Stem cells for biological assays of novel drugs and predictive toxicology (stembancc)

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Project Title: Stem cells for biological assays of novel drugs and predictive toxicology (stembancc)
Project Number: CORDIS-203708
Project web address: Follow on CORDIS
Organization: F. Hoffmann - La Roche Ltd., Switzerland, Basel
Collaborators: Medical Research Council, GB
University Of Edinburgh, GB
Tel Aviv University, IL
Hebrew University Of Jerusalem, IL
University Of Birmingham, GB
University College London, GB
King'S College London, GB
Charité Universität Medicine, DE
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
The Chancellor, Masters And Scholars Of The University Of Cambridge, GB
University Of Newcastle Upon Tyne, GB
Université De Technologie De Compiègne, FR
Institut National De La Sante Et De La Recherche Medicale, FR
Medizinische Hochschule Hannover, DE
Janssen Pharmaceutica N.V., BE
Universite De Geneve, CH
Novo-Nordisk A/S, DK
Université De Lausanne, CH
Pfizer Ltd, GB
Eli Lilly Company Limited, GB
Merck Kommanditgesellschaft Auf Aktien, DE
Astra Zeneca Ab, SE
Region Hovedstaden, DK
Helmholtz Zentrum Muenchen- Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh, DE
Institut National De L' Environnement Et Des Risques Ineris, FR
Medizinische Universitat Innsbruck, AT
Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen, DE
Islensk Erfdagreining Ehf, IS
Orion Corporation, FI
Sanofi-Aventis Recherche & Developpement, FR
Boehriger Ingelheim International Gmbh, DE
Abbvie Deutschland Gmbh & Co. Kg, DE
Universitat Zu Lubeck, DE
Concentris Research Management Gmbh, DE
Univercell-Biosolutions, FR
Principal Investigators (PI): Lea Pais, IL
Greta Borg-Carbott, GB
Eveline Fräßdorf, DE
Jürgen Ertel, DE
Jonsson Frosti, IS
Eva Lindgren, SE
Birgit Steckel-Hamann, GB
Jorgen Dirach, DK
Marcus Kostka, DE
Ninog Péresse, DE
May Chung, GB
Nicolas Jeanjean, FR
Henk Sipma, BE
Hani Ben-Yehuda, IL
Gill Wells, GB
Jodie Claridge, GB
Frank Dittrich, DE
Emmanouil Dermitzakis, CH
Ameli Schwalber, DE
Daniel Walker, GB
Lydia Boutigny, FR
Damien Baratte, FR
Fiona Edler, GB
Frank-Christophe Lintz, DE
Kimmo Norrena, FI
Hugo Haemmerle, DE
Pia Heidenberg, SE
Monique Guis, FR
Jo Dekkers, GB
Marie-Gabrielle Zurich, CH
Kirsten Hjelm, DK
Darren Storey, GB
Wolfram Rieneck, AT
Maik Eckelt, DE
Mirza Max, GB
Guillaume Costecalde, FR
Martin Graf, CH
 
Project Description:
StemBANCC, comprising internationally renowned investigators, is ideally positioned to deliver a unique European biorepository and drug discovery pipeline based upon human induced pluripotent stem cells (hiPSC). This unrivalled opportunity will address the pressing therapeutic need in neurodegeneration, neurodysfunction and diabetes. We have immediate access to richly phenotyped subjects with a wealth of clinical data. Furthermore our cohorts include genetic and genome data, allowing us to carefully select subjects for hiPSC based disease model development. This clinical-genetic stratification is essential to ensure that cellular models display disease and therapy relevant phenotypes. hiPSC reprogramming is undertaken by an internationally respected centre, providing robust, reliable and timely delivery of hiPSCs; ensures the biorepository only houses quality assured hiPSC lines; and reduces unwanted variability in assays. We have leading experts in hiPSC differentiation, providing protocols with over 99% efficiency in producing cortical excitatory neurons and cardiomyocytes, which following up-scaling will meet demands of high throughput assays. StemBANCC will deliver a comprehensive ‘omics’ dataset on over 1500 stem cell lines. This includes cells taken at different lineage stages, after therapeutic challenge, monogenic and complex variants, and with matched isogenic controls. The integration of this network/pathway data will define core etiopathological processes, therapeutic generality, reveal on- and off-target effects, allow candidate therapeutic repositioning and decouple tolerance and toxicity pathways. The large-scale integrated datasets then directly guide the disease specific targeted assays, designed to maximize utility in low and high- through compound screening programs. Assay development undertaken by the StemBANCC proposed central test facility thereby provides the final component of our hiPSC platform for drug discovery, development and safety.
