Molecular basis of the outer membrane permeability

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Project Title: Molecular basis of the outer membrane permeability
Project Number: CORDIS-203712
Project web address: Follow on CORDIS
Organization: Glaxosmithkline Research And Development Limited, United Kingdom, Stevenage
Collaborators: Centre National De La Recherche Scientifique (Cnrs), FR
Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V., DE
Università Degli Studi Di Cagliari, IT
University Of Newcastle Upon Tyne, GB
Janssen Pharmaceutica N.V., BE
Universite De Geneve, CH
Assistance Publique - Hopitaux De Paris, FR
Universitaetsklinikum Freiburg, DE
Astra Zeneca Ab, SE
The University Court Of The University Of St Andrews, GB
University College Dublin, National University Of Ireland, Dublin, IE
Societe Civile Synchrotron Soleil, FR
Jacobs University Bremen Ggmbh, DE
Nanion Technologies Gmbh, DE
Universite D'Aix Marseille, FR
Sanofi-Aventis Recherche & Developpement, FR
Bruker Daltonik Gmbh, DE
Fundacio Centre De Recerca En Salut International De Barcelona, ES
European Screeningport Gmbh, DE
Yelen, FR
The Hyve B.V., NL
Ionovation Gmbh, DE
Basilea Pharmaceutica International Ag, CH
Gritsystems A/S, DK
Nanospot Gmbh, DE
Principal Investigators (PI): Donal Doolan, IE
Trish Starrs, GB
Celine Damon, FR
Ronald Kieschnick, DE
Eva Lindgren, SE
Niels Fertig, DE
Yves Le Ray, FR
Gaelle Bujan, FR
Kristien Bonroy, BE
Alix Pillot, FR
Mira Grättinger, DE
Michael Prestele, DE
Amanda Gregory, GB
Kristina Wege, DE
Maren Mihlan, DE
Frederic Galli, FR
Luciano Colombo, IT
Nicolas Vidal, FR
Kees Van Bochove, NL
Jordi Vila, ES
Karsten Gall, DE
Rachel Benzies, CH
Ina Shvartsman, DE
Laurenz Kellenberger, CH
Claus Stie Kallesøe, DK
Christian Van Delden, CH
Sebastian Giehring, DE
Robert Stavenger, GB
 
Project Description:
Overcoming the barriers that the cell envelope and efflux pumps provide to Gram-negative bacteria is a major bottleneck in the discovery and development of new antibiotics. To respond to this Call we are extending our current network on antibiotic translocation and propose an ambitious project ranging from identification of novel resistance mechanisms in clinical bacterial isolates to crystallization of molecular resistance components and all-atom modeling to determine the kinetics of permeation. Our particular strength lies in the identification and quantification of transport proteins involved in membrane permeation at the cellular level combined with our expertise in quantifying the rate limiting steps of translocation at atomic level. Based on our experience we intend to:1. develop multiple assays to determine intracellular concentrations of small molecules2. increase the overall structural knowledge of outer membrane proteins3. extend knowledge on active-uptake transport systems, such as iron transport4. identify novel targets whose modulation can alter the penetration of other small molecules5. obtain as complete a picture as possible of small molecule penetration into and efflux out of bacterial cellsCombining the research question at different levels we expect to understand the complexity of membrane permeability. In particular, we are convinced that our molecular approach is able to provide a general template for a guided design of antibiotics to achieve high permeability. In addition, we will create a data base to allow the sharing of antibacterial R&D information on an unprecedented level. Also, via careful analysis of this information we intend to provide learnings as best practices that will lead to an increase in the overall efficiency of antibacterial R&D.
 
Project Terms:
There are no related terms in database.
Project Title: Molecular basis of the outer membrane permeability
Project Number: CORDIS-203712
Project web address: Follow on CORDIS
Organization: Glaxosmithkline Research And Development Limited, United Kingdom, Stevenage
Collaborators: Centre National De La Recherche Scientifique (Cnrs), FR
Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V., DE
Università Degli Studi Di Cagliari, IT
University Of Newcastle Upon Tyne, GB
Janssen Pharmaceutica N.V., BE
Universite De Geneve, CH
Assistance Publique - Hopitaux De Paris, FR
Universitaetsklinikum Freiburg, DE
Astra Zeneca Ab, SE
The University Court Of The University Of St Andrews, GB
University College Dublin, National University Of Ireland, Dublin, IE
Societe Civile Synchrotron Soleil, FR
Jacobs University Bremen Ggmbh, DE
Nanion Technologies Gmbh, DE
Universite D'Aix Marseille, FR
Sanofi-Aventis Recherche & Developpement, FR
Bruker Daltonik Gmbh, DE
Fundacio Centre De Recerca En Salut International De Barcelona, ES
European Screeningport Gmbh, DE
Yelen, FR
The Hyve B.V., NL
Ionovation Gmbh, DE
Basilea Pharmaceutica International Ag, CH
Gritsystems A/S, DK
Nanospot Gmbh, DE
Principal Investigators (PI): Donal Doolan, IE
Trish Starrs, GB
Celine Damon, FR
Ronald Kieschnick, DE
Eva Lindgren, SE
Niels Fertig, DE
Yves Le Ray, FR
Gaelle Bujan, FR
Kristien Bonroy, BE
Alix Pillot, FR
Mira Grättinger, DE
Michael Prestele, DE
Amanda Gregory, GB
Kristina Wege, DE
Maren Mihlan, DE
Frederic Galli, FR
Luciano Colombo, IT
Nicolas Vidal, FR
Kees Van Bochove, NL
Jordi Vila, ES
Karsten Gall, DE
Rachel Benzies, CH
Ina Shvartsman, DE
Laurenz Kellenberger, CH
Claus Stie Kallesøe, DK
Christian Van Delden, CH
Sebastian Giehring, DE
Robert Stavenger, GB
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2013
Project Start Date: 1 January 2013
Project End Date: 31 December 2017
Project program: FP7-JTI
 
