Bluegenics – from gene to bioactive product: exploiting marine genomics for an innovative and sustainable european blue biotechnology industry

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Project Title: Bluegenics – from gene to bioactive product: exploiting marine genomics for an innovative and sustainable european blue biotechnology industry
Project Number: CORDIS-104248
Project web address: Follow on CORDIS
Organization: Universitaetsmedizin Der Johannes Gutenberg-Universitaet Mainz, Germany, Mainz
Collaborators: Uppsala University, SE
University Of East Anglia, GB
Museum National D'Histoire Naturelle, FR
Università Degli Studi Di Napoli Federico Ii, IT
Eidgenoessische Technische Hochschule Zuerich, CH
Rheinische Friedrich-Wilhelms-Universitat Bonn, DE
The University Court Of The University Of St Andrews, GB
Matis Ohf, IS
Ruder Boskovic Institute, HR
Nanotecmarin Gmbh, DE
Bioalvo S.A., PT
Biotrend - Inovacao E Engenharia Em Biotecnologia Sa, PT
National Research Center For Geoanalysis, CN
Prokazyme Ehf, IS
Manros Therapeutics, FR
Fidelta D.O.O. Za Istrazivanje I Razvoj, HR
Saebyli Ehf, IS
Principal Investigators (PI): Renato Batel, HR
Trish Starrs, GB
Daniela Hasenpusch, DE
Silvia Tschauder, DE
Patricia Calado, PT
Anna Kristin Danielsdottir, IS
Chris Killen, GB
Xiaohong Wang, CN
Heinz C Schröder, DE
Jakob Kristjansson, IS
Laurent Meijer, FR
Vanessa Demanoff, FR
Gunilla Eriksson, SE
Alfonso Mangoni, IT
Lidija Herceg Harjacek, HR
Asgeir Gudnason, IS
Susanne Jäger, CH
Bruno Sommer Ferreira, PT
 
Project Description:
Marine organisms, in particular sponges and their associated microorganisms, are an inexhaustible source of novel bioactive (lead) compounds for biomedical application. Industrial exploitation of this natural resource using traditional approaches is, however, hampered, with a few exceptions, by unsolvable supply problems - despite of numerous efforts in the past. Therefore, there is, very likely, only one way: to start from the genes encoding the bioproducts, or their biosynthetic pathways, to sustainably obtain the active molecules in sufficient amounts. The aim of the presented industry-driven integrating project is to combine the knowledge in marine genomics, chemogenetics and advanced chemistry to produce recombinantly prepared novel secondary metabolite (lead) compounds and analogous from them, as well as pharmacologically active peptides, and to bring them up to the pre-clinical, and hopefully also to the clinical studies. This ambitious approach is based on breakthrough discoveries and the results of previous successful EU projects of members of the applying consortium, including European leaders (or worldwide leaders) in marine (sponge) genomics, metagenomics (polyketide synthase clusters), combinatorial biosynthesis and marine natural product chemistry/structure elucidation. This multidisciplinary project, driven by high-tech genomics-based SMEs with dedicated interest in bringing marine-biotechnology-derived products to the market, will also involve the discovery and sustainable production of bioactive molecules from hitherto unexploited extreme environments, such as hydrothermal vents and deep-sea sources, and the expression/scale-up of unique enzymes/proteins of biomedical and biotechnological interest. The molecular-biology-based strategies developed in this project for a sustainable exploitation of aquatic molecular biodiversity will further strengthen the international position and effectiveness of European (SME-based) blue biotechnology industry.
 
