FR
Celine Damon, FR
Ulrich Kessler, CH
Wim Van Oijen, NL
Stefania Varotto, IT
Gerhard Fuchs, DE
Carsten Malmwieck, DE
Wim Leep, NL
Youngjoo Ko, KR
Jianmei Shi, CN
Jens Bricke, DE
Marlien Vos, NL
Louise Van Der Kaaden, NL
Patrick Chaltin, BE
Yu-Jin Cheng,
Margret Schwab, DE
Jacques Rohayem, DE
 
Project Description:
RNA virus infections kill millions of humans annually, largely due to the lack of suitable vaccines and drugs to control them. This problem is addressed in this FP7 call and in response a consortium of Europe’s and Asia’s leading molecular virologists, structural biologists, medicinal chemists and bioinformaticians has been brought together to generate a state-of-the-art drug discovery and design programme. The project aims to identify Small molecule Inhibitor Leads Versus Emerging and neglected RNA viruses (SILVER). It will focus its activities on selected medically important RNA viruses for which the development of drugs is considered essential (Dengue-, entero- and paramyxoviruses), whereas other relatively neglected and/or emerging RNA viruses will be explored to identify the most promising viral protein targets and antiviral compounds. A pipeline strategy has been developed to enable the inclusion in SILVER of viruses at all levels of existing knowledge. Targets for potential drugs include infectious virus, structurally characterised viral enzymes and other proteins. Leads for currently available antiviral drugs have been identified by screening compound libraries in virus-infected cell culture systems and in vitro assays using purified viral enzymes. Selective inhibitors of viral replication have also been (and are being) derived using detailed structural knowledge of viral proteins and structure-based drug design. Hits will be assayed using individual viral protein targets and replicative proteins in complex with viral RNA. The potential protective activity of the most potent inhibitors, that have a favourable (in vitro) ADME-tox profile, will be assessed in relevant infection models in animals. Licenses on promising compounds or compound classes will be presented to the interested pharmaceutical industry. The SILVER consortium will be well placed to play a major role in contributing to the international effort to develop strategies to improve world health.
 
Project Terms:
medical biotechnology medicine and health
Project Title: Small-molecule inhibitor leads versus emerging and neglected rna viruses
Project Number: CORDIS-96747
Project web address: Follow on CORDIS
Organization: Universite D'Aix Marseille, France, Marseille
Collaborators: Katholieke Universiteit Leuven, BE
Freie Universität Berlin, DE
Centre National De La Recherche Scientifique, FR
Università Degli Studi Di Milano, IT
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
Universitaet Hamburg, DE
University Of Luebeck, DE
Univ Innsbruck, AT
Universität Leipzig, DE
Universiteit Utrecht, NL
Universitaetsklinikum Heidelberg, DE
Global Phasing Limited, GB
Agencia Estatal Consejo Superior De Investigaciones Cientificas, ES
Erasmus Universitair Medisch Centrum Rotterdam, NL
Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, CN
Academisch Ziekenhuis Leiden - Leids Universitair Medisch Centrum, NL
Institute Pasteur, FR
Stichting Katholieke Universiteit / Radboud University Medical Center, NL
Pike Pharma Gmbh, CH
Korea Research Institute Of Chemical Technology, KR
Centrum Voor Innovatie En Stimulatievan Medicijnontwikkeling Leuven Vzw, BE
National Central University,
Riboxx Gmbh, DE
Principal Investigators (PI): Gérard Bricogne, GB
Kurt Habitzel, AT
Linda Polik, GB
Thorsten Brietz, DE
Elke Lammertyn, BE
Jocelyn Mere, FR
Eusebio Jimenez Arroyo, ES
Nadia Khelef, FR
Celine Damon, FR
Ulrich Kessler, CH
Wim Van Oijen, NL
Stefania Varotto, IT
Gerhard Fuchs, DE
Carsten Malmwieck, DE
Wim Leep, NL
Youngjoo Ko, KR
Jianmei Shi, CN
Jens Bricke, DE
Marlien Vos, NL
Louise Van Der Kaaden, NL
Patrick Chaltin, BE
Yu-Jin Cheng,
Margret Schwab, DE
Jacques Rohayem, DE
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2010
Project Start Date: 1 October 2010
Project End Date: 31 March 2015
Project program: FP7-HEALTH
 