Project Funding Information:
Funding Mechanism: JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)
Year Funding Organization Total Funding, $
2013 European Research Council $26,342,806
Project Title: Molecular basis of the outer membrane permeability
Project Number: CORDIS-203712
Project web address: Follow on CORDIS
Organization: Glaxosmithkline Research And Development Limited, United Kingdom, Stevenage
Collaborators: Centre National De La Recherche Scientifique (Cnrs), FR
Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V., DE
Università Degli Studi Di Cagliari, IT
University Of Newcastle Upon Tyne, GB
Janssen Pharmaceutica N.V., BE
Universite De Geneve, CH
Assistance Publique - Hopitaux De Paris, FR
Universitaetsklinikum Freiburg, DE
Astra Zeneca Ab, SE
The University Court Of The University Of St Andrews, GB
University College Dublin, National University Of Ireland, Dublin, IE
Societe Civile Synchrotron Soleil, FR
Jacobs University Bremen Ggmbh, DE
Nanion Technologies Gmbh, DE
Universite D'Aix Marseille, FR
Sanofi-Aventis Recherche & Developpement, FR
Bruker Daltonik Gmbh, DE
Fundacio Centre De Recerca En Salut International De Barcelona, ES
European Screeningport Gmbh, DE
Yelen, FR
The Hyve B.V., NL
Ionovation Gmbh, DE
Basilea Pharmaceutica International Ag, CH
Gritsystems A/S, DK
Nanospot Gmbh, DE
Principal Investigators (PI): Donal Doolan, IE
Trish Starrs, GB
Celine Damon, FR
Ronald Kieschnick, DE
Eva Lindgren, SE
Niels Fertig, DE
Yves Le Ray, FR
Gaelle Bujan, FR
Kristien Bonroy, BE
Alix Pillot, FR
Mira Grättinger, DE
Michael Prestele, DE
Amanda Gregory, GB
Kristina Wege, DE
Maren Mihlan, DE
Frederic Galli, FR
Luciano Colombo, IT
Nicolas Vidal, FR
Kees Van Bochove, NL
Jordi Vila, ES
Karsten Gall, DE
Rachel Benzies, CH
Ina Shvartsman, DE
Laurenz Kellenberger, CH
Claus Stie Kallesøe, DK
Christian Van Delden, CH
Sebastian Giehring, DE
Robert Stavenger, GB
 
Title FY Funding
There are no results for this project in database.
Project Title: Molecular basis of the outer membrane permeability
Project Number: CORDIS-203712
Project web address: Follow on CORDIS
Organization: Glaxosmithkline Research And Development Limited, United Kingdom, Stevenage
Collaborators: Centre National De La Recherche Scientifique (Cnrs), FR
Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V., DE
Università Degli Studi Di Cagliari, IT
University Of Newcastle Upon Tyne, GB
Janssen Pharmaceutica N.V., BE
Universite De Geneve, CH
Assistance Publique - Hopitaux De Paris, FR
Universitaetsklinikum Freiburg, DE
Astra Zeneca Ab, SE
The University Court Of The University Of St Andrews, GB
University College Dublin, National University Of Ireland, Dublin, IE
Societe Civile Synchrotron Soleil, FR
Jacobs University Bremen Ggmbh, DE
Nanion Technologies Gmbh, DE
Universite D'Aix Marseille, FR
Sanofi-Aventis Recherche & Developpement, FR
Bruker Daltonik Gmbh, DE
Fundacio Centre De Recerca En Salut International De Barcelona, ES
European Screeningport Gmbh, DE
Yelen, FR
The Hyve B.V., NL
Ionovation Gmbh, DE
Basilea Pharmaceutica International Ag, CH
Gritsystems A/S, DK
Nanospot Gmbh, DE
Principal Investigators (PI): Donal Doolan, IE
Trish Starrs, GB
Celine Damon, FR
Ronald Kieschnick, DE
Eva Lindgren, SE
Niels Fertig, DE
Yves Le Ray, FR
Gaelle Bujan, FR
Kristien Bonroy, BE
Alix Pillot, FR
Mira Grättinger, DE
Michael Prestele, DE
Amanda Gregory, GB
Kristina Wege, DE
Maren Mihlan, DE
Frederic Galli, FR
Luciano Colombo, IT
Nicolas Vidal, FR
Kees Van Bochove, NL
Jordi Vila, ES
Karsten Gall, DE
Rachel Benzies, CH
Ina Shvartsman, DE
Laurenz Kellenberger, CH
Claus Stie Kallesøe, DK
Christian Van Delden, CH
Sebastian Giehring, DE
Robert Stavenger, GB
 
