Image-guided pancreatic cancer therapy

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Project Title: Image-guided pancreatic cancer therapy
Project Number: CORDIS-110781
Project web address: Follow on CORDIS
Organization: Technische Universiteit Eindhoven, Netherlands, Eindhoven
Collaborators: Philips Gmbh, DE
Philips Electronics Nederland B.V., NL
Universitair Medisch Centrum Utrecht, NL
Philips Technologie Gmbh, DE
Imasonic Sas, FR
Philips Oy, FI
Neagen Oy, FI
Principal Investigators (PI): Patrick Keur, NL
Sébastien Ubbiali, FR
Marieke Krispijn, NL
Frans Pelgrim, DE
Leon F Luwijs, NL
Johanna Tanhuamaki, FI
Lasse Jyrkinen, FI
Lars Lindner, DE
 
Project Description:
The aim of the iPaCT project is to address the unmet clinical need for an improved therapy of pancreatic cancer by developing a new integrated technology platform for image-guided thermal therapy. Yearly, 280000 new cases of pancreatic cancer are diagnosed worldwide. Being usually diagnosed late stage and without any efficient therapy available, basically all patients die with an average life expectancy of only a few months after diagnosis, leading to an overall low prevalence in society. Therefore, pancreatic cancer is a rare disease with an urgent clinical need for a new and improved therapeutic option.A potential breakthrough solution for the treatment of pancreatic cancer can be found in thermal therapies using high intensity focused ultrasound (HIFU) combined with local, temperature-triggered drug delivery. We propose a novel US-MR-HIFU system that integrates HIFU with two imaging modalities, i.e. Magnetic Resonance Imaging (MRI) and diagnostic Ultrasound (US) for image guidance of thermal ablation (T=60⁰C) and/or hyperthermia (T=42-43⁰C) of pancreatic tumours. For image-guided drug delivery, new temperature-sensitive nanocarriers will be developed that provide a high local dose of chemotherapeutic drug. Multimodal (molecular) imaging information, simultaneously acquired using the US-MR-HIFU platform, provides motion compensated temperature feedback as well as visualization of perfusion and drug uptake in the target tissue allowing personalized therapy.The consortium, including two innovative SMEs (Imasonic, Neagen), two hospitals (Klinikum der Universität München and University Medical Center Utrecht), Eindhoven University of Technology and Philips (a medical device company), represents the total chain from technology development, preclinical testing to clinical translation guaranteeing a clear route for later clinical use and a route to market for the SMEs partners, leveraging the competencies and strengths of a leading global healthcare company.
 
Project Terms:
life sciences
Project Title: Image-guided pancreatic cancer therapy
Project Number: CORDIS-110781
Project web address: Follow on CORDIS
Organization: Technische Universiteit Eindhoven, Netherlands, Eindhoven
Collaborators: Philips Gmbh, DE
Philips Electronics Nederland B.V., NL
Universitair Medisch Centrum Utrecht, NL
Philips Technologie Gmbh, DE
Imasonic Sas, FR
Philips Oy, FI
Neagen Oy, FI
Principal Investigators (PI): Patrick Keur, NL
Sébastien Ubbiali, FR
Marieke Krispijn, NL
Frans Pelgrim, DE
Leon F Luwijs, NL
Johanna Tanhuamaki, FI
Lasse Jyrkinen, FI
Lars Lindner, DE
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology > Cancer & related diseases > Malignant neoplasms (including in situ) > Gastrointestinal cancers > Pancreatic Cancer
 
Other Information:
Fiscal Year: 2014
Project Start Date: 1 January 2014
Project End Date: 31 December 2017
Project program: FP7-HEALTH
 
Project Funding Information:
Funding Mechanism: CP-FP - Small or medium-scale focused research project
Year Funding Organization Total Funding, $
2014 European Research Council $9,473,270