Neurotrophic cochlear implant for severe hearing loss

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Project Title: Neurotrophic cochlear implant for severe hearing loss
Project Number: CORDIS-104052
Project web address: Follow on CORDIS
Organization: Nsgene A/S, Denmark, Ballerup
Collaborators: Karolinska Institutet, SE
Medizinische Hochschule Hannover, DE
Dando, Weiss & Colucci Limited, GB
Med-El Elektromedizinische Geraete Gmbh, AT
Principal Investigators (PI): Lars Wahlberg, DK
Miles Davies, SE
Isabelle Weiss, GB
Frank Dittrich, DE
Raimund Naschberger, AT
 
Project Description:
Sixteen percent of adult Europeans suffer from hearing loss, great enough to adversely affect their daily life. Over the age of 80, 50% of the population is suffering from hearing loss. A large portion of this population is affected by sensoryneural hearing loss (SNHL), a consequence of a progressive degeneration of the primary auditory neurons (ANs), the afferent neurons of the cochlea. These ANs are the target cells of the neurotrophic cochlear implant – a neural prosthesis that will be designed by the partners of NeuEar to provide both electric auditory cues and regenerative neurotrophic factor(s) to severe-profoundly deaf patients. The ongoing degeneration of ANs that occurs over time is a limiting factor in current cochlear implant efficacy. The exogenous application of neurotrophic factors can prevent these degenerative changes. This project aims to develop an encapsulated cell (EC) therapy device capable of long-term intracochlear neurotrophin production in combination with a cochlear electrode implant. The aim is also to develop a versatile encapsulated cell implant that could be used to deliver regenerative factors to the cochlea even without the electrode part in future applications. The project brings together an SME capable of making clinically and regulatory compliant EC therapy devices with an industrial partner already on the market with a successful cochlear implant. These companies will work closely with two academic partners with expertise and resources to select, evaluate, and validate the neurotrophic cochlear implant. It is the intention of this consortium to make a clinically relevant implant with an associated preclinical package for regulatory submission over the next three years. Another SME will implement an efficient exploitation and dissemination structure, including a patent strategy to enable partnering and fund-raising for further clinical development, regulatory approval, commercialization, and marketing.
 
Project Terms:
scientific research
Project Title: Neurotrophic cochlear implant for severe hearing loss
Project Number: CORDIS-104052
Project web address: Follow on CORDIS
Organization: Nsgene A/S, Denmark, Ballerup
Collaborators: Karolinska Institutet, SE
Medizinische Hochschule Hannover, DE
Dando, Weiss & Colucci Limited, GB
Med-El Elektromedizinische Geraete Gmbh, AT
Principal Investigators (PI): Lars Wahlberg, DK
Miles Davies, SE
Isabelle Weiss, GB
Frank Dittrich, DE
Raimund Naschberger, AT
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology
 
Other Information:
Fiscal Year: 2012
Project Start Date: 1 September 2012
Project End Date: 31 December 2015
Project program: FP7-HEALTH
 
Project Funding Information:
Funding Mechanism: CP-FP - Small or medium-scale focused research project
Year Funding Organization Total Funding, $
2012 European Research Council $9,168,811
Project Title: Neurotrophic cochlear implant for severe hearing loss
Project Number: CORDIS-104052
Project web address: Follow on CORDIS
Organization: Nsgene A/S, Denmark, Ballerup
Collaborators: Karolinska Institutet, SE
Medizinische Hochschule Hannover, DE
Dando, Weiss & Colucci Limited, GB
Med-El Elektromedizinische Geraete Gmbh, AT
Principal Investigators (PI): Lars Wahlberg, DK
Miles Davies, SE
Isabelle Weiss, GB
Frank Dittrich, DE
Raimund Naschberger, AT
 
Title FY Funding
There are no results for this project in database.
Project Title: Neurotrophic cochlear implant for severe hearing loss
Project Number: CORDIS-104052
Project web address: Follow on CORDIS
Organization: Nsgene A/S, Denmark, Ballerup
Collaborators: Karolinska Institutet, SE
Medizinische Hochschule Hannover, DE
Dando, Weiss & Colucci Limited, GB
Med-El Elektromedizinische Geraete Gmbh, AT
Principal Investigators (PI): Lars Wahlberg, DK
Miles Davies, SE
Isabelle Weiss, GB
Frank Dittrich, DE
Raimund Naschberger, AT
 
Project number Project title Principal investigator
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Project Title: Neurotrophic cochlear implant for severe hearing loss
Project Number: CORDIS-104052
Project web address: Follow on CORDIS
Organization: Nsgene A/S, Denmark, Ballerup
Collaborators: Karolinska Institutet, SE
Medizinische Hochschule Hannover, DE
Dando, Weiss & Colucci Limited, GB
Med-El Elektromedizinische Geraete Gmbh, AT
Principal Investigators (PI): Lars Wahlberg, DK
Miles Davies, SE
Isabelle Weiss, GB
Frank Dittrich, DE
Raimund Naschberger, AT
 
Title Journal Year Country Rel