Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being - the frailomic initiative

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Project Title: Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being - the frailomic initiative
Project Number: CORDIS-106299
Project web address: Follow on CORDIS
Organization: Servicio Madrileno De Salud, Spain, Madrid
Collaborators: World Health Organization, CH
Universidad Autonoma De Madrid, ES
Consiglio Nazionale Delle Ricerche, IT
Institut National De La Sante Et De La Recherche Medicale, FR
Universitat De Valencia, ES
Université De Bordeaux, FR
Univ Innsbruck, AT
Centre Hospitalier Universitaire De Toulouse, FR
Azienda Sanitaria Di Firenze, IT
Deutsches Institut Fuer Ernaehrungsforschung, Potsdam-Rehbruecke, DE
Friedrich Schiller Universitat Jena, DE
Mosaiques Diagnostics Gmbh, DE
University Of Bedfordshire, GB
Servicio De Salud De Castilla La Mancha, ES
Istituto Nazionale Di Riposo E Cura Per Anziani Inrca, IT
Azienda Ospedaliero-Universitaria Di Parma, IT
Sistemas Genomicos Sl, ES
Cardiff Metropolitan University, GB
Yh Youhealth Ab, SE
Evercyte Gmbh, AT
San Raffaele S.P.A., IT
Life Length Sl, ES
Diabetes Frail Ltd, GB
Niche Science & Technology Ltd, GB
Azienda Unita' Sanitaria Locale Toscana Centro, IT
Innovacion Desarrollo Y Transferencia De Tecnologia Sa, ES
Principal Investigators (PI): Chatterji Somnath, CH
Harald Mischak, DE
Mª Carmen Puerta, ES
Angeles Sanchis, ES
Otto Kanzler, AT
Adeline Barre, FR
Rebeca Miñambres Herráiz, ES
Stephen Matlin, ES
Alan Sinclair, GB
Arif Urfan, GB
Belen Riquelme Garcia, ES
Corinne Joffre, FR
Jérémy Bonnassies, FR
Guido Poli, IT
Ilaria Monici, IT
Tilman Grune, DE
Maria Loewinger, DE
Susanne Dahl, SE
Caterina Flore, IT
Peter Quantick, GB
Gema Roque Giraldo, ES
Beatriz Gallego Gómez, ES
Pidder Jansen-Duerr, AT
Grazia Palermi, IT
Tim Hardman, GB
Rossella Zucchelli, IT
 
Project Description:
The forecasted increase in the number of older people for this century will be accompanied by an increase of those with disabilities. Disability is usually preceded by a condition named frailty that encompasses changes associated with ageing, life styles and chronic diseases. To detect and intervene on it is of outstanding importance to prevent disability, as recovery from disability is unlikely. Recent documents stress the necessity of testing the clinical utility (in terms of risk prediction, diagnosis validity and prognostic significance) of the existing definition of frailty by using combinations of clinical criteria (current definition) and lab Biomarkers (BMs).We will measure the levels of blood and urine omic-based BMs in old people selected from eight cohorts, which include up to 75,000 participants, using standardized and innovative technology (WP1). This figure will allow us to test the research questions with a high power and validity. Combining these lab BMs with clinical BMs, we will develop predictive, diagnostic and prognostic models (WP2), with its modulation by nutrition and physical activity, in general old population and in old people showing some characteristics that confer a high risk for developing frailty (selected cardiovascular risk factors and diseases) (WP4). After that, a selected set of BMs will be validated prospectively (WP3) and assessed to find the best-fitted models (WP4). These models will guide the development of the ready-to-use kits to be implemented in the clinical settings. These kits will be at the center of dissemination and exploitation activities (WP5, WP6).A well-balanced consortium distributed over the individual tasks in the respective work packages will carry it out, with a strong participation of SMEs. In summary, FRAILOMIC is original, relevant, pertinent, feasible, overcome the usual research bottlenecks on Biomarkers, and fits perfectly with the topics addressed by the HEALTH.2012.2.1.1-2 call in human subjects
 
