Anti-biopharmaceutical immunization:prediction and analysis of clinical relevance to minimize the risk

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Project Title: Anti-biopharmaceutical immunization:prediction and analysis of clinical relevance to minimize the risk
Project Number: CORDIS-203697
Project web address: Follow on CORDIS
Organization: Glaxosmithkline Research And Development Limited, United Kingdom, Stevenage
Collaborators: University College London, GB
Heinrich-Heine-Universitat At Dusseldorf, DE
University Hospital Basel, CH
Karolinska Institutet, SE
Centre National De La Recherche Scientifique (Cnrs), FR
Institut National De La Sante Et De La Recherche Medicale, FR
Istituto Giannina Gaslini, IT
Università Degli Studi Di Firenze, IT
Academisch Ziekenhuis Leiden, NL
Novo-Nordisk A/S, DK
Pfizer Ltd, GB
Assistance Publique - Hopitaux De Paris, FR
Merck Kommanditgesellschaft Auf Aktien, DE
Novartis Pharma Ag, CH
Commissariat A L'Energie Atomique Et Aux Energies Alternatives, FR
Region Hovedstaden, DK
Universitaetsklinikum Bonn, DE
Queen Mary, University Of London, GB
Medizinische Universitat Innsbruck, AT
Bayer Pharma Ag, DE
Fundacio Hospital Universitari Vall D'Hebron - Institut De Recerca, ES
Ucb Biopharma Sprl, BE
Fondazione Per L'Istituto Di Ricerca In Biomedicina, CH
Alta Ricerca E Sviluppo In Biotecnologie S.R.L.U., IT
Sanofi-Aventis Recherche & Developpement, FR
Klinikum Rechts Der Isar Der Technischen Universitat Munchen, DE
Bundesinstitut Fur Impfstoffe Und Biomedizinische Arzneimittel, DE
Drk-Blutspendedienst Baden-Württemberg – Hessen Gemeinnützige Gmbh, DE
Univerzita Karlova, CZ
Medical Research Infrastructure Development And Health Services Fund By The Sheba Medical Center, IL
The Health Corporation – Rambam, IL
Groupe D'Etudes Therapeutiques Desaffections Inflammatoires Digestives Association, FR
Scicross Ab, SE
Ipsen Innovation S.A.S., FR
Biomonitor A/S, DK
Principal Investigators (PI): Greta Borg-Carbott, GB
Laurence Parmantier, FR
Eliane Deck-Chaumont, FR
Cristiana Tozzi, IT
Cristina Dolfi, IT
Simon Dresse, BE
Barbara Stolz, CH
Ninog Péresse, DE
Rädlein Renate, DE
Stefanie Larisch, DE
Beate Becker, DE
Giorgio Noseda, CH
Alix Pillot, FR
Kristyna Matejkova, CZ
Eve Keret, IL
Lluis Masso, ES
Tanya Szendeffy, GB
Erwin J Van Der Meijden, NL
Petra Freitag, DE
Julie Demolin, FR
Jørgen Dirach, DK
Nathalie Piton, FR
Per Soelberg Sorensen, DK
Pierre Dönnes, SE
Philippe Bardin, FR
J J Van Roozendaal, NL
Thomas Dehmel, DE
Florian Deisenhammer, AT
Camille Seze-Goimier, FR
Christoph Königs, DE
Johan Forsslöf, SE
Marie Holde-Jensen, DK
Ronya Rubinstein, IL
David Reynolds, GB
Ludwig Kappos, CH
Jörg Schüttrumpf, DE
Gabriella Marinari, IT
Daniel J Sikkema, GB
 
Project Description:
The ABIRISK project provides an integrated approach to the study of immunization against biopharmaceuticals, bringing together a unique panel of experts from different disciplines. ABIRISK will involve many of the European leaders in rheumatology, gastroenterology, hemophilia and multiple sclerosis, caring for ~30,000 patients treated with biopharmaceuticals, with ~10,000 additional patients recruited per year. This should lead to the constitution of the largest possible cohort in Europe for the study of immunogenicity, a condition critical for the success of the program. ABIRISK will also benefit from the unique expertise of immunologist partners in the development of innovative strategies for