Cardiovascular control in normal and disease states

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Project Title: Cardiovascular control in normal and disease states
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 5R37HL033107-18
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project Description:
The major goals of this research proposal are to describe and analyze cardiovascular control mechanisms with particular emphasis on the autonomic nervous system in normal healthy conscious animals, instrumented for direct and instantaneous measurements and radiotelemetry of coronary and regional blood flows and vascular resistances, ventricular function and myocardial contractility. Miniature pressure gauges will be implanted in the left and right ventricles and aorta, ultrasonic dimension transducers will be opposed on the endocardial surfaces of the left ventricle and Doppler ultrasonic or electromagnetic flow probes will be placed on the ascending aorta, coronary, mesenteric, renal and iliac arteries. In order to achieve these goals several specific interlocking groups of projects are planned. First of all, the afferent limb of the autonomic nervous system controlling the circulation will be examined, e.g., regulation by arterial baroreceptors, chemoreceptors, pulmonary inflation receptors, and low pressure vagal afferents. Secondly efferent autonomic control of ventricular performance, the coronary circulation, and the regional circulations will be studied. Thirdly, autonomic control during exercise will be examined. Thus, the aim of this research proposal is to gain a clearer understanding of the control of the cardiovascular system by the autonomic nervous system in the normal conscious animal.
 
Project Terms:
autonomic nervous system heart function hemodynamics cardiovascular disorder nitroglycerin anesthesia baroreceptors vasopressins pentobarbital angiotensin II myocardial ischemia /hypoxia hemorrhage vascular resistance exercise heart circulation heart dimension /size tachycardia myocardial infarction heart contraction kidney circulation cardiac glycosides cardiotonic agents vasoactive agent renin angiotensin system baboons splenectomy dogs telemetry muscle stimulant ultrasound blood flow measurement blood pressure methoxamine isoproterenol
Project Title: Cardiovascular control in normal and disease states
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 5R37HL033107-18
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology > Cardiovascular and cerebrovascular diseases > Cerebrovascular disease
 
Other Information:
Fiscal Year: 1984
Project Start Date: 1 January 1983
Project End Date: 30 June 2002
Administering Institute Or Center: HL
 
Project Funding Information:
Total Funding: $574,827
Total Cost: $574,827
Year Funding Organization Total Funding, $
2001 NATIONAL HEART, LUNG, AND BLOOD INSTITUTE $574,827
Project Title: Cardiovascular control in normal and disease states
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 5R37HL033107-18
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project_number Title Year FY Total Cost
There are no results for this project in database.
Project Title: Cardiovascular control in normal and disease states
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 5R37HL033107-18
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project number Project title Organization FY Funding Organization FY Total Cost
5R01HL102472-02Intrinsic Vascular Smooth Muscle Cell StiffnessUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2013NATIONAL HEART
$453,532
5R01HL093481-04Adenylyl cyclase isoforms in hypertrophy and heart failureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2012NATIONAL HEART
$469,235
5R01HL106511-02Skeletal Muscle Basis for Improved Exercise Endurance in AC5 KOUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2012NATIONAL HEART
$453,345
