Biological foundation for the safety classification of engineered nanomaterials (enm): systems biology approaches to understand interactions of enm with living organisms and the environment

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Project Title: Biological foundation for the safety classification of engineered nanomaterials (enm): systems biology approaches to understand interactions of enm with living organisms and the environment
Project Number: CORDIS-106911
Project web address: Follow on CORDIS
Organization: Tyoeterveyslaitos, Finland, Helsinki
Collaborators: University Of Manchester, GB
University College London, GB
Fondazione Telethon, IT
Zhejiang University, CN
Leidos Biomedical Research, Inc., US
Danmark Tekniske Universitet, DK
University Of Plymouth, GB
Karolinska Institutet, SE
Universite De Bordeaux I, FR
Heriot-Watt University, GB
Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek Tno*, NL
Solvay Sa, BE
Universita Degli Studi Di Salerno, IT
Université De Bordeaux, FR
Institute Of Occupational Medicine, GB
Universitaet Leipzig, DE
Helsingin Yliopisto, FI
National Institute For Occupational Safety And Health, US
University College Dublin, National University Of Ireland, Dublin, IE
Turun Yliopisto, FI
Teknologian Tutkimuskeskus Vtt, FI
Inkoa Sistemas, S.L, ES
Plasmachem Produktions- Und Handel Gmbh, DE
Nanocyl S.A., BE
Eidgenössische Materialprüfungs- Und Forschungsanstalt, CH
Asociacion Centro De Investigacion Cooperativa En Biomateriales - Cic Biomagune, ES
Fundaçao Universidade De Brasília, BR
Noordwes-Universiteit, ZA
Acondicionamiento Tarrasense Associacion, ES
National Health Laboratory Services, ZA
Biotesys Gmbh, DE
Nanologica Ab, SE
Biobyte Solutions Gmbh, DE
Insight Publishers Limited, GB
Polimeros Y Sistemas De Aplicacion Tecnica Sl, ES
Misvik Biology Oy, FI
Polymer Factory Sweden Ab, SE
Principal Investigators (PI): Eva Olszewska-Day, GB
Alexey A Kalachev, DE
Fritz Krombach, DE
Greta Borg-Carbott, GB
Donal Doolan, IE
Nathalie Luizi, BE
Irene Mearelli, IT
Tiina Berg, FI
Per-Olof Larsson, SE
Kai Savolainen, FI
Anna Shvedova, US
Susy Makari, GB
Changyou Gao, CN
Claire Faichnie, GB
Alfonso Egaña, ES
Ivica Letunic, DE
Amro Satti, ES
Mari Riipinen, FI
Esther Zondervan-Van Den Beuken, NL
Irina Estrela-Lopis, DE
Amado Lacruz, ES
William Davis, GB
Dirk Dressler, DE
Katel Goeden, FR
Vesa Hongisto, FI
Richard Handy, GB
Idoia Unzueta, ES
Scott Mcneil, US
Jørgen Schlundt, DK
Paulo Cesar De Morais, BR
Erik Van Miert, BE
Andreas Nyström, SE
Tagliaferri Roberto, IT
Victor Wepener, ZA
Mary Gulumian, ZA
Peter Wick, CH
Roland Grafström, FI
Roberto Hanoi Labrador Montero, SE
 
Project Description:
The main objective of this research proposal is to identify and elaborate those characteristics of ENM that determine their biological hazard potential. This potential includes the ability of ENM to induce damage at the cellular, tissue, or organism levels by interacting with cellular structures leading to impairment of key cellular functions. These adverse effects may be mediated by ENM-induced alterations in gene expression and translation, but may involve also epigenetic transformation of genetic functions. We believe that it will be possible to create a set of biomarkers of ENM toxicity that are relevant in assessing and predicting the safety and toxicity of ENM across species. The ENM-organism interaction is complex and depends, not simply on the composition of ENM core, but particularly on its physico-chemical properties. In fact, important physico-chemical properties are largely governed by their surface properties. All of these factors determine the binding of different biomolecules on the surface of the ENM, the formation of a corona around the ENM core. Thus, any positive or negative biological effect of ENM in organisms may be dynamically modulated by the bio-molecule corona associated with or substituted into the ENM surface rather than the ENM on its own. The bio-molecule corona of seemingly identical ENM cores may undergo dynamic changes during their passage through different biological compartments; in other words, their biological effects are governed by this complex surface chemistry. We propose that understanding the fundamental characteristics of ENM underpinning their biological effects will provide a sound foundation with which to classify ENM according to their safety. Therefore, the overarching objective of this research is to provide a means to develop a safety classification of ENM based on an understanding of their interactions with living organisms at the molecular, cellular, and organism levels based on their material characteristics.
