Modifiable risk and protective factors for suicidal behaviors in the us army

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Project Title: Modifiable risk and protective factors for suicidal behaviors in the us army
Project Number: 5U01MH087981-05
Project web address: Follow on NIH
Organization: Henry M. Jackson Fdn For The Adv Mil/Med, United States, Maryland, ROCKVILLE
Principal Investigators (PI): Ursano Robert J, US
Stein Murray B, US
 
Project Description:
This application is submitted in response to RFA-MH-09-140 by an interdisciplinary team from four institutions: the Uniformed Services University of the Health Sciences (USUHS), Harvard Medical School (HMS), the University of Michigan (UM), and Columbia University (CU), The team has unparalleled expertise in research on military mental health (USUHS), general population psychiatric epidemiology (HMS), large-scale epidemiological data collection (UM), and neurobiological-clinical research on suicidal behaviors (CU). We propose a multi-phase epidemiological study that considers diverse psychosocial and neurobiological risk and protective factors for suicidal behaviors and secondary outcomes in order to make evidence-based recommendations for implementation of Army suicide prevention interventions. An enriched version of the Army Suicide Event Report (ASER) system will be developed to define the primary outcomes incorporating information from the DoD Medical Mortality Registry (MMR) and Total Army Injury and Health Outcomes Database (TAIHOD). Our study design will include both a retrospective case-control component for quick efficient hypothesis testing and a prospective survey component to predict subsequent suicidal behaviors and secondary outcomes (onset, persistence, worsening of DSM-IV disorders, suicide ideation, suicide plans). We will also use data from the ongoing Pre- and Post-Deployment Health Reassessment Program (PDHRP) surveys as secondary outcomes. The case-control survey will study soldiers who made nonfatal attempts and relatives of soldiers who committed suicide in a psychological autopsy framework. Parallel data will be collected from carefully matched controls. Blood samples and, in the case of nonfatal attempters and their controls, saliva samples will be collected to allow neurobiological risk and protective factors to be studied. The survey component will include active duty personnel across all phases of Army service. Survey reports will be link to subsequent ASER records and PDHRP reports to study prospective associations of predictors with suicidal behaviors and secondary outcomes. A number of innovative measurement, design and analysis features will be used to increase chances of discovering effective intervention possibilities. RELEVANCE: The problem of Army suicide is one of great importance because an effective military force requires its members to be not only physically healthy but also mentally healthy. The relevance of a current study of Army suicide is heightened by the alarming rise in the suicide rate of US Army personnel over the past five years. The research proposed here has the potential to be of great value in helping the Army select optimally effective interventions to address this problem.
 
Project Terms:
accomplished suicide address administrative database adverse outcome aptitude tests army personnel autopsy base baseline surveys behavioral blood specimen candidate disease gene career case control case-control studies characteristics clinical clinical research cohort collaborations computers cost cost effectiveness data data collection data files databases decision making design development disease drinking drug usage dsm-iv effective intervention epidemiologic studies epidemiology evaluation event evidence based guidelines experience exposure to feeling suicidal follow-up future general population generations genetic genetic risk genome-wide health health sciences high risk hormones human resources individual injury innovation institution intervention intervention effect interview judgment learning life link marital violence measurement medical medical records medical schools member mental disorders mental health methods michigan military personnel modifiable risk mortality neglect neurobiology outcome performance pharmacy facility phase population attributable risks prevent preventive intervention primary outcome principal investigator probability probability samples procedures programs prospective prospective studies protocols documentation psychologic psychology psychosocial recording of previous events records recruitment activity reducing suicide registries relative (related person) reporting research research design research personnel research study resilience respondent response risk risk assessment risk estimate saliva sample size sampling secondary outcome series services simulation social soldier stress suicidal behavior suicidal risk suicide suicide attempt suicide prevention suicide rate surveys survival analysis system testing the sun time universities update work
Project Title: Modifiable risk and protective factors for suicidal behaviors in the us army
Project Number: 5U01MH087981-05
Project web address: Follow on NIH
Organization: Henry M. Jackson Fdn For The Adv Mil/Med, United States, Maryland, ROCKVILLE
Principal Investigators (PI): Ursano Robert J, US
Stein Murray B, US
 
Other Information:
Fiscal Year: 2009
Project Start Date: 16 July 2009
Project End Date: 30 June 2015
Project program: Research Project--Cooperative Agreements
 
Project Funding Information:
Funding Mechanism: Non-SBIR/STTR RPGs
Year Funding Organization Total Funding, $
2013 NIH - National Institute Of Mental Health $10,000,000
Project Title: Modifiable risk and protective factors for suicidal behaviors in the us army
Project Number: 5U01MH087981-05
Project web address: Follow on NIH
Organization: Henry M. Jackson Fdn For The Adv Mil/Med, United States, Maryland, ROCKVILLE
Principal Investigators (PI): Ursano Robert J, US
Stein Murray B, US
 
