Diabetes research on patient stratification

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Project Title: Diabetes research on patient stratification
Project Number: CORDIS-203699
Project web address: Follow on CORDIS
Organization: Sanofi-Aventis Deutschland Gmbh, Germany, Frankfurt Am-Main
Collaborators: Lund University, SE
Eberhard Karl University Of Tuebingen, DE
University Of Dundee, GB
University Of Bath, GB
University Of Ulm, DE
Consiglio Nazionale Delle Ricerche, IT
Danmark Tekniske Universitet, DK
University Of Exeter, GB
Centre National De La Recherche Scientifique (Cnrs), FR
Kobenhavns Universitet, DK
Imperial College Of Science, Technology And Medicine, GB
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
University Of Newcastle Upon Tyne, GB
Academisch Ziekenhuis Leiden, NL
Universite De Geneve, CH
Novo-Nordisk A/S, DK
Eli Lilly Company Limited, GB
Kungliga Tekniska Hoegskolan, SE
Centre Hospitalier Régional Et Universitaire De Lille, FR
Helmholtz Zentrum Muenchen- Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh, DE
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, ES
Itä-Suomen Yliopisto, FI
Boehriger Ingelheim International Gmbh, DE
Stichting Vu, NL
Institut De Recherche International Servier, FR
Principal Investigators (PI): Juergen Ertel, DE
Helen Gallon, GB
Pete Hompstead, GB
Stephen Conway, GB
Frank Gleixner, DE
Birgit Steckel-Hamann, GB
Jacqueline Postma, SE
Kristina Holdgaard-Sorensen, DK
Gaynor Hughes, GB
Ake Eriksson, SE
Emmanouil Dermitzakis, CH
Tiina Reinikainen, FI
Karin Wibier, NL
Michel Telkamp, NL
Guillaume Tueux, FR
Inger Lund Pedersen, DK
Tanya Palalic, GB
Mcleod Alison-Carleton, GB
Arnold Boon, DK
Rolf Goeggel, DE
Sandra Dupire, FR
Michela Matteoli, IT
Juan M Abolafia, ES
Andreas Fritsche, DE
Carole Poher, FR
Hartmut Ruetten, DE
 
Project Description:
The overarching aims of the DIRECT consortium, consisting of 20 leading academic groups in diabetes and 5 EFPIA companies, are to identify biomarkers that address current bottlenecks in diabetes drug development and to develop a stratified medicines approach to treatment of type 2 diabetes with either existing or novel therapies.There is heterogeneity in who develops diabetes, the rate at which their subsequent diabetes progresses, how they respond to diabetes therapy and who develops micro- and macrovascular complications. In the DIRECT consortium we propose to identify biomarkers to identify subtypes with rapid diabetes development and progression and altered response to diabetes treatments, and develop and use these biomarkers in clinical trials.Two phenotyping work packages will focus on glycaemic deterioration and therapeutic response. For each, the DIRECT consortium brings considerable existing resource, which will be augmented by large-scale prospective cohort collection with intensive physiological and imaging phenotyping. Additional data will be added, such as existing studies on acute response to intravenous beta-cell secretagogues, and functional genomics on human islets, liver, muscle and adipose tissue, to maximise the power and utility of an innovative integrated biology approach. To enable computational multi-level integration across phenotypes and data types, a robust and secure data repository will be developed with strict data governance. As the ultimate aim of DIRECT is patient stratification, biomarkers arising from the discovery work will be used to design one or more prospective clinical trials. These will validate the biomarker(s) of interest, and establish utility in clinical practice and/or trial design and drug development. As a result, this consortium offers considerable potential to achieve major progress towards a personalized medicines approach to the treatment of type 2 diabetes.
 
Project Terms:
There are no related terms in database.
Project Title: Diabetes research on patient stratification
Project Number: CORDIS-203699
Project web address: Follow on CORDIS
Organization: Sanofi-Aventis Deutschland Gmbh, Germany, Frankfurt Am-Main
Collaborators: Lund University, SE
Eberhard Karl University Of Tuebingen, DE
University Of Dundee, GB
University Of Bath, GB
University Of Ulm, DE
Consiglio Nazionale Delle Ricerche, IT
Danmark Tekniske Universitet, DK
University Of Exeter, GB
Centre National De La Recherche Scientifique (Cnrs), FR
Kobenhavns Universitet, DK
Imperial College Of Science, Technology And Medicine, GB
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
University Of Newcastle Upon Tyne, GB
Academisch Ziekenhuis Leiden, NL
Universite De Geneve, CH
Novo-Nordisk A/S, DK
Eli Lilly Company Limited, GB
Kungliga Tekniska Hoegskolan, SE
Centre Hospitalier Régional Et Universitaire De Lille, FR
Helmholtz Zentrum Muenchen- Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh, DE
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, ES
Itä-Suomen Yliopisto, FI
Boehriger Ingelheim International Gmbh, DE
Stichting Vu, NL
Institut De Recherche International Servier, FR
Principal Investigators (PI): Juergen Ertel, DE
Helen Gallon, GB
Pete Hompstead, GB
Stephen Conway, GB
Frank Gleixner, DE
Birgit Steckel-Hamann, GB
Jacqueline Postma, SE
Kristina Holdgaard-Sorensen, DK
Gaynor Hughes, GB
Ake Eriksson, SE
Emmanouil Dermitzakis, CH
Tiina Reinikainen, FI
Karin Wibier, NL
Michel Telkamp, NL
Guillaume Tueux, FR
Inger Lund Pedersen, DK
Tanya Palalic, GB
Mcleod Alison-Carleton, GB
Arnold Boon, DK
Rolf Goeggel, DE
Sandra Dupire, FR
Michela Matteoli, IT
Juan M Abolafia, ES
Andreas Fritsche, DE
Carole Poher, FR
Hartmut Ruetten, DE
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2012
Project Start Date: 1 February 2012
Project End Date: 31 January 2019
Project program: FP7-JTI
 
