Proteomic prediction and renin angiotensin aldosterone system inhibition prevention of early diabetic nephropathy in type 2 diabetic patients with normoalbuminuria

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Project Title: Proteomic prediction and renin angiotensin aldosterone system inhibition prevention of early diabetic nephropathy in type 2 diabetic patients with normoalbuminuria
Project Number: CORDIS-101813
Project web address: Follow on CORDIS
Organization: Steno Diabetes Center A/S, Denmark, Gentofte
Collaborators: University Of Glasgow, GB
University Of Zurich, CH
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Akademisch Ziekenhuis Groningen, NL
Mosaiques Diagnostics Gmbh, DE
Gwt-Tud Gmbh, DE
Geniko Nosokomeio Athinas Ippokrateio, GR
Institut Klinické A Experimentální Mediciny, CZ
Universitair Ziekenhuis Gent, BE
Deutsches Rheuma-Forschungszentrum Berlin, Ein Leibniz-Institut, DE
Stichting Vu, NL
Univerzita Karlova, CZ
Stichting Vumc, NL
Instituto De Investigacion Sanitaria De La Fundacion Jimenez Diaz, ES
Klinikum St Georg Ggmbh, DE
Diabetologen Hessen Eg, DE
Hannover Clinical Trial Center Gmbh, DE
Diabetes And Vascular Research Foundation, NL
Rd Nephrologie Sas, FR
Principal Investigators (PI): Harald Mischak, DE
Gerjan Navis, NL
Joe Galloway, GB
Maria Grazia Pezzoni, IT
Eveline Fräßdorf, DE
Peter Rossing, DK
Femke Rutters, NL
Ivan Rychlik, CZ
Sandra Krause, DE
Marijn Speeckaert, BE
Marina Noutsou, GR
Goce Spasovski, MK
Joachim Beige, DE
Andreas Serra, CH
Reinhold Preiss, DE
Yvonne Koppelman, NL
Heiko Von Der Leyen, DE
Petr Boucek, CZ
Adriaan Kooy, NL
Alberto Ortiz, ES
Angel Argiles, FR
 
Project Description:
Patients with diabetes are at risk of developing diabetic nephropathy, which will ultimately result in the requirement for renal replacement therapy and is also associated with high cardiovascular morbidity and mortality. Detection of low concentrations of albuminuria in urine (microalbuminuria) is the current clinical standard for detecting those at significant risk and targeting preventive treatment. However, albuminuria is of low specificity at early stages of disease, and of considerable biological variability, hence a poor predictor at early stages of disease. In two independent studies we have demonstrated that urinary proteomics offers the prospect of detecting nephropathy earlier in the preclinical phase, enabling targeted treatment at an earlier stage. We propose to assess the potential of this technology to identify normoalbuminuric patients at risk and to target therapy with an aldosterone receptor antagonist (spironolactone) as add-on to recommended therapy including angiotensin converting enzyme (ACE) inhibition or angiotensin II receptor blockers (ARBs) according to national guidelines. We will test the following hypotheses: (1) urinary proteomics predicts progression of albuminuria (as a surrogate marker for the development of overt nephropathy) in a cohort of 3280 type 2 diabetic patients with normal urinary albumin excretion, and (2) early initiation of intensive preventive therapy directed by urinary proteomics reduces progression of albuminuria in those 20 % at high risk and thereby delay progression to overt nephropathy and spare treatment for those with low risk, paving the way of personalised medicine. This will be the first biomarker-directed therapy trial for primary prevention of diabetic kidney disease. Additional clinical and circulating biomarkers will be assessed and models to predict progression of albuminuria including clinical factors, biomarkers and proteomics will be developed.
 
Project Terms:
life sciences
Project Title: Proteomic prediction and renin angiotensin aldosterone system inhibition prevention of early diabetic nephropathy in type 2 diabetic patients with normoalbuminuria
Project Number: CORDIS-101813
Project web address: Follow on CORDIS
Organization: Steno Diabetes Center A/S, Denmark, Gentofte
Collaborators: University Of Glasgow, GB
University Of Zurich, CH
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Akademisch Ziekenhuis Groningen, NL
Mosaiques Diagnostics Gmbh, DE
Gwt-Tud Gmbh, DE
Geniko Nosokomeio Athinas Ippokrateio, GR
Institut Klinické A Experimentální Mediciny, CZ
Universitair Ziekenhuis Gent, BE
Deutsches Rheuma-Forschungszentrum Berlin, Ein Leibniz-Institut, DE
Stichting Vu, NL
Univerzita Karlova, CZ
Stichting Vumc, NL
Instituto De Investigacion Sanitaria De La Fundacion Jimenez Diaz, ES
Klinikum St Georg Ggmbh, DE
Diabetologen Hessen Eg, DE
Hannover Clinical Trial Center Gmbh, DE
Diabetes And Vascular Research Foundation, NL
Rd Nephrologie Sas, FR
Principal Investigators (PI): Harald Mischak, DE
Gerjan Navis, NL
Joe Galloway, GB
Maria Grazia Pezzoni, IT
Eveline Fräßdorf, DE
Peter Rossing, DK
Femke Rutters, NL
Ivan Rychlik, CZ
Sandra Krause, DE
Marijn Speeckaert, BE
Marina Noutsou, GR
Goce Spasovski, MK
Joachim Beige, DE
Andreas Serra, CH
Reinhold Preiss, DE
Yvonne Koppelman, NL
Heiko Von Der Leyen, DE
Petr Boucek, CZ
Adriaan Kooy, NL
Alberto Ortiz, ES
Angel Argiles, FR
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2012
Project Start Date: 1 January 2011
Project End Date: 31 December 2017
Project program: FP7-HEALTH
 