 
Project Terms:
There are no related terms in database.
Project Title: Stem cells for biological assays of novel drugs and predictive toxicology (stembancc)
Project Number: CORDIS-203708
Project web address: Follow on CORDIS
Organization: F. Hoffmann - La Roche Ltd., Switzerland, Basel
Collaborators: Medical Research Council, GB
University Of Edinburgh, GB
Tel Aviv University, IL
Hebrew University Of Jerusalem, IL
University Of Birmingham, GB
University College London, GB
King'S College London, GB
Charité Universität Medicine, DE
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
The Chancellor, Masters And Scholars Of The University Of Cambridge, GB
University Of Newcastle Upon Tyne, GB
Université De Technologie De Compiègne, FR
Institut National De La Sante Et De La Recherche Medicale, FR
Medizinische Hochschule Hannover, DE
Janssen Pharmaceutica N.V., BE
Universite De Geneve, CH
Novo-Nordisk A/S, DK
Université De Lausanne, CH
Pfizer Ltd, GB
Eli Lilly Company Limited, GB
Merck Kommanditgesellschaft Auf Aktien, DE
Astra Zeneca Ab, SE
Region Hovedstaden, DK
Helmholtz Zentrum Muenchen- Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh, DE
Institut National De L' Environnement Et Des Risques Ineris, FR
Medizinische Universitat Innsbruck, AT
Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen, DE
Islensk Erfdagreining Ehf, IS
Orion Corporation, FI
Sanofi-Aventis Recherche & Developpement, FR
Boehriger Ingelheim International Gmbh, DE
Abbvie Deutschland Gmbh & Co. Kg, DE
Universitat Zu Lubeck, DE
Concentris Research Management Gmbh, DE
Univercell-Biosolutions, FR
Principal Investigators (PI): Lea Pais, IL
Greta Borg-Carbott, GB
Eveline Fräßdorf, DE
Jürgen Ertel, DE
Jonsson Frosti, IS
Eva Lindgren, SE
Birgit Steckel-Hamann, GB
Jorgen Dirach, DK
Marcus Kostka, DE
Ninog Péresse, DE
May Chung, GB
Nicolas Jeanjean, FR
Henk Sipma, BE
Hani Ben-Yehuda, IL
Gill Wells, GB
Jodie Claridge, GB
Frank Dittrich, DE
Emmanouil Dermitzakis, CH
Ameli Schwalber, DE
Daniel Walker, GB
Lydia Boutigny, FR
Damien Baratte, FR
Fiona Edler, GB
Frank-Christophe Lintz, DE
Kimmo Norrena, FI
Hugo Haemmerle, DE
Pia Heidenberg, SE
Monique Guis, FR
Jo Dekkers, GB
Marie-Gabrielle Zurich, CH
Kirsten Hjelm, DK
Darren Storey, GB
Wolfram Rieneck, AT
Maik Eckelt, DE
Mirza Max, GB
Guillaume Costecalde, FR
Martin Graf, CH
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2012
Project Start Date: 1 October 2012
Project End Date: 30 September 2017
Project program: FP7-JTI
 
Project Funding Information:
