Cardiovascular control in normal and disease states

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Project Title: Cardiovascular control in normal and disease states
Project Number: 7R37HL033107-17
Project web address: Follow on NIH
Organization: Univ Of Med/Dent Of Nj-Nj Medical School, United States, New Jersey, NEWARK
Principal Investigators (PI): Vatner Stephen F, US
 
Project Description:
The major goals of this research proposal are to describe and analyze cardiovascular control mechanisms with particular emphasis on the autonomic nervous system in normal healthy conscious animals, instrumented for direct and instantaneous measurements and radiotelemetry of coronary and regional blood flows and vascular resistances, ventricular function and myocardial contractility. Miniature pressure gauges will be implanted in the left and right ventricles and aorta, ultrasonic dimension transducers will be opposed on the endocardial surfaces of the left ventricle and Doppler ultrasonic or electromagnetic flow probes will be placed on the ascending aorta, coronary, mesenteric, renal and iliac arteries. In order to achieve these goals several specific interlocking groups of projects are planned. First of all, the afferent limb of the autonomic nervous system controlling the circulation will be examined, e.g., regulation by arterial baroreceptors, chemoreceptors, pulmonary inflation receptors, and low pressure vagal afferents. Secondly efferent autonomic control of ventricular performance, the coronary circulation,and the regional circulations will be studied. Thirdly, autonomic control during exercise will be examined. Thus, the aim of this research proposal is togain a clearer understanding of the control of the cardiovascular system by the autonomic nervous system in the normal conscious animal.
 
Project Terms:
autonomic nervous system heart function hemodynamics cardiovascular disorder nitroglycerin anesthesia baroreceptors vasopressins pentobarbital angiotensin ii myocardial ischemia /hypoxia hemorrhage vascular resistance exercise heart circulation heart dimension /size tachycardia myocardial infarction heart contraction kidney circulation cardiac glycosides cardiotonic agents vasoactive agent renin angiotensin system baboons splenectomy dogs telemetry muscle stimulant ultrasound blood flow measurement blood pressure methoxamine isoproterenol
Project Title: Cardiovascular control in normal and disease states
Project Number: 7R37HL033107-17
Project web address: Follow on NIH
Organization: Univ Of Med/Dent Of Nj-Nj Medical School, United States, New Jersey, NEWARK
Principal Investigators (PI): Vatner Stephen F, US
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology > Cardiovascular and cerebrovascular diseases
 
Other Information:
Fiscal Year: 1984
Project Start Date: 1 January 1983
Project End Date: 30 June 2002
Project program: Method to Extend Research in Time (MERIT) Award
 
Project Funding Information:
Funding Mechanism: Research project grants
Year Funding Organization Total Funding, $
2000 NIH - National Heart, Lung, And Blood Institute $624,461
Project Title: Cardiovascular control in normal and disease states
Project Number: 7R37HL033107-17
Project web address: Follow on NIH
Organization: Univ Of Med/Dent Of Nj-Nj Medical School, United States, New Jersey, NEWARK
Principal Investigators (PI): Vatner Stephen F, US
 
Title FY Funding
There are no results for this project in database.
Project Title: Cardiovascular control in normal and disease states
Project Number: 7R37HL033107-17
Project web address: Follow on NIH
Organization: Univ Of Med/Dent Of Nj-Nj Medical School, United States, New Jersey, NEWARK
Principal Investigators (PI): Vatner Stephen F, US
 
Project Title Organization FY Funding
Cardiovascular Control In Normal And Disease StatesUniv Of Med/Dent Of Nj-Nj Medical School2001$574,827
Cardiovascular Control In Normal And Disease StatesUniv Of Med/Dent Of Nj-Nj Medical School2000$624,461
Project Title: Cardiovascular control in normal and disease states
Project Number: 7R37HL033107-17
Project web address: Follow on NIH
Organization: Univ Of Med/Dent Of Nj-Nj Medical School, United States, New Jersey, NEWARK
Principal Investigators (PI): Vatner Stephen F, US
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Cardiovascular control in normal and disease states
Project Number: 7R37HL033107-17
Project web address: Follow on NIH
Organization: Univ Of Med/Dent Of Nj-Nj Medical School, United States, New Jersey, NEWARK
Principal Investigators (PI): Vatner Stephen F, US
 