Title FY Funding
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Project Title: Modifiable risk and protective factors for suicidal behaviors in the us army
Project Number: 5U01MH087981-05
Project web address: Follow on NIH
Organization: Henry M. Jackson Fdn For The Adv Mil/Med, United States, Maryland, ROCKVILLE
Principal Investigators (PI): Ursano Robert J, US
Stein Murray B, US
 
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Project Title: Modifiable risk and protective factors for suicidal behaviors in the us army
Project Number: 5U01MH087981-05
Project web address: Follow on NIH
Organization: Henry M. Jackson Fdn For The Adv Mil/Med, United States, Maryland, ROCKVILLE
Principal Investigators (PI): Ursano Robert J, US
Stein Murray B, US
 
Title Journal Year Country Rel
Risk Factors, Methods, and Timing of Suicide Attempts Among US Army Soldiers. JAMA Psychiatry 2016 united states
Suicide Attempts in the US Army--Reply. JAMA Psychiatry 2016 united states
Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers. JAMA Psychiatry 2016 united states
A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke. Mol Psychiatry 2016 england
Barriers to Initiating and Continuing Mental Health Treatment Among Soldiers in the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). Mil Med 2016 united states
Predicting suicides after outpatient mental health visits in the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). Mol Psychiatry 2016 england
Predicting non-familial major physical violent crime perpetration in the US Army from administrative data. Psychol Med 2016 england
An Examination of Potential Misclassification of Army Suicides: Results from the Army Study to Assess Risk and Resilience in Servicemembers. Suicide Life Threat Behav 2016 england
Cross-Phenotype Polygenic Risk Score Analysis of Persistent Post-Concussive Symptoms in U.S. Army Soldiers with Deployment-Acquired Traumatic Brain Injury. J Neurotrauma 2016 united states
Predicting suicides after psychiatric hospitalization in US Army soldiers: the Army Study To Assess Risk and rEsilience in Servicemembers (Army STARRS). JAMA Psychiatry 2015 united states
Mental Disorders, Comorbidity, and Pre-enlistment Suicidal Behavior Among New Soldiers in the U.S. Army: Results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). Suicide Life Threat Behav 2015
Occupational differences in US Army suicide rates. Psychol Med 2015 england
Measurement of latent cognitive abilities involved in concept identification learning. J Clin Exp Neuropsychol 2015 england
Mental Health Treatment Among Soldiers With Current Mental Disorders in the Army Study to Assess Risk and Resilience in Service Members (Army STARRS). Mil Med 2015 united states
Nonfatal Suicidal Behaviors in U.S. Army Administrative Records, 2004-2009: Results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). Psychiatry 2015 united states
Suicide Attempts in the US Army During the Wars in Afghanistan and Iraq, 2004 to 2009. JAMA Psychiatry 2015 united states
Serotonin States and Social Anxiety. JAMA Psychiatry 2015 united states
Lifetime prevalence of DSM-IV mental disorders among new soldiers in the U.S. Army: results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). Depress Anxiety 2015 united states
Prevalence and correlates of suicidal behavior among new soldiers in the U.S. Army: results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). Depress Anxiety 2015 united states
APPROXIMATING A DSM-5 DIAGNOSIS OF PTSD USING DSM-IV CRITERIA. Depress Anxiety 2015 united states
Understanding the elevated suicide risk of female soldiers during deployments. Psychol Med 2015 england
Sociodemographic and career history predictors of suicide mortality in the United States Army 2004-2009. Psychol Med 2014 england
Thirty-day prevalence of DSM-IV mental disorders among nondeployed soldiers in the US Army: results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). JAMA Psychiatry 2014 united states
Risk factors for accident death in the U.S. Army, 2004-2009. Am J Prev Med 2014 netherlands
The Army study to assess risk and resilience in servicemembers (Army STARRS). Psychiatry 2014 united states
Classifying U.S. Army Military Occupational Specialties using the Occupational Information Network. Mil Med 2014 united states
Prevalence and correlates of suicidal behavior among soldiers: results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). JAMA Psychiatry 2014 united states
Predictors of suicide and accident death in the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS): results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). JAMA Psychiatry 2014 united states
Parallel psychometric and cognitive modeling analyses of the Penn Face Memory Test in the Army Study to Assess Risk and Resilience in Servicemembers. J Clin Exp Neuropsychol 2013 england
Field procedures in the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). Int J Methods Psychiatr Res 2013 united states
Design of the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). Int J Methods Psychiatr Res 2013 united states
Response bias, weighting adjustments, and design effects in the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). Int J Methods Psychiatr Res 2013 united states
Clinical reappraisal of the Composite International Diagnostic Interview Screening Scales (CIDI-SC) in the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). Int J Methods Psychiatr Res 2013 united states
Prevalence of DSM-IV major depression among U.S. military personnel: meta-analysis and simulation. Mil Med 2012 united states
Projected rates of psychological disorders and suicidality among soldiers based on simulations of matched general population data. Mil Med 2012 united states