An integrated european ‘flagship’ program driving mechanism-based toxicity testing and risk assessment for the 21st century

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Project Title: An integrated european ‘flagship’ program driving mechanism-based toxicity testing and risk assessment for the 21st century
Project Number: CORDIS-198787
Project web address: Follow on CORDIS
Organization: Universiteit Leiden, Netherlands, Leiden
Collaborators: Johns Hopkins University, US
Medical Research Council, GB
European Molecular Biology Laboratory, DE
Istituto Superiore Di Sanita, IT
Katholieke Universiteit Leuven, BE
Simcyp, Ltd, GB
Karolinska Institutet, SE
Kobenhavns Universitet, DK
Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V., DE
Ruprecht-Karls-Universitaet Heidelberg, DE
Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek Tno*, NL
Academisch Ziekenhuis Leiden, NL
Unilever Uk Central Resources Ltd, GB
L'Oréal Sa, FR
Institut National De L'Environnement Industriel Et Des Risques, FR
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Universiteit Maastricht, NL
Universitat Pompeu Fabra, ES
Arttic, FR
F. Hoffmann - La Roche Ltd., CH
Universitat Konstanz, DE
Universitat Wien, AT
Forschungsgesellschaft Für Arbeitsphysiologie Und Arbeitsschutz E.V., DE
Steinbeis Gmbh & Co. Kg Fuer Technologietransfer, DE
Lhasa Ltd, GB
Medizinische Universität Innsbruck, AT
Bio Detection Systems B.V., NL
Cyprotex Discovery Ltd, GB
Bundesanstalt Fuer Arbeitsschutz Und Arbeitsmedizin, DE
Biotalentum Tudasfejleszto Kft, HU
Basf Se, DE
Fundacion Para La Investigacion Del Hospital Universitario La Fe De La Comunidad Valenciana, ES
Douglas Connect Gmbh, CH
Insphero Ag, CH
Cosmetics Europe - The Personal Care Association, BE
The Open Phacts Foundation, GB
The Danish Environmental Agency, DK
Tissuse Gmbh, DE
 
Project Description:
The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemicals with little background information. The project will focus on repeated dose systemic toxicity (liver, kidney, lung and nervous system) as well as developmental/reproduction toxicity. Different human tiered test systems are integrated to balance speed, cost and biological complexity. EU-ToxRisk extensively integrates the adverse outcome pathway (AOP)-based toxicity testing concept. Therefore, advanced technologies, including high throughput transcriptomics, RNA interference, and high throughput microscopy, will provide quantitative and mechanistic underpinning of AOPs and key events (KE). The project combines in silico tools and in vitro assays by computational modelling approaches to provide quantitative data on the activation of KE of AOP. This information, together with detailed toxicokinetics data, and in vitro-in vivo extrapolation algorithms forms the basis for improved hazard and risk assessment. The EU-ToxRisk work plan is structured along a broad spectrum of case studies, driven by the cosmetics, (agro)-chemical, pharma industry together with regulators. The approach involves iterative training, testing, optimization and validation phases to establish fit-for-purpose integrated approaches to testing and assessment with key EU-ToxRisk methodologies. The test systems will be combined to a flexible service package for exploitation and continued impact across industry sectors and regulatory application. The proof-of-concept for the new mechanism-based testing strategy will make EU-ToxRisk the flagship in Europe for animal-free chemical safety assessment.
 
Project Terms:
There are no related terms in database.
Project Title: An integrated european ‘flagship’ program driving mechanism-based toxicity testing and risk assessment for the 21st century
Project Number: CORDIS-198787
Project web address: Follow on CORDIS
Organization: Universiteit Leiden, Netherlands, Leiden
Collaborators: Johns Hopkins University, US
Medical Research Council, GB
European Molecular Biology Laboratory, DE
Istituto Superiore Di Sanita, IT
Katholieke Universiteit Leuven, BE
Simcyp, Ltd, GB
Karolinska Institutet, SE
Kobenhavns Universitet, DK
Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V., DE
Ruprecht-Karls-Universitaet Heidelberg, DE
Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek Tno*, NL
Academisch Ziekenhuis Leiden, NL
Unilever Uk Central Resources Ltd, GB
L'Oréal Sa, FR
Institut National De L'Environnement Industriel Et Des Risques, FR
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Universiteit Maastricht, NL
Universitat Pompeu Fabra, ES
Arttic, FR
F. Hoffmann - La Roche Ltd., CH
Universitat Konstanz, DE
Universitat Wien, AT
Forschungsgesellschaft Für Arbeitsphysiologie Und Arbeitsschutz E.V., DE
Steinbeis Gmbh & Co. Kg Fuer Technologietransfer, DE
Lhasa Ltd, GB
Medizinische Universität Innsbruck, AT
Bio Detection Systems B.V., NL
Cyprotex Discovery Ltd, GB
Bundesanstalt Fuer Arbeitsschutz Und Arbeitsmedizin, DE
Biotalentum Tudasfejleszto Kft, HU
Basf Se, DE
Fundacion Para La Investigacion Del Hospital Universitario La Fe De La Comunidad Valenciana, ES
Douglas Connect Gmbh, CH
Insphero Ag, CH
Cosmetics Europe - The Personal Care Association, BE
The Open Phacts Foundation, GB
The Danish Environmental Agency, DK
Tissuse Gmbh, DE
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2016
Project Start Date: 1 January 2015
Project End Date: 31 December 2021
Project program: H2020-EU.3.1.
 
