Collaboration on the optimisation of macromolecular pharmaceutical access to cellular targets

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Project Title: Collaboration on the optimisation of macromolecular pharmaceutical access to cellular targets
Project Number: CORDIS-203704
Project web address: Follow on CORDIS
Organization: Sanofi-Aventis Deutschland Gmbh, Germany, Frankfurt Am-Main
Collaborators: Stockholm University, SE
University Of Zurich, CH
Cardiff University, GB
Ludwig Maximilian University, DE
Universiteit Gent, BE
Kobenhavns Universitet, DK
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
Novo-Nordisk A/S, DK
Universiteit Utrecht, NL
Helsingin Yliopisto, FI
Merck Kg Aa, DE
Pfizer Ltd, GB
Glaxosmithkline Research And Development Limited, GB
Universitat Wien, AT
Norges Teknisk-Naturvitenskapelige Universitet Ntnu, NO
Universiteit Leiden, NL
Bioneer As, DK
Helmholtz-Zentrum Fuer Infektionsforschung Gmbh, DE
Boehringer Ingelheim International Gmbh, DE
Abbvie Deutschland Gmbh & Co. Kg, DE
Pharmacoidea Fejleszto Es Szolgaltato Kft., HU
Principal Investigators (PI): Ton Brouwer, NL
Margo Baele, BE
Michael Strätz, DE
Sanna-Maija Kiviranta, FI
Linda Pialek, GB
Olga Krylova, GB
Sally Miles, GB
Monika Bernhardt, DE
Andreas Plückthun, CH
Helmut Schaschl, AT
Eevi Laukkanen, GB
Stefan Cornelis De Graaf, NO
Martin De Geest, NL
Frank-Christophe Lintz, DE
Toby Brunt, DK
Lars H Pedersen, DK
Kenneth Lindholm, DK
Ninog Péresse, DE
Rolf Göggel, DE
Letoha Tamas, HU
Maryam Hansson Edalat, SE
Ekkehard Leberer, DE
 
Project Description:
Most biopharmaceuticals (BP) currently on the market are recombinant proteins which are parenterally administered. These would benefit from more patient-friendly routes of administration. Moreover, new classes of BP (e.g. siRNA, miRNA, DARPins) with specificity for intracellular targets hold promise but await the advent of efficient delivery systems before their potential can be realised into therapeutic products. Solving the bottleneck of BP delivery is one of the main incentives of the pharmaceutical industry as this would allow a broadening of the spectrum of potential targets for therapeutic intervention needed to fill their drug pipelines. COMPACT represents Europe’s frontrunners in pharmaceutics, nanotechnology, biology, chemistry, engineering and imaging who will work in close collaboration with EFPIA on the delivery issues with BP. The main objectives are (1) to identify and understand transport pathways across biological barriers and cell membranes that can be utilized for delivery of BP, (2) to construct, characterise and preclincally validate BP formulations for non-invasive delivery of BP, with an emphasis on oral, airway and (trans)dermal delivery and for transport over the BBB. This will be achieved by setting up sophisticated in vitro models of biological barriers and appropriate animal models to find pathways that can be used for effective delivery of BP. In parallel, we will alter the BP either by chemical or biological engineering or by nano-formulations to enhance their uptake or transport over biological barriers.To be able to follow the transport,advanced imaging techniques will be utilised. The unique feature of this consortium is the alliance of experts in different research fields that complement each other in this challenging task. It is only the concerted action of such an interdisciplinary consortium that can make a difference in finding constructive solutions to the problem of poor bioavailability and target accessibility of BP.
 
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Project Title: Collaboration on the optimisation of macromolecular pharmaceutical access to cellular targets
Project Number: CORDIS-203704
Project web address: Follow on CORDIS
Organization: Sanofi-Aventis Deutschland Gmbh, Germany, Frankfurt Am-Main
Collaborators: Stockholm University, SE
University Of Zurich, CH
Cardiff University, GB
Ludwig Maximilian University, DE
Universiteit Gent, BE
Kobenhavns Universitet, DK
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
Novo-Nordisk A/S, DK
Universiteit Utrecht, NL
Helsingin Yliopisto, FI
Merck Kg Aa, DE
Pfizer Ltd, GB
Glaxosmithkline Research And Development Limited, GB
Universitat Wien, AT
Norges Teknisk-Naturvitenskapelige Universitet Ntnu, NO
Universiteit Leiden, NL
Bioneer As, DK
Helmholtz-Zentrum Fuer Infektionsforschung Gmbh, DE
Boehringer Ingelheim International Gmbh, DE
Abbvie Deutschland Gmbh & Co. Kg, DE
Pharmacoidea Fejleszto Es Szolgaltato Kft., HU
Principal Investigators (PI): Ton Brouwer, NL
Margo Baele, BE
Michael Strätz, DE
Sanna-Maija Kiviranta, FI
Linda Pialek, GB
Olga Krylova, GB
Sally Miles, GB
Monika Bernhardt, DE
Andreas Plückthun, CH
Helmut Schaschl, AT
Eevi Laukkanen, GB
Stefan Cornelis De Graaf, NO
Martin De Geest, NL
Frank-Christophe Lintz, DE
Toby Brunt, DK
Lars H Pedersen, DK
Kenneth Lindholm, DK
Ninog Péresse, DE
Rolf Göggel, DE
Letoha Tamas, HU
Maryam Hansson Edalat, SE
Ekkehard Leberer, DE
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2012
Project Start Date: 1 November 2012
Project End Date: 31 October 2017
Project program: FP7-JTI
 