5T32HL069752-09Integrative mechanisms in Cardiovascular DiseaseUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2012NATIONAL HEART
$209,834
5R01HL033107-27Cardiovascular Control in Normal and Disease StatesUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2011NATIONAL HEART
$670,274
1R01HL106511-01A1Skeletal Muscle Basis for Improved Exercise Endurance in AC5 KOUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2011NATIONAL HEART
$468,800
5P01AG027211-05Longevity and Stress ResistanceUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2011NATIONAL INSTITUTE ON AGING
$2,037,769
5P20HL101420-02AC5 Inhibitor Treatment for Heart FailureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2011NATIONAL HEART
$779,111
5R01HL093481-03Adenylyl cyclase isoforms in hypertrophy and heart failureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2011NATIONAL HEART
$468,924
5T32HL069752-08Integrative mechanisms in Cardiovascular DiseaseUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2011NATIONAL HEART
$170,402
5P01HL069020-10-6Molecular Mechanisms in Chronically Stunned MyocardiumUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$342,976
5P01AG027211-04Longevity and Stress ResistanceUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL INSTITUTE ON AGING
$2,054,477
1R01HL102472-01Intrinsic Vascular Smooth Muscle Cell StiffnessUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$491,296
1P20HL101420-01AC5 Inhibitor Treatment for Heart FailureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$779,111
5T32HL069752-07Integrative mechanisms in Cardiovascular DiseaseUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$271,048
5R01HL093481-02Adenylyl cyclase isoforms in hypertrophy and heart failureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$473,661
5R01HL033107-26Cardiovascular Control in Normal and Disease StatesUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$737,225
5P01AG027211-03Longevity and Stress ResistanceUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2009NATIONAL INSTITUTE ON AGING
$2,182,671
5P01HL069020-09-6Molecular Mechanisms in Chronically Stunned MyocardiumUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2009NATIONAL HEART
$335,213
5R01HL033107-25Cardiovascular Control in Normal and Disease StatesUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2009NATIONAL HEART
$752,274
Project Title: Cardiovascular control in normal and disease states
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 5R37HL033107-18
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Cardiovascular control in normal and disease states
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 5R37HL033107-18
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Title Abstract Authors Year Rel
Regulation of coronary resistance vessels and large coronary arteries. The American journal of cardiology. 1985 Sep 18 56 (9) :16E-22E Vatner, S F 1985
Effects of altered site of electrical activation on myocardial performance during inotropic stimulation. Circulation. 1985 May 71 (5) :1010-6 Heyndrickx, G R;Vilaine, J P;Knight, D R;Vatner, S F 1985
beta-Adrenergic and cholinergic receptors in hypertension-induced hypertrophy. Hypertension. 1985 May-Jun 7 (3 Pt 2) :I55-60 Vatner, D E;Kirby, D A;Homcy, C J;Vatner, S F 1985
Autonomic mechanisms regulating myocardial contractility in conscious animals. Pharmacology &therapeutics. 1985 29 (2) :221-38 Fujii, A M;Vatner, S F 1985
Effects of a calcium channel blocker on cardiac output distribution in conscious hypertensive dogs. Hypertension. 1985 May-Jun 7 (3 Pt 1) :380-5 Knight, D R;Kirby, D A;Vatner, S F 1985
Mechanisms of supersensitivity to sympathomimetic amines in the chronically denervated heart of the conscious dog. Circulation research. 1985 Jul 57 (1) :55-64 Vatner, D E;Lavallee, M;Amano, J;Finizola, A;Homcy, C J;Vatner, S F 1985