Project Funding Information:
Funding Mechanism: JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)
Year Funding Organization Total Funding, $
2012 European Research Council $47,823,899
Project Title: Diabetes research on patient stratification
Project Number: CORDIS-203699
Project web address: Follow on CORDIS
Organization: Sanofi-Aventis Deutschland Gmbh, Germany, Frankfurt Am-Main
Collaborators: Lund University, SE
Eberhard Karl University Of Tuebingen, DE
University Of Dundee, GB
University Of Bath, GB
University Of Ulm, DE
Consiglio Nazionale Delle Ricerche, IT
Danmark Tekniske Universitet, DK
University Of Exeter, GB
Centre National De La Recherche Scientifique (Cnrs), FR
Kobenhavns Universitet, DK
Imperial College Of Science, Technology And Medicine, GB
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
University Of Newcastle Upon Tyne, GB
Academisch Ziekenhuis Leiden, NL
Universite De Geneve, CH
Novo-Nordisk A/S, DK
Eli Lilly Company Limited, GB
Kungliga Tekniska Hoegskolan, SE
Centre Hospitalier Régional Et Universitaire De Lille, FR
Helmholtz Zentrum Muenchen- Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh, DE
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, ES
Itä-Suomen Yliopisto, FI
Boehriger Ingelheim International Gmbh, DE
Stichting Vu, NL
Institut De Recherche International Servier, FR
Principal Investigators (PI): Juergen Ertel, DE
Helen Gallon, GB
Pete Hompstead, GB
Stephen Conway, GB
Frank Gleixner, DE
Birgit Steckel-Hamann, GB
Jacqueline Postma, SE
Kristina Holdgaard-Sorensen, DK
Gaynor Hughes, GB
Ake Eriksson, SE
Emmanouil Dermitzakis, CH
Tiina Reinikainen, FI
Karin Wibier, NL
Michel Telkamp, NL
Guillaume Tueux, FR
Inger Lund Pedersen, DK
Tanya Palalic, GB
Mcleod Alison-Carleton, GB
Arnold Boon, DK
Rolf Goeggel, DE
Sandra Dupire, FR
Michela Matteoli, IT
Juan M Abolafia, ES
Andreas Fritsche, DE
Carole Poher, FR
Hartmut Ruetten, DE
 
Title FY Funding
There are no results for this project in database.
Project Title: Diabetes research on patient stratification
Project Number: CORDIS-203699
Project web address: Follow on CORDIS
Organization: Sanofi-Aventis Deutschland Gmbh, Germany, Frankfurt Am-Main
Collaborators: Lund University, SE
Eberhard Karl University Of Tuebingen, DE
University Of Dundee, GB
University Of Bath, GB
University Of Ulm, DE
Consiglio Nazionale Delle Ricerche, IT
Danmark Tekniske Universitet, DK
University Of Exeter, GB
Centre National De La Recherche Scientifique (Cnrs), FR
Kobenhavns Universitet, DK
Imperial College Of Science, Technology And Medicine, GB
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
University Of Newcastle Upon Tyne, GB
Academisch Ziekenhuis Leiden, NL
Universite De Geneve, CH
Novo-Nordisk A/S, DK
Eli Lilly Company Limited, GB
Kungliga Tekniska Hoegskolan, SE
Centre Hospitalier Régional Et Universitaire De Lille, FR
Helmholtz Zentrum Muenchen- Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh, DE
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, ES
Itä-Suomen Yliopisto, FI
Boehriger Ingelheim International Gmbh, DE
Stichting Vu, NL
Institut De Recherche International Servier, FR
Principal Investigators (PI): Juergen Ertel, DE
Helen Gallon, GB
Pete Hompstead, GB
Stephen Conway, GB
Frank Gleixner, DE
Birgit Steckel-Hamann, GB
Jacqueline Postma, SE
Kristina Holdgaard-Sorensen, DK
Gaynor Hughes, GB
Ake Eriksson, SE
Emmanouil Dermitzakis, CH
Tiina Reinikainen, FI
Karin Wibier, NL
Michel Telkamp, NL
Guillaume Tueux, FR
Inger Lund Pedersen, DK
Tanya Palalic, GB
Mcleod Alison-Carleton, GB
Arnold Boon, DK
Rolf Goeggel, DE
Sandra Dupire, FR
Michela Matteoli, IT
Juan M Abolafia, ES
Andreas Fritsche, DE
Carole Poher, FR
Hartmut Ruetten, DE
 
