The life study

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Project Title: The life study
Project Number: 5U01AG022376-08
Project web address: Follow on NIH
Organization: University Of Florida, United States, Florida, GAINESVILLE
Principal Investigators (PI): Pahor Marco, US
 
Project Description:
As life expectancy in the US continues to rise, the maintenance of independence among older Americans has emerged as a major clinical and public health priority. Efficient and reliable locomotion, or the ability to move without assistance, is a fundamental feature of human functioning. Older people who lose mobility are less likely to remain in the community, have higher rates of morbidity, mortality, and hospitalizations and experience a poorer quality of life. Several studies have shown that regular physical activity improves physical performance, but definitive evidence showing that mobility disability can be prevented is lacking. A Phase 3 randomized, controlled trial is needed to fill this evidence gap. This application is a competitive renewal for the Physical Exercise to Prevent Disability pilot study, lay title Lifestyle Interventions and Independence For Elders - LIFE pilot study. The Data Safety Monitoring Board unanimously determined that all pilot study benchmarks, including infrastructure, quality control, recruitment, adherence with the interventions, retention, safety, outcomes rates, outcomes definition refinement, and sample size estimates, were successfully achieved. We propose conducting a Phase 3, single-masked multicenter randomized controlled trial to compare a moderate-intensity physical activity program to a successful aging health education program in sedentary older persons who are at risk of disability. This trial will enable us to address the aims listed below. The primary aim is to assess the long-term effects of the proposed interventions on the primary outcome of major mobility disability, as operationalized by the inability to walk 400 m. Secondary aims focus on assessing the relative effects of the interventions on the following secondary outcomes: cognitive function; serious fall injuries; persistent mobility disability; the combined outcome of major mobility disability or death; disability in activities of daily living; and cost-effectiveness. Tertiary aims relate to assessing the relative effects of the interventions on (a) the combined outcome of mild cognitive impairment or dementia and (b) physical performance within pre-specified subgroups defined on the basis of ethnicity/race, gender and baseline physical performance; and (c) to explore time by intervention interactions on the SPPB score and 400 m walk speed endpoints. The proposed trial will provide definitive evidence regarding whether physical activity is effective and practical for preventing major mobility disability.
 
Project Terms:
activities of daily living address adherence aging american animals applications grants base benchmarking cessation of life characteristics clinical clinical practice clinical trials data monitoring committees clinically relevant cognitive function communities cost effective cost effectiveness data data collection dementia disability effectiveness elderly ethnic origin evidence based practice exercise experience failure falls functional outcomes gender geriatrics guidelines health health education health policy hospitalization human improved individual injury intervention intervention effect knowledge life expectancy lifestyle intervention locomotion long-term effects maintenance masks meetings mild cognitive impairment morbidity - disease rate mortality outcome outcome assessment participant performance persons phase physical activity pilot projects population heterogeneity population study prevent prevention primary outcome programs public health public health priorities public health relevance quality control quality of life race randomized controlled trials relative (related person) research infrastructure risk safety sample size secondary outcome sedentary societies specific qualifier value speed structure subgroup time united states walking
Project Title: The life study
Project Number: 5U01AG022376-08
Project web address: Follow on NIH
Organization: University Of Florida, United States, Florida, GAINESVILLE
Principal Investigators (PI): Pahor Marco, US
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2003
Project Start Date: 30 September 2003
Project End Date: 30 November 2015
Project program: Research Project--Cooperative Agreements
 
Project Funding Information:
Funding Mechanism: Non-SBIR/STTR RPGs
Year Funding Organization Total Funding, $
2013 NIH - National Institute On Aging $14,065,943
Project Title: The life study
Project Number: 5U01AG022376-08
Project web address: Follow on NIH
Organization: University Of Florida, United States, Florida, GAINESVILLE
Principal Investigators (PI): Pahor Marco, US
 
Title FY Funding
Uf ecg reading center 2013 $60751
Uf field center 2013 $1408241
Uf admin coordinating center 2013 $12596951
Project Title: The life study
Project Number: 5U01AG022376-08
Project web address: Follow on NIH
Organization: University Of Florida, United States, Florida, GAINESVILLE
Principal Investigators (PI): Pahor Marco, US
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: The life study
Project Number: 5U01AG022376-08
Project web address: Follow on NIH
Organization: University Of Florida, United States, Florida, GAINESVILLE
Principal Investigators (PI): Pahor Marco, US
 