Norepinephrine-induced beta 1-adrenergic peripheral vasodilation in conscious dogs. The American journal of physiology. 1985 Jul 249 (1 Pt 2) :H49-56 Vatner, S F;Knight, D R;Hintze, T H 1985
Direct versus indirect pressor and vasoconstrictor actions of angiotensin in conscious dogs. Hypertension. 1985 Mar-Apr 7 (2) :253-61 Fujii, A M;Vatner, S F 1985
Effects of volume expansion on renal nerve activity, renal blood flow, and sodium and water excretion in conscious dogs. The American journal of physiology. 1985 Nov 249 (5 Pt 2) :F680-7 Morita, H;Vatner, S F 1985
Effects of hemorrhage on renal nerve activity in conscious dogs. Circulation research. 1985 Nov 57 (5) :788-93 Morita, H;Vatner, S F 1985
Vagal regulation of arginine vasopressin in conscious dogs. The American journal of physiology. 1986 Jul 251 (1 Pt 2) :H19-23 Morita, H;Manders, W T;Skelton, M M;Cowley Jr, A W;Vatner, S F 1986
Vagally mediated regulation of renal function in conscious primates. The American journal of physiology. 1986 Apr 250 (4 Pt 2) :H546-9 Vatner, S F;Manders, W T;Knight, D R 1986
Subtypes of beta-adrenergic receptors in bovine coronary arteries. Circulation research. 1986 Oct 59 (4) :463-73 Vatner, D E;Knight, D R;Homcy, C J;Vatner, S F;Young, M A 1986
Nifedipine attenuates both alpha-1 and alpha-2 adrenoceptor-mediated pressor and vasoconstrictor responses in conscious dogs and primates. The Journal of pharmacology and experimental therapeutics. 1986 Dec 239 (3) :648-53 Woodman, O L;Constantine, J W;Vatner, S F 1986
Enhanced adrenergic constriction of iliac artery with removal of endothelium in conscious dogs. The American journal of physiology. 1986 May 250 (5 Pt 2) :H892-7 Young, M A;Vatner, S F 1986
Cardiovascular responses to the stimulation of alpha-1 and alpha-2 adrenoceptors in the conscious dog. The Journal of pharmacology and experimental therapeutics. 1986 Apr 237 (1) :86-91 Woodman, O L;Vatner, S F 1986
Regulation of large coronary arteries. Circulation research. 1986 Dec 59 (6) :579-96 Young, M A;Vatner, S F 1986
Augmented catecholamine uptake by the heart during hemorrhage in the conscious dog. The American journal of physiology. 1986 Jan 250 (1 Pt 2) :H76-81 Woodman, O L;Amano, J;Hintze, T H;Vatner, S F 1986
Autonomic control of large coronary arteries and resistance vessels. Progress in cardiovascular diseases. 1987 Nov-Dec 30 (3) :211-34 Young, M A;Knight, D R;Vatner, S F 1987
Calcium channel blockers induce preferential coronary vasodilation by an alpha 1-mechanism. The American journal of physiology. 1987 Sep 253 (3 Pt 2) :H604-13 Knight, D R;Vatner, S F 1987
Blood flow- and endothelium-mediated vasomotion of iliac arteries in conscious dogs. Circulation research. 1987 Nov 61 (5 Pt 2) :II88-93 Young, M A;Vatner, S F 1987
Coronary vasoconstriction mediated by alpha 1- and alpha 2-adrenoceptors in conscious dogs. The American journal of physiology. 1987 Aug 253 (2 Pt 2) :H388-93 Woodman, O L;Vatner, S F 1987
Enhanced responsiveness to carotid baroreceptor unloading in conscious dogs during development of perinephritic hypertension. Circulation research. 1987 Nov 61 (5) :678-86 Kirby, D A;Vatner, S F 1987
Baroreflex mechanisms buffering alpha-adrenergic agonists in conscious dogs. The American journal of physiology. 1987 Oct 253 (4 Pt 2) :H728-36 Fujii, A M;Vatner, S F 1987
Effects of left circumflex coronary flow transducer implantation on posterior wall innervation. The American journal of physiology. 1987 Mar 252 (3 Pt 2) :H536-9 Knight, D R;Thomas Jr, J X;Randall, W C;Vatner, S F 1987
Alpha-adrenergic vasoconstriction and receptor subtypes in large coronary arteries of calves. The American journal of physiology. 1988 Dec 255 (6 Pt 2) :H1452-9 Young, M A;Vatner, D E;Knight, D R;Graham, R M;Homcy, C J;Vatner, S F 1988
Parasympathetic coronary vasoconstriction induced by nicotine in conscious calves. Circulation research. 1988 May 62 (5) :891-5 Young, M A;Knight, D R;Vatner, S F 1988