Funding Mechanism: JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)
Year Funding Organization Total Funding, $
2012 European Research Council $58,677,880
Project Title: Stem cells for biological assays of novel drugs and predictive toxicology (stembancc)
Project Number: CORDIS-203708
Project web address: Follow on CORDIS
Organization: F. Hoffmann - La Roche Ltd., Switzerland, Basel
Collaborators: Medical Research Council, GB
University Of Edinburgh, GB
Tel Aviv University, IL
Hebrew University Of Jerusalem, IL
University Of Birmingham, GB
University College London, GB
King'S College London, GB
Charité Universität Medicine, DE
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
The Chancellor, Masters And Scholars Of The University Of Cambridge, GB
University Of Newcastle Upon Tyne, GB
Université De Technologie De Compiègne, FR
Institut National De La Sante Et De La Recherche Medicale, FR
Medizinische Hochschule Hannover, DE
Janssen Pharmaceutica N.V., BE
Universite De Geneve, CH
Novo-Nordisk A/S, DK
Université De Lausanne, CH
Pfizer Ltd, GB
Eli Lilly Company Limited, GB
Merck Kommanditgesellschaft Auf Aktien, DE
Astra Zeneca Ab, SE
Region Hovedstaden, DK
Helmholtz Zentrum Muenchen- Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh, DE
Institut National De L' Environnement Et Des Risques Ineris, FR
Medizinische Universitat Innsbruck, AT
Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen, DE
Islensk Erfdagreining Ehf, IS
Orion Corporation, FI
Sanofi-Aventis Recherche & Developpement, FR
Boehriger Ingelheim International Gmbh, DE
Abbvie Deutschland Gmbh & Co. Kg, DE
Universitat Zu Lubeck, DE
Concentris Research Management Gmbh, DE
Univercell-Biosolutions, FR
Principal Investigators (PI): Lea Pais, IL
Greta Borg-Carbott, GB
Eveline Fräßdorf, DE
Jürgen Ertel, DE
Jonsson Frosti, IS
Eva Lindgren, SE
Birgit Steckel-Hamann, GB
Jorgen Dirach, DK
Marcus Kostka, DE
Ninog Péresse, DE
May Chung, GB
Nicolas Jeanjean, FR
Henk Sipma, BE
Hani Ben-Yehuda, IL
Gill Wells, GB
Jodie Claridge, GB
Frank Dittrich, DE
Emmanouil Dermitzakis, CH
Ameli Schwalber, DE
Daniel Walker, GB
Lydia Boutigny, FR
Damien Baratte, FR
Fiona Edler, GB
Frank-Christophe Lintz, DE
Kimmo Norrena, FI
Hugo Haemmerle, DE
Pia Heidenberg, SE
Monique Guis, FR
Jo Dekkers, GB
Marie-Gabrielle Zurich, CH
Kirsten Hjelm, DK
Darren Storey, GB
Wolfram Rieneck, AT
Maik Eckelt, DE
Mirza Max, GB
Guillaume Costecalde, FR
Martin Graf, CH
 
Title FY Funding
There are no results for this project in database.
