European consortium for high-throughput research in rare kidney diseases

  • Description
  • Details
  • Subprojects
  • History
  • Relations
  • Publications
Project Title: European consortium for high-throughput research in rare kidney diseases
Project Number: CORDIS-105363
Project web address: Follow on CORDIS
Organization: Universitaetsklinikum Heidelberg, Germany, Heidelberg
Collaborators: University Of Bristol, GB
University Of Zurich, CH
University Of Manchester, GB
University College London, GB
Katholieke Universiteit Leuven, BE
Stichting Katholieke Universiteit, NL
University Of Newcastle Upon Tyne, GB
Institut National De La Sante Et De La Recherche Medicale, FR
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Assistance Publique - Hopitaux De Paris, FR
Hacettepe University, TR
Genomatix Software Gmbh, DE
Oulun Yliopisto, FI
Universitair Medisch Centrum Utrecht, NL
Agencia Estatal Consejo Superior De Investigaciones Cientificas, ES
Karlsruher Institut Fuer Technologie, DE
Mosaiques Diagnostics Gmbh, DE
Philogen Spa, IT
Metabometrix Limited, GB
Gabo:Mi Gesellschaft Für Ablauforganisation :Milliarium Mbh & Co. Kg, DE
University Of Michigan The Regents Of The University Of Michigan, US
Leibniz-Institut Fur Naturstoff-Forschung Und Infektionsbiologie Ev Hans Knoell Institute, DE
Philochem Ag, CH
Comprehensive Biomarker Center Gmbh, DE
Cmast, BE
Acquifer Ag, DE
Multiplicom Nv, BE
Principal Investigators (PI): Greta Borg-Carbott, GB
Birgit Fuchs, DE
Alberto Sereno Alvarez, ES
Arto Eljander, FI
Thorsten Brietz, DE
Maria Grazia Pezzoni, IT
Sarah Malevé, BE
Michael Ramm, DE
Aleona Blinova, GB
Elodie Mahieu-Wedande, GB
Nicolas Jeanjean, FR
Katherine Boylan, GB
Wim Van Oijen, NL
Alix Pillot, FR
Christine Koch, US
Natascha Kindsvogel, DE
Chiara Falciani, IT
Joost Warsanis, NL
John Lindon, GB
Ralf Mulflur, DE
Petra Zürbig, DE
Luc Lammens, BE
Fatih Ozaltin, TR
Sarah Wulhfard, CH
Karin Van Den Eeden, BE
Olivier Devuyst, CH
André Brändli, DE
Markus Beier, DE
Korbinian Grote, DE
 
Project Description:
EURenOmics will integrate several established consortia devoted to rare kidney diseases with eminent need and potential for diagnostic and therapeutic progress (i.e. steroid resistant nephrotic syndrome, membranous nephropathy, tubulopathies, complement disorders such a haemolytic uraemic syndrome, and congenital kidney malformations). The Consortium has access to the largest clinical cohorts assembled to date (collectively >10,000 patients) with detailed phenotypic information and comprehensive biorepositories containing DNA, blood, urine, amniotic fluid and kidney tissue. The project aims to (1) identify the genetic and epigenetic causes and modifiers of disease and their molecular pathways; (2) define a novel mechanistic disease ontology beyond phenotypical or morphological description; (3) develop innovative technologies allowing rapid diagnostic testing; (4) discover and validate biomarkers of disease activity, prognosis and treatment responses; and (5) develop in vitro and in vivo disease models and apply high-throughput compound library screening. For these purposes we will integrate comprehensive data sets from next generation exome and whole-genome sequencing, ChiP-sequencing, tissue transcriptome and antigen/epitope profiling, and miRNome, proteome/peptidome, and metabolome screening in different body fluids within and across conventional diagnostic categories. These data will be combined in a systems biology approach with high-resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models (‘functiomics’) to identify disease-associated genetic variants involved in monogenic or complex genetic transmission, disease-defining molecular signatures, and potential targets for therapeutic intervention. These efforts will converge in the development of innovative diagnostic tools and biomarkers and efficient screening strategies for novel therapeutic agents.
 
