Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression

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Project Title: Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression
Project Number: CORDIS-101811
Project web address: Follow on CORDIS
Organization: Steno Diabetes Center A/S, Denmark, Gentofte
Collaborators: University Of Newcastle Upon Tyne, GB
Dublin City University, IE
Teknologian Tutkimuskeskus Vtt, FI
Itä-Suomen Yliopisto, FI
Fundacio Institut D'Investigacio Biomedica De Bellvitge, ES
Fundacio Institut De Recerca Biomedica (Irb Barcelona), ES
Pintail Ltd, IE
Metabolon Inc Corporation, US
Voluntary Health Insurance Board, IE
Principal Investigators (PI): Adriana Grosu, ES
Ciaran Clissmann, IE
Tiina Reinikainen, FI
Amanda Gregory, GB
Laia Lagunas, ES
Walter Gall, US
Donal O'Gorman, IE
Jing Tang, FI
Bernadette Carr, IE
John Nolan, DK
 
Project Description:
Type 2 diabetes (T2DM) is preventable by sustained changes in diet and physical exercise. Despite this, modern societies are already approaching 10% population prevalence of diabetes, and another 15% with pre-diabetes. The costs of T2DM are huge, approaching 10% of all health costs. Prevention of diabetes is a priority for national healthcare agencies and for the health insurance industry. Investment in prevention and lifestyle programmes requires a solid evidence-base for targeting and customising these interventions in a cost-effective manner. Translation of the findings from T2DM prevention studies to the benefit of general public health has not yet been possible.DEXLIFE will identify novel diagnostic and predictive biomarkers (i) to detect the progression toward diabetes in high risk individuals and (ii) that are responsive to lifestyle interventions known to be effective in diabetes prevention. New biomarkers alone will be insufficient to alter the course of diabetes progression. We bring a strong translational focus to this proposal, by setting the main intervention in the real-life context of a major health insurance system. The accumulated phenotyping repertoire from an extensive panel of –omic analyses will be refined and modelled into a new diagnostic panel for the allocation of high risk subjects to individualised preventive regimens.Our multi-disciplinary team has a strong track record in clinical diabetes and metabolism. Several unique clinical cohorts will provide the basis for a series of clinical, physiological and mechanistic investigations, which will identify, monitor and analyse the impact of biomarkers over time. An exercise and dietary intervention study will be included in two specific cohorts, enabling us to assess the impact of such interventions on plasma biomarkers and functional tissue-based markers. Project clinical and industry partners will support the translation of our findings into clinical practice.
 
Project Terms:
life sciences
Project Title: Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression
Project Number: CORDIS-101811
Project web address: Follow on CORDIS
Organization: Steno Diabetes Center A/S, Denmark, Gentofte
Collaborators: University Of Newcastle Upon Tyne, GB
Dublin City University, IE
Teknologian Tutkimuskeskus Vtt, FI
Itä-Suomen Yliopisto, FI
Fundacio Institut D'Investigacio Biomedica De Bellvitge, ES
Fundacio Institut De Recerca Biomedica (Irb Barcelona), ES
Pintail Ltd, IE
Metabolon Inc Corporation, US
Voluntary Health Insurance Board, IE
Principal Investigators (PI): Adriana Grosu, ES
Ciaran Clissmann, IE
Tiina Reinikainen, FI
Amanda Gregory, GB
Laia Lagunas, ES
Walter Gall, US
Donal O'Gorman, IE
Jing Tang, FI
Bernadette Carr, IE
John Nolan, DK
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology > Metabolic and endocrine disorders > Diabetes mellitus II-type (insulin non-dependent)
 
Other Information:
Fiscal Year: 2012
Project Start Date: 1 January 2011
Project End Date: 31 December 2015
Project program: FP7-HEALTH
 
Project Funding Information:
Funding Mechanism: CP-FP - Small or medium-scale focused research project
Year Funding Organization Total Funding, $
2012 European Research Council $8,703,230