 
Project Terms:
scientific research
Project Title: Biological foundation for the safety classification of engineered nanomaterials (enm): systems biology approaches to understand interactions of enm with living organisms and the environment
Project Number: CORDIS-106911
Project web address: Follow on CORDIS
Organization: Tyoeterveyslaitos, Finland, Helsinki
Collaborators: University Of Manchester, GB
University College London, GB
Fondazione Telethon, IT
Zhejiang University, CN
Leidos Biomedical Research, Inc., US
Danmark Tekniske Universitet, DK
University Of Plymouth, GB
Karolinska Institutet, SE
Universite De Bordeaux I, FR
Heriot-Watt University, GB
Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek Tno*, NL
Solvay Sa, BE
Universita Degli Studi Di Salerno, IT
Université De Bordeaux, FR
Institute Of Occupational Medicine, GB
Universitaet Leipzig, DE
Helsingin Yliopisto, FI
National Institute For Occupational Safety And Health, US
University College Dublin, National University Of Ireland, Dublin, IE
Turun Yliopisto, FI
Teknologian Tutkimuskeskus Vtt, FI
Inkoa Sistemas, S.L, ES
Plasmachem Produktions- Und Handel Gmbh, DE
Nanocyl S.A., BE
Eidgenössische Materialprüfungs- Und Forschungsanstalt, CH
Asociacion Centro De Investigacion Cooperativa En Biomateriales - Cic Biomagune, ES
Fundaçao Universidade De Brasília, BR
Noordwes-Universiteit, ZA
Acondicionamiento Tarrasense Associacion, ES
National Health Laboratory Services, ZA
Biotesys Gmbh, DE
Nanologica Ab, SE
Biobyte Solutions Gmbh, DE
Insight Publishers Limited, GB
Polimeros Y Sistemas De Aplicacion Tecnica Sl, ES
Misvik Biology Oy, FI
Polymer Factory Sweden Ab, SE
Principal Investigators (PI): Eva Olszewska-Day, GB
Alexey A Kalachev, DE
Fritz Krombach, DE
Greta Borg-Carbott, GB
Donal Doolan, IE
Nathalie Luizi, BE
Irene Mearelli, IT
Tiina Berg, FI
Per-Olof Larsson, SE
Kai Savolainen, FI
Anna Shvedova, US
Susy Makari, GB
Changyou Gao, CN
Claire Faichnie, GB
Alfonso Egaña, ES
Ivica Letunic, DE
Amro Satti, ES
Mari Riipinen, FI
Esther Zondervan-Van Den Beuken, NL
Irina Estrela-Lopis, DE
Amado Lacruz, ES
William Davis, GB
Dirk Dressler, DE
Katel Goeden, FR
Vesa Hongisto, FI
Richard Handy, GB
Idoia Unzueta, ES
Scott Mcneil, US
Jørgen Schlundt, DK
Paulo Cesar De Morais, BR
Erik Van Miert, BE
Andreas Nyström, SE
Tagliaferri Roberto, IT
Victor Wepener, ZA
Mary Gulumian, ZA
Peter Wick, CH
Roland Grafström, FI
Roberto Hanoi Labrador Montero, SE
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2013
Project Start Date: 1 April 2013
Project End Date: 31 March 2017
Project program: FP7-NMP
 
Project Funding Information:
Funding Mechanism: CP-IP - Large-scale integrating project
Year Funding Organization Total Funding, $
2013 European Research Council $15,142,307
Project Title: Biological foundation for the safety classification of engineered nanomaterials (enm): systems biology approaches to understand interactions of enm with living organisms and the environment
Project Number: CORDIS-106911
Project web address: Follow on CORDIS
Organization: Tyoeterveyslaitos, Finland, Helsinki
Collaborators: University Of Manchester, GB
University College London, GB
Fondazione Telethon, IT
