Advanced materials for cardiac regeneration (amcare)

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Project Title: Advanced materials for cardiac regeneration (amcare)
Project Number: CORDIS-110863
Project web address: Follow on CORDIS
Organization: Royal College Of Surgeons In Ireland, Ireland, Dublin
Collaborators: Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V., DE
Innova Srl, IT
Boston Scientific Ireland Limited, IE
The Provost, Fellows, Foundation Scholars & The Other Members Of Board Of The College Of The Holy & Undivided Trinity Of Queen Elizabeth Near Dublin, IE
Explora Srl, IT
Celyad, BE
Contipro Biotech Sro, CZ
Adjucor Gmbh, DE
Principal Investigators (PI): Christoph Schulte, DE
Deirdre Savage, IE
Davide De Lucrezia, IT
Eva Cerna, CZ
Aymeric Seron, BE
Aiden Flanagan, IE
Tommaso Foglia, IT
Stephen Wildhirt, DE
Meinrad Gawaz, DE
Garry Duffy, IE
 
Project Description:
The Advanced Materials for Cardiac Regeneration (AMCARE) consortium aims to establish a translational research program to develop truly restorative therapies for acute myocardial infarction repair (MI) by optimising cardiac progenitor cell (CPC) therapy using smart biomaterials and advanced drug delivery, and coupling these therapeutics with minimally-invasive surgical devices. Two distinct biomaterial delivery systems for CPCs will be investigated in the AMCARE work programme including HA-based patches (CardioPatch) and HA-hydrogels (CardioGel). We also propose to develop two prototypes of new surgical devices [C-CathGel and SPREDS] that will ensure a minimally invasive delivery and fixation approach that is safe and effective for each therapeutic. The combinations of advanced material carriers and surgical devices will be assessed in a large animal model of acute-MI to best align our approach to clinical translation. The novel formulations and delivery methods will help post-MI patients in restoring cardiac function by targeting for repair the underlying myocardium damage, and could potentially decrease morbidity and mortality in the future. These goals will be achieved by integrating numerous areas of materials science and stem cell biology as well as leaders in the field of medical devices, biomaterials and cardiovascular regeneration. We thus aim to improve long-term healthcare of EU citizens by offering a revolutionary therapeutic modality for the treatment of acute-MI.
 
Project Terms:
scientific research
Project Title: Advanced materials for cardiac regeneration (amcare)
Project Number: CORDIS-110863
Project web address: Follow on CORDIS
Organization: Royal College Of Surgeons In Ireland, Ireland, Dublin
Collaborators: Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V., DE
Innova Srl, IT
Boston Scientific Ireland Limited, IE
The Provost, Fellows, Foundation Scholars & The Other Members Of Board Of The College Of The Holy & Undivided Trinity Of Queen Elizabeth Near Dublin, IE
Explora Srl, IT
Celyad, BE
Contipro Biotech Sro, CZ
Adjucor Gmbh, DE
Principal Investigators (PI): Christoph Schulte, DE
Deirdre Savage, IE
Davide De Lucrezia, IT
Eva Cerna, CZ
Aymeric Seron, BE
Aiden Flanagan, IE
Tommaso Foglia, IT
Stephen Wildhirt, DE
Meinrad Gawaz, DE
Garry Duffy, IE
 
Project Categories:
Natural Sciences > Anti-aging strategies > Bioengineering & regeneration > Stem cells
 
Other Information:
Fiscal Year: 2013
Project Start Date: 1 November 2013
Project End Date: 31 October 2017
Project program: FP7-NMP
 
Project Funding Information:
Funding Mechanism: CP-TP - Collaborative Project targeted to a special group (such as SMEs)
Year Funding Organization Total Funding, $
2013 European Research Council $9,563,958