King of hearts, joints and lungs; periodontal pathogens as etiologic factor in ra, cvd and copd and their impact on treatment strategies.

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Project Title: King of hearts, joints and lungs; periodontal pathogens as etiologic factor in ra, cvd and copd and their impact on treatment strategies.
Project Number: CORDIS-106057
Project web address: Follow on CORDIS
Organization: Universitetet I Bergen, Norway, Bergen
Collaborators: University Of Birmingham, GB
University Of Bern, CH
Karolinska Institutet, SE
Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V., DE
Aarhus Universitet, DK
Universitetet I Oslo, NO
Uniwersytet Jagiellonski, PL
Hadassah Medical Organization, IL
Agencia Estatal Consejo Superior De Investigaciones Cientificas, ES
Anaxomics Biotech, S.L., ES
Principal Investigators (PI): Andrea Zeumann, DE
Alberto Sereno Alvarez, ES
Caroline Hamilton, SE
May Chung, GB
Liv-Grethe Gudmundsen, NO
Hadas Lemberg, IL
Vesna Radovanovic, ES
Agata Potempa, PL
Per Arenfeldt Omdal, NO
Pernille Leth Stentov, DK
Sigrun Eick, CH
 
Project Description:
Extensive clinical and epidemiological data clearly shows that chronic periodontal disease (PD), the most prevalent infectious inflammatory disease of mankind, is strongly linked to systemic inflammatory diseases such as cardiovascular diseases (CVD) , rheumatoid arthritis (RA) , and chronic obstructive pulmonary disease (COPD) . Taking into account that up to 30% of the adult population worldwide suffers from severe periodontitis , the impact of this disease on human health is immense and has been recognized by World Health Organization . Nevertheless, in many EU countries PD is a neglected disease, both by the population in general and health-care personnel. Often this negligence comes to the point that, like a hair-loss, the tooth-loss due to periodontitis is still considered as a normal inevitable event associated with aging. To combat this misconception and conceive novel approaches to prevent and/or treat CVD, RA, and COPD we will explore highly innovative ideas that these non-communicable diseases are at least aggravated, if not initiated, by periodontal infection.Results emanating from our project will: i) elucidate a relationship between the presence of specific periodontal pathogens and severity of systemic diseases; ii) show that extensive periodontal treatment improves clinical parameters of investigated systemic diseases; iii) reveal the impact of eradication of specific periodontal pathogen on the level of inflammatory markers; iv) develop novel, periodontal-pathogen specific bactericidal compounds based on periodontal glutaminyl cyclase (QC), the enzyme essential for these pathogens vitality.This will reduce mortality and ameliorated quality of life of CVD, RA, and COPD patients. All of these will be possible based on the knowledge of mechanisms beyond the causative links between specific pathogen driven periodontal disease and CVD, RA, and COPD revealed by research program outlined in this project.
 
Project Terms:
scientific research
Project Title: King of hearts, joints and lungs; periodontal pathogens as etiologic factor in ra, cvd and copd and their impact on treatment strategies.
Project Number: CORDIS-106057
Project web address: Follow on CORDIS
Organization: Universitetet I Bergen, Norway, Bergen
Collaborators: University Of Birmingham, GB
University Of Bern, CH
Karolinska Institutet, SE
Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V., DE
Aarhus Universitet, DK
Universitetet I Oslo, NO
Uniwersytet Jagiellonski, PL
Hadassah Medical Organization, IL
Agencia Estatal Consejo Superior De Investigaciones Cientificas, ES
Anaxomics Biotech, S.L., ES
Principal Investigators (PI): Andrea Zeumann, DE
Alberto Sereno Alvarez, ES
Caroline Hamilton, SE
May Chung, GB
Liv-Grethe Gudmundsen, NO
Hadas Lemberg, IL
Vesna Radovanovic, ES
Agata Potempa, PL
Per Arenfeldt Omdal, NO
Pernille Leth Stentov, DK
Sigrun Eick, CH
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology
 
Other Information:
Fiscal Year: 2013
Project Start Date: 1 April 2013
Project End Date: 31 March 2017
Project program: FP7-HEALTH
 
Project Funding Information:
Funding Mechanism: CP-FP - Small or medium-scale focused research project
Year Funding Organization Total Funding, $
2013 European Research Council $8,621,343