Project Title Organization FY Funding
Diabetes Research On Patient StratificationSanofi-Aventis Deutschland Gmbh2012$47,823,899
Project Title: Diabetes research on patient stratification
Project Number: CORDIS-203699
Project web address: Follow on CORDIS
Organization: Sanofi-Aventis Deutschland Gmbh, Germany, Frankfurt Am-Main
Collaborators: Lund University, SE
Eberhard Karl University Of Tuebingen, DE
University Of Dundee, GB
University Of Bath, GB
University Of Ulm, DE
Consiglio Nazionale Delle Ricerche, IT
Danmark Tekniske Universitet, DK
University Of Exeter, GB
Centre National De La Recherche Scientifique (Cnrs), FR
Kobenhavns Universitet, DK
Imperial College Of Science, Technology And Medicine, GB
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
University Of Newcastle Upon Tyne, GB
Academisch Ziekenhuis Leiden, NL
Universite De Geneve, CH
Novo-Nordisk A/S, DK
Eli Lilly Company Limited, GB
Kungliga Tekniska Hoegskolan, SE
Centre Hospitalier Régional Et Universitaire De Lille, FR
Helmholtz Zentrum Muenchen- Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh, DE
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, ES
Itä-Suomen Yliopisto, FI
Boehriger Ingelheim International Gmbh, DE
Stichting Vu, NL
Institut De Recherche International Servier, FR
Principal Investigators (PI): Juergen Ertel, DE
Helen Gallon, GB
Pete Hompstead, GB
Stephen Conway, GB
Frank Gleixner, DE
Birgit Steckel-Hamann, GB
Jacqueline Postma, SE
Kristina Holdgaard-Sorensen, DK
Gaynor Hughes, GB
Ake Eriksson, SE
Emmanouil Dermitzakis, CH
Tiina Reinikainen, FI
Karin Wibier, NL
Michel Telkamp, NL
Guillaume Tueux, FR
Inger Lund Pedersen, DK
Tanya Palalic, GB
Mcleod Alison-Carleton, GB
Arnold Boon, DK
Rolf Goeggel, DE
Sandra Dupire, FR
Michela Matteoli, IT
Juan M Abolafia, ES
Andreas Fritsche, DE
Carole Poher, FR
Hartmut Ruetten, DE
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Diabetes research on patient stratification
Project Number: CORDIS-203699
Project web address: Follow on CORDIS
Organization: Sanofi-Aventis Deutschland Gmbh, Germany, Frankfurt Am-Main
Collaborators: Lund University, SE
Eberhard Karl University Of Tuebingen, DE
University Of Dundee, GB
University Of Bath, GB
University Of Ulm, DE
Consiglio Nazionale Delle Ricerche, IT
Danmark Tekniske Universitet, DK
University Of Exeter, GB
Centre National De La Recherche Scientifique (Cnrs), FR
Kobenhavns Universitet, DK
Imperial College Of Science, Technology And Medicine, GB
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
University Of Newcastle Upon Tyne, GB
Academisch Ziekenhuis Leiden, NL
Universite De Geneve, CH
Novo-Nordisk A/S, DK
Eli Lilly Company Limited, GB
Kungliga Tekniska Hoegskolan, SE
Centre Hospitalier Régional Et Universitaire De Lille, FR
Helmholtz Zentrum Muenchen- Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh, DE
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, ES
Itä-Suomen Yliopisto, FI
Boehriger Ingelheim International Gmbh, DE
Stichting Vu, NL
Institut De Recherche International Servier, FR
Principal Investigators (PI): Juergen Ertel, DE
Helen Gallon, GB
Pete Hompstead, GB
Stephen Conway, GB
Frank Gleixner, DE
Birgit Steckel-Hamann, GB
Jacqueline Postma, SE
Kristina Holdgaard-Sorensen, DK
Gaynor Hughes, GB
Ake Eriksson, SE
Emmanouil Dermitzakis, CH
Tiina Reinikainen, FI
Karin Wibier, NL
Michel Telkamp, NL
Guillaume Tueux, FR
Inger Lund Pedersen, DK
Tanya Palalic, GB
Mcleod Alison-Carleton, GB
Arnold Boon, DK
Rolf Goeggel, DE
Sandra Dupire, FR
Michela Matteoli, IT
Juan M Abolafia, ES
Andreas Fritsche, DE
Carole Poher, FR
Hartmut Ruetten, DE
 
Title Journal Year Country Rel