Project Terms:
scientific research
Project Title: Bluegenics – from gene to bioactive product: exploiting marine genomics for an innovative and sustainable european blue biotechnology industry
Project Number: CORDIS-104248
Project web address: Follow on CORDIS
Organization: Universitaetsmedizin Der Johannes Gutenberg-Universitaet Mainz, Germany, Mainz
Collaborators: Uppsala University, SE
University Of East Anglia, GB
Museum National D'Histoire Naturelle, FR
Università Degli Studi Di Napoli Federico Ii, IT
Eidgenoessische Technische Hochschule Zuerich, CH
Rheinische Friedrich-Wilhelms-Universitat Bonn, DE
The University Court Of The University Of St Andrews, GB
Matis Ohf, IS
Ruder Boskovic Institute, HR
Nanotecmarin Gmbh, DE
Bioalvo S.A., PT
Biotrend - Inovacao E Engenharia Em Biotecnologia Sa, PT
National Research Center For Geoanalysis, CN
Prokazyme Ehf, IS
Manros Therapeutics, FR
Fidelta D.O.O. Za Istrazivanje I Razvoj, HR
Saebyli Ehf, IS
Principal Investigators (PI): Renato Batel, HR
Trish Starrs, GB
Daniela Hasenpusch, DE
Silvia Tschauder, DE
Patricia Calado, PT
Anna Kristin Danielsdottir, IS
Chris Killen, GB
Xiaohong Wang, CN
Heinz C Schröder, DE
Jakob Kristjansson, IS
Laurent Meijer, FR
Vanessa Demanoff, FR
Gunilla Eriksson, SE
Alfonso Mangoni, IT
Lidija Herceg Harjacek, HR
Asgeir Gudnason, IS
Susanne Jäger, CH
Bruno Sommer Ferreira, PT
 
Project Categories:
Natural Sciences > Clinical Trials & Therapy > Treatment
 
Other Information:
Fiscal Year: 2012
Project Start Date: 1 August 2012
Project End Date: 31 July 2016
Project program: FP7-KBBE
 
Project Funding Information:
Funding Mechanism: CP-TP - Collaborative Project targeted to a special group (such as SMEs)
Year Funding Organization Total Funding, $
2012 European Research Council $8,961,037
Project Title: Bluegenics – from gene to bioactive product: exploiting marine genomics for an innovative and sustainable european blue biotechnology industry
Project Number: CORDIS-104248
Project web address: Follow on CORDIS
Organization: Universitaetsmedizin Der Johannes Gutenberg-Universitaet Mainz, Germany, Mainz
Collaborators: Uppsala University, SE
University Of East Anglia, GB
Museum National D'Histoire Naturelle, FR
Università Degli Studi Di Napoli Federico Ii, IT
Eidgenoessische Technische Hochschule Zuerich, CH
Rheinische Friedrich-Wilhelms-Universitat Bonn, DE
The University Court Of The University Of St Andrews, GB
Matis Ohf, IS
Ruder Boskovic Institute, HR
Nanotecmarin Gmbh, DE
Bioalvo S.A., PT
Biotrend - Inovacao E Engenharia Em Biotecnologia Sa, PT
National Research Center For Geoanalysis, CN
Prokazyme Ehf, IS
Manros Therapeutics, FR
Fidelta D.O.O. Za Istrazivanje I Razvoj, HR
Saebyli Ehf, IS
Principal Investigators (PI): Renato Batel, HR
Trish Starrs, GB
Daniela Hasenpusch, DE
Silvia Tschauder, DE
Patricia Calado, PT
Anna Kristin Danielsdottir, IS
Chris Killen, GB
Xiaohong Wang, CN
Heinz C Schröder, DE
Jakob Kristjansson, IS
Laurent Meijer, FR
Vanessa Demanoff, FR
Gunilla Eriksson, SE
Alfonso Mangoni, IT
Lidija Herceg Harjacek, HR
Asgeir Gudnason, IS
Susanne Jäger, CH
Bruno Sommer Ferreira, PT
 
Project Title Organization FY Funding
Bluegenics – From Gene To Bioactive Product: Exploiting Marine Genomics For An Innovative And Sustainable European Blue Biotechnology IndustryUniversitaetsmedizin Der Johannes Gutenberg-Universitaet Mainz2012$8,961,037