Project Funding Information:
Funding Mechanism: RIA - Research and Innovation action
Year Funding Organization Total Funding, $
2016 European Research Council $33,134,369
Project Title: An integrated european ‘flagship’ program driving mechanism-based toxicity testing and risk assessment for the 21st century
Project Number: CORDIS-198787
Project web address: Follow on CORDIS
Organization: Universiteit Leiden, Netherlands, Leiden
Collaborators: Johns Hopkins University, US
Medical Research Council, GB
European Molecular Biology Laboratory, DE
Istituto Superiore Di Sanita, IT
Katholieke Universiteit Leuven, BE
Simcyp, Ltd, GB
Karolinska Institutet, SE
Kobenhavns Universitet, DK
Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V., DE
Ruprecht-Karls-Universitaet Heidelberg, DE
Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek Tno*, NL
Academisch Ziekenhuis Leiden, NL
Unilever Uk Central Resources Ltd, GB
L'Oréal Sa, FR
Institut National De L'Environnement Industriel Et Des Risques, FR
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Universiteit Maastricht, NL
Universitat Pompeu Fabra, ES
Arttic, FR
F. Hoffmann - La Roche Ltd., CH
Universitat Konstanz, DE
Universitat Wien, AT
Forschungsgesellschaft Für Arbeitsphysiologie Und Arbeitsschutz E.V., DE
Steinbeis Gmbh & Co. Kg Fuer Technologietransfer, DE
Lhasa Ltd, GB
Medizinische Universität Innsbruck, AT
Bio Detection Systems B.V., NL
Cyprotex Discovery Ltd, GB
Bundesanstalt Fuer Arbeitsschutz Und Arbeitsmedizin, DE
Biotalentum Tudasfejleszto Kft, HU
Basf Se, DE
Fundacion Para La Investigacion Del Hospital Universitario La Fe De La Comunidad Valenciana, ES
Douglas Connect Gmbh, CH
Insphero Ag, CH
Cosmetics Europe - The Personal Care Association, BE
The Open Phacts Foundation, GB
The Danish Environmental Agency, DK
Tissuse Gmbh, DE
 
Title FY Funding
There are no results for this project in database.
Project Title: An integrated european ‘flagship’ program driving mechanism-based toxicity testing and risk assessment for the 21st century
Project Number: CORDIS-198787
Project web address: Follow on CORDIS
Organization: Universiteit Leiden, Netherlands, Leiden
Collaborators: Johns Hopkins University, US
Medical Research Council, GB
European Molecular Biology Laboratory, DE
Istituto Superiore Di Sanita, IT
Katholieke Universiteit Leuven, BE
Simcyp, Ltd, GB
Karolinska Institutet, SE
Kobenhavns Universitet, DK
Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V., DE
Ruprecht-Karls-Universitaet Heidelberg, DE
Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek Tno*, NL
Academisch Ziekenhuis Leiden, NL
Unilever Uk Central Resources Ltd, GB
L'Oréal Sa, FR
Institut National De L'Environnement Industriel Et Des Risques, FR
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Universiteit Maastricht, NL
Universitat Pompeu Fabra, ES
Arttic, FR
F. Hoffmann - La Roche Ltd., CH
Universitat Konstanz, DE
Universitat Wien, AT
Forschungsgesellschaft Für Arbeitsphysiologie Und Arbeitsschutz E.V., DE
Steinbeis Gmbh & Co. Kg Fuer Technologietransfer, DE
Lhasa Ltd, GB
Medizinische Universität Innsbruck, AT
Bio Detection Systems B.V., NL
Cyprotex Discovery Ltd, GB
Bundesanstalt Fuer Arbeitsschutz Und Arbeitsmedizin, DE
Biotalentum Tudasfejleszto Kft, HU
Basf Se, DE
Fundacion Para La Investigacion Del Hospital Universitario La Fe De La Comunidad Valenciana, ES
Douglas Connect Gmbh, CH
Insphero Ag, CH
Cosmetics Europe - The Personal Care Association, BE
The Open Phacts Foundation, GB
The Danish Environmental Agency, DK
Tissuse Gmbh, DE
 