Project Title: Stem cells for biological assays of novel drugs and predictive toxicology (stembancc)
Project Number: CORDIS-203708
Project web address: Follow on CORDIS
Organization: F. Hoffmann - La Roche Ltd., Switzerland, Basel
Collaborators: Medical Research Council, GB
University Of Edinburgh, GB
Tel Aviv University, IL
Hebrew University Of Jerusalem, IL
University Of Birmingham, GB
University College London, GB
King'S College London, GB
Charité Universität Medicine, DE
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
The Chancellor, Masters And Scholars Of The University Of Cambridge, GB
University Of Newcastle Upon Tyne, GB
Université De Technologie De Compiègne, FR
Institut National De La Sante Et De La Recherche Medicale, FR
Medizinische Hochschule Hannover, DE
Janssen Pharmaceutica N.V., BE
Universite De Geneve, CH
Novo-Nordisk A/S, DK
Université De Lausanne, CH
Pfizer Ltd, GB
Eli Lilly Company Limited, GB
Merck Kommanditgesellschaft Auf Aktien, DE
Astra Zeneca Ab, SE
Region Hovedstaden, DK
Helmholtz Zentrum Muenchen- Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh, DE
Institut National De L' Environnement Et Des Risques Ineris, FR
Medizinische Universitat Innsbruck, AT
Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen, DE
Islensk Erfdagreining Ehf, IS
Orion Corporation, FI
Sanofi-Aventis Recherche & Developpement, FR
Boehriger Ingelheim International Gmbh, DE
Abbvie Deutschland Gmbh & Co. Kg, DE
Universitat Zu Lubeck, DE
Concentris Research Management Gmbh, DE
Univercell-Biosolutions, FR
Principal Investigators (PI): Lea Pais, IL
Greta Borg-Carbott, GB
Eveline Fräßdorf, DE
Jürgen Ertel, DE
Jonsson Frosti, IS
Eva Lindgren, SE
Birgit Steckel-Hamann, GB
Jorgen Dirach, DK
Marcus Kostka, DE
Ninog Péresse, DE
May Chung, GB
Nicolas Jeanjean, FR
Henk Sipma, BE
Hani Ben-Yehuda, IL
Gill Wells, GB
Jodie Claridge, GB
Frank Dittrich, DE
Emmanouil Dermitzakis, CH
Ameli Schwalber, DE
Daniel Walker, GB
Lydia Boutigny, FR
Damien Baratte, FR
Fiona Edler, GB
Frank-Christophe Lintz, DE
Kimmo Norrena, FI
Hugo Haemmerle, DE
Pia Heidenberg, SE
Monique Guis, FR
Jo Dekkers, GB
Marie-Gabrielle Zurich, CH
Kirsten Hjelm, DK
Darren Storey, GB
Wolfram Rieneck, AT
Maik Eckelt, DE
Mirza Max, GB
Guillaume Costecalde, FR
Martin Graf, CH
 
Project Title Organization FY Funding
Stem Cells For Biological Assays Of Novel Drugs And Predictive Toxicology (Stembancc)F. Hoffmann - La Roche Ltd.2012$58,677,880
Project Title: Stem cells for biological assays of novel drugs and predictive toxicology (stembancc)
Project Number: CORDIS-203708
Project web address: Follow on CORDIS
Organization: F. Hoffmann - La Roche Ltd., Switzerland, Basel
Collaborators: Medical Research Council, GB
University Of Edinburgh, GB
Tel Aviv University, IL
Hebrew University Of Jerusalem, IL
University Of Birmingham, GB
University College London, GB
King'S College London, GB
Charité Universität Medicine, DE
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
The Chancellor, Masters And Scholars Of The University Of Cambridge, GB
University Of Newcastle Upon Tyne, GB
Université De Technologie De Compiègne, FR
Institut National De La Sante Et De La Recherche Medicale, FR
Medizinische Hochschule Hannover, DE
Janssen Pharmaceutica N.V., BE
Universite De Geneve, CH
Novo-Nordisk A/S, DK
Université De Lausanne, CH
Pfizer Ltd, GB
Eli Lilly Company Limited, GB
Merck Kommanditgesellschaft Auf Aktien, DE
Astra Zeneca Ab, SE
Region Hovedstaden, DK
Helmholtz Zentrum Muenchen- Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh, DE
