The human early-life exposome – novel tools for integrating early-life environmental exposures and child health across europe

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Project Title: The human early-life exposome – novel tools for integrating early-life environmental exposures and child health across europe
Project Number: CORDIS-105690
Project web address: Follow on CORDIS
Organization: Centre De Recerca En Epidemiologia Ambiental, Spain, Barcelona
Collaborators: Imperial College Of Science, Technology And Medicine, GB
Institut National De La Sante Et De La Recherche Medicale, FR
Universidad De Santiago De Compostela, ES
Fundació Centre De Regulacio Genomica, ES
Institut National De L' Environnement Et Des Risques Ineris, FR
Vytauto Didziojo Universitetas, LT
Hylobates Consulting Srl, IT
Panepistimio Kritis, GR
Bradford Teaching Hospitals Nhs Foundation Trust, GB
Folkehelseinstituttet, NO
Sensing & Control Systems Sl, ES
Veiligheids- En Gezondheidsregio Gelderland-Midden, NL
Principal Investigators (PI): Tatjana Palalic, GB
Evelyne Bertino, FR
Eleni Karkanaki, GR
Martin Cacheiro Martinez, ES
Lydia Boutigny, FR
Francesca Bucchini, IT
Xavier Estivill, ES
Dangirute Radzeviciene, LT
Cahtrine Thomsen, NO
Alberto Fernandez, ES
Jeroen Smit, NL
John French, GB
Diana Van Gent, ES
 
Project Description:
The aim of HELIX is to exploit novel tools and methods (remote sensing/GIS-based spatial methods, omics-based approaches, biomarkers of exposure, exposure devices and models, statistical tools for combined exposures, novel study designs, and burden of disease methodologies), to characterise early-life exposure to a wide range of environmental hazards, and integrate and link these with data on major child health outcomes (growth and obesity, neurodevelopment, immune system), thus developing an “Early-Life Exposome” approach.HELIX uses six existing, prospective birth cohort studies as the only realistic and feasible way to obtain the comprehensive, longitudinal, human data needed to build this early-life exposome. These cohorts have already collected large amounts of data as part of national and EU-funded projects. Results will be integrated with data from European cohorts (>300,000 subjects) and registers, to estimate health impacts at the large European scale.HELIX will make a major contribution to the integrated exposure concept by developing an exposome toolkit and database that will: 1) measure a wide range of major chemical and physical environmental hazards in food, consumer products, water, air, noise, and the built environment, in pre and postnatal periods; 2) integrate data on individual, temporal, and toxicokinetic variability, and on multiple exposures, which will greatly reduce uncertainty in exposure estimates; 3) determine molecular profiles and biological pathways associated with multiple exposures using omics tools; 4) provide exposure-response estimates and thresholds for multiple exposures and child health; and 5) estimate the burden of childhood disease in Europe due to multiple environmental exposures. This integration of the chemical, physical and molecular environment during critical early-life periods will lead to major improvements in health risk and impact assessments and thus to improved prevention strategies for vulnerable populations.
 
Project Terms:
scientific research