Programming synthetic networks for bio-based production of value chemicals

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Project Title: Programming synthetic networks for bio-based production of value chemicals
Project Number: CORDIS-111191
Project web address: Follow on CORDIS
Organization: Danmark Tekniske Universitet, Denmark, Kgs. Lyngby
Collaborators: University Of Warwick, GB
Technische Universitat Darmstadt, DE
Evolva Sa, CH
Biosyntia Aps, DK
Bacmine Sl, ES
Principal Investigators (PI): Peter Hedges, GB
Dick Veldhuis, NL
Melanie Meermann-Zimmermann, DE
Birte Rasmussen, DK
Andreas Laustsen, DK
Michael Naesby, CH
Pablo Pomposiello Miravent, ES
 
Project Description:
The global chemical industry is transitioning from petrochemical production processes to bio-based production processes. This transition creates a clear market need for technologies that reduce the development time and cost of cell factories. PROMYS will develop, validate and implement a novel synthetic biology platform technology termed ligand responsive regulation and selection systems. Ligand responsive regulation and selection systems are biological devices that integrate biological sensing modules, within larger regulatory networks to control cellular programs. This technology will drastically accelerate the construction, optimization and performance of cell factories by enabling industrial users to impose non-natural objectives on the engineered cell factory. PROMYS will address three major challenges in metabolic engineering that limit the development of new cell factories:1) Synthetic pathway construction2) Cell factory optimization3) Control of populations during fermentationLigand responsive regulation and selection systems will directly couple the presence of a desired chemical product or flux state within a cell, to the survival of the cell. As such, they allow the in vivo identification of the needle (e.g. functional pathway or optimized cell factories) in a haystack (e.g. large libraries). In addition, the technology developed in PROMYS will be applied to deliver increased fermentation yields by continuously selecting for high yielding cell factories within the fermentation population.PROMYS is industry driven and designed such that the expected innovations of each work package have a direct commercialization partner, which is willing to commit the necessary resources to develop commercial products from the innovation.
 
Project Terms:
agriculture biotechnology environmental protection scientific research
Project Title: Programming synthetic networks for bio-based production of value chemicals
Project Number: CORDIS-111191
Project web address: Follow on CORDIS
Organization: Danmark Tekniske Universitet, Denmark, Kgs. Lyngby
Collaborators: University Of Warwick, GB
Technische Universitat Darmstadt, DE
Evolva Sa, CH
Biosyntia Aps, DK
Bacmine Sl, ES
Principal Investigators (PI): Peter Hedges, GB
Dick Veldhuis, NL
Melanie Meermann-Zimmermann, DE
Birte Rasmussen, DK
Andreas Laustsen, DK
Michael Naesby, CH
Pablo Pomposiello Miravent, ES
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2013
Project Start Date: 1 December 2013
Project End Date: 30 November 2017
Project program: FP7-KBBE
 
Project Funding Information:
Funding Mechanism: CP-TP - Collaborative Project targeted to a special group (such as SMEs)
Year Funding Organization Total Funding, $
2013 European Research Council $10,309,296
Project Title: Programming synthetic networks for bio-based production of value chemicals
Project Number: CORDIS-111191
Project web address: Follow on CORDIS
Organization: Danmark Tekniske Universitet, Denmark, Kgs. Lyngby
Collaborators: University Of Warwick, GB
Technische Universitat Darmstadt, DE
Evolva Sa, CH
Biosyntia Aps, DK
Bacmine Sl, ES
Principal Investigators (PI): Peter Hedges, GB
Dick Veldhuis, NL
Melanie Meermann-Zimmermann, DE
Birte Rasmussen, DK
Andreas Laustsen, DK
Michael Naesby, CH
Pablo Pomposiello Miravent, ES
 
Title FY Funding
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Project Title: Programming synthetic networks for bio-based production of value chemicals
Project Number: CORDIS-111191
Project web address: Follow on CORDIS
Organization: Danmark Tekniske Universitet, Denmark, Kgs. Lyngby
Collaborators: University Of Warwick, GB
Technische Universitat Darmstadt, DE
Evolva Sa, CH
Biosyntia Aps, DK
Bacmine Sl, ES
Principal Investigators (PI): Peter Hedges, GB
Dick Veldhuis, NL
Melanie Meermann-Zimmermann, DE
Birte Rasmussen, DK
Andreas Laustsen, DK
Michael Naesby, CH
Pablo Pomposiello Miravent, ES
 
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