Institut National De L' Environnement Et Des Risques Ineris, FR
Medizinische Universitat Innsbruck, AT
Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen, DE
Islensk Erfdagreining Ehf, IS
Orion Corporation, FI
Sanofi-Aventis Recherche & Developpement, FR
Boehriger Ingelheim International Gmbh, DE
Abbvie Deutschland Gmbh & Co. Kg, DE
Universitat Zu Lubeck, DE
Concentris Research Management Gmbh, DE
Univercell-Biosolutions, FR
Principal Investigators (PI): Lea Pais, IL
Greta Borg-Carbott, GB
Eveline Fräßdorf, DE
Jürgen Ertel, DE
Jonsson Frosti, IS
Eva Lindgren, SE
Birgit Steckel-Hamann, GB
Jorgen Dirach, DK
Marcus Kostka, DE
Ninog Péresse, DE
May Chung, GB
Nicolas Jeanjean, FR
Henk Sipma, BE
Hani Ben-Yehuda, IL
Gill Wells, GB
Jodie Claridge, GB
Frank Dittrich, DE
Emmanouil Dermitzakis, CH
Ameli Schwalber, DE
Daniel Walker, GB
Lydia Boutigny, FR
Damien Baratte, FR
Fiona Edler, GB
Frank-Christophe Lintz, DE
Kimmo Norrena, FI
Hugo Haemmerle, DE
Pia Heidenberg, SE
Monique Guis, FR
Jo Dekkers, GB
Marie-Gabrielle Zurich, CH
Kirsten Hjelm, DK
Darren Storey, GB
Wolfram Rieneck, AT
Maik Eckelt, DE
Mirza Max, GB
Guillaume Costecalde, FR
Martin Graf, CH
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Stem cells for biological assays of novel drugs and predictive toxicology (stembancc)
Project Number: CORDIS-203708
Project web address: Follow on CORDIS
Organization: F. Hoffmann - La Roche Ltd., Switzerland, Basel
Collaborators: Medical Research Council, GB
University Of Edinburgh, GB
Tel Aviv University, IL
Hebrew University Of Jerusalem, IL
University Of Birmingham, GB
University College London, GB
King'S College London, GB
Charité Universität Medicine, DE
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
The Chancellor, Masters And Scholars Of The University Of Cambridge, GB
University Of Newcastle Upon Tyne, GB
Université De Technologie De Compiègne, FR
Institut National De La Sante Et De La Recherche Medicale, FR
Medizinische Hochschule Hannover, DE
Janssen Pharmaceutica N.V., BE
Universite De Geneve, CH
Novo-Nordisk A/S, DK
Université De Lausanne, CH
Pfizer Ltd, GB
Eli Lilly Company Limited, GB
Merck Kommanditgesellschaft Auf Aktien, DE
Astra Zeneca Ab, SE
Region Hovedstaden, DK
Helmholtz Zentrum Muenchen- Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh, DE
Institut National De L' Environnement Et Des Risques Ineris, FR
Medizinische Universitat Innsbruck, AT
Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen, DE
Islensk Erfdagreining Ehf, IS
Orion Corporation, FI
Sanofi-Aventis Recherche & Developpement, FR
Boehriger Ingelheim International Gmbh, DE
Abbvie Deutschland Gmbh & Co. Kg, DE
Universitat Zu Lubeck, DE
Concentris Research Management Gmbh, DE
Univercell-Biosolutions, FR
Principal Investigators (PI): Lea Pais, IL
Greta Borg-Carbott, GB
Eveline Fräßdorf, DE
Jürgen Ertel, DE
Jonsson Frosti, IS
Eva Lindgren, SE
Birgit Steckel-Hamann, GB
Jorgen Dirach, DK
Marcus Kostka, DE
Ninog Péresse, DE
May Chung, GB
Nicolas Jeanjean, FR
Henk Sipma, BE
Hani Ben-Yehuda, IL
Gill Wells, GB
Jodie Claridge, GB
Frank Dittrich, DE
Emmanouil Dermitzakis, CH
Ameli Schwalber, DE
Daniel Walker, GB
Lydia Boutigny, FR
Damien Baratte, FR
Fiona Edler, GB
Frank-Christophe Lintz, DE
Kimmo Norrena, FI
Hugo Haemmerle, DE
Pia Heidenberg, SE
Monique Guis, FR
Jo Dekkers, GB
Marie-Gabrielle Zurich, CH
Kirsten Hjelm, DK
Darren Storey, GB
Wolfram Rieneck, AT
Maik Eckelt, DE
Mirza Max, GB
Guillaume Costecalde, FR
Martin Graf, CH
 
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