predicting the immunogenicity of biopharmaceuticals and for defining its mechanisms. The large number of patients enrolled in the ABIRISK cohorts should make it possible to study the genetic basis of immunogenicity in a new way. We will standardize all clinical and biological information before its integration into a large database for evaluation of the clinical relevance of immunization against biopharmaceuticals and stratification of the risk to patients as a function of factors linked to treatment or to the individual. Computational biology and biostatistical modeling will be used to develop models for predicting immunogenicity that will be validated with the ABIRISK database.The complementarity between the clinical partners from different disciplines, immunologists, methodologists and biostatisticians will create a unique task force for studies of biopharmaceutical immunogenicity. The direct outcomes of the proposed work will be greater understanding of the mechanisms involved in the emergence of anti-drug antibodies, the development of new methods for predicting immunogenicity and a comprehensive view of the respective value of predictive tools, and guidelines for the development of new biopharmaceuticals and patient care.
 
Project Terms:
There are no related terms in database.
Project Title: Anti-biopharmaceutical immunization:prediction and analysis of clinical relevance to minimize the risk
Project Number: CORDIS-203697
Project web address: Follow on CORDIS
Organization: Glaxosmithkline Research And Development Limited, United Kingdom, Stevenage
Collaborators: University College London, GB
Heinrich-Heine-Universitat At Dusseldorf, DE
University Hospital Basel, CH
Karolinska Institutet, SE
Centre National De La Recherche Scientifique (Cnrs), FR
Institut National De La Sante Et De La Recherche Medicale, FR
Istituto Giannina Gaslini, IT
Università Degli Studi Di Firenze, IT
Academisch Ziekenhuis Leiden, NL
Novo-Nordisk A/S, DK
Pfizer Ltd, GB
Assistance Publique - Hopitaux De Paris, FR
Merck Kommanditgesellschaft Auf Aktien, DE
Novartis Pharma Ag, CH
Commissariat A L'Energie Atomique Et Aux Energies Alternatives, FR
Region Hovedstaden, DK
Universitaetsklinikum Bonn, DE
Queen Mary, University Of London, GB
Medizinische Universitat Innsbruck, AT
Bayer Pharma Ag, DE
Fundacio Hospital Universitari Vall D'Hebron - Institut De Recerca, ES
Ucb Biopharma Sprl, BE
Fondazione Per L'Istituto Di Ricerca In Biomedicina, CH
Alta Ricerca E Sviluppo In Biotecnologie S.R.L.U., IT
Sanofi-Aventis Recherche & Developpement, FR
Klinikum Rechts Der Isar Der Technischen Universitat Munchen, DE
Bundesinstitut Fur Impfstoffe Und Biomedizinische Arzneimittel, DE
Drk-Blutspendedienst Baden-Württemberg – Hessen Gemeinnützige Gmbh, DE
Univerzita Karlova, CZ
Medical Research Infrastructure Development And Health Services Fund By The Sheba Medical Center, IL
The Health Corporation – Rambam, IL
Groupe D'Etudes Therapeutiques Desaffections Inflammatoires Digestives Association, FR
Scicross Ab, SE
Ipsen Innovation S.A.S., FR
Biomonitor A/S, DK
Principal Investigators (PI): Greta Borg-Carbott, GB
Laurence Parmantier, FR
Eliane Deck-Chaumont, FR
Cristiana Tozzi, IT
Cristina Dolfi, IT
Simon Dresse, BE
Barbara Stolz, CH
Ninog Péresse, DE
Rädlein Renate, DE
Stefanie Larisch, DE
Beate Becker, DE
Giorgio Noseda, CH
Alix Pillot, FR
Kristyna Matejkova, CZ
Eve Keret, IL
Lluis Masso, ES
Tanya Szendeffy, GB
Erwin J Van Der Meijden, NL
