Quantitative imaging in cancer: connecting cellular processes with therapy

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Project Title: Quantitative imaging in cancer: connecting cellular processes with therapy
Project Number: CORDIS-203689
Project web address: Follow on CORDIS
Organization: European Organisation For Research & Treatment Of Cancer, Belgium, Brussels
Collaborators: University Of Manchester, GB
King'S College London, GB
Stichting Katholieke Universiteit, NL
Imperial College Of Science, Technology And Medicine, GB
Westfaelische Wilhelms-Universitaet Muenster, DE
The Chancellor, Masters And Scholars Of The University Of Cambridge, GB
Institut National De La Sante Et De La Recherche Medicale, FR
Institute Of Cancer Research : Royal Cancer Hospital, GB
Eidgenoessische Technische Hochschule Zuerich, CH
F. Hoffmann - La Roche Ltd., CH
Pfizer Ltd, GB
Glaxosmithkline Research And Development Limited, GB
Eli Lilly Company Limited, GB
Merck Kommanditgesellschaft Auf Aktien, DE
Cancer Research Uk, GB
Astra Zeneca Ab, SE
Erasmus Universitair Medisch Centrum Rotterdam, NL
Sanofi-Aventis Recherche & Developpement, FR
Amgen Nv, BE
Stichting Maastricht Radiation Oncology Maastro Clinic, NL
Stichting Vu, NL
Universitair Ziekenhuis Antwerpen, BE
Keosys S.A.S., FR
Principal Investigators (PI): Ron Irwin, GB
Linda A Everse, NL
Renata Schaeffer, GB
Katharina Steinberg, DE
Emma Ryley, GB
Yodry Vasquez, GB
Eva Lindgren, SE
Birgit Steckel-Hamann, GB
Jason Hannon, CH
Olga Krylova, GB
Sally Miles, GB
Ninog Péresse, DE
Floor Franssen, NL
Carole Meads, GB
Elizabeth Fay, GB
Daisy Van Mieghem, BE
Dina Falkenreck, FR
Anthony Mottier, FR
Jean-Paul Pasquet, FR
Jaap Kuij, NL
Andrea Kroon, NL
Rodolphe Eyraud, BE
Dario Neri, CH
Yan Liu, BE
 
Project Description:
The QuIC-ConCePT consortium has 2 objectives: 1.(90% of resource, WP2-5) to qualify 3 specific imaging biomarkers (IBs) of tumour cell proliferation, apoptosis, and necrosis, to allow drug developers to demonstrate reliably modulation of these pathologic processes in tumours in patients in realistic trials. Our vision for January 2016 is that drug developers can incorporate these IBs for decision-making in Phase I trials of investigational therapies, confident that the IBs are technically valid, that a measured change in the IB faithfully reflects the desired change in the underlying tumour pathology, and that the IBs can be readily deployed in multiple cancer centres in a robust, consistent, ethical, and cost-effective way acceptable to patients.2.(10% of resource, WP6) includes a portfolio of innovative approaches to devise, evaluate and introduce IBs of invasion and metastasis.The IBs of tumour cell proliferation and necrosis will be developed respectively from FLT PET and ADC MRI respectively. Initial apoptosis plans focus on ICMT11 PET, possibly with other IBs introduced later. The project will be delivered using a portfolio of animal (WP2), human (WP3), image analysis (WP4) and regulatory (WP5) work. The project will be coordinated and the interdependent workpackages integrated in WP1. These WPs will deliver image acquisition and analysis protocols which are technically valid, standardised and suitable for multicentre use. We will evaluate reproducibility, effects of intervention, timing, dose-response, and imaging-histopathology correlation in animals and patients. The project is timely, and highly likely to deliver IBs which will markedly improve drug development, and benefit cancer patients in Europe and globally. The managing entity (EORTC) is already world-leading in the qualification of IBs, and the consortium includes in the academic and EFPIA partners some of the world's most productive and innovative physicians and scientists in cancer imaging.
 
Project Terms:
There are no related terms in database.
Project Title: Quantitative imaging in cancer: connecting cellular processes with therapy
Project Number: CORDIS-203689
Project web address: Follow on CORDIS
Organization: European Organisation For Research & Treatment Of Cancer, Belgium, Brussels
Collaborators: University Of Manchester, GB
King'S College London, GB
Stichting Katholieke Universiteit, NL
Imperial College Of Science, Technology And Medicine, GB
Westfaelische Wilhelms-Universitaet Muenster, DE
The Chancellor, Masters And Scholars Of The University Of Cambridge, GB
Institut National De La Sante Et De La Recherche Medicale, FR
Institute Of Cancer Research : Royal Cancer Hospital, GB
Eidgenoessische Technische Hochschule Zuerich, CH
F. Hoffmann - La Roche Ltd., CH
Pfizer Ltd, GB
Glaxosmithkline Research And Development Limited, GB
Eli Lilly Company Limited, GB
Merck Kommanditgesellschaft Auf Aktien, DE
Cancer Research Uk, GB
Astra Zeneca Ab, SE
Erasmus Universitair Medisch Centrum Rotterdam, NL
Sanofi-Aventis Recherche & Developpement, FR
Amgen Nv, BE
Stichting Maastricht Radiation Oncology Maastro Clinic, NL
Stichting Vu, NL
Universitair Ziekenhuis Antwerpen, BE
Keosys S.A.S., FR
Principal Investigators (PI): Ron Irwin, GB
Linda A Everse, NL
Renata Schaeffer, GB
Katharina Steinberg, DE
Emma Ryley, GB
Yodry Vasquez, GB
Eva Lindgren, SE
Birgit Steckel-Hamann, GB
Jason Hannon, CH
Olga Krylova, GB
Sally Miles, GB
Ninog Péresse, DE
Floor Franssen, NL
Carole Meads, GB
Elizabeth Fay, GB
Daisy Van Mieghem, BE
Dina Falkenreck, FR
Anthony Mottier, FR
Jean-Paul Pasquet, FR
Jaap Kuij, NL
Andrea Kroon, NL
Rodolphe Eyraud, BE
Dario Neri, CH
Yan Liu, BE
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology > Cancer & related diseases > Malignant neoplasms (including in situ)
 
