Holistic evaluation of light and multiwave applications to high resolution imaging in ophthalmic translational research revisiting the helmholtzian synergies

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Project Title: Holistic evaluation of light and multiwave applications to high resolution imaging in ophthalmic translational research revisiting the helmholtzian synergies
Project Number: CORDIS-191153
Project web address: Follow on CORDIS
Organization: Fondation De Cooperation Scientifique Voir Et Entendre, France, Paris
Principal Investigators (PI): José-Alain Sahel, FR
 
Project Description:
The HELMHOLTZ project associates two leading neighbouring institutions: the Institut de la Vision (Fondation Voir et Entendre) and the Institut Langevin (Fondation Pierre-Gilles de Gennes) committed to boost the integration of technological research in photonics, acoustics and ultrasound with translational research on vision impairment, in order to co-develop and validate prototypes for non-invasive in vivo structural and functional dynamic imaging technologies for ophthalmology.Innovative imaging tools will rely on emerging concepts such as ultrafast ultrasound, laser Doppler holography, full field and ultrafast cell resolution optical coherence tomography (OCT), bi-photon microscopy. These will enable both structural and functional analyses of the ocular tissues, with strong focus on the macula, the central part of the retina which is affected by the most severe disabling conditions, e.g. retinal dystrophies, age-related macular degeneration, glaucoma, vascular diseases, diabetic retinopathy, toxicities. We shall explore: 1) the subcellular and dynamic structure of photoreceptors, 2) changes in vascular flow and 3) functional imaging of the visual system from retina to cortex. Massive data acquisition and ultrafast numerical signal processing will take advantage of GPU-based parallel computing and of new asynchronous visual sensors. Continuous feedbacks from animal and human studies will lead to refine or redefine the prototypes jointly.These new diagnostic tools will address unmet medical needs by improving the understanding of retinal pathophysiology, defining new biomarkers for disease progressions and enabling clinicians to select the best suited emerging therapies, from neuroprotection to gene therapy and visual restoration. As the most optically and functionally approachable part of the brain, the retina will thus exemplify and validate major streams of technological innovations for care by enhancing cross-fertilization between biomedicine and physics.
 
Project Terms:
scientific research
Project Title: Holistic evaluation of light and multiwave applications to high resolution imaging in ophthalmic translational research revisiting the helmholtzian synergies
Project Number: CORDIS-191153
Project web address: Follow on CORDIS
Organization: Fondation De Cooperation Scientifique Voir Et Entendre, France, Paris
Principal Investigators (PI): José-Alain Sahel, FR
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology > Eye diseases > Age-related Macular Degeneration (AMD)
 
Other Information:
Fiscal Year: 2014
Project Start Date: 1 August 2014
Project End Date: 31 July 2020
Project program: FP7-IDEAS-ERC
 
Project Funding Information:
Funding Mechanism: ERC-SyG - Synergy grant
Year Funding Organization Total Funding, $
2014 European Research Council $13,048,115
Project Title: Holistic evaluation of light and multiwave applications to high resolution imaging in ophthalmic translational research revisiting the helmholtzian synergies
Project Number: CORDIS-191153
Project web address: Follow on CORDIS
Organization: Fondation De Cooperation Scientifique Voir Et Entendre, France, Paris
Principal Investigators (PI): José-Alain Sahel, FR
 
Title FY Funding
There are no results for this project in database.
Project Title: Holistic evaluation of light and multiwave applications to high resolution imaging in ophthalmic translational research revisiting the helmholtzian synergies
Project Number: CORDIS-191153
Project web address: Follow on CORDIS
Organization: Fondation De Cooperation Scientifique Voir Et Entendre, France, Paris
Principal Investigators (PI): José-Alain Sahel, FR
 
Project Title Organization FY Funding
Holistic Evaluation Of Light And Multiwave Applications To High Resolution Imaging In Ophthalmic Translational Research Revisiting The Helmholtzian SynergiesFondation De Cooperation Scientifique Voir Et Entendre2014$13,048,115
Project Title: Holistic evaluation of light and multiwave applications to high resolution imaging in ophthalmic translational research revisiting the helmholtzian synergies
Project Number: CORDIS-191153
Project web address: Follow on CORDIS
Organization: Fondation De Cooperation Scientifique Voir Et Entendre, France, Paris
Principal Investigators (PI): José-Alain Sahel, FR
 
Project number Project title Principal investigator
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Project Title: Holistic evaluation of light and multiwave applications to high resolution imaging in ophthalmic translational research revisiting the helmholtzian synergies
Project Number: CORDIS-191153
Project web address: Follow on CORDIS
Organization: Fondation De Cooperation Scientifique Voir Et Entendre, France, Paris
Principal Investigators (PI): José-Alain Sahel, FR
 
Title Journal Year Country Rel