The ngf system and its interplay with endocannabinoid signalling, from peripheral sensory terminals to the brain: new targets for the development of next generation drugs for neuropathic pain

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Project Title: The ngf system and its interplay with endocannabinoid signalling, from peripheral sensory terminals to the brain: new targets for the development of next generation drugs for neuropathic pain
Project Number: CORDIS-185456
Project web address: Follow on CORDIS
Organization: Scuola Normale Superiore, Italy, Pisa
Collaborators: University Of Salamanca, ES
King'S College London, GB
Aarhus Universitet, DK
Institut National De La Sante Et De La Recherche Medicale, FR
European Brain Research Institute R Ita Levi-Montalcini Fondazione*Ebri, IT
Medizinische Universitaet Wien, AT
Genomnia Srl, IT
Levicept Ltd, GB
Principal Investigators (PI): Paul Labbett, GB
Lone Romar Larsen, DK
Jérémy Bonnassies, FR
María De Los Ángeles Serrano García, ES
Jürgen Sandkühler, AT
Anna Moles, IT
Silvia Marinelli, IT
Simon Westbrook, GB
Larissa Zoni, IT
 
Project Description:
So far, there are no effective treatments for neuropathic pain (NP), and current treatments suffer from serious unwanted side effects.The NGF ligand-receptor system has recently emerged as a novel target for NP of great therapeutic potential, a master regulator, controlling both neuropathic and inflammatory components. Besides being a multi-component system, it also modulates the endocannabinoid (EC) signalling. Blocking the NGF signaling system is therefore a rational and thoroughly validated approach to pain therapy. Extensive evidence for potent analgesic efficacy of antiNGF mAbs has been obtained in preclinical models and in clinical trials,showing remarkable analgesic efficacy and creating great expectations for this new class of analgesic compounds.However, potential safety concerns related to off-target side effects have been raised and recently the FDA called for more preclinical research. To fully exploit the huge therapeutic potential of NGF system, we built a consortium of leading researchers in the NGF, EC and pain scientific arena.The innovative proposal will investigate new strategies for the treatment of different NP forms, based on the NGF system and its interplay with EC signalling, focussing at different levels of the pain transmission and perception systems.The project results will provide solid, mechanism-based grounds for the development of already identified second-generation therapeutics, based on the “NGF target” system, as well as for the identification and validation of new druggable targets emerging from the elucidated mechanisms. It will also identify biomarkers for NP, validated in animal models and clinical samples, that could result in future clinical benefits, for the stratification of patients suffering from different neuropathies and their treatment.The project will contribute to the understanding and controlling NP mechanisms, with an interdisciplinary approach, leading to the development of next-generation NGF targeting drugs.
 
Project Terms:
life sciences
Project Title: The ngf system and its interplay with endocannabinoid signalling, from peripheral sensory terminals to the brain: new targets for the development of next generation drugs for neuropathic pain
Project Number: CORDIS-185456
Project web address: Follow on CORDIS
Organization: Scuola Normale Superiore, Italy, Pisa
Collaborators: University Of Salamanca, ES
King'S College London, GB
Aarhus Universitet, DK
Institut National De La Sante Et De La Recherche Medicale, FR
European Brain Research Institute R Ita Levi-Montalcini Fondazione*Ebri, IT
Medizinische Universitaet Wien, AT
Genomnia Srl, IT
Levicept Ltd, GB
Principal Investigators (PI): Paul Labbett, GB
Lone Romar Larsen, DK
Jérémy Bonnassies, FR
María De Los Ángeles Serrano García, ES
Jürgen Sandkühler, AT
Anna Moles, IT
Silvia Marinelli, IT
Simon Westbrook, GB
Larissa Zoni, IT
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2014
Project Start Date: 1 April 2014
Project End Date: 31 March 2017
Project program: FP7-HEALTH
 
Project Funding Information:
Funding Mechanism: CP-FP - Small or medium-scale focused research project
Year Funding Organization Total Funding, $
2014 European Research Council $8,666,176
Project Title: The ngf system and its interplay with endocannabinoid signalling, from peripheral sensory terminals to the brain: new targets for the development of next generation drugs for neuropathic pain
Project Number: CORDIS-185456
Project web address: Follow on CORDIS
Organization: Scuola Normale Superiore, Italy, Pisa
Collaborators: University Of Salamanca, ES
King'S College London, GB
Aarhus Universitet, DK
Institut National De La Sante Et De La Recherche Medicale, FR
European Brain Research Institute R Ita Levi-Montalcini Fondazione*Ebri, IT
Medizinische Universitaet Wien, AT
Genomnia Srl, IT
Levicept Ltd, GB
Principal Investigators (PI): Paul Labbett, GB
Lone Romar Larsen, DK
Jérémy Bonnassies, FR
María De Los Ángeles Serrano García, ES
Jürgen Sandkühler, AT
Anna Moles, IT
Silvia Marinelli, IT
Simon Westbrook, GB
Larissa Zoni, IT
 
Project number Project title Principal investigator
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