Project Funding Information:
Funding Mechanism: JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)
Year Funding Organization Total Funding, $
2012 European Research Council $32,981,897
Project Title: Collaboration on the optimisation of macromolecular pharmaceutical access to cellular targets
Project Number: CORDIS-203704
Project web address: Follow on CORDIS
Organization: Sanofi-Aventis Deutschland Gmbh, Germany, Frankfurt Am-Main
Collaborators: Stockholm University, SE
University Of Zurich, CH
Cardiff University, GB
Ludwig Maximilian University, DE
Universiteit Gent, BE
Kobenhavns Universitet, DK
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
Novo-Nordisk A/S, DK
Universiteit Utrecht, NL
Helsingin Yliopisto, FI
Merck Kg Aa, DE
Pfizer Ltd, GB
Glaxosmithkline Research And Development Limited, GB
Universitat Wien, AT
Norges Teknisk-Naturvitenskapelige Universitet Ntnu, NO
Universiteit Leiden, NL
Bioneer As, DK
Helmholtz-Zentrum Fuer Infektionsforschung Gmbh, DE
Boehringer Ingelheim International Gmbh, DE
Abbvie Deutschland Gmbh & Co. Kg, DE
Pharmacoidea Fejleszto Es Szolgaltato Kft., HU
Principal Investigators (PI): Ton Brouwer, NL
Margo Baele, BE
Michael Strätz, DE
Sanna-Maija Kiviranta, FI
Linda Pialek, GB
Olga Krylova, GB
Sally Miles, GB
Monika Bernhardt, DE
Andreas Plückthun, CH
Helmut Schaschl, AT
Eevi Laukkanen, GB
Stefan Cornelis De Graaf, NO
Martin De Geest, NL
Frank-Christophe Lintz, DE
Toby Brunt, DK
Lars H Pedersen, DK
Kenneth Lindholm, DK
Ninog Péresse, DE
Rolf Göggel, DE
Letoha Tamas, HU
Maryam Hansson Edalat, SE
Ekkehard Leberer, DE
 
Project Title Organization FY Funding
Collaboration On The Optimisation Of Macromolecular Pharmaceutical Access To Cellular TargetsSanofi-Aventis Deutschland Gmbh2012$32,981,897
Project Title: Collaboration on the optimisation of macromolecular pharmaceutical access to cellular targets
Project Number: CORDIS-203704
Project web address: Follow on CORDIS
Organization: Sanofi-Aventis Deutschland Gmbh, Germany, Frankfurt Am-Main
Collaborators: Stockholm University, SE
University Of Zurich, CH
Cardiff University, GB
Ludwig Maximilian University, DE
Universiteit Gent, BE
Kobenhavns Universitet, DK
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
Novo-Nordisk A/S, DK
Universiteit Utrecht, NL
Helsingin Yliopisto, FI
Merck Kg Aa, DE
Pfizer Ltd, GB
Glaxosmithkline Research And Development Limited, GB
Universitat Wien, AT
Norges Teknisk-Naturvitenskapelige Universitet Ntnu, NO
Universiteit Leiden, NL
Bioneer As, DK
Helmholtz-Zentrum Fuer Infektionsforschung Gmbh, DE
Boehringer Ingelheim International Gmbh, DE
Abbvie Deutschland Gmbh & Co. Kg, DE
Pharmacoidea Fejleszto Es Szolgaltato Kft., HU
Principal Investigators (PI): Ton Brouwer, NL
Margo Baele, BE
Michael Strätz, DE
Sanna-Maija Kiviranta, FI
Linda Pialek, GB
Olga Krylova, GB
Sally Miles, GB
Monika Bernhardt, DE
Andreas Plückthun, CH
Helmut Schaschl, AT
Eevi Laukkanen, GB
Stefan Cornelis De Graaf, NO
Martin De Geest, NL
Frank-Christophe Lintz, DE
Toby Brunt, DK
Lars H Pedersen, DK
Kenneth Lindholm, DK
Ninog Péresse, DE
Rolf Göggel, DE
Letoha Tamas, HU
Maryam Hansson Edalat, SE
Ekkehard Leberer, DE
 
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