Petra Freitag, DE
Julie Demolin, FR
Jørgen Dirach, DK
Nathalie Piton, FR
Per Soelberg Sorensen, DK
Pierre Dönnes, SE
Philippe Bardin, FR
J J Van Roozendaal, NL
Thomas Dehmel, DE
Florian Deisenhammer, AT
Camille Seze-Goimier, FR
Christoph Königs, DE
Johan Forsslöf, SE
Marie Holde-Jensen, DK
Ronya Rubinstein, IL
David Reynolds, GB
Ludwig Kappos, CH
Jörg Schüttrumpf, DE
Gabriella Marinari, IT
Daniel J Sikkema, GB
 
Project Categories:
Natural Sciences > Clinical Trials & Therapy > Clinical trials
 
Other Information:
Fiscal Year: 2012
Project Start Date: 1 March 2012
Project End Date: 28 February 2017
Project program: FP7-JTI
 
Project Funding Information:
Funding Mechanism: JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)
Year Funding Organization Total Funding, $
2012 European Research Council $35,027,298
Project Title: Anti-biopharmaceutical immunization:prediction and analysis of clinical relevance to minimize the risk
Project Number: CORDIS-203697
Project web address: Follow on CORDIS
Organization: Glaxosmithkline Research And Development Limited, United Kingdom, Stevenage
Collaborators: University College London, GB
Heinrich-Heine-Universitat At Dusseldorf, DE
University Hospital Basel, CH
Karolinska Institutet, SE
Centre National De La Recherche Scientifique (Cnrs), FR
Institut National De La Sante Et De La Recherche Medicale, FR
Istituto Giannina Gaslini, IT
Università Degli Studi Di Firenze, IT
Academisch Ziekenhuis Leiden, NL
Novo-Nordisk A/S, DK
Pfizer Ltd, GB
Assistance Publique - Hopitaux De Paris, FR
Merck Kommanditgesellschaft Auf Aktien, DE
Novartis Pharma Ag, CH
Commissariat A L'Energie Atomique Et Aux Energies Alternatives, FR
Region Hovedstaden, DK
Universitaetsklinikum Bonn, DE
Queen Mary, University Of London, GB
Medizinische Universitat Innsbruck, AT
Bayer Pharma Ag, DE
Fundacio Hospital Universitari Vall D'Hebron - Institut De Recerca, ES
Ucb Biopharma Sprl, BE
Fondazione Per L'Istituto Di Ricerca In Biomedicina, CH
Alta Ricerca E Sviluppo In Biotecnologie S.R.L.U., IT
Sanofi-Aventis Recherche & Developpement, FR
Klinikum Rechts Der Isar Der Technischen Universitat Munchen, DE
Bundesinstitut Fur Impfstoffe Und Biomedizinische Arzneimittel, DE
Drk-Blutspendedienst Baden-Württemberg – Hessen Gemeinnützige Gmbh, DE
Univerzita Karlova, CZ
Medical Research Infrastructure Development And Health Services Fund By The Sheba Medical Center, IL
The Health Corporation – Rambam, IL
Groupe D'Etudes Therapeutiques Desaffections Inflammatoires Digestives Association, FR
Scicross Ab, SE
Ipsen Innovation S.A.S., FR
Biomonitor A/S, DK
Principal Investigators (PI): Greta Borg-Carbott, GB
Laurence Parmantier, FR
Eliane Deck-Chaumont, FR
Cristiana Tozzi, IT
Cristina Dolfi, IT
Simon Dresse, BE
Barbara Stolz, CH
Ninog Péresse, DE
Rädlein Renate, DE
Stefanie Larisch, DE
Beate Becker, DE
Giorgio Noseda, CH
Alix Pillot, FR
Kristyna Matejkova, CZ
Eve Keret, IL
Lluis Masso, ES
Tanya Szendeffy, GB
Erwin J Van Der Meijden, NL
Petra Freitag, DE
Julie Demolin, FR
Jørgen Dirach, DK
Nathalie Piton, FR
Per Soelberg Sorensen, DK
Pierre Dönnes, SE
Philippe Bardin, FR
J J Van Roozendaal, NL
Thomas Dehmel, DE
Florian Deisenhammer, AT
Camille Seze-Goimier, FR
Christoph Königs, DE
Johan Forsslöf, SE
Marie Holde-Jensen, DK
Ronya Rubinstein, IL
David Reynolds, GB
Ludwig Kappos, CH
Jörg Schüttrumpf, DE
Gabriella Marinari, IT
Daniel J Sikkema, GB
 
Title FY Funding
There are no results for this project in database.