Project Terms:
scientific research
Project Title: Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being - the frailomic initiative
Project Number: CORDIS-106299
Project web address: Follow on CORDIS
Organization: Servicio Madrileno De Salud, Spain, Madrid
Collaborators: World Health Organization, CH
Universidad Autonoma De Madrid, ES
Consiglio Nazionale Delle Ricerche, IT
Institut National De La Sante Et De La Recherche Medicale, FR
Universitat De Valencia, ES
Université De Bordeaux, FR
Univ Innsbruck, AT
Centre Hospitalier Universitaire De Toulouse, FR
Azienda Sanitaria Di Firenze, IT
Deutsches Institut Fuer Ernaehrungsforschung, Potsdam-Rehbruecke, DE
Friedrich Schiller Universitat Jena, DE
Mosaiques Diagnostics Gmbh, DE
University Of Bedfordshire, GB
Servicio De Salud De Castilla La Mancha, ES
Istituto Nazionale Di Riposo E Cura Per Anziani Inrca, IT
Azienda Ospedaliero-Universitaria Di Parma, IT
Sistemas Genomicos Sl, ES
Cardiff Metropolitan University, GB
Yh Youhealth Ab, SE
Evercyte Gmbh, AT
San Raffaele S.P.A., IT
Life Length Sl, ES
Diabetes Frail Ltd, GB
Niche Science & Technology Ltd, GB
Azienda Unita' Sanitaria Locale Toscana Centro, IT
Innovacion Desarrollo Y Transferencia De Tecnologia Sa, ES
Principal Investigators (PI): Chatterji Somnath, CH
Harald Mischak, DE
Mª Carmen Puerta, ES
Angeles Sanchis, ES
Otto Kanzler, AT
Adeline Barre, FR
Rebeca Miñambres Herráiz, ES
Stephen Matlin, ES
Alan Sinclair, GB
Arif Urfan, GB
Belen Riquelme Garcia, ES
Corinne Joffre, FR
Jérémy Bonnassies, FR
Guido Poli, IT
Ilaria Monici, IT
Tilman Grune, DE
Maria Loewinger, DE
Susanne Dahl, SE
Caterina Flore, IT
Peter Quantick, GB
Gema Roque Giraldo, ES
Beatriz Gallego Gómez, ES
Pidder Jansen-Duerr, AT
Grazia Palermi, IT
Tim Hardman, GB
Rossella Zucchelli, IT
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology > Cardiovascular and cerebrovascular diseases
 
Other Information:
Fiscal Year: 2013
Project Start Date: 1 January 2013
Project End Date: 31 December 2017
Project program: FP7-HEALTH
 
Project Funding Information:
Funding Mechanism: CP-IP - Large-scale integrating project
Year Funding Organization Total Funding, $
2013 European Research Council $17,035,394
Project Title: Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being - the frailomic initiative
Project Number: CORDIS-106299
Project web address: Follow on CORDIS
Organization: Servicio Madrileno De Salud, Spain, Madrid
Collaborators: World Health Organization, CH
Universidad Autonoma De Madrid, ES
Consiglio Nazionale Delle Ricerche, IT
Institut National De La Sante Et De La Recherche Medicale, FR
Universitat De Valencia, ES
Université De Bordeaux, FR
Univ Innsbruck, AT
Centre Hospitalier Universitaire De Toulouse, FR
Azienda Sanitaria Di Firenze, IT
Deutsches Institut Fuer Ernaehrungsforschung, Potsdam-Rehbruecke, DE
Friedrich Schiller Universitat Jena, DE
Mosaiques Diagnostics Gmbh, DE
University Of Bedfordshire, GB
Servicio De Salud De Castilla La Mancha, ES
Istituto Nazionale Di Riposo E Cura Per Anziani Inrca, IT
Azienda Ospedaliero-Universitaria Di Parma, IT
Sistemas Genomicos Sl, ES
Cardiff Metropolitan University, GB
Yh Youhealth Ab, SE
Evercyte Gmbh, AT
San Raffaele S.P.A., IT
Life Length Sl, ES
Diabetes Frail Ltd, GB
Niche Science & Technology Ltd, GB
Azienda Unita' Sanitaria Locale Toscana Centro, IT
Innovacion Desarrollo Y Transferencia De Tecnologia Sa, ES
Principal Investigators (PI): Chatterji Somnath, CH
Harald Mischak, DE
Mª Carmen Puerta, ES
Angeles Sanchis, ES
Otto Kanzler, AT
Adeline Barre, FR
Rebeca Miñambres Herráiz, ES
Stephen Matlin, ES
Alan Sinclair, GB
Arif Urfan, GB
Belen Riquelme Garcia, ES
Corinne Joffre, FR
Jérémy Bonnassies, FR
Guido Poli, IT
Ilaria Monici, IT
Tilman Grune, DE
Maria Loewinger, DE
Susanne Dahl, SE
Caterina Flore, IT
Peter Quantick, GB
Gema Roque Giraldo, ES
Beatriz Gallego Gómez, ES
Pidder Jansen-Duerr, AT
Grazia Palermi, IT
Tim Hardman, GB
Rossella Zucchelli, IT
 
