Targets and biomarkers for antiepileptogenesis

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Project Title: Targets and biomarkers for antiepileptogenesis
Project Number: CORDIS-111305
Project web address: Follow on CORDIS
Organization: Lund University, Sweden, Lund
Collaborators: Ben-Gurion University Of The Negev, IL
University College London, GB
Imperial College Of Science, Technology And Medicine, GB
Università Degli Studi Di Ferrara, IT
Medizinische Hochschule Hannover, DE
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Arttic, FR
Universitaetsklinikum Bonn, DE
Life And Brain Gmbh, DE
Stiftung Tieraerztliche Hochschule Hannover, DE
Itä-Suomen Yliopisto, FI
Instytut Biologii Doswiadczalnej Im. M. Nenckiego Polskiej Akademii Nauk, PL
Universite D'Aix Marseille, FR
Gabo:Mi Gesellschaft Für Ablauforganisation :Milliarium Mbh & Co. Kg, DE
Bioviron Sarl, FR
To-Bbb Technologies Bv, NL
Nanomerics Ltd, GB
Microvitae Technologies Sas, FR
Principal Investigators (PI): Merab Kokaia, SE
Birgit Fuchs, DE
Maria Grazia Pezzoni, IT
Daphna Tripto, IL
Tatjana Palalic, GB
Celine Damon, FR
Marta Rucinska, PL
Beate Becker, DE
Frank Dittrich, DE
Martin Dietz, FR
Tiina Reinikainen, FI
Hervé Berthommé, FR
Dario Di Luca, IT
Gulseren Yalvac, NL
Peter Joppe, DE
Kamila Kolasinska, GB
Andreas G Schatzlein, GB
Sijme Zeilemaker, NL
Thierry Hervé, FR
Heinz Beck, DE
 
Project Description:
Epilepsy is a devastating condition affecting over 50 million people worldwide. This multidisciplinary project is focused on the process leading to epilepsy, epileptogenesis, in adults. Our main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and development of seizures. Our central premise and vision is that a combinatorial approach is necessary to identify appropriate biomarkers and develop effective antiepileptogenic therapeutics. The project will focus on identifying novel biomarkers and their combinations for epileptogenesis after potentially epileptogenic brain insults in clinically relevant animal models, such as traumatic brain injury (TBI) and status epilepticus (SE); explore multiple basic mechanisms of epileptogenesis and their mutual interactions related to cell degeneration, circuit reorganization, inflammatory processes, free radical formation, altered neurogenesis, BBB dysfunction, genetic and epigenetic alterations; and translating these findings towards the clinic by validating biomarkers identified from animal models in human post TBI brain tissue and blood samples, post-mortem brain tissue in individuals that died soon after SE, and human brain and blood samples from chronic epilepsy cases. The project will identify novel combinatorial biomarkers and novel disease-modifying combinatorial treatment strategies for epileptogenesis, create an Epilepsy Preclinical Biobank, and validate translational potential of results from animal models in human tissue. To adequately address the proposed goals, the project will develop technological breakthroughs, such as completely novel chemogenetic approaches, novel MRI techniques, novel multimodal organic recording devices for simultaneous recordings of EEG / cellular unit activity and biochemical measurements, novel bioluminescence for in vivo promoter activity analysis, and novel systems biology approaches.
 
Project Terms:
life sciences
Project Title: Targets and biomarkers for antiepileptogenesis
Project Number: CORDIS-111305
Project web address: Follow on CORDIS
Organization: Lund University, Sweden, Lund
Collaborators: Ben-Gurion University Of The Negev, IL
University College London, GB
Imperial College Of Science, Technology And Medicine, GB
Università Degli Studi Di Ferrara, IT
Medizinische Hochschule Hannover, DE
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Arttic, FR
Universitaetsklinikum Bonn, DE
Life And Brain Gmbh, DE
Stiftung Tieraerztliche Hochschule Hannover, DE
Itä-Suomen Yliopisto, FI
Instytut Biologii Doswiadczalnej Im. M. Nenckiego Polskiej Akademii Nauk, PL
Universite D'Aix Marseille, FR
Gabo:Mi Gesellschaft Für Ablauforganisation :Milliarium Mbh & Co. Kg, DE
Bioviron Sarl, FR
To-Bbb Technologies Bv, NL
Nanomerics Ltd, GB
Microvitae Technologies Sas, FR
Principal Investigators (PI): Merab Kokaia, SE
Birgit Fuchs, DE
Maria Grazia Pezzoni, IT
Daphna Tripto, IL
Tatjana Palalic, GB
Celine Damon, FR
Marta Rucinska, PL
Beate Becker, DE
Frank Dittrich, DE
Martin Dietz, FR
Tiina Reinikainen, FI
Hervé Berthommé, FR
Dario Di Luca, IT
Gulseren Yalvac, NL
Peter Joppe, DE
Kamila Kolasinska, GB
Andreas G Schatzlein, GB
Sijme Zeilemaker, NL
Thierry Hervé, FR
Heinz Beck, DE
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2013
Project Start Date: 1 November 2013
Project End Date: 31 October 2018
Project program: FP7-HEALTH
 
Project Funding Information:
Funding Mechanism: CP-IP - Large-scale integrating project
Year Funding Organization Total Funding, $
2013 European Research Council $17,352,609