Project Title: Anti-biopharmaceutical immunization:prediction and analysis of clinical relevance to minimize the risk
Project Number: CORDIS-203697
Project web address: Follow on CORDIS
Organization: Glaxosmithkline Research And Development Limited, United Kingdom, Stevenage
Collaborators: University College London, GB
Heinrich-Heine-Universitat At Dusseldorf, DE
University Hospital Basel, CH
Karolinska Institutet, SE
Centre National De La Recherche Scientifique (Cnrs), FR
Institut National De La Sante Et De La Recherche Medicale, FR
Istituto Giannina Gaslini, IT
Università Degli Studi Di Firenze, IT
Academisch Ziekenhuis Leiden, NL
Novo-Nordisk A/S, DK
Pfizer Ltd, GB
Assistance Publique - Hopitaux De Paris, FR
Merck Kommanditgesellschaft Auf Aktien, DE
Novartis Pharma Ag, CH
Commissariat A L'Energie Atomique Et Aux Energies Alternatives, FR
Region Hovedstaden, DK
Universitaetsklinikum Bonn, DE
Queen Mary, University Of London, GB
Medizinische Universitat Innsbruck, AT
Bayer Pharma Ag, DE
Fundacio Hospital Universitari Vall D'Hebron - Institut De Recerca, ES
Ucb Biopharma Sprl, BE
Fondazione Per L'Istituto Di Ricerca In Biomedicina, CH
Alta Ricerca E Sviluppo In Biotecnologie S.R.L.U., IT
Sanofi-Aventis Recherche & Developpement, FR
Klinikum Rechts Der Isar Der Technischen Universitat Munchen, DE
Bundesinstitut Fur Impfstoffe Und Biomedizinische Arzneimittel, DE
Drk-Blutspendedienst Baden-Württemberg – Hessen Gemeinnützige Gmbh, DE
Univerzita Karlova, CZ
Medical Research Infrastructure Development And Health Services Fund By The Sheba Medical Center, IL
The Health Corporation – Rambam, IL
Groupe D'Etudes Therapeutiques Desaffections Inflammatoires Digestives Association, FR
Scicross Ab, SE
Ipsen Innovation S.A.S., FR
Biomonitor A/S, DK
Principal Investigators (PI): Greta Borg-Carbott, GB
Laurence Parmantier, FR
Eliane Deck-Chaumont, FR
Cristiana Tozzi, IT
Cristina Dolfi, IT
Simon Dresse, BE
Barbara Stolz, CH
Ninog Péresse, DE
Rädlein Renate, DE
Stefanie Larisch, DE
Beate Becker, DE
Giorgio Noseda, CH
Alix Pillot, FR
Kristyna Matejkova, CZ
Eve Keret, IL
Lluis Masso, ES
Tanya Szendeffy, GB
Erwin J Van Der Meijden, NL
Petra Freitag, DE
Julie Demolin, FR
Jørgen Dirach, DK
Nathalie Piton, FR
Per Soelberg Sorensen, DK
Pierre Dönnes, SE
Philippe Bardin, FR
J J Van Roozendaal, NL
Thomas Dehmel, DE
Florian Deisenhammer, AT
Camille Seze-Goimier, FR
Christoph Königs, DE
Johan Forsslöf, SE
Marie Holde-Jensen, DK
Ronya Rubinstein, IL
David Reynolds, GB
Ludwig Kappos, CH
Jörg Schüttrumpf, DE
Gabriella Marinari, IT
Daniel J Sikkema, GB
 
Project Title Organization FY Funding