Title FY Funding
There are no results for this project in database.
Project Title: Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being - the frailomic initiative
Project Number: CORDIS-106299
Project web address: Follow on CORDIS
Organization: Servicio Madrileno De Salud, Spain, Madrid
Collaborators: World Health Organization, CH
Universidad Autonoma De Madrid, ES
Consiglio Nazionale Delle Ricerche, IT
Institut National De La Sante Et De La Recherche Medicale, FR
Universitat De Valencia, ES
Université De Bordeaux, FR
Univ Innsbruck, AT
Centre Hospitalier Universitaire De Toulouse, FR
Azienda Sanitaria Di Firenze, IT
Deutsches Institut Fuer Ernaehrungsforschung, Potsdam-Rehbruecke, DE
Friedrich Schiller Universitat Jena, DE
Mosaiques Diagnostics Gmbh, DE
University Of Bedfordshire, GB
Servicio De Salud De Castilla La Mancha, ES
Istituto Nazionale Di Riposo E Cura Per Anziani Inrca, IT
Azienda Ospedaliero-Universitaria Di Parma, IT
Sistemas Genomicos Sl, ES
Cardiff Metropolitan University, GB
Yh Youhealth Ab, SE
Evercyte Gmbh, AT
San Raffaele S.P.A., IT
Life Length Sl, ES
Diabetes Frail Ltd, GB
Niche Science & Technology Ltd, GB
Azienda Unita' Sanitaria Locale Toscana Centro, IT
Innovacion Desarrollo Y Transferencia De Tecnologia Sa, ES
Principal Investigators (PI): Chatterji Somnath, CH
Harald Mischak, DE
Mª Carmen Puerta, ES
Angeles Sanchis, ES
Otto Kanzler, AT
Adeline Barre, FR
Rebeca Miñambres Herráiz, ES
Stephen Matlin, ES
Alan Sinclair, GB
Arif Urfan, GB
Belen Riquelme Garcia, ES
Corinne Joffre, FR
Jérémy Bonnassies, FR
Guido Poli, IT
Ilaria Monici, IT
Tilman Grune, DE
Maria Loewinger, DE
Susanne Dahl, SE
Caterina Flore, IT
Peter Quantick, GB
Gema Roque Giraldo, ES
Beatriz Gallego Gómez, ES
Pidder Jansen-Duerr, AT
Grazia Palermi, IT
Tim Hardman, GB
Rossella Zucchelli, IT
 
