Loc: hiv prevention trials network

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Project Title: Loc: hiv prevention trials network
Project Number: 5UM1AI068619-09
Project web address: Follow on NIH
Organization: Family Health International, United States, North Carolina, RESEARCH TRIANGLE PARK
Principal Investigators (PI): El-Sadr Wafaa M, US
Cohen Myron S, US
 
Project Description:
The mission of the HIV Prevention Trials Network (HPTN) is to conduct research designed to identify the best combinations of HIV prevention interventions to prevent HIV infection in populations at the highest risk for this infection. The HPTN will be led by Drs. Wafaa EI-Sadr, Columbia University, and Myron S. Cohen, University of North Carolina at Chapel Hill, and supported by experienced operations, laboratory and statistical and data centers. The HPTN will address and support the two research Priority Areas in order to achieve the following eight Specific Aims: Specific Aims for Priority Area 1: Integrate Strategies to Prevent HIV Infection: Aim 1: To develop an integrated strategy to prevent HIV infection in young women in Southern Africa; Aim 2: To develop integrated strategies to prevent HIV infection in men who have sex with men (MSM); Sub-aim 2a: To identify an integrated strategy to prevent HIV acquisition in HIV-uninfected MSM and transgender women in the Americas; Sub-aim 2b: To identify an integrated strategy to prevent HIV transmission from HIV-infected MSM in the United States (U.S.); Aim 3: To develop an integrated strategy to prevent HIV infection in injection drug users (IDUs) in Eastern Europe and Asia; Aim 4: To implement an integrated strategy to virtually eliminate (<1%) HIV transmission in discordant couples in sub-Saharan Africa {SSA}; Aim 5: To develop methods to engage MSM in SSA in prevention research, paving the way for development of an integrated strategy to prevent HIV infection in this population Specific Aims for Priority Area 2: Pre-exposure Prophylaxis {PrEP}: Aim 6: To evaluate the efficacy of an ARV regimen containing maraviroc (MVC) for PrEP; Aim 7: To develop new agents for PrEP with favorable profiles, including long lasting agents; Aim 8: To develop pharmacostatistical models to define the role of new agents for PrEP. RELEVANCE: The research proposed by the HIV Prevention Trials Network (HPTN) aims to combine known interventions and identify new ones to stop the transmission of HIV infection with the goal of inspiring changes in public health policy and practice, and to ending the HIV epidemic.
 
Project Terms:
address africa south of the sahara aids prevention americas area couples data development eastern europe epidemic experience far east goals health policy health practice high risk hiv hiv infections hiv prevention trials network infection injecting drug user intervention laboratories men who have sex with men methods mission modeling myron new agents north carolina operation population prevent prevention research preventive intervention prophylactic treatment public health regimen research research design research priority role southern africa transgender women transmission process united states universities young woman behavioral and social science clinical research clinical trials and supportive activities drug abuse (nida only) hiv/aids infectious diseases prevention sexual and gender minorities (sgm/lgbt*) substance abuse
Project Title: Loc: hiv prevention trials network
Project Number: 5UM1AI068619-09
Project web address: Follow on NIH
Organization: Family Health International, United States, North Carolina, RESEARCH TRIANGLE PARK
Principal Investigators (PI): El-Sadr Wafaa M, US
Cohen Myron S, US
 
Project Categories:
Behavioral and Social Sciences > Population studies
 
Other Information:
Fiscal Year: 2006
Project Start Date: 1 June 2006
Project End Date: 30 November 2020
Project program: Research Project with Complex Structure Cooperative Agreement
 
Project Funding Information:
Funding Mechanism: Non-SBIR/STTR RPGs
Year Funding Organization Total Funding, $
2015 NIH - National Institute Of Allergy And Infectious Diseases $23,261,055
Project Title: Loc: hiv prevention trials network
Project Number: 5UM1AI068619-09
Project web address: Follow on NIH
Organization: Family Health International, United States, North Carolina, RESEARCH TRIANGLE PARK
Principal Investigators (PI): El-Sadr Wafaa M, US
Cohen Myron S, US
 
Title FY Funding
There are no results for this project in database.
Project Title: Loc: hiv prevention trials network
Project Number: 5UM1AI068619-09
Project web address: Follow on NIH
Organization: Family Health International, United States, North Carolina, RESEARCH TRIANGLE PARK
Principal Investigators (PI): El-Sadr Wafaa M, US
Cohen Myron S, US
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Loc: hiv prevention trials network
Project Number: 5UM1AI068619-09
Project web address: Follow on NIH
Organization: Family Health International, United States, North Carolina, RESEARCH TRIANGLE PARK
Principal Investigators (PI): El-Sadr Wafaa M, US
Cohen Myron S, US
 