Project Terms:
scientific research
Project Title: European consortium for high-throughput research in rare kidney diseases
Project Number: CORDIS-105363
Project web address: Follow on CORDIS
Organization: Universitaetsklinikum Heidelberg, Germany, Heidelberg
Collaborators: University Of Bristol, GB
University Of Zurich, CH
University Of Manchester, GB
University College London, GB
Katholieke Universiteit Leuven, BE
Stichting Katholieke Universiteit, NL
University Of Newcastle Upon Tyne, GB
Institut National De La Sante Et De La Recherche Medicale, FR
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Assistance Publique - Hopitaux De Paris, FR
Hacettepe University, TR
Genomatix Software Gmbh, DE
Oulun Yliopisto, FI
Universitair Medisch Centrum Utrecht, NL
Agencia Estatal Consejo Superior De Investigaciones Cientificas, ES
Karlsruher Institut Fuer Technologie, DE
Mosaiques Diagnostics Gmbh, DE
Philogen Spa, IT
Metabometrix Limited, GB
Gabo:Mi Gesellschaft Für Ablauforganisation :Milliarium Mbh & Co. Kg, DE
University Of Michigan The Regents Of The University Of Michigan, US
Leibniz-Institut Fur Naturstoff-Forschung Und Infektionsbiologie Ev Hans Knoell Institute, DE
Philochem Ag, CH
Comprehensive Biomarker Center Gmbh, DE
Cmast, BE
Acquifer Ag, DE
Multiplicom Nv, BE
Principal Investigators (PI): Greta Borg-Carbott, GB
Birgit Fuchs, DE
Alberto Sereno Alvarez, ES
Arto Eljander, FI
Thorsten Brietz, DE
Maria Grazia Pezzoni, IT
Sarah Malevé, BE
Michael Ramm, DE
Aleona Blinova, GB
Elodie Mahieu-Wedande, GB
Nicolas Jeanjean, FR
Katherine Boylan, GB
Wim Van Oijen, NL
Alix Pillot, FR
Christine Koch, US
Natascha Kindsvogel, DE
Chiara Falciani, IT
Joost Warsanis, NL
John Lindon, GB
Ralf Mulflur, DE
Petra Zürbig, DE
Luc Lammens, BE
Fatih Ozaltin, TR
Sarah Wulhfard, CH
Karin Van Den Eeden, BE
Olivier Devuyst, CH
André Brändli, DE
Markus Beier, DE
Korbinian Grote, DE
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2012
Project Start Date: 1 October 2012
Project End Date: 30 September 2017
Project program: FP7-HEALTH
 
Project Funding Information:
Funding Mechanism: CP-IP - Large-scale integrating project
Year Funding Organization Total Funding, $
2012 European Research Council $17,440,369
Project Title: European consortium for high-throughput research in rare kidney diseases
Project Number: CORDIS-105363
Project web address: Follow on CORDIS
Organization: Universitaetsklinikum Heidelberg, Germany, Heidelberg
Collaborators: University Of Bristol, GB
University Of Zurich, CH
University Of Manchester, GB
University College London, GB
Katholieke Universiteit Leuven, BE
Stichting Katholieke Universiteit, NL
University Of Newcastle Upon Tyne, GB
Institut National De La Sante Et De La Recherche Medicale, FR
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Assistance Publique - Hopitaux De Paris, FR
Hacettepe University, TR
Genomatix Software Gmbh, DE
Oulun Yliopisto, FI
Universitair Medisch Centrum Utrecht, NL
Agencia Estatal Consejo Superior De Investigaciones Cientificas, ES
Karlsruher Institut Fuer Technologie, DE
Mosaiques Diagnostics Gmbh, DE
Philogen Spa, IT
Metabometrix Limited, GB
Gabo:Mi Gesellschaft Für Ablauforganisation :Milliarium Mbh & Co. Kg, DE
University Of Michigan The Regents Of The University Of Michigan, US
Leibniz-Institut Fur Naturstoff-Forschung Und Infektionsbiologie Ev Hans Knoell Institute, DE
Philochem Ag, CH
Comprehensive Biomarker Center Gmbh, DE
Cmast, BE
Acquifer Ag, DE
Multiplicom Nv, BE
Principal Investigators (PI): Greta Borg-Carbott, GB
Birgit Fuchs, DE
Alberto Sereno Alvarez, ES
Arto Eljander, FI
Thorsten Brietz, DE
Maria Grazia Pezzoni, IT
Sarah Malevé, BE
Michael Ramm, DE
Aleona Blinova, GB
Elodie Mahieu-Wedande, GB
Nicolas Jeanjean, FR
Katherine Boylan, GB
Wim Van Oijen, NL
Alix Pillot, FR
Christine Koch, US
Natascha Kindsvogel, DE
Chiara Falciani, IT
Joost Warsanis, NL
John Lindon, GB
Ralf Mulflur, DE
Petra Zürbig, DE
Luc Lammens, BE
Fatih Ozaltin, TR
Sarah Wulhfard, CH
Karin Van Den Eeden, BE
Olivier Devuyst, CH
André Brändli, DE
Markus Beier, DE
Korbinian Grote, DE
 