Project Title Organization FY Funding
Utility Of Omic-Based Biomarkers In Characterizing Older Individuals At Risk For Frailty, Its Progression To Disability And General Consequences To Health And Well-Being - The Frailomic InitiativeServicio Madrileno De Salud2013$17,035,394
Project Title: Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being - the frailomic initiative
Project Number: CORDIS-106299
Project web address: Follow on CORDIS
Organization: Servicio Madrileno De Salud, Spain, Madrid
Collaborators: World Health Organization, CH
Universidad Autonoma De Madrid, ES
Consiglio Nazionale Delle Ricerche, IT
Institut National De La Sante Et De La Recherche Medicale, FR
Universitat De Valencia, ES
Université De Bordeaux, FR
Univ Innsbruck, AT
Centre Hospitalier Universitaire De Toulouse, FR
Azienda Sanitaria Di Firenze, IT
Deutsches Institut Fuer Ernaehrungsforschung, Potsdam-Rehbruecke, DE
Friedrich Schiller Universitat Jena, DE
Mosaiques Diagnostics Gmbh, DE
University Of Bedfordshire, GB
Servicio De Salud De Castilla La Mancha, ES
Istituto Nazionale Di Riposo E Cura Per Anziani Inrca, IT
Azienda Ospedaliero-Universitaria Di Parma, IT
Sistemas Genomicos Sl, ES
Cardiff Metropolitan University, GB
Yh Youhealth Ab, SE
Evercyte Gmbh, AT
San Raffaele S.P.A., IT
Life Length Sl, ES
Diabetes Frail Ltd, GB
Niche Science & Technology Ltd, GB
Azienda Unita' Sanitaria Locale Toscana Centro, IT
Innovacion Desarrollo Y Transferencia De Tecnologia Sa, ES
Principal Investigators (PI): Chatterji Somnath, CH
Harald Mischak, DE
Mª Carmen Puerta, ES
Angeles Sanchis, ES
Otto Kanzler, AT
Adeline Barre, FR
Rebeca Miñambres Herráiz, ES
Stephen Matlin, ES
Alan Sinclair, GB
Arif Urfan, GB
Belen Riquelme Garcia, ES
Corinne Joffre, FR
Jérémy Bonnassies, FR
Guido Poli, IT
Ilaria Monici, IT
Tilman Grune, DE
Maria Loewinger, DE
Susanne Dahl, SE
Caterina Flore, IT
Peter Quantick, GB
Gema Roque Giraldo, ES
Beatriz Gallego Gómez, ES
Pidder Jansen-Duerr, AT
Grazia Palermi, IT
Tim Hardman, GB
Rossella Zucchelli, IT
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being - the frailomic initiative
Project Number: CORDIS-106299
Project web address: Follow on CORDIS
Organization: Servicio Madrileno De Salud, Spain, Madrid
Collaborators: World Health Organization, CH
Universidad Autonoma De Madrid, ES
Consiglio Nazionale Delle Ricerche, IT
Institut National De La Sante Et De La Recherche Medicale, FR
Universitat De Valencia, ES
Université De Bordeaux, FR
Univ Innsbruck, AT
Centre Hospitalier Universitaire De Toulouse, FR
Azienda Sanitaria Di Firenze, IT
Deutsches Institut Fuer Ernaehrungsforschung, Potsdam-Rehbruecke, DE
Friedrich Schiller Universitat Jena, DE
Mosaiques Diagnostics Gmbh, DE
University Of Bedfordshire, GB
Servicio De Salud De Castilla La Mancha, ES
Istituto Nazionale Di Riposo E Cura Per Anziani Inrca, IT
Azienda Ospedaliero-Universitaria Di Parma, IT
Sistemas Genomicos Sl, ES
Cardiff Metropolitan University, GB
Yh Youhealth Ab, SE
Evercyte Gmbh, AT
San Raffaele S.P.A., IT
Life Length Sl, ES
Diabetes Frail Ltd, GB
Niche Science & Technology Ltd, GB
Azienda Unita' Sanitaria Locale Toscana Centro, IT
Innovacion Desarrollo Y Transferencia De Tecnologia Sa, ES
Principal Investigators (PI): Chatterji Somnath, CH
Harald Mischak, DE
Mª Carmen Puerta, ES
Angeles Sanchis, ES
Otto Kanzler, AT
Adeline Barre, FR
Rebeca Miñambres Herráiz, ES
Stephen Matlin, ES
Alan Sinclair, GB
Arif Urfan, GB
Belen Riquelme Garcia, ES
Corinne Joffre, FR
Jérémy Bonnassies, FR
Guido Poli, IT
Ilaria Monici, IT
Tilman Grune, DE
Maria Loewinger, DE
Susanne Dahl, SE
Caterina Flore, IT
Peter Quantick, GB
Gema Roque Giraldo, ES
Beatriz Gallego Gómez, ES
Pidder Jansen-Duerr, AT
Grazia Palermi, IT
Tim Hardman, GB
Rossella Zucchelli, IT
 
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