Title Journal Year Country Rel
Analysis and Interpretation of Accelerometry Data in Older Adults: The LIFE Study. J Gerontol A Biol Sci Med Sci 2016 united states
Actigraphy features for predicting mobility disability in older adults. Physiol Meas 2016 england
Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial. J Am Geriatr Soc 2016 united states
Cost-effectiveness of the LIFE Physical Activity Intervention for Older Adults at Increased Risk for Mobility Disability. J Gerontol A Biol Sci Med Sci 2016 united states
Effect of structured physical activity on prevention of serious fall injuries in adults aged 70-89: randomized clinical trial (LIFE Study). BMJ 2016 england
Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study. J Am Med Dir Assoc 2016 united states
Socioeconomic differences in the benefits of structured physical activity compared with health education on the prevention of major mobility disability in older adults: the LIFE study. J Epidemiol Community Health 2016 england
Genetic Moderators of the Impact of Physical Activity on Depressive Symptoms. J Frailty Aging 2016 france
Hypertension and Its Role in Cognitive Function: Current Evidence and Challenges for the Future. Am J Hypertens 2016 united states
Effect of Structured Physical Activity on Respiratory Outcomes in Sedentary Elderly Adults with Mobility Limitations. J Am Geriatr Soc 2016 united states
Effect of a 24-Month Physical Activity Intervention vs Health Education on Cognitive Outcomes in Sedentary Older Adults: The LIFE Randomized Trial. JAMA 2015 united states
The MAT-sf: identifying risk for major mobility disability. J Gerontol A Biol Sci Med Sci 2015 united states
Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations - The LIFE Study. Exp Gerontol 2015 england
Effects of a One-Year Physical Activity Program on Serum C-Terminal Agrin Fragment (CAF) Concentrations among Mobility-Limited Older Adults. J Nutr Health Aging 2015 france
Prevalence of metabolic syndrome and its association with physical capacity, disability, and self-rated health in Lifestyle Interventions and Independence for Elders Study participants. J Am Geriatr Soc 2015 united states
Associations Between Ankle-Brachial Index and Cognitive Function: Results From the Lifestyle Interventions and Independence for Elders Trial. J Am Med Dir Assoc 2015 united states
A physical activity intervention to treat the frailty syndrome in older persons-results from the LIFE-P study. J Gerontol A Biol Sci Med Sci 2015 united states
Association of objectively measured physical activity with cardiovascular risk in mobility-limited older adults. J Am Heart Assoc 2015 england
Low-intensity walking activity is associated with better health. J Appl Gerontol 2014 united states
The effects of a long-term physical activity intervention on serum uric acid in older adults at risk for physical disability. J Aging Phys Act 2014 united states
Behavioral medicine in the 21st century: transforming the Road Less Traveled into the American Way of Life. Ann Behav Med 2014 united states
Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA 2014 united states
Respiratory impairment and dyspnea and their associations with physical inactivity and mobility in sedentary community-dwelling older persons. J Am Geriatr Soc 2014 united states
Sleep-wake disturbances in sedentary community-dwelling elderly adults with functional limitations. J Am Geriatr Soc 2014 united states
The LIFE Cognition Study: design and baseline characteristics. Clin Interv Aging 2014 new zealand
Physical activity and resting pulse rate in older adults: findings from a randomized controlled trial. Am Heart J 2014 united states
Genetic influence on exercise-induced changes in physical function among mobility-limited older adults. Physiol Genomics 2014 united states
Identification of misdiagnosed fronto-temporal dementia using APOE genotype and phenotype-genotype correlation analyses. Curr Alzheimer Res 2014 united arab emirates
The impact of sarcopenia on a physical activity intervention: the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P). J Nutr Health Aging 2014 france
Performance of a computer-based assessment of cognitive function measures in two cohorts of seniors. Int J Geriatr Psychiatry 2013 england
Using the NIH Toolbox in special populations: considerations for assessment of pediatric, geriatric, culturally diverse, non-English-speaking, and disabled individuals. Neurology 2013 united states
Lifestyle interventions and independence for elders study: recruitment and baseline characteristics. J Gerontol A Biol Sci Med Sci 2013 united states
NIH toolbox for assessment of neurological and behavioral function. Neurology 2013 united states
Emotion assessment using the NIH Toolbox. Neurology 2013 united states
Commentary: Luke and Cooper are wrong: physical activity has a crucial role in weight management and determinants of obesity. Int J Epidemiol 2013 england
Physical activity increases gains in and prevents loss of physical function: results from the lifestyle interventions and independence for elders pilot study. J Gerontol A Biol Sci Med Sci 2013 united states
Promoting physical activity for elders with compromised function: the lifestyle interventions and independence for elders (LIFE) study physical activity intervention. Clin Interv Aging 2013 new zealand
The MAT-sf: clinical relevance and validity. J Gerontol A Biol Sci Med Sci 2013 united states