Project Funding Information:
Funding Mechanism: CP-IP - Large-scale integrating project
Year Funding Organization Total Funding, $
2010 European Research Council $24,089,713
Project Title: Small-molecule inhibitor leads versus emerging and neglected rna viruses
Project Number: CORDIS-96747
Project web address: Follow on CORDIS
Organization: Universite D'Aix Marseille, France, Marseille
Collaborators: Katholieke Universiteit Leuven, BE
Freie Universität Berlin, DE
Centre National De La Recherche Scientifique, FR
Università Degli Studi Di Milano, IT
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
Universitaet Hamburg, DE
University Of Luebeck, DE
Univ Innsbruck, AT
Universität Leipzig, DE
Universiteit Utrecht, NL
Universitaetsklinikum Heidelberg, DE
Global Phasing Limited, GB
Agencia Estatal Consejo Superior De Investigaciones Cientificas, ES
Erasmus Universitair Medisch Centrum Rotterdam, NL
Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, CN
Academisch Ziekenhuis Leiden - Leids Universitair Medisch Centrum, NL
Institute Pasteur, FR
Stichting Katholieke Universiteit / Radboud University Medical Center, NL
Pike Pharma Gmbh, CH
Korea Research Institute Of Chemical Technology, KR
Centrum Voor Innovatie En Stimulatievan Medicijnontwikkeling Leuven Vzw, BE
National Central University,
Riboxx Gmbh, DE
Principal Investigators (PI): Gérard Bricogne, GB
Kurt Habitzel, AT
Linda Polik, GB
Thorsten Brietz, DE
Elke Lammertyn, BE
Jocelyn Mere, FR
Eusebio Jimenez Arroyo, ES
Nadia Khelef, FR
Celine Damon, FR
Ulrich Kessler, CH
Wim Van Oijen, NL
Stefania Varotto, IT
Gerhard Fuchs, DE
Carsten Malmwieck, DE
Wim Leep, NL
Youngjoo Ko, KR
Jianmei Shi, CN
Jens Bricke, DE
Marlien Vos, NL
Louise Van Der Kaaden, NL
Patrick Chaltin, BE
Yu-Jin Cheng,
Margret Schwab, DE
Jacques Rohayem, DE
 
Title FY Funding
There are no results for this project in database.
Project Title: Small-molecule inhibitor leads versus emerging and neglected rna viruses
Project Number: CORDIS-96747
Project web address: Follow on CORDIS
Organization: Universite D'Aix Marseille, France, Marseille
Collaborators: Katholieke Universiteit Leuven, BE
Freie Universität Berlin, DE
Centre National De La Recherche Scientifique, FR
Università Degli Studi Di Milano, IT
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
Universitaet Hamburg, DE
University Of Luebeck, DE
Univ Innsbruck, AT
Universität Leipzig, DE
Universiteit Utrecht, NL
Universitaetsklinikum Heidelberg, DE
Global Phasing Limited, GB
Agencia Estatal Consejo Superior De Investigaciones Cientificas, ES
Erasmus Universitair Medisch Centrum Rotterdam, NL
Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, CN
Academisch Ziekenhuis Leiden - Leids Universitair Medisch Centrum, NL
Institute Pasteur, FR
Stichting Katholieke Universiteit / Radboud University Medical Center, NL
Pike Pharma Gmbh, CH
Korea Research Institute Of Chemical Technology, KR
Centrum Voor Innovatie En Stimulatievan Medicijnontwikkeling Leuven Vzw, BE
National Central University,
Riboxx Gmbh, DE
Principal Investigators (PI): Gérard Bricogne, GB
Kurt Habitzel, AT
Linda Polik, GB
Thorsten Brietz, DE
Elke Lammertyn, BE
Jocelyn Mere, FR
Eusebio Jimenez Arroyo, ES
Nadia Khelef, FR
Celine Damon, FR
Ulrich Kessler, CH
Wim Van Oijen, NL
Stefania Varotto, IT
Gerhard Fuchs, DE
Carsten Malmwieck, DE
Wim Leep, NL
Youngjoo Ko, KR
Jianmei Shi, CN
Jens Bricke, DE
Marlien Vos, NL
Louise Van Der Kaaden, NL
Patrick Chaltin, BE
Yu-Jin Cheng,
Margret Schwab, DE
Jacques Rohayem, DE
 