Anti-Biopharmaceutical Immunization:Prediction And Analysis Of Clinical Relevance To Minimize The RiskGlaxosmithkline Research And Development Limited2012$35,027,298
Project Title: Anti-biopharmaceutical immunization:prediction and analysis of clinical relevance to minimize the risk
Project Number: CORDIS-203697
Project web address: Follow on CORDIS
Organization: Glaxosmithkline Research And Development Limited, United Kingdom, Stevenage
Collaborators: University College London, GB
Heinrich-Heine-Universitat At Dusseldorf, DE
University Hospital Basel, CH
Karolinska Institutet, SE
Centre National De La Recherche Scientifique (Cnrs), FR
Institut National De La Sante Et De La Recherche Medicale, FR
Istituto Giannina Gaslini, IT
Università Degli Studi Di Firenze, IT
Academisch Ziekenhuis Leiden, NL
Novo-Nordisk A/S, DK
Pfizer Ltd, GB
Assistance Publique - Hopitaux De Paris, FR
Merck Kommanditgesellschaft Auf Aktien, DE
Novartis Pharma Ag, CH
Commissariat A L'Energie Atomique Et Aux Energies Alternatives, FR
Region Hovedstaden, DK
Universitaetsklinikum Bonn, DE
Queen Mary, University Of London, GB
Medizinische Universitat Innsbruck, AT
Bayer Pharma Ag, DE
Fundacio Hospital Universitari Vall D'Hebron - Institut De Recerca, ES
Ucb Biopharma Sprl, BE
Fondazione Per L'Istituto Di Ricerca In Biomedicina, CH
Alta Ricerca E Sviluppo In Biotecnologie S.R.L.U., IT
Sanofi-Aventis Recherche & Developpement, FR
Klinikum Rechts Der Isar Der Technischen Universitat Munchen, DE
Bundesinstitut Fur Impfstoffe Und Biomedizinische Arzneimittel, DE
Drk-Blutspendedienst Baden-Württemberg – Hessen Gemeinnützige Gmbh, DE
Univerzita Karlova, CZ
Medical Research Infrastructure Development And Health Services Fund By The Sheba Medical Center, IL
The Health Corporation – Rambam, IL
Groupe D'Etudes Therapeutiques Desaffections Inflammatoires Digestives Association, FR
Scicross Ab, SE
Ipsen Innovation S.A.S., FR
Biomonitor A/S, DK
Principal Investigators (PI): Greta Borg-Carbott, GB
Laurence Parmantier, FR
Eliane Deck-Chaumont, FR
Cristiana Tozzi, IT
Cristina Dolfi, IT
Simon Dresse, BE
Barbara Stolz, CH
Ninog Péresse, DE
Rädlein Renate, DE
Stefanie Larisch, DE
Beate Becker, DE
Giorgio Noseda, CH
Alix Pillot, FR
Kristyna Matejkova, CZ
Eve Keret, IL
Lluis Masso, ES
Tanya Szendeffy, GB
Erwin J Van Der Meijden, NL
Petra Freitag, DE
Julie Demolin, FR
Jørgen Dirach, DK
Nathalie Piton, FR
Per Soelberg Sorensen, DK
Pierre Dönnes, SE
Philippe Bardin, FR
J J Van Roozendaal, NL
Thomas Dehmel, DE
Florian Deisenhammer, AT
Camille Seze-Goimier, FR
Christoph Königs, DE
Johan Forsslöf, SE
Marie Holde-Jensen, DK
Ronya Rubinstein, IL
David Reynolds, GB
Ludwig Kappos, CH
Jörg Schüttrumpf, DE
Gabriella Marinari, IT
