Personalized diagnostics and treatment of high risk coronary artery disease patients

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Project Title: Personalized diagnostics and treatment of high risk coronary artery disease patients
Project Number: CORDIS-106244
Project web address: Follow on CORDIS
Organization: Biomedical Research Foundation, Academy Of Athens, Greece, Athens
Collaborators: University Of Zurich, CH
Charité Universität Medicine, DE
Università Degli Studi Di Milano, IT
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
Ruprecht-Karls-Universitaet Heidelberg, DE
Tampereen Yliopisto, FI
Genoway S.A., FR
A. Persidis & Sia O.E., GR
Zora Biosciences Oy, FI
Comprehensive Biomarker Center Gmbh, DE
Synlab Holding Gmbh, DE
Principal Investigators (PI): Andreas Persidis, GR
Dimitris Raptis, GR
Linda Pialek, GB
Martina Eickmann, DE
Sergio Longo, IT
Susanna Airila, FI
Ralf Weigel, DE
Markus Beier, DE
Winfried März, DE
Riikka Katainen, FI
Ulf Landmesser, CH
Gaelle Le Bel, FR
 
Project Description:
Although the accurate diagnosis and prevention of coronary artery disease (CAD), acute myocardial infarction (AMI) and death is a major public health issue, risk stratification for CAD with current diagnostic tools is not properly supporting clinical decision making. RiskyCAD’s overall goal is to identify novel biomarkers for asymptomatic patients in high risk of major coronary events, and develop new diagnostic tools and ‘personalized’ therapeutic strategies for this selected group of patients.Taking advantage of the latest technologies, we will look into new biomarkers for asymptomatic patients in high risk of CAD using some of the finest cohorts (WP1), identify new molecules and develop new diagnostic kits that will be further validated in additional cohorts (WP6). We will generate reprogrammed iPS cell based human models for the study of metabolic aberrations in selected individual vulnerable CAD patients (WP2). We will identify defects, e.g. in liver lipid metabolism, in high risk CAD patients (WP3) and test targeted treatments in traditional and new preclinical animal models to provide proof-of-concept level evidence (WP4, WP5). As our approach is based on well characterized patients and phenotypes, we will generate clinically applicable stratification methods that will allow targeted treatment and patient enrichment for clinical trials (WP1). Unique predictive modelling and link identification platforms including Drug Repositioning will be used to select drugs or drug combinations that will best match the patient’s biomarker profile (WP7).The final (translational) outcomes of this project will be: (i) a set of distinct biomarker test(s) for asymptomatic patients in high risk of CAD that can be ordered both by primary care physicians and specialized cardiologists from routine clinical laboratories; (ii) new CAD risk estimation models; (iii) a set of repositioned drugs ready to be exploited further for the optimal treatment of patients in high risk of CA
 
Project Terms:
scientific research
Project Title: Personalized diagnostics and treatment of high risk coronary artery disease patients
Project Number: CORDIS-106244
Project web address: Follow on CORDIS
Organization: Biomedical Research Foundation, Academy Of Athens, Greece, Athens
Collaborators: University Of Zurich, CH
Charité Universität Medicine, DE
Università Degli Studi Di Milano, IT
The Chancellor, Masters And Scholars Of The University Of Oxford, GB
Ruprecht-Karls-Universitaet Heidelberg, DE
Tampereen Yliopisto, FI
Genoway S.A., FR
A. Persidis & Sia O.E., GR
Zora Biosciences Oy, FI
Comprehensive Biomarker Center Gmbh, DE
Synlab Holding Gmbh, DE
Principal Investigators (PI): Andreas Persidis, GR
Dimitris Raptis, GR
Linda Pialek, GB
Martina Eickmann, DE
Sergio Longo, IT
Susanna Airila, FI
Ralf Weigel, DE
Markus Beier, DE
Winfried März, DE
Riikka Katainen, FI
Ulf Landmesser, CH
Gaelle Le Bel, FR
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology > Cardiovascular and cerebrovascular diseases
 
Other Information:
Fiscal Year: 2012
Project Start Date: 1 November 2012
Project End Date: 31 October 2017
Project program: FP7-HEALTH
 
Project Funding Information:
Funding Mechanism: CP-FP - Small or medium-scale focused research project
Year Funding Organization Total Funding, $
2012 European Research Council $8,692,107