Title Journal Year Country Rel
Venues for Meeting Sex Partners and Partner HIV Risk Characteristics: HIV Prevention Trials Network (HPTN064) Women's HIV Seroincidence Study (ISIS). AIDS Behav 2016 united states
Antiretroviral Medication Adherence and Amplified HIV Transmission Risk Among Sexually Active HIV-Infected Individuals in Three Diverse International Settings. AIDS Behav 2016 united states
Brief Report: HIV Drug Resistance in Adults Failing Early Antiretroviral Treatment: Results From the HIV Prevention Trials Network 052 Trial. J Acquir Immune Defic Syndr 2016 united states
Socioecological factors influencing women's HIV risk in the United States: qualitative findings from the women's HIV SeroIncidence study (HPTN 064). BMC Public Health 2016 england
Using Cognitive Interviews to Enhance Measurement in Empirical Bioethics: Developing a Measure of the Preventive Misconception in Biomedical HIV Prevention Trials. AJOB Empir Bioeth 2016 united states
Economic Resources and HIV Preventive Behaviors Among School-Enrolled Young Women in Rural South Africa (HPTN 068). AIDS Behav 2016 united states
Transgender Women in Clinical Trials of Pre-Exposure Prophylaxis. J Acquir Immune Defic Syndr 2016 united states
HPTN 068: A Randomized Control Trial of a Conditional Cash Transfer to Reduce HIV Infection in Young Women in South Africa-Study Design and Baseline Results. AIDS Behav 2016 united states
Costs of Expanded Rapid HIV Testing in Four Emergency Departments. Public Health Rep 2016 united states
Frequency and predictors of estimated HIV transmissions and bacterial STI acquisition among HIV-positive patients in HIV care across three continents. J Int AIDS Soc 2016 switzerland
Transgender People and HIV Prevention: What We Know and What We Need to Know, a Call to Action. J Acquir Immune Defic Syndr 2016 united states
Engaging Transgender People in NIH-Funded HIV/AIDS Clinical Trials Research. J Acquir Immune Defic Syndr 2016 united states
Symptoms, Side Effects and Adherence in the iPrEx Open-Label Extension. Clin Infect Dis 2016 united states
The promise and pitfalls of long-acting injectable agents for HIV prevention. Curr Opin HIV AIDS 2016 united states
Economic, Legal, and Social Hardships Associated with HIV Risk among Black Men who have Sex with Men in Six US Cities. J Urban Health 2016 united states
Pharmacology supports on-demand PrEP. Lancet HIV 2016 netherlands
Population health and individualized care in the global AIDS response: synergy or conflict? AIDS 2016 england
Antiretroviral drug use in a cross-sectional population survey in Africa: NIMH Project Accept (HPTN 043). J Acquir Immune Defic Syndr 2016 united states
Antiretroviral Therapy for the Prevention of HIV-1 Transmission. N Engl J Med 2016 united states
Post-traumatic Stress Disorder Symptoms and Mental Health over Time among Low-Income Women at Increased Risk of HIV in the U.S. J Health Care Poor Underserved 2016 united states
Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study. Lancet HIV 2016 netherlands
The Relationship between Alcohol Outlets, HIV Risk Behavior, and HSV-2 Infection among South African Young Women: A Cross-Sectional Study. PLoS One 2015 united states
Regression to the mean and changes in risk behavior following study enrollment in a cohort of U.S. women at risk for HIV. Ann Epidemiol 2015 united states
HPTN 062: A Pilot Randomized Controlled Trial Exploring the Effect of a Motivational-Interviewing Intervention on Sexual Behavior among Individuals with Acute HIV Infection in Lilongwe, Malawi. PLoS One 2015 united states
A Comparison of Referred Sexual Partners to Their Community Recruited Counterparts in The BROTHERS Project (HPTN 061). AIDS Behav 2015 united states
Adherence to Early Antiretroviral Therapy: Results From HPTN 052, a Phase III, Multinational Randomized Trial of ART to Prevent HIV-1 Sexual Transmission in Serodiscordant Couples. J Acquir Immune Defic Syndr 2015 united states
Optimizing the protection of research participants and personnel in HIV-related research where TB is prevalent: practical solutions for improving infection control. J Acquir Immune Defic Syndr 2014 united states
Massive benefits of antiretroviral therapy in Africa. J Infect Dis 2014 united states
Engaging, recruiting, and retaining black men who have sex with men in research studies: don't underestimate the importance of staffing--lessons learned from HPTN 061, the BROTHERS study. J Public Health Manag Pract 2014 united states
HPTN 071 (PopART): a cluster-randomized trial of the population impact of an HIV combination prevention intervention including universal testing and treatment: mathematical model. PLoS One 2014 united states
HIV diversity as a biomarker for HIV incidence estimation: including a high-resolution melting diversity assay in a multiassay algorithm. J Clin Microbiol 2014 united states
Exploring the relationship between incarceration and HIV among black men who have sex with men in the United States. J Acquir Immune Defic Syndr 2014 united states
Concomitant socioeconomic, behavioral, and biological factors associated with the disproportionate HIV infection burden among Black men who have sex with men in 6 U.S. cities. PLoS One 2014 united states
Types of female partners reported by black men who have sex with men and women (MSMW) and associations with intercourse frequency, unprotected sex and HIV and STI prevalence. AIDS Behav 2014 united states
