Novel methods leading to new medications in depression and schizophrenia

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Project Title: Novel methods leading to new medications in depression and schizophrenia
Project Number: CORDIS-203680
Project web address: Follow on CORDIS
Organization: H. Lundbeck A/S, Denmark, Valby
Collaborators: Bar-Ilan University, IL
University Of Manchester, GB
King'S College London, GB
Karolinska Institutet, SE
The Chancellor, Masters And Scholars Of The University Of Cambridge, GB
Janssen Pharmaceutica N.V., BE
F. Hoffmann - La Roche Ltd., CH
Pfizer Ltd, GB
Eli Lilly Company Limited, GB
Novartis Pharma Ag, CH
Astra Zeneca Ab, SE
Agencia Estatal Consejo Superior De Investigaciones Cientificas, ES
Gabo:Mi Gesellschaft Für Ablauforganisation :Milliarium Mbh & Co. Kg, DE
Islensk Erfdagreining Ehf, IS
Zentralinstitut Für Seelische Gesundheit (Central Institute Of Mental Health), DE
Orion Corporation, FI
Institut De Recherches Servier S.A.S, FR
Psynova Neurotech Ltd, GB
Abbvie Deutschland Gmbh & Co. Kg, DE
 
Project Description:
Despite dramatic advances in molecular and imaging technologies and nearly 1 5,000 articles on schizophrenia and depression (S&D) there are few novel treatments. We think this is because of three major “bottle-necks”: a lack of etiologically-driven or pathophysiologically-accurate animal models; a lack of tests that provide indication of efficacy in healthy volunteers; and the reliance of clinical trials on DSM categories which provide a collection of biologically heterogeneous patients. Our broad working hypothesis is that a focus on cross-species endophenotypes, testing in healthy volunteers and finding biologically-homogenous groups of patients will overcome existing limitations in target identification, early triage and clinical trials. To implement this idea six leading European institutions and two SMEs will partner with the EFPIA to: a) develop animal models that carry confirmed genetic risks, and in these animals to focus on cross-species endophenotypes (e.g., cognitive function, electrophysiology) to facilitate new drug discovery; b) validate the use of fMRI-based endopheno types in genetically-selected healthy volunteers and patients as early and surrogate markers for efficacy; and to combine this with PET approaches for plasma-kinetics to brain-dynamics modelling to provide guidance regarding optimal clinical trial design; and c) identify pharmacogenetic and multi-omic biomarkers that can be used to stratify patients within an umbrella DSM-diagnosis, thus allowing for ) targeted clinical trials, individualized treatment and back-translation of subgroup-specific biomarkers into preclinical drug discovery. To increase the chance of a breakthrough we will implement new analytical approaches (e.g. support vector machine learning algorithms; Bayesian analyses) and willactively collaborate with other ongoing international efforts (esp. the Biomarkers Consortium, NIH).
 
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