Title FY Funding
There are no results for this project in database.
Project Title: European consortium for high-throughput research in rare kidney diseases
Project Number: CORDIS-105363
Project web address: Follow on CORDIS
Organization: Universitaetsklinikum Heidelberg, Germany, Heidelberg
Collaborators: University Of Bristol, GB
University Of Zurich, CH
University Of Manchester, GB
University College London, GB
Katholieke Universiteit Leuven, BE
Stichting Katholieke Universiteit, NL
University Of Newcastle Upon Tyne, GB
Institut National De La Sante Et De La Recherche Medicale, FR
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Assistance Publique - Hopitaux De Paris, FR
Hacettepe University, TR
Genomatix Software Gmbh, DE
Oulun Yliopisto, FI
Universitair Medisch Centrum Utrecht, NL
Agencia Estatal Consejo Superior De Investigaciones Cientificas, ES
Karlsruher Institut Fuer Technologie, DE
Mosaiques Diagnostics Gmbh, DE
Philogen Spa, IT
Metabometrix Limited, GB
Gabo:Mi Gesellschaft Für Ablauforganisation :Milliarium Mbh & Co. Kg, DE
University Of Michigan The Regents Of The University Of Michigan, US
Leibniz-Institut Fur Naturstoff-Forschung Und Infektionsbiologie Ev Hans Knoell Institute, DE
Philochem Ag, CH
Comprehensive Biomarker Center Gmbh, DE
Cmast, BE
Acquifer Ag, DE
Multiplicom Nv, BE
Principal Investigators (PI): Greta Borg-Carbott, GB
Birgit Fuchs, DE
Alberto Sereno Alvarez, ES
Arto Eljander, FI
Thorsten Brietz, DE
Maria Grazia Pezzoni, IT
Sarah Malevé, BE
Michael Ramm, DE
Aleona Blinova, GB
Elodie Mahieu-Wedande, GB
Nicolas Jeanjean, FR
Katherine Boylan, GB
Wim Van Oijen, NL
Alix Pillot, FR
Christine Koch, US
Natascha Kindsvogel, DE
Chiara Falciani, IT
Joost Warsanis, NL
John Lindon, GB
Ralf Mulflur, DE
Petra Zürbig, DE
Luc Lammens, BE
Fatih Ozaltin, TR
Sarah Wulhfard, CH
Karin Van Den Eeden, BE
Olivier Devuyst, CH
André Brändli, DE
Markus Beier, DE
Korbinian Grote, DE
 
