Cells into organs: functional genomics for development and disease of mesodermal organ systems

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Project Title: Cells into organs: functional genomics for development and disease of mesodermal organ systems
Project Number: CORDIS-75325
Project web address: Follow on CORDIS
Organization: Leiden University, Netherlands, Leiden
Collaborators: University Of Geneva, CH
University Of Sheffield, GB
University College London, GB
Institut Pasteur, FR
Royal Netherlands Academy Of Arts And Science, NL
The Chancellor, Masters And Scholars Of The University Of Cambridge, GB
Fondazione Centro San Raffaele Del Monte Tabor, IT
Max-Planck-Gesellschaft, DE
Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii, ES
Erasmus University Medical Center, NL
Instituto Gulbenkian De Ciencia/ Fundacao Calouste Gulbenkian, PT
Forschungsinstitut Fur Molekulare Pathologie Ges. M.B.H., Research Institute Of Molecular Pathology, AT
Instituto De Medicina Molecular, PT
Centre De Medicina Regenerativa De Barcelona, PT
Principal Investigators (PI): Stern Claudio D, GB
Margaret Buckingham, FR
James Cuthbert Smith, GB
Guilio Cossu, IT
Frank Grosveld, NL
Philip William Ingham/, GB
Antonio Jacinto, PT
Herbert Jaeckle, DE
Erwin Wagner, AT
Walter Gehring, CH
Denis Duboule, CH
Antony John Durston, NL
Joaquin Rodriguez Leon, PT
Antony Durston, NL
 
Project Description:
New approaches to treating disease are set to revolutionise health care. Cancers will increasingly be treated by targeted molecules, not cytotoxic drugs. Manipulating stem cells for cell and tissue replacement therapies holds great promise for treatment of degenerative disease and injury. Both approaches depend critically on detailed knowledge of molecular and cellular events governing normal differentiation of target organs and tissues. This knowledge provides the basis for organ and tissue engineering. Very important life threatening or disabling diseases affect mesodermal organ systems. Heart failure and strokes resulting from atherosclerosis, kidney failure, muscular dystrophy, osteoporosis, tumours and leukaemia are caused either by defects in embryonic development of mesoderm containing organ systems or their function.. These diseases represent the principal obstacles to reaching a healthy old age. This proposal contributes to the knowledge base on which new diagnostic and therapeutic approaches will be based. We will elucidate molecular and cellular processes underlying embryonic specification and differentiation of mesodermal organs. It is clear that many developmental master genes later have key roles in regulating function and that cancers abusively reactivate developmental subroutines. We integrate established methodologies of developmental genetics and experimental embryology with sophisticated modern cell biology and new methodologies of genome scale analysis enabled by genome sequencing. The new technologies will reveal many genes which function in building a specific organ system or in directing a particular aspect of embryogenesis. Analysing these genes, investigating their functions, and placing them in developmental cascades as well as following the cells they affect, will reveal new aspects of organ development, extending and completing existing knowledge.
 
Project Terms:
biotechnology life sciences
Project Title: Cells into organs: functional genomics for development and disease of mesodermal organ systems
Project Number: CORDIS-75325
Project web address: Follow on CORDIS
Organization: Leiden University, Netherlands, Leiden
Collaborators: University Of Geneva, CH
University Of Sheffield, GB
University College London, GB
Institut Pasteur, FR
Royal Netherlands Academy Of Arts And Science, NL
The Chancellor, Masters And Scholars Of The University Of Cambridge, GB
Fondazione Centro San Raffaele Del Monte Tabor, IT
Max-Planck-Gesellschaft, DE
Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii, ES
Erasmus University Medical Center, NL
Instituto Gulbenkian De Ciencia/ Fundacao Calouste Gulbenkian, PT
Forschungsinstitut Fur Molekulare Pathologie Ges. M.B.H., Research Institute Of Molecular Pathology, AT
Instituto De Medicina Molecular, PT
Centre De Medicina Regenerativa De Barcelona, PT
Principal Investigators (PI): Stern Claudio D, GB
Margaret Buckingham, FR
James Cuthbert Smith, GB
Guilio Cossu, IT
Frank Grosveld, NL
Philip William Ingham/, GB
Antonio Jacinto, PT
Herbert Jaeckle, DE
Erwin Wagner, AT
Walter Gehring, CH
Denis Duboule, CH
Antony John Durston, NL
Joaquin Rodriguez Leon, PT
Antony Durston, NL
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2004
Project Start Date: 1 April 2004
Project End Date: 31 March 2009
Project program: FP6-LIFESCIHEALTH
 
Project Funding Information:
Funding Mechanism: NoE - Network of Excellence
Year Funding Organization Total Funding, $
2004 European Research Council $58,636,600