Sympathetic activation induces asynchronous contraction in awake dogs with regional denervation. The American journal of physiology. 1988 Aug 255 (2 Pt 2) :H358-65 Knight, D R;Shen, Y T;Thomas Jr, J X;Randall, W C;Vatner, S F 1988
Reduced subendocardial myocardial perfusion as one mechanism for congestive heart failure. The American journal of cardiology. 1988 Sep 9 62 (8) :94E-98E Vatner, S F 1988
Opiate receptor-mediated decrease in renal nerve activity during hypotensive hemorrhage in conscious rabbits. Circulation research. 1988 Jul 63 (1) :165-72 Morita, H;Nishida, Y;Motochigawa, H;Uemura, N;Hosomi, H;Vatner, S F 1988
Natriuretic and diuretic effects of infusion of atrial natriuretic factor in conscious dogs. The American journal of physiology. 1989 Oct 257 (4 Pt 2) :F565-73 Ohanian, J;Young, M A;Shen, Y T;Gaivin, R;Vatner, S F;Graham, R M 1989
Subendomyocardial exhaustion of blood flow reserve and increased fibrosis in conscious dogs with heart failure. Circulation research. 1989 Oct 65 (4) :971-80 Hittinger, L;Shannon, R P;Bishop, S P;Gelpi, R J;Vatner, S F 1989
Species differences in regulation of alpha-adrenergic receptor function. The American journal of physiology. 1989 Nov 257 (5 Pt 2) :R1110-6 Shen, Y T;Vatner, D E;Gagnon, H E;Vatner, S F 1989
Selective alpha 1-adrenergic blockade, lipids, and coronary heart disease risk. Considerations in the treatment of mild hypertension. The American journal of medicine. 1989 Aug 16 87 (2A) :53S-56S Graham, R M 1989
A novel guanine nucleotide-binding protein coupled to the alpha 1-adrenergic receptor. II. Purification, characterization, and reconstitution. The Journal of biological chemistry. 1990 Nov 5 265 (31) :18952-60 Im, M J;Riek, R P;Graham, R M 1990
Identification and structural characterization of alpha 1-adrenergic receptor subtypes. Molecular pharmacology. 1990 Apr 37 (4) :526-34 Terman, B I;Riek, R P;Grodski, A;Hess, H J;Graham, R M 1990
A novel guanine nucleotide-binding protein coupled to the alpha 1-adrenergic receptor. I. Identification by photolabeling or membrane and ternary complex preparation. The Journal of biological chemistry. 1990 Nov 5 265 (31) :18944-51 Im, M J;Graham, R M 1990
Role of intact cardiac nerves and reflex mechanisms in desensitization to catecholamines in conscious dogs. The Journal of clinical investigation. 1990 Dec 86 (6) :2046-53 Nejima, J;Uemura, N;Vatner, D E;Homcy, C J;Hintze, T H;Vatner, S F 1990
Alpha- and beta-adrenergic control of large coronary arteries in conscious calves. Basic research in cardiology. 1990 85 Suppl 1 () :97-109 Young, M A;Vatner, D E;Vatner, S F 1990
Relative roles of cardiac receptors and arterial baroreceptors during hemorrhage in conscious dogs. Circulation research. 1990 Feb 66 (2) :397-405 Shen, Y T;Knight, D R;Thomas Jr, J X;Vatner, S F 1990
Endothelium and blood flow mediated vasomotion in the conscious dog. Basic research in cardiology. 1991 86 Suppl 2 () :59-68 Bigaud, M;Vatner, S F 1991
Changes in diastolic cardiac function in developing and stable perinephritic hypertension in conscious dogs. Circulation research. 1991 Feb 68 (2) :555-67 Gelpi, R J;Pasipoularides, A;Lader, A S;Patrick, T A;Chase, N;Hittinger, L;Shannon, R P;Bishop, S P;Vatner, S F 1991
Relative roles of cardiac and arterial baroreceptors in vasopressin regulation during hemorrhage in conscious dogs. Circulation research. 1991 May 68 (5) :1422-36 Shen, Y T;Cowley Jr, A W;Vatner, S F 1991
Acetylcholine-induced coronary vasoconstriction and vasodilation in tranquilized baboons. Circulation research. 1991 Sep 69 (3) :706-13 Knight, D R;Shen, Y T;Young, M A;Vatner, S F 1991
Alterations in myocardial contractility in conscious dogs with dilated cardiomyopathy. The American journal of physiology. 1991 Jun 260 (6 Pt 2) :H1903-11 Shannon, R P;Komamura, K;Stambler, B S;Bigaud, M;Manders, W T;Vatner, S F 1991