Title Journal Year Country Rel
Regulation of coronary resistance vessels and large coronary arteries. Am J Cardiol 1985 united states
Autonomic mechanisms regulating myocardial contractility in conscious animals. Pharmacol Ther 1985 england
Mechanisms of supersensitivity to sympathomimetic amines in the chronically denervated heart of the conscious dog. Circ Res 1985 united states
Effects of volume expansion on renal nerve activity, renal blood flow, and sodium and water excretion in conscious dogs. Am J Physiol 1985 united states
beta-Adrenergic and cholinergic receptors in hypertension-induced hypertrophy. Hypertension 1985 united states
Direct versus indirect pressor and vasoconstrictor actions of angiotensin in conscious dogs. Hypertension 1985 united states
Effects of altered site of electrical activation on myocardial performance during inotropic stimulation. Circulation 1985 united states
Norepinephrine-induced beta 1-adrenergic peripheral vasodilation in conscious dogs. Am J Physiol 1985 united states
Effects of hemorrhage on renal nerve activity in conscious dogs. Circ Res 1985 united states
Effects of a calcium channel blocker on cardiac output distribution in conscious hypertensive dogs. Hypertension 1985 united states
Subtypes of beta-adrenergic receptors in bovine coronary arteries. Circ Res 1986 united states
Cardiovascular responses to the stimulation of alpha-1 and alpha-2 adrenoceptors in the conscious dog. J Pharmacol Exp Ther 1986 united states
Augmented catecholamine uptake by the heart during hemorrhage in the conscious dog. Am J Physiol 1986 united states
Regulation of large coronary arteries. Circ Res 1986 united states
Vagal regulation of arginine vasopressin in conscious dogs. Am J Physiol 1986 united states
Vagally mediated regulation of renal function in conscious primates. Am J Physiol 1986 united states
Enhanced adrenergic constriction of iliac artery with removal of endothelium in conscious dogs. Am J Physiol 1986 united states
Nifedipine attenuates both alpha-1 and alpha-2 adrenoceptor-mediated pressor and vasoconstrictor responses in conscious dogs and primates. J Pharmacol Exp Ther 1986 united states
Myocardial ischemic protection in natural mammalian hibernation. Basic Res Cardiol 2015 germany
Novel mechanisms for caspase inhibition protecting cardiac function with chronic pressure overload. Basic Res Cardiol 2013 germany
Temporal analysis of vascular smooth muscle cell elasticity and adhesion reveals oscillation waveforms that differ with aging. Aging Cell 2012 england
Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5. Heart Fail Rev 2010 united states
Gene program for cardiac cell survival induced by transient ischemia in conscious pigs. Proc Natl Acad Sci U S A 2001 united states
Voltage-dependent calcium channel promoter restores baroreflex sensitivity in conscious dogs with heart failure. Circulation 1998 united states
Lack of desensitization and enhanced efficiency of calcium channel promoter in conscious dogs with heart failure. Am J Physiol 1998 united states
Depressed heart rate variability and arterial baroreflex in conscious transgenic mice with overexpression of cardiac Gsalpha. Circ Res 1998 united states
Overexpression of myocardial Gsalpha prevents full expression of catecholamine desensitization despite increased beta-adrenergic receptor kinase. J Clin Invest 1998 united states
Ineffective perfusion-contraction matching in conscious, chronically instrumented pigs with an extended period of coronary stenosis. Circ Res 1998 united states
Selective large coronary endothelial dysfunction in conscious dogs with chronic coronary pressure overload. Am J Physiol 1998 united states
Apoptosis of cardiac myocytes in Gsalpha transgenic mice. Circ Res 1999 united states
An alpha-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes. Am J Physiol 1999 united states
Reduced subendocardial ryanodine receptors and consequent effects on cardiac function in conscious dogs with left ventricular hypertrophy. Circ Res 1999 united states
Mechanisms of desensitization to a PDE inhibitor (milrinone) in conscious dogs with heart failure. Am J Physiol 1999 united states