Project Funding Information:
Funding Mechanism: CP-FP - Small or medium-scale focused research project
Year Funding Organization Total Funding, $
2012 European Research Council $9,706,655
Project Title: Proteomic prediction and renin angiotensin aldosterone system inhibition prevention of early diabetic nephropathy in type 2 diabetic patients with normoalbuminuria
Project Number: CORDIS-101813
Project web address: Follow on CORDIS
Organization: Steno Diabetes Center A/S, Denmark, Gentofte
Collaborators: University Of Glasgow, GB
University Of Zurich, CH
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Akademisch Ziekenhuis Groningen, NL
Mosaiques Diagnostics Gmbh, DE
Gwt-Tud Gmbh, DE
Geniko Nosokomeio Athinas Ippokrateio, GR
Institut Klinické A Experimentální Mediciny, CZ
Universitair Ziekenhuis Gent, BE
Deutsches Rheuma-Forschungszentrum Berlin, Ein Leibniz-Institut, DE
Stichting Vu, NL
Univerzita Karlova, CZ
Stichting Vumc, NL
Instituto De Investigacion Sanitaria De La Fundacion Jimenez Diaz, ES
Klinikum St Georg Ggmbh, DE
Diabetologen Hessen Eg, DE
Hannover Clinical Trial Center Gmbh, DE
Diabetes And Vascular Research Foundation, NL
Rd Nephrologie Sas, FR
Principal Investigators (PI): Harald Mischak, DE
Gerjan Navis, NL
Joe Galloway, GB
Maria Grazia Pezzoni, IT
Eveline Fräßdorf, DE
Peter Rossing, DK
Femke Rutters, NL
Ivan Rychlik, CZ
Sandra Krause, DE
Marijn Speeckaert, BE
Marina Noutsou, GR
Goce Spasovski, MK
Joachim Beige, DE
Andreas Serra, CH
Reinhold Preiss, DE
Yvonne Koppelman, NL
Heiko Von Der Leyen, DE
Petr Boucek, CZ
Adriaan Kooy, NL
Alberto Ortiz, ES
Angel Argiles, FR
 
Project Title Organization FY Funding
Proteomic Prediction And Renin Angiotensin Aldosterone System Inhibition Prevention Of Early Diabetic Nephropathy In Type 2 Diabetic Patients With NormoalbuminuriaSteno Diabetes Center A/S2012$9,706,655
Project Title: Proteomic prediction and renin angiotensin aldosterone system inhibition prevention of early diabetic nephropathy in type 2 diabetic patients with normoalbuminuria
Project Number: CORDIS-101813
Project web address: Follow on CORDIS
Organization: Steno Diabetes Center A/S, Denmark, Gentofte
Collaborators: University Of Glasgow, GB
University Of Zurich, CH
Istituto Di Ricerche Farmacologiche Mario Negri, IT
Akademisch Ziekenhuis Groningen, NL
Mosaiques Diagnostics Gmbh, DE
Gwt-Tud Gmbh, DE
Geniko Nosokomeio Athinas Ippokrateio, GR
Institut Klinické A Experimentální Mediciny, CZ
Universitair Ziekenhuis Gent, BE
Deutsches Rheuma-Forschungszentrum Berlin, Ein Leibniz-Institut, DE
Stichting Vu, NL
Univerzita Karlova, CZ
Stichting Vumc, NL
Instituto De Investigacion Sanitaria De La Fundacion Jimenez Diaz, ES
Klinikum St Georg Ggmbh, DE
Diabetologen Hessen Eg, DE
Hannover Clinical Trial Center Gmbh, DE
Diabetes And Vascular Research Foundation, NL
Rd Nephrologie Sas, FR
Principal Investigators (PI): Harald Mischak, DE
Gerjan Navis, NL
Joe Galloway, GB
Maria Grazia Pezzoni, IT
Eveline Fräßdorf, DE
Peter Rossing, DK
Femke Rutters, NL
Ivan Rychlik, CZ
Sandra Krause, DE
Marijn Speeckaert, BE
Marina Noutsou, GR
Goce Spasovski, MK
Joachim Beige, DE
Andreas Serra, CH
Reinhold Preiss, DE
Yvonne Koppelman, NL
Heiko Von Der Leyen, DE
Petr Boucek, CZ
Adriaan Kooy, NL
Alberto Ortiz, ES
Angel Argiles, FR
 
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