Project Title Organization FY Funding
Small-Molecule Inhibitor Leads Versus Emerging And Neglected Rna VirusesUniversite D'Aix Marseille2010$24,089,713
Project Title: Small-molecule inhibitor leads versus emerging and neglected rna viruses
Project Number: CORDIS-96747
Project web address: Follow on CORDIS
Organization: Universite D'Aix Marseille, France, Marseille
Collaborators: Katholieke Universiteit Leuven, BE
Freie Universität Berlin, DE
Centre National De La Recherche Scientifique, FR
Università Degli Studi Di Milano, IT
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
Universitaet Hamburg, DE
University Of Luebeck, DE
Univ Innsbruck, AT
Universität Leipzig, DE
Universiteit Utrecht, NL
Universitaetsklinikum Heidelberg, DE
Global Phasing Limited, GB
Agencia Estatal Consejo Superior De Investigaciones Cientificas, ES
Erasmus Universitair Medisch Centrum Rotterdam, NL
Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, CN
Academisch Ziekenhuis Leiden - Leids Universitair Medisch Centrum, NL
Institute Pasteur, FR
Stichting Katholieke Universiteit / Radboud University Medical Center, NL
Pike Pharma Gmbh, CH
Korea Research Institute Of Chemical Technology, KR
Centrum Voor Innovatie En Stimulatievan Medicijnontwikkeling Leuven Vzw, BE
National Central University,
Riboxx Gmbh, DE
Principal Investigators (PI): Gérard Bricogne, GB
Kurt Habitzel, AT
Linda Polik, GB
Thorsten Brietz, DE
Elke Lammertyn, BE
Jocelyn Mere, FR
Eusebio Jimenez Arroyo, ES
Nadia Khelef, FR
Celine Damon, FR
Ulrich Kessler, CH
Wim Van Oijen, NL
Stefania Varotto, IT
Gerhard Fuchs, DE
Carsten Malmwieck, DE
Wim Leep, NL
Youngjoo Ko, KR
Jianmei Shi, CN
Jens Bricke, DE
Marlien Vos, NL
Louise Van Der Kaaden, NL
Patrick Chaltin, BE
Yu-Jin Cheng,
Margret Schwab, DE
Jacques Rohayem, DE
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Small-molecule inhibitor leads versus emerging and neglected rna viruses
Project Number: CORDIS-96747
Project web address: Follow on CORDIS
Organization: Universite D'Aix Marseille, France, Marseille
Collaborators: Katholieke Universiteit Leuven, BE
Freie Universität Berlin, DE
Centre National De La Recherche Scientifique, FR
Università Degli Studi Di Milano, IT
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
Universitaet Hamburg, DE
University Of Luebeck, DE
Univ Innsbruck, AT
Universität Leipzig, DE
Universiteit Utrecht, NL
Universitaetsklinikum Heidelberg, DE
Global Phasing Limited, GB
Agencia Estatal Consejo Superior De Investigaciones Cientificas, ES
Erasmus Universitair Medisch Centrum Rotterdam, NL
Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, CN
Academisch Ziekenhuis Leiden - Leids Universitair Medisch Centrum, NL
Institute Pasteur, FR
Stichting Katholieke Universiteit / Radboud University Medical Center, NL
Pike Pharma Gmbh, CH
Korea Research Institute Of Chemical Technology, KR
Centrum Voor Innovatie En Stimulatievan Medicijnontwikkeling Leuven Vzw, BE
National Central University,
Riboxx Gmbh, DE
Principal Investigators (PI): Gérard Bricogne, GB
Kurt Habitzel, AT
Linda Polik, GB
Thorsten Brietz, DE
Elke Lammertyn, BE
Jocelyn Mere, FR
Eusebio Jimenez Arroyo, ES
Nadia Khelef, FR
Celine Damon, FR
Ulrich Kessler, CH
Wim Van Oijen, NL
Stefania Varotto, IT
Gerhard Fuchs, DE
Carsten Malmwieck, DE
Wim Leep, NL
Youngjoo Ko, KR
Jianmei Shi, CN
Jens Bricke, DE
Marlien Vos, NL
Louise Van Der Kaaden, NL
Patrick Chaltin, BE
Yu-Jin Cheng,
Margret Schwab, DE
Jacques Rohayem, DE
 
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