Daniel J Sikkema, GB
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Anti-biopharmaceutical immunization:prediction and analysis of clinical relevance to minimize the risk
Project Number: CORDIS-203697
Project web address: Follow on CORDIS
Organization: Glaxosmithkline Research And Development Limited, United Kingdom, Stevenage
Collaborators: University College London, GB
Heinrich-Heine-Universitat At Dusseldorf, DE
University Hospital Basel, CH
Karolinska Institutet, SE
Centre National De La Recherche Scientifique (Cnrs), FR
Institut National De La Sante Et De La Recherche Medicale, FR
Istituto Giannina Gaslini, IT
Università Degli Studi Di Firenze, IT
Academisch Ziekenhuis Leiden, NL
Novo-Nordisk A/S, DK
Pfizer Ltd, GB
Assistance Publique - Hopitaux De Paris, FR
Merck Kommanditgesellschaft Auf Aktien, DE
Novartis Pharma Ag, CH
Commissariat A L'Energie Atomique Et Aux Energies Alternatives, FR
Region Hovedstaden, DK
Universitaetsklinikum Bonn, DE
Queen Mary, University Of London, GB
Medizinische Universitat Innsbruck, AT
Bayer Pharma Ag, DE
Fundacio Hospital Universitari Vall D'Hebron - Institut De Recerca, ES
Ucb Biopharma Sprl, BE
Fondazione Per L'Istituto Di Ricerca In Biomedicina, CH
Alta Ricerca E Sviluppo In Biotecnologie S.R.L.U., IT
Sanofi-Aventis Recherche & Developpement, FR
Klinikum Rechts Der Isar Der Technischen Universitat Munchen, DE
Bundesinstitut Fur Impfstoffe Und Biomedizinische Arzneimittel, DE
Drk-Blutspendedienst Baden-Württemberg – Hessen Gemeinnützige Gmbh, DE
Univerzita Karlova, CZ
Medical Research Infrastructure Development And Health Services Fund By The Sheba Medical Center, IL
The Health Corporation – Rambam, IL
Groupe D'Etudes Therapeutiques Desaffections Inflammatoires Digestives Association, FR
Scicross Ab, SE
Ipsen Innovation S.A.S., FR
Biomonitor A/S, DK
Principal Investigators (PI): Greta Borg-Carbott, GB
Laurence Parmantier, FR
Eliane Deck-Chaumont, FR
Cristiana Tozzi, IT
Cristina Dolfi, IT
Simon Dresse, BE
Barbara Stolz, CH
Ninog Péresse, DE
Rädlein Renate, DE
Stefanie Larisch, DE
Beate Becker, DE
Giorgio Noseda, CH
Alix Pillot, FR
Kristyna Matejkova, CZ
Eve Keret, IL
Lluis Masso, ES
Tanya Szendeffy, GB
Erwin J Van Der Meijden, NL
Petra Freitag, DE
Julie Demolin, FR
Jørgen Dirach, DK
Nathalie Piton, FR
Per Soelberg Sorensen, DK
Pierre Dönnes, SE
Philippe Bardin, FR
J J Van Roozendaal, NL
Thomas Dehmel, DE
Florian Deisenhammer, AT
Camille Seze-Goimier, FR
Christoph Königs, DE
Johan Forsslöf, SE
Marie Holde-Jensen, DK
Ronya Rubinstein, IL
David Reynolds, GB
Ludwig Kappos, CH
Jörg Schüttrumpf, DE
Gabriella Marinari, IT
Daniel J Sikkema, GB
 
Title Journal Year Country Rel