Zhejiang University, CN
Leidos Biomedical Research, Inc., US
Danmark Tekniske Universitet, DK
University Of Plymouth, GB
Karolinska Institutet, SE
Universite De Bordeaux I, FR
Heriot-Watt University, GB
Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek Tno*, NL
Solvay Sa, BE
Universita Degli Studi Di Salerno, IT
Université De Bordeaux, FR
Institute Of Occupational Medicine, GB
Universitaet Leipzig, DE
Helsingin Yliopisto, FI
National Institute For Occupational Safety And Health, US
University College Dublin, National University Of Ireland, Dublin, IE
Turun Yliopisto, FI
Teknologian Tutkimuskeskus Vtt, FI
Inkoa Sistemas, S.L, ES
Plasmachem Produktions- Und Handel Gmbh, DE
Nanocyl S.A., BE
Eidgenössische Materialprüfungs- Und Forschungsanstalt, CH
Asociacion Centro De Investigacion Cooperativa En Biomateriales - Cic Biomagune, ES
Fundaçao Universidade De Brasília, BR
Noordwes-Universiteit, ZA
Acondicionamiento Tarrasense Associacion, ES
National Health Laboratory Services, ZA
Biotesys Gmbh, DE
Nanologica Ab, SE
Biobyte Solutions Gmbh, DE
Insight Publishers Limited, GB
Polimeros Y Sistemas De Aplicacion Tecnica Sl, ES
Misvik Biology Oy, FI
Polymer Factory Sweden Ab, SE
Principal Investigators (PI): Eva Olszewska-Day, GB
Alexey A Kalachev, DE
Fritz Krombach, DE
Greta Borg-Carbott, GB
Donal Doolan, IE
Nathalie Luizi, BE
Irene Mearelli, IT
Tiina Berg, FI
Per-Olof Larsson, SE
Kai Savolainen, FI
Anna Shvedova, US
Susy Makari, GB
Changyou Gao, CN
Claire Faichnie, GB
Alfonso Egaña, ES
Ivica Letunic, DE
Amro Satti, ES
Mari Riipinen, FI
Esther Zondervan-Van Den Beuken, NL
Irina Estrela-Lopis, DE
Amado Lacruz, ES
William Davis, GB
Dirk Dressler, DE
Katel Goeden, FR
Vesa Hongisto, FI
Richard Handy, GB
Idoia Unzueta, ES
Scott Mcneil, US
Jørgen Schlundt, DK
Paulo Cesar De Morais, BR
Erik Van Miert, BE
Andreas Nyström, SE
Tagliaferri Roberto, IT
Victor Wepener, ZA
Mary Gulumian, ZA
Peter Wick, CH
Roland Grafström, FI
Roberto Hanoi Labrador Montero, SE
 
Title FY Funding
There are no results for this project in database.
Project Title: Biological foundation for the safety classification of engineered nanomaterials (enm): systems biology approaches to understand interactions of enm with living organisms and the environment
Project Number: CORDIS-106911
Project web address: Follow on CORDIS
Organization: Tyoeterveyslaitos, Finland, Helsinki
Collaborators: University Of Manchester, GB
University College London, GB
Fondazione Telethon, IT
Zhejiang University, CN
Leidos Biomedical Research, Inc., US
Danmark Tekniske Universitet, DK
University Of Plymouth, GB
Karolinska Institutet, SE
Universite De Bordeaux I, FR
Heriot-Watt University, GB
Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek Tno*, NL
Solvay Sa, BE
Universita Degli Studi Di Salerno, IT
Université De Bordeaux, FR
Institute Of Occupational Medicine, GB
Universitaet Leipzig, DE
Helsingin Yliopisto, FI
National Institute For Occupational Safety And Health, US
University College Dublin, National University Of Ireland, Dublin, IE
Turun Yliopisto, FI
Teknologian Tutkimuskeskus Vtt, FI
Inkoa Sistemas, S.L, ES
Plasmachem Produktions- Und Handel Gmbh, DE
Nanocyl S.A., BE