Project Title Organization FY Funding
European Consortium For High-Throughput Research In Rare Kidney DiseasesUniversitaetsklinikum Heidelberg2012$17,440,369
Project Title: European consortium for high-throughput research in rare kidney diseases
Project Number: CORDIS-105363
Project web address: Follow on CORDIS
Organization: Universitaetsklinikum Heidelberg, Germany, Heidelberg
Collaborators: University Of Bristol, GB
University Of Zurich, CH
University Of Manchester, GB
University College London, GB
Katholieke Universiteit Leuven, BE
Stichting Katholieke Universiteit, NL
University Of Newcastle Upon Tyne, GB
Institut National De La Sante Et De La Recherche Medicale, FR
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Assistance Publique - Hopitaux De Paris, FR
Hacettepe University, TR
Genomatix Software Gmbh, DE
Oulun Yliopisto, FI
Universitair Medisch Centrum Utrecht, NL
Agencia Estatal Consejo Superior De Investigaciones Cientificas, ES
Karlsruher Institut Fuer Technologie, DE
Mosaiques Diagnostics Gmbh, DE
Philogen Spa, IT
Metabometrix Limited, GB
Gabo:Mi Gesellschaft Für Ablauforganisation :Milliarium Mbh & Co. Kg, DE
University Of Michigan The Regents Of The University Of Michigan, US
Leibniz-Institut Fur Naturstoff-Forschung Und Infektionsbiologie Ev Hans Knoell Institute, DE
Philochem Ag, CH
Comprehensive Biomarker Center Gmbh, DE
Cmast, BE
Acquifer Ag, DE
Multiplicom Nv, BE
Principal Investigators (PI): Greta Borg-Carbott, GB
Birgit Fuchs, DE
Alberto Sereno Alvarez, ES
Arto Eljander, FI
Thorsten Brietz, DE
Maria Grazia Pezzoni, IT
Sarah Malevé, BE
Michael Ramm, DE
Aleona Blinova, GB
Elodie Mahieu-Wedande, GB
Nicolas Jeanjean, FR
Katherine Boylan, GB
Wim Van Oijen, NL
Alix Pillot, FR
Christine Koch, US
Natascha Kindsvogel, DE
Chiara Falciani, IT
Joost Warsanis, NL
John Lindon, GB
Ralf Mulflur, DE
Petra Zürbig, DE
Luc Lammens, BE
Fatih Ozaltin, TR
Sarah Wulhfard, CH
Karin Van Den Eeden, BE
Olivier Devuyst, CH
André Brändli, DE
Markus Beier, DE
Korbinian Grote, DE
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: European consortium for high-throughput research in rare kidney diseases
Project Number: CORDIS-105363
Project web address: Follow on CORDIS
Organization: Universitaetsklinikum Heidelberg, Germany, Heidelberg
Collaborators: University Of Bristol, GB
University Of Zurich, CH
University Of Manchester, GB
University College London, GB
Katholieke Universiteit Leuven, BE
Stichting Katholieke Universiteit, NL
University Of Newcastle Upon Tyne, GB
Institut National De La Sante Et De La Recherche Medicale, FR
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Assistance Publique - Hopitaux De Paris, FR
Hacettepe University, TR
Genomatix Software Gmbh, DE
Oulun Yliopisto, FI
Universitair Medisch Centrum Utrecht, NL
Agencia Estatal Consejo Superior De Investigaciones Cientificas, ES
Karlsruher Institut Fuer Technologie, DE
Mosaiques Diagnostics Gmbh, DE
Philogen Spa, IT
Metabometrix Limited, GB
Gabo:Mi Gesellschaft Für Ablauforganisation :Milliarium Mbh & Co. Kg, DE
University Of Michigan The Regents Of The University Of Michigan, US
Leibniz-Institut Fur Naturstoff-Forschung Und Infektionsbiologie Ev Hans Knoell Institute, DE
Philochem Ag, CH
Comprehensive Biomarker Center Gmbh, DE
Cmast, BE
Acquifer Ag, DE
Multiplicom Nv, BE
Principal Investigators (PI): Greta Borg-Carbott, GB
Birgit Fuchs, DE
Alberto Sereno Alvarez, ES
Arto Eljander, FI
Thorsten Brietz, DE
Maria Grazia Pezzoni, IT
Sarah Malevé, BE
Michael Ramm, DE
Aleona Blinova, GB
Elodie Mahieu-Wedande, GB
Nicolas Jeanjean, FR
Katherine Boylan, GB
Wim Van Oijen, NL
Alix Pillot, FR
Christine Koch, US
Natascha Kindsvogel, DE
Chiara Falciani, IT
Joost Warsanis, NL
John Lindon, GB
Ralf Mulflur, DE
Petra Zürbig, DE
Luc Lammens, BE
Fatih Ozaltin, TR
Sarah Wulhfard, CH
Karin Van Den Eeden, BE
Olivier Devuyst, CH
André Brändli, DE
Markus Beier, DE
Korbinian Grote, DE
 
Title Journal Year Country Rel