Progressive loss of myocardial ATP due to a loss of total purines during the development of heart failure in dogs: a compensatory role for the parallel loss of creatine. Circulation 1999 united states
An adenosine agonist and preconditioning shift the distribution of myocardial blood flow in conscious pigs. Am J Physiol 1999 united states
Cyclosporine attenuates pressure-overload hypertrophy in mice while enhancing susceptibility to decompensation and heart failure. Circ Res 1999 united states
Effects of anaesthesia and recent surgery on diastolic function. Cardiovasc Res 1994 england
Left ventricular systolic dysfunction precedes diastolic dysfunction during myocardial ischemia in conscious dogs. Am J Physiol 1994 united states
Factors involved in delaying the rise in peripheral resistance in developing heart failure. Am J Physiol 1994 united states
Peripheral vascular effects of beta-3 adrenergic receptor stimulation in conscious dogs. J Pharmacol Exp Ther 1994 united states
Exercise induces cardiac dysfunction in both moderate, compensated and severe hypertrophy. Circulation 1994 united states
Effects of hypertrophy on left atrial and ventricular compliance and plasma ANF levels in conscious dogs. Am J Physiol 1995 united states
Role of blood doping in the coronary vasoconstrictor response to cocaine. Circulation 1995 united states
Effects of ryanodine on cardiac contraction, excitation-contraction coupling and "Treppe" in the conscious dog. J Mol Cell Cardiol 1995 england
Adrenergic responsiveness is reduced, while baseline cardiac function is preserved in old adult conscious monkeys. Am J Physiol 1995 united states
Hemodynamic mechanisms responsible for reduced subendocardial coronary reserve in dogs with severe left ventricular hypertrophy. Circulation 1995 united states
Ubiquity of myocardial stunning. Basic Res Cardiol 1995 germany
Splenic contraction-induced increases in arterial O2 reduce requirement for CBF in conscious dogs. Am J Physiol 1995 united states
Intravenous cocaine induces platelet activation in the conscious dog. Circulation 1995 united states
Mechanism of impaired myocardial function during progressive coronary stenosis in conscious pigs. Hibernation versus stunning? Circ Res 1995 united states
Innate protection of baboon myocardium: effects of coronary artery occlusion and reperfusion. Am J Physiol 1996 united states
Identification and functional role of beta-adrenergic receptor subtypes in primate and rodent: in vivo versus isolated myocytes. J Mol Cell Cardiol 1996 england
Differences in beta 3-adrenergic receptor cardiovascular regulation in conscious primates, rats and dogs. J Pharmacol Exp Ther 1996 united states
Adverse effects of chronic endogenous sympathetic drive induced by cardiac GS alpha overexpression. Circ Res 1996 united states
Inotropic reserve and histological appearance of hibernating myocardium in conscious pigs with ameroid-induced coronary stenosis. Basic Res Cardiol 1996 germany
Spatial heterogeneity of myocardial blood flow presages salvage versus necrosis with coronary artery reperfusion in conscious baboons. Circulation 1996 united states
Neurally mediated cardiac effects of forskolin in conscious dogs. Am J Physiol 1996 united states
Downregulation of caveolin by chronic beta-adrenergic receptor stimulation in mice. Am J Physiol 1997 united states
Effects of a novel inotropic agent, BAY y 5959, in conscious dogs: comparison with dobutamine and milrinone. Am J Physiol 1997 united states
Effects of chronic beta-adrenergic receptor stimulation in mice. J Mol Cell Cardiol 1997 england
Effects of renin inhibition compared to angiotensin converting enzyme inhibition in conscious dogs with pacing-induced heart failure. Cardiovasc Res 1997 netherlands
Delayed enhanced nitric oxide-mediated coronary vasodilation following brief ischemia and prolonged reperfusion in conscious dogs. Circ Res 1997 united states
Cardiomyopathy induced by cardiac Gs alpha overexpression. Am J Physiol 1997 united states
Effects of cardiac denervation on development of heart failure and catecholamine desensitization. Circulation 1997 united states
Localisation of cardiac GS alpha in transgenic mice overexpressing GS alpha. J Mol Cell Cardiol 1997 england