Eidgenössische Materialprüfungs- Und Forschungsanstalt, CH
Asociacion Centro De Investigacion Cooperativa En Biomateriales - Cic Biomagune, ES
Fundaçao Universidade De Brasília, BR
Noordwes-Universiteit, ZA
Acondicionamiento Tarrasense Associacion, ES
National Health Laboratory Services, ZA
Biotesys Gmbh, DE
Nanologica Ab, SE
Biobyte Solutions Gmbh, DE
Insight Publishers Limited, GB
Polimeros Y Sistemas De Aplicacion Tecnica Sl, ES
Misvik Biology Oy, FI
Polymer Factory Sweden Ab, SE
Principal Investigators (PI): Eva Olszewska-Day, GB
Alexey A Kalachev, DE
Fritz Krombach, DE
Greta Borg-Carbott, GB
Donal Doolan, IE
Nathalie Luizi, BE
Irene Mearelli, IT
Tiina Berg, FI
Per-Olof Larsson, SE
Kai Savolainen, FI
Anna Shvedova, US
Susy Makari, GB
Changyou Gao, CN
Claire Faichnie, GB
Alfonso Egaña, ES
Ivica Letunic, DE
Amro Satti, ES
Mari Riipinen, FI
Esther Zondervan-Van Den Beuken, NL
Irina Estrela-Lopis, DE
Amado Lacruz, ES
William Davis, GB
Dirk Dressler, DE
Katel Goeden, FR
Vesa Hongisto, FI
Richard Handy, GB
Idoia Unzueta, ES
Scott Mcneil, US
Jørgen Schlundt, DK
Paulo Cesar De Morais, BR
Erik Van Miert, BE
Andreas Nyström, SE
Tagliaferri Roberto, IT
Victor Wepener, ZA
Mary Gulumian, ZA
Peter Wick, CH
Roland Grafström, FI
Roberto Hanoi Labrador Montero, SE
 
Project Title Organization FY Funding
Biological Foundation For The Safety Classification Of Engineered Nanomaterials (Enm): Systems Biology Approaches To Understand Interactions Of Enm With Living Organisms And The EnvironmentTyoeterveyslaitos2013$15,142,307
Project Title: Biological foundation for the safety classification of engineered nanomaterials (enm): systems biology approaches to understand interactions of enm with living organisms and the environment
Project Number: CORDIS-106911
Project web address: Follow on CORDIS
Organization: Tyoeterveyslaitos, Finland, Helsinki
Collaborators: University Of Manchester, GB
University College London, GB
Fondazione Telethon, IT
Zhejiang University, CN
Leidos Biomedical Research, Inc., US
Danmark Tekniske Universitet, DK
University Of Plymouth, GB
Karolinska Institutet, SE
Universite De Bordeaux I, FR
Heriot-Watt University, GB
Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek Tno*, NL
Solvay Sa, BE
Universita Degli Studi Di Salerno, IT
Université De Bordeaux, FR
Institute Of Occupational Medicine, GB
Universitaet Leipzig, DE
Helsingin Yliopisto, FI
National Institute For Occupational Safety And Health, US
University College Dublin, National University Of Ireland, Dublin, IE
Turun Yliopisto, FI
Teknologian Tutkimuskeskus Vtt, FI
Inkoa Sistemas, S.L, ES
Plasmachem Produktions- Und Handel Gmbh, DE
Nanocyl S.A., BE
Eidgenössische Materialprüfungs- Und Forschungsanstalt, CH
Asociacion Centro De Investigacion Cooperativa En Biomateriales - Cic Biomagune, ES
Fundaçao Universidade De Brasília, BR
Noordwes-Universiteit, ZA
Acondicionamiento Tarrasense Associacion, ES
National Health Laboratory Services, ZA
Biotesys Gmbh, DE
Nanologica Ab, SE
Biobyte Solutions Gmbh, DE
Insight Publishers Limited, GB
Polimeros Y Sistemas De Aplicacion Tecnica Sl, ES
Misvik Biology Oy, FI
Polymer Factory Sweden Ab, SE
Principal Investigators (PI): Eva Olszewska-Day, GB
Alexey A Kalachev, DE
