Dietary fibers supporting gut and immune function - from polysaccharide compound to health claim

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Project Title: Dietary fibers supporting gut and immune function - from polysaccharide compound to health claim
Project Number: CORDIS-101664
Project web address: Follow on CORDIS
Organization: Stichting Wageningen Research, Netherlands, Wageningen
Collaborators: Wageningen University, NL
Institut Pasteur, FR
Institut National De La Recherche Agronomique, FR
Teagasc - Agriculture And Food Development Authority, IE
Alma Mater Studiorum - University Of Bologna, IT
The University Court Of The University Of Aberdeen, GB
Orebro University, SE
Nofima As, NO
Winclove Bio Industries Bv, NL
Genetic Analysis As, NO
Prodigest, BE
Crc Clinical Research Center Kiel Gmbh, DE
Immitec Norge As, NO
Swedish Oat Fiber Ab, SE
De Groot-Weevers Philippus Josephus, NL
Bioactor Bv, NL
Principal Investigators (PI): Nadia Khelef, FR
Ian Tough, GB
Martin Cooney, IE
Emilie Briand-Dubreuil, FR
Ann-Britt Ivarsson, SE
Jerry Wells, NL
Morten Isaksen, NO
Anne Risbraathe, NO
Gastone Castellani, IT
Sam Possemiers, BE
Christiane Laue, DE
Jan Oddvar Johansen, NO
Saskia Van Hemert, NL
Frédéric Prothon, SE
Philippus Josephus De Groot, NL
Hans Van Der Saag, NL
Jurriaan Mes, NL
 
Project Description:
The project goal is to support the development of functional food ingredients and products that are beneficial for the human gut & immune system and therefore of crucial importance for quality of life. The project will study the effects of specific non-digestible polysaccharides which have shown health potential in this field. The health effects of NPS will be focused around enhancing immune defence against pathogens, the reduction of infectious diseases like common cold and influenza of elderly and will make use of EFSA supported biomarkers that enable immune function claims and underpin the mechanism involved. The studied mechanisms are the innate and adaptive immune system and the possible involvement of the microbiota and microbiota-mediated products. To achieve this goal new and existing NPS will be studied for their health effects in a systematic way by developing a toolbox of dedicated assays and models that can be used by industry and authorities to study and approve food ingredients with a similar health focus. The project will: 1) perform biochemical analyses to study compounds, effect of processing and bioavailability, 2) develop standardized in vitro screening methods to be able to predict in vivo effects, 3) use dedicated in vivo and ex vivo analyses to study mechanisms of action and to validate biomarkers and 4) use and validate this knowledge in an intervention study. By combining the knowledge that will be gained from molecular, cellular and whole-organism studies, the goal will be to understand the bioactive mechanisms of these NPS and use this knowledge to design functional food products. SMEs make a very large contribution to the project, both as beneficiary of the products and as a technology service provider related to health research. This proposed project should provide the scientific basis for international nutritional organisations to recommend an immune-related functional health claim for some of the NPS studied.
 
Project Terms:
food
Project Title: Dietary fibers supporting gut and immune function - from polysaccharide compound to health claim
Project Number: CORDIS-101664
Project web address: Follow on CORDIS
Organization: Stichting Wageningen Research, Netherlands, Wageningen
Collaborators: Wageningen University, NL
Institut Pasteur, FR
Institut National De La Recherche Agronomique, FR
Teagasc - Agriculture And Food Development Authority, IE
Alma Mater Studiorum - University Of Bologna, IT
The University Court Of The University Of Aberdeen, GB
Orebro University, SE
Nofima As, NO
Winclove Bio Industries Bv, NL
Genetic Analysis As, NO
Prodigest, BE
Crc Clinical Research Center Kiel Gmbh, DE
Immitec Norge As, NO
Swedish Oat Fiber Ab, SE
De Groot-Weevers Philippus Josephus, NL
Bioactor Bv, NL
Principal Investigators (PI): Nadia Khelef, FR
Ian Tough, GB
Martin Cooney, IE
Emilie Briand-Dubreuil, FR
Ann-Britt Ivarsson, SE
Jerry Wells, NL
Morten Isaksen, NO
Anne Risbraathe, NO
Gastone Castellani, IT
Sam Possemiers, BE
Christiane Laue, DE
Jan Oddvar Johansen, NO
Saskia Van Hemert, NL
Frédéric Prothon, SE
Philippus Josephus De Groot, NL
Hans Van Der Saag, NL
Jurriaan Mes, NL
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2012
Project Start Date: 1 January 2011
Project End Date: 30 June 2016
Project program: FP7-KBBE
 
Project Funding Information:
Funding Mechanism: CP-TP - Collaborative Project targeted to a special group (such as SMEs)
Year Funding Organization Total Funding, $
2012 European Research Council $8,634,592