Other Information:
Fiscal Year: 2011
Project Start Date: 1 September 2011
Project End Date: 31 December 2017
Project program: FP7-JTI
 
Project Funding Information:
Funding Mechanism: JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)
Year Funding Organization Total Funding, $
2011 European Research Council $17,003,932
Project Title: Quantitative imaging in cancer: connecting cellular processes with therapy
Project Number: CORDIS-203689
Project web address: Follow on CORDIS
Organization: European Organisation For Research & Treatment Of Cancer, Belgium, Brussels
Collaborators: University Of Manchester, GB
King'S College London, GB
Stichting Katholieke Universiteit, NL
Imperial College Of Science, Technology And Medicine, GB
Westfaelische Wilhelms-Universitaet Muenster, DE
The Chancellor, Masters And Scholars Of The University Of Cambridge, GB
Institut National De La Sante Et De La Recherche Medicale, FR
Institute Of Cancer Research : Royal Cancer Hospital, GB
Eidgenoessische Technische Hochschule Zuerich, CH
F. Hoffmann - La Roche Ltd., CH
Pfizer Ltd, GB
Glaxosmithkline Research And Development Limited, GB
Eli Lilly Company Limited, GB
Merck Kommanditgesellschaft Auf Aktien, DE
Cancer Research Uk, GB
Astra Zeneca Ab, SE
Erasmus Universitair Medisch Centrum Rotterdam, NL
Sanofi-Aventis Recherche & Developpement, FR
Amgen Nv, BE
Stichting Maastricht Radiation Oncology Maastro Clinic, NL
Stichting Vu, NL
Universitair Ziekenhuis Antwerpen, BE
Keosys S.A.S., FR
Principal Investigators (PI): Ron Irwin, GB
Linda A Everse, NL
Renata Schaeffer, GB
Katharina Steinberg, DE
Emma Ryley, GB
Yodry Vasquez, GB
Eva Lindgren, SE
Birgit Steckel-Hamann, GB
Jason Hannon, CH
Olga Krylova, GB
Sally Miles, GB
Ninog Péresse, DE
Floor Franssen, NL
Carole Meads, GB
Elizabeth Fay, GB
Daisy Van Mieghem, BE
Dina Falkenreck, FR
Anthony Mottier, FR
Jean-Paul Pasquet, FR
Jaap Kuij, NL
Andrea Kroon, NL
Rodolphe Eyraud, BE
Dario Neri, CH
Yan Liu, BE
 
Title FY Funding
There are no results for this project in database.
Project Title: Quantitative imaging in cancer: connecting cellular processes with therapy
Project Number: CORDIS-203689
Project web address: Follow on CORDIS
Organization: European Organisation For Research & Treatment Of Cancer, Belgium, Brussels
Collaborators: University Of Manchester, GB
King'S College London, GB
Stichting Katholieke Universiteit, NL
Imperial College Of Science, Technology And Medicine, GB
Westfaelische Wilhelms-Universitaet Muenster, DE
The Chancellor, Masters And Scholars Of The University Of Cambridge, GB
Institut National De La Sante Et De La Recherche Medicale, FR
Institute Of Cancer Research : Royal Cancer Hospital, GB
Eidgenoessische Technische Hochschule Zuerich, CH
F. Hoffmann - La Roche Ltd., CH
Pfizer Ltd, GB
Glaxosmithkline Research And Development Limited, GB
Eli Lilly Company Limited, GB
Merck Kommanditgesellschaft Auf Aktien, DE
Cancer Research Uk, GB
Astra Zeneca Ab, SE
Erasmus Universitair Medisch Centrum Rotterdam, NL
Sanofi-Aventis Recherche & Developpement, FR
Amgen Nv, BE
Stichting Maastricht Radiation Oncology Maastro Clinic, NL
Stichting Vu, NL
Universitair Ziekenhuis Antwerpen, BE
Keosys S.A.S., FR
Principal Investigators (PI): Ron Irwin, GB
Linda A Everse, NL
Renata Schaeffer, GB
Katharina Steinberg, DE
Emma Ryley, GB
Yodry Vasquez, GB
Eva Lindgren, SE
Birgit Steckel-Hamann, GB
Jason Hannon, CH
Olga Krylova, GB
Sally Miles, GB
Ninog Péresse, DE
Floor Franssen, NL
Carole Meads, GB
Elizabeth Fay, GB
Daisy Van Mieghem, BE
Dina Falkenreck, FR
Anthony Mottier, FR
Jean-Paul Pasquet, FR
Jaap Kuij, NL
Andrea Kroon, NL
Rodolphe Eyraud, BE
Dario Neri, CH
Yan Liu, BE
 