Inotropic response to norepinephrine is augmented early and maintained late in conscious dogs with perinephritic hypertension. Circulation research. 1991 Feb 68 (2) :543-54 Shannon, R P;Gelpi, R J;Hittinger, L;Vatner, D E;Homcy, C J;Graham, R M;Vatner, S F 1991
Effects of atrial natriuretic factor on blood flow distribution and vascular resistance in conscious dogs. The American journal of physiology. 1991 Jun 260 (6 Pt 2) :H1893-902 Shen, Y T;Graham, R M;Vatner, S F 1991
Mechanisms of alpha 1-adrenergic vascular desensitization in conscious dogs. Circulation research. 1992 Nov 71 (5) :1185-99 Kiuchi, K;Vatner, D E;Uemura, N;Bigaud, M;Hasebe, N;Hempel, D M;Graham, R M;Vatner, S F 1992
Alterations in left ventricular diastolic function in conscious dogs with pacing-induced heart failure. The Journal of clinical investigation. 1992 Jun 89 (6) :1825-38 Komamura, K;Shannon, R P;Pasipoularides, A;Ihara, T;Lader, A S;Patrick, T A;Bishop, S P;Vatner, S F 1992
Coronary vascular mechanisms involved in decompensation from hypertrophy to heart failure. Journal of the American College of Cardiology. 1993 Oct 22 (4 Suppl A) :34A-40A Vatner, S F;Hittinger, L 1993
Exhaustion of Frank-Starling mechanism in conscious dogs with heart failure. The American journal of physiology. 1993 Oct 265 (4 Pt 2) :H1119-31 Komamura, K;Shannon, R P;Ihara, T;Shen, Y T;Mirsky, I;Bishop, S P;Vatner, S F 1993
Myocardial beta-adrenergic receptor function during the development of pacing-induced heart failure. The Journal of clinical investigation. 1993 Mar 91 (3) :907-14 Kiuchi, K;Shannon, R P;Komamura, K;Cohen, D J;Bianchi, C;Homcy, C J;Vatner, S F;Vatner, D E 1993
Myocardial perfusion dependent and independent mechanisms of regional myocardial dysfunction in hypertrophy. Basic research in cardiology. 1993 88 Suppl 1 () :81-95 Vatner, S F;Hittinger, L 1993
Effects of a K+ATP channel opener, lemakalim, on systemic, coronary and regional vascular dynamics in conscious dogs: comparison with nifedipine, adenosine, nitroglycerin and acetylcholine. The Journal of pharmacology and experimental therapeutics. 1993 May 265 (2) :1026-37 Shen, Y T;Vatner, S F 1993
Depressed beta-adrenergic receptor- and endothelium-mediated vasodilation in conscious dogs with heart failure. Circulation research. 1993 Dec 73 (6) :1013-23 Kiuchi, K;Sato, N;Shannon, R P;Vatner, D E;Morgan, K;Vatner, S F 1993
Impaired regional subendocardial coronary flow reserve in conscious dogs with pacing-induced heart failure. The American journal of physiology. 1993 Sep 265 (3 Pt 2) :H801-9 Shannon, R P;Komamura, K;Shen, Y T;Bishop, S P;Vatner, S F 1993
Increased alpha 1-adrenergic vascular sensitivity during development of hypertension in conscious dogs. The American journal of physiology. 1993 Apr 264 (4 Pt 2) :H1259-68 Uemura, N;Vatner, D E;Shen, Y T;Wang, J;Vatner, S F 1993
Factors involved in delaying the rise in peripheral resistance in developing heart failure. The American journal of physiology. 1994 Jul 267 (1 Pt 2) :H211-6 Kiuchi, K;Shannon, R P;Sato, N;Bigaud, M;Lajoie, C;Morgan, K G;Vatner, S F 1994
Peripheral vascular effects of beta-3 adrenergic receptor stimulation in conscious dogs. The Journal of pharmacology and experimental therapeutics. 1994 Jan 268 (1) :466-73 Shen, Y T;Zhang, H;Vatner, S F 1994
Effects of anaesthesia and recent surgery on diastolic function. Cardiovascular research. 1994 Mar 28 (3) :325-36 Ihara, T;Shannon, R P;Komamura, K;Pasipoularides, A;Patrick, T;Shen, Y T;Vatner, S F 1994
Exercise induces cardiac dysfunction in both moderate, compensated and severe hypertrophy. Circulation. 1994 May 89 (5) :2219-31 Hittinger, L;Patrick, T;Ihara, T;Hasebe, N;Shen, Y T;Kalthof, B;Shannon, R P;Vatner, S F 1994
Left ventricular systolic dysfunction precedes diastolic dysfunction during myocardial ischemia in conscious dogs. The American journal of physiology. 1994 Jul 267 (1 Pt 2) :H333-43 Ihara, T;Komamura, K;Shen, Y T;Patrick, T A;Mirsky, I;Shannon, R P;Vatner, S F 1994