Project Title Organization FY Funding
Molecular Basis Of The Outer Membrane PermeabilityGlaxosmithkline Research And Development Limited2013$26,342,806
Project Title: Molecular basis of the outer membrane permeability
Project Number: CORDIS-203712
Project web address: Follow on CORDIS
Organization: Glaxosmithkline Research And Development Limited, United Kingdom, Stevenage
Collaborators: Centre National De La Recherche Scientifique (Cnrs), FR
Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V., DE
Università Degli Studi Di Cagliari, IT
University Of Newcastle Upon Tyne, GB
Janssen Pharmaceutica N.V., BE
Universite De Geneve, CH
Assistance Publique - Hopitaux De Paris, FR
Universitaetsklinikum Freiburg, DE
Astra Zeneca Ab, SE
The University Court Of The University Of St Andrews, GB
University College Dublin, National University Of Ireland, Dublin, IE
Societe Civile Synchrotron Soleil, FR
Jacobs University Bremen Ggmbh, DE
Nanion Technologies Gmbh, DE
Universite D'Aix Marseille, FR
Sanofi-Aventis Recherche & Developpement, FR
Bruker Daltonik Gmbh, DE
Fundacio Centre De Recerca En Salut International De Barcelona, ES
European Screeningport Gmbh, DE
Yelen, FR
The Hyve B.V., NL
Ionovation Gmbh, DE
Basilea Pharmaceutica International Ag, CH
Gritsystems A/S, DK
Nanospot Gmbh, DE
Principal Investigators (PI): Donal Doolan, IE
Trish Starrs, GB
Celine Damon, FR
Ronald Kieschnick, DE
Eva Lindgren, SE
Niels Fertig, DE
Yves Le Ray, FR
Gaelle Bujan, FR
Kristien Bonroy, BE
Alix Pillot, FR
Mira Grättinger, DE
Michael Prestele, DE
Amanda Gregory, GB
Kristina Wege, DE
Maren Mihlan, DE
Frederic Galli, FR
Luciano Colombo, IT
Nicolas Vidal, FR
Kees Van Bochove, NL
Jordi Vila, ES
Karsten Gall, DE
Rachel Benzies, CH
Ina Shvartsman, DE
Laurenz Kellenberger, CH
Claus Stie Kallesøe, DK
Christian Van Delden, CH
Sebastian Giehring, DE
Robert Stavenger, GB
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Molecular basis of the outer membrane permeability
Project Number: CORDIS-203712
Project web address: Follow on CORDIS
Organization: Glaxosmithkline Research And Development Limited, United Kingdom, Stevenage
Collaborators: Centre National De La Recherche Scientifique (Cnrs), FR
Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V., DE
Università Degli Studi Di Cagliari, IT
University Of Newcastle Upon Tyne, GB
Janssen Pharmaceutica N.V., BE
Universite De Geneve, CH
Assistance Publique - Hopitaux De Paris, FR
Universitaetsklinikum Freiburg, DE
Astra Zeneca Ab, SE
The University Court Of The University Of St Andrews, GB
University College Dublin, National University Of Ireland, Dublin, IE
Societe Civile Synchrotron Soleil, FR
Jacobs University Bremen Ggmbh, DE
Nanion Technologies Gmbh, DE
Universite D'Aix Marseille, FR
Sanofi-Aventis Recherche & Developpement, FR
Bruker Daltonik Gmbh, DE
Fundacio Centre De Recerca En Salut International De Barcelona, ES
European Screeningport Gmbh, DE
Yelen, FR
The Hyve B.V., NL
Ionovation Gmbh, DE
Basilea Pharmaceutica International Ag, CH
Gritsystems A/S, DK
Nanospot Gmbh, DE
Principal Investigators (PI): Donal Doolan, IE
Trish Starrs, GB
Celine Damon, FR
Ronald Kieschnick, DE
Eva Lindgren, SE
Niels Fertig, DE
Yves Le Ray, FR
Gaelle Bujan, FR
Kristien Bonroy, BE
Alix Pillot, FR
Mira Grättinger, DE
Michael Prestele, DE
Amanda Gregory, GB
Kristina Wege, DE
Maren Mihlan, DE
Frederic Galli, FR
Luciano Colombo, IT
Nicolas Vidal, FR
Kees Van Bochove, NL
Jordi Vila, ES
Karsten Gall, DE
Rachel Benzies, CH
Ina Shvartsman, DE
Laurenz Kellenberger, CH
Claus Stie Kallesøe, DK
Christian Van Delden, CH
Sebastian Giehring, DE
Robert Stavenger, GB
 
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