Project Title Organization FY Funding
Quantitative Imaging In Cancer: Connecting Cellular Processes With TherapyEuropean Organisation For Research & Treatment Of Cancer2011$17,003,932
Project Title: Quantitative imaging in cancer: connecting cellular processes with therapy
Project Number: CORDIS-203689
Project web address: Follow on CORDIS
Organization: European Organisation For Research & Treatment Of Cancer, Belgium, Brussels
Collaborators: University Of Manchester, GB
King'S College London, GB
Stichting Katholieke Universiteit, NL
Imperial College Of Science, Technology And Medicine, GB
Westfaelische Wilhelms-Universitaet Muenster, DE
The Chancellor, Masters And Scholars Of The University Of Cambridge, GB
Institut National De La Sante Et De La Recherche Medicale, FR
Institute Of Cancer Research : Royal Cancer Hospital, GB
Eidgenoessische Technische Hochschule Zuerich, CH
F. Hoffmann - La Roche Ltd., CH
Pfizer Ltd, GB
Glaxosmithkline Research And Development Limited, GB
Eli Lilly Company Limited, GB
Merck Kommanditgesellschaft Auf Aktien, DE
Cancer Research Uk, GB
Astra Zeneca Ab, SE
Erasmus Universitair Medisch Centrum Rotterdam, NL
Sanofi-Aventis Recherche & Developpement, FR
Amgen Nv, BE
Stichting Maastricht Radiation Oncology Maastro Clinic, NL
Stichting Vu, NL
Universitair Ziekenhuis Antwerpen, BE
Keosys S.A.S., FR
Principal Investigators (PI): Ron Irwin, GB
Linda A Everse, NL
Renata Schaeffer, GB
Katharina Steinberg, DE
Emma Ryley, GB
Yodry Vasquez, GB
Eva Lindgren, SE
Birgit Steckel-Hamann, GB
Jason Hannon, CH
Olga Krylova, GB
Sally Miles, GB
Ninog Péresse, DE
Floor Franssen, NL
Carole Meads, GB
Elizabeth Fay, GB
Daisy Van Mieghem, BE
Dina Falkenreck, FR
Anthony Mottier, FR
Jean-Paul Pasquet, FR
Jaap Kuij, NL
Andrea Kroon, NL
Rodolphe Eyraud, BE
Dario Neri, CH
Yan Liu, BE
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Quantitative imaging in cancer: connecting cellular processes with therapy
Project Number: CORDIS-203689
Project web address: Follow on CORDIS
Organization: European Organisation For Research & Treatment Of Cancer, Belgium, Brussels
Collaborators: University Of Manchester, GB
King'S College London, GB
Stichting Katholieke Universiteit, NL
Imperial College Of Science, Technology And Medicine, GB
Westfaelische Wilhelms-Universitaet Muenster, DE
The Chancellor, Masters And Scholars Of The University Of Cambridge, GB
Institut National De La Sante Et De La Recherche Medicale, FR
Institute Of Cancer Research : Royal Cancer Hospital, GB
Eidgenoessische Technische Hochschule Zuerich, CH
F. Hoffmann - La Roche Ltd., CH
Pfizer Ltd, GB
Glaxosmithkline Research And Development Limited, GB
Eli Lilly Company Limited, GB
Merck Kommanditgesellschaft Auf Aktien, DE
Cancer Research Uk, GB
Astra Zeneca Ab, SE
Erasmus Universitair Medisch Centrum Rotterdam, NL
Sanofi-Aventis Recherche & Developpement, FR
Amgen Nv, BE
Stichting Maastricht Radiation Oncology Maastro Clinic, NL
Stichting Vu, NL
Universitair Ziekenhuis Antwerpen, BE
Keosys S.A.S., FR
Principal Investigators (PI): Ron Irwin, GB
Linda A Everse, NL
Renata Schaeffer, GB
Katharina Steinberg, DE
Emma Ryley, GB
Yodry Vasquez, GB
Eva Lindgren, SE
Birgit Steckel-Hamann, GB
Jason Hannon, CH
Olga Krylova, GB
Sally Miles, GB
Ninog Péresse, DE
Floor Franssen, NL
Carole Meads, GB
Elizabeth Fay, GB
Daisy Van Mieghem, BE
Dina Falkenreck, FR
Anthony Mottier, FR
Jean-Paul Pasquet, FR
Jaap Kuij, NL
Andrea Kroon, NL
Rodolphe Eyraud, BE
Dario Neri, CH
Yan Liu, BE
 
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