Fritz Krombach, DE
Greta Borg-Carbott, GB
Donal Doolan, IE
Nathalie Luizi, BE
Irene Mearelli, IT
Tiina Berg, FI
Per-Olof Larsson, SE
Kai Savolainen, FI
Anna Shvedova, US
Susy Makari, GB
Changyou Gao, CN
Claire Faichnie, GB
Alfonso Egaña, ES
Ivica Letunic, DE
Amro Satti, ES
Mari Riipinen, FI
Esther Zondervan-Van Den Beuken, NL
Irina Estrela-Lopis, DE
Amado Lacruz, ES
William Davis, GB
Dirk Dressler, DE
Katel Goeden, FR
Vesa Hongisto, FI
Richard Handy, GB
Idoia Unzueta, ES
Scott Mcneil, US
Jørgen Schlundt, DK
Paulo Cesar De Morais, BR
Erik Van Miert, BE
Andreas Nyström, SE
Tagliaferri Roberto, IT
Victor Wepener, ZA
Mary Gulumian, ZA
Peter Wick, CH
Roland Grafström, FI
Roberto Hanoi Labrador Montero, SE
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Biological foundation for the safety classification of engineered nanomaterials (enm): systems biology approaches to understand interactions of enm with living organisms and the environment
Project Number: CORDIS-106911
Project web address: Follow on CORDIS
Organization: Tyoeterveyslaitos, Finland, Helsinki
Collaborators: University Of Manchester, GB
University College London, GB
Fondazione Telethon, IT
Zhejiang University, CN
Leidos Biomedical Research, Inc., US
Danmark Tekniske Universitet, DK
University Of Plymouth, GB
Karolinska Institutet, SE
Universite De Bordeaux I, FR
Heriot-Watt University, GB
Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek Tno*, NL
Solvay Sa, BE
Universita Degli Studi Di Salerno, IT
Université De Bordeaux, FR
Institute Of Occupational Medicine, GB
Universitaet Leipzig, DE
Helsingin Yliopisto, FI
National Institute For Occupational Safety And Health, US
University College Dublin, National University Of Ireland, Dublin, IE
Turun Yliopisto, FI
Teknologian Tutkimuskeskus Vtt, FI
Inkoa Sistemas, S.L, ES
Plasmachem Produktions- Und Handel Gmbh, DE
Nanocyl S.A., BE
Eidgenössische Materialprüfungs- Und Forschungsanstalt, CH
Asociacion Centro De Investigacion Cooperativa En Biomateriales - Cic Biomagune, ES
Fundaçao Universidade De Brasília, BR
Noordwes-Universiteit, ZA
Acondicionamiento Tarrasense Associacion, ES
National Health Laboratory Services, ZA
Biotesys Gmbh, DE
Nanologica Ab, SE
Biobyte Solutions Gmbh, DE
Insight Publishers Limited, GB
Polimeros Y Sistemas De Aplicacion Tecnica Sl, ES
Misvik Biology Oy, FI
Polymer Factory Sweden Ab, SE
Principal Investigators (PI): Eva Olszewska-Day, GB
Alexey A Kalachev, DE
Fritz Krombach, DE
Greta Borg-Carbott, GB
Donal Doolan, IE
Nathalie Luizi, BE
Irene Mearelli, IT
Tiina Berg, FI
Per-Olof Larsson, SE
Kai Savolainen, FI
Anna Shvedova, US
Susy Makari, GB
Changyou Gao, CN
Claire Faichnie, GB
Alfonso Egaña, ES
Ivica Letunic, DE
Amro Satti, ES
Mari Riipinen, FI
Esther Zondervan-Van Den Beuken, NL
Irina Estrela-Lopis, DE
Amado Lacruz, ES
William Davis, GB
Dirk Dressler, DE
Katel Goeden, FR
Vesa Hongisto, FI
Richard Handy, GB
Idoia Unzueta, ES
Scott Mcneil, US
Jørgen Schlundt, DK
Paulo Cesar De Morais, BR
Erik Van Miert, BE
Andreas Nyström, SE
Tagliaferri Roberto, IT
Victor Wepener, ZA
Mary Gulumian, ZA
Peter Wick, CH
Roland Grafström, FI
Roberto Hanoi Labrador Montero, SE
 
Title Journal Year Country Rel