Characteristics of multiple and concurrent partnerships among women at high risk for HIV infection. J Acquir Immune Defic Syndr 2014 united states
The high prevalence of incarceration history among Black men who have sex with men in the United States: associations and implications. Am J Public Health 2014 united states
HPTN 062: a feasibility and acceptability pilot intervention to reduce HIV transmission risk behaviors among individuals with acute and early HIV infection in Lilongwe, Malawi. AIDS Behav 2014 united states
Overcoming biological, behavioral, and structural vulnerabilities: new directions in research to decrease HIV transmission in men who have sex with men. J Acquir Immune Defic Syndr 2013 united states
Integrated strategies for combination HIV prevention: principles and examples for men who have sex with men in the Americas and heterosexual African populations. J Acquir Immune Defic Syndr 2013 united states
Preexposure prophylaxis for HIV prevention: where have we been and where are we going? J Acquir Immune Defic Syndr 2013 united states
Associations between drug use and sexual risks among heterosexual men in the Philippines. Int J STD AIDS 2013 england
Antiretroviral pharmacology in mucosal tissues. J Acquir Immune Defic Syndr 2013 united states
Performance of a limiting-antigen avidity enzyme immunoassay for cross-sectional estimation of HIV incidence in the United States. PLoS One 2013 united states
When to start ART in Africa. N Engl J Med 2013 united states
An expanded behavioral paradigm for prevention and treatment of HIV-1 infection. J Acquir Immune Defic Syndr 2013 united states
Ethics and pre-exposure prophylaxis for HIV infection. J Acquir Immune Defic Syndr 2013 united states
Not just the needle: the state of HIV-prevention science among substance users and future directions. J Acquir Immune Defic Syndr 2013 united states
HIV testing patterns among black men who have sex with men: a qualitative typology. PLoS One 2013 united states
HIV-1 transmission during early antiretroviral therapy: evaluation of two HIV-1 transmission events in the HPTN 052 prevention study. PLoS One 2013 united states
Safety and tolerability of tenofovir for preexposure prophylaxis among men who have sex with men. J Acquir Immune Defic Syndr 2013 united states
Antiretroviral therapy for prevention is a combination strategy. Curr HIV/AIDS Rep 2013 united states
Rapid HIV self-testing: long in coming but opportunities beckon. AIDS 2013 england
The HIV epidemic among women in the United States: a persistent puzzle. J Womens Health (Larchmt) 2013 united states
When to start ART in Africa--an urgent research priority. N Engl J Med 2013 united states
Can combination prevention strategies reduce HIV transmission in generalized epidemic settings in Africa? The HPTN 071 (PopART) study plan in South Africa and Zambia. J Acquir Immune Defic Syndr 2013 united states
Differences in substance use, psychosocial characteristics and HIV-related sexual risk behavior between Black men who have sex with men only (BMSMO) and Black men who have sex with men and women (BMSMW) in six US cities. J Urban Health 2013 united states
Antiretroviral therapy for prevention of HIV and tuberculosis: a promising intervention but not a panacea. J Acquir Immune Defic Syndr 2013 united states
Mobile VCT: reaching men and young people in urban and rural South African pilot studies (NIMH Project Accept, HPTN 043). AIDS Behav 2013 united states
Preventing HIV infection in women. J Acquir Immune Defic Syndr 2013 united states
Preventing HIV among young people: research priorities for the future. J Acquir Immune Defic Syndr 2013 united states
HIV acquisition among women from selected areas of the United States: a cohort study. Ann Intern Med 2013 united states
The detection and management of early HIV infection: a clinical and public health emergency. J Acquir Immune Defic Syndr 2013 united states
Short-term safety of buprenorphine/naloxone in HIV-seronegative opioid-dependent Chinese and Thai drug injectors enrolled in HIV Prevention Trials Network 058. Int J Drug Policy 2012 netherlands
Statistical considerations for the HPTN 052 Study to evaluate the effectiveness of early versus delayed antiretroviral strategies to prevent the sexual transmission of HIV-1 in serodiscordant couples. Contemp Clin Trials 2012 united states
HIV treatment as prevention and HPTN 052. Curr Opin HIV AIDS 2012 united states
Modeling interventions to assess HIV epidemic impact in Africa. J Acquir Immune Defic Syndr 2011 united states
Antiretroviral prophylaxis: a defining moment in HIV control. Lancet 2011 england
AIDS in America--forgotten but not gone. N Engl J Med 2010 united states
Preventing HIV infection in women: a global health imperative. Clin Infect Dis 2010 united states
HIV-prevention science at a crossroads: advances in reducing sexual risk. Curr Opin HIV AIDS 2009 united states
HIV infection and tuberculosis in South Africa: an urgent need to escalate the public health response. Lancet 2009 england
International perspectives on the collection, storage, and testing of human biospecimens in HIV research. IRB 2008 united states
Partnering for Care in HIV Prevention Trials. J Empir Res Hum Res Ethics 2008 united states