Project Title Organization FY Funding
Project Title: An integrated european ‘flagship’ program driving mechanism-based toxicity testing and risk assessment for the 21st century
Project Number: CORDIS-198787
Project web address: Follow on CORDIS
Organization: Universiteit Leiden, Netherlands, Leiden
Collaborators: Johns Hopkins University, US
Medical Research Council, GB
European Molecular Biology Laboratory, DE
Istituto Superiore Di Sanita, IT
Katholieke Universiteit Leuven, BE
Simcyp, Ltd, GB
Karolinska Institutet, SE
Kobenhavns Universitet, DK
Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V., DE
Ruprecht-Karls-Universitaet Heidelberg, DE
Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek Tno*, NL
Academisch Ziekenhuis Leiden, NL
Unilever Uk Central Resources Ltd, GB
L'Oréal Sa, FR
Institut National De L'Environnement Industriel Et Des Risques, FR
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Universiteit Maastricht, NL
Universitat Pompeu Fabra, ES
Arttic, FR
F. Hoffmann - La Roche Ltd., CH
Universitat Konstanz, DE
Universitat Wien, AT
Forschungsgesellschaft Für Arbeitsphysiologie Und Arbeitsschutz E.V., DE
Steinbeis Gmbh & Co. Kg Fuer Technologietransfer, DE
Lhasa Ltd, GB
Medizinische Universität Innsbruck, AT
Bio Detection Systems B.V., NL
Cyprotex Discovery Ltd, GB
Bundesanstalt Fuer Arbeitsschutz Und Arbeitsmedizin, DE
Biotalentum Tudasfejleszto Kft, HU
Basf Se, DE
Fundacion Para La Investigacion Del Hospital Universitario La Fe De La Comunidad Valenciana, ES
Douglas Connect Gmbh, CH
Insphero Ag, CH
Cosmetics Europe - The Personal Care Association, BE
The Open Phacts Foundation, GB
The Danish Environmental Agency, DK
Tissuse Gmbh, DE
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: An integrated european ‘flagship’ program driving mechanism-based toxicity testing and risk assessment for the 21st century
Project Number: CORDIS-198787
Project web address: Follow on CORDIS
Organization: Universiteit Leiden, Netherlands, Leiden
Collaborators: Johns Hopkins University, US
Medical Research Council, GB
European Molecular Biology Laboratory, DE
Istituto Superiore Di Sanita, IT
Katholieke Universiteit Leuven, BE
Simcyp, Ltd, GB
Karolinska Institutet, SE
Kobenhavns Universitet, DK
Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V., DE
Ruprecht-Karls-Universitaet Heidelberg, DE
Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek Tno*, NL
Academisch Ziekenhuis Leiden, NL
Unilever Uk Central Resources Ltd, GB
L'Oréal Sa, FR
Institut National De L'Environnement Industriel Et Des Risques, FR
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Universiteit Maastricht, NL
Universitat Pompeu Fabra, ES
Arttic, FR
F. Hoffmann - La Roche Ltd., CH
Universitat Konstanz, DE
Universitat Wien, AT
Forschungsgesellschaft Für Arbeitsphysiologie Und Arbeitsschutz E.V., DE
Steinbeis Gmbh & Co. Kg Fuer Technologietransfer, DE
Lhasa Ltd, GB
Medizinische Universität Innsbruck, AT
Bio Detection Systems B.V., NL
Cyprotex Discovery Ltd, GB
Bundesanstalt Fuer Arbeitsschutz Und Arbeitsmedizin, DE
Biotalentum Tudasfejleszto Kft, HU
Basf Se, DE
Fundacion Para La Investigacion Del Hospital Universitario La Fe De La Comunidad Valenciana, ES
Douglas Connect Gmbh, CH
Insphero Ag, CH
Cosmetics Europe - The Personal Care Association, BE
The Open Phacts Foundation, GB
The Danish Environmental Agency, DK
Tissuse Gmbh, DE
 
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