Effects of hypertrophy on left atrial and ventricular compliance and plasma ANF levels in conscious dogs. The American journal of physiology.. 1995 Feb 268 (2 Pt 2) :H781-7 Hasebe, N;Hittinger, L;Kohin, S;Shen, Y T;Graham, R M;Vatner, S F 1995
Intravenous cocaine induces platelet activation in the conscious dog. Circulation.. 1995 Mar 1 91 (5) :1336-40 Kugelmass, A D;Shannon, R P;Yeo, E L;Ware, J A 1995
Mechanism of impaired myocardial function during progressive coronary stenosis in conscious pigs. Hibernation versus stunning? Circulation research.. 1995 Mar 76 (3) :479-88 Shen, Y T;Vatner, S F 1995
Ubiquity of myocardial stunning. Basic research in cardiology.. 1995 Jul-Aug 90 (4) :253-6 Vatner, S F;Heyndrickx, G R 1995
Role of blood doping in the coronary vasoconstrictor response to cocaine. Circulation.. 1995 Jul 1 92 (1) :96-105 Shannon, R P;Manders, W T;Shen, Y T 1995
Hemodynamic mechanisms responsible for reduced subendocardial coronary reserve in dogs with severe left ventricular hypertrophy. Circulation.. 1995 Aug 15 92 (4) :978-86 Hittinger, L;Mirsky, I;Shen, Y T;Patrick, T A;Bishop, S P;Vatner, S F 1995
Effects of ryanodine on cardiac contraction, excitation-contraction coupling and Treppe in the conscious dog. Journal of molecular and cellular cardiology.. 1995 Oct 27 (10) :2111-21 Kalthof, B;Sato, N;Iwase, M;Shen, Y T;Mirsky, I;Patrick, T A;Vatner, S F 1995
Splenic contraction-induced increases in arterial O2 reduce requirement for CBF in conscious dogs. The American journal of physiology.. 1995 Aug 269 (2 Pt 2) :H491-503 Sato, N;Shen, Y T;Kiuchi, K;Shannon, R P;Vatner, S F 1995
Adrenergic responsiveness is reduced, while baseline cardiac function is preserved in old adult conscious monkeys. The American journal of physiology.. 1995 Nov 269 (5 Pt 2) :H1664-71 Sato, N;Kiuchi, K;Shen, Y T;Vatner, S F;Vatner, D E 1995
Inotropic reserve and histological appearance of hibernating myocardium in conscious pigs with ameroid-induced coronary stenosis. Basic research in cardiology.. 1996 Nov-Dec 91 (6) :479-85 Shen, Y T;Kudej, R K;Bishop, S P;Vatner, S F 1996
Spatial heterogeneity of myocardial blood flow presages salvage versus necrosis with coronary artery reperfusion in conscious baboons. Circulation.. 1996 Nov 1 94 (9) :2210-5 Ghaleh, B;Shen, Y T;Vatner, S F 1996
Innate protection of baboon myocardium: effects of coronary artery occlusion and reperfusion. The American journal of physiology.. 1996 May 270 (5 Pt 2) :H1812-8 Shen, Y T;Fallon, J T;Iwase, M;Vatner, S F 1996
Adverse effects of chronic endogenous sympathetic drive induced by cardiac GS alpha overexpression. Circulation research.. 1996 Apr 78 (4) :517-24 Iwase, M;Bishop, S P;Uechi, M;Vatner, D E;Shannon, R P;Kudej, R K;Wight, D C;Wagner, T E;Ishikawa, Y;Homcy, C J;Vatner, S F 1996
Differences in beta 3-adrenergic receptor cardiovascular regulation in conscious primates, rats and dogs. The Journal of pharmacology and experimental therapeutics.. 1996 Sep 278 (3) :1435-43 Shen, Y T;Cervoni, P;Claus, T;Vatner, S F 1996
Neurally mediated cardiac effects of forskolin in conscious dogs. The American journal of physiology.. 1996 Oct 271 (4 Pt 2) :H1473-82 Iwase, M;Ishikawa, Y;Shen, Y T;Shannon, R P;Sato, N;Ganguly, P K;Eki, T;Vatner, D F;Vatner, S F 1996
Identification and functional role of beta-adrenergic receptor subtypes in primate and rodent: in vivo versus isolated myocytes. Journal of molecular and cellular cardiology.. 1996 Jun 28 (6) :1307-17 Cui, Y;Shen, Y T;Kalthof, B;Iwase, M;Sato, N;Uechi, M;Vatner, S F;Vatner, D E 1996
Cardiomyopathy induced by cardiac Gs alpha overexpression. The American journal of physiology.. 1997 Jan 272 (1 Pt 2) :H585-9 Iwase, M; Uechi, M; Vatner, D E; Asai, K; Shannon, R P; Kudej, R K; Wagner, T E; Wight, D C; Patrick, T A; Ishikawa, Y; Homcy, C J; Vatner, S F 1997
Effects of cardiac denervation on development of heart failure and catecholamine desensitization. Circulation.. 1997 Apr 15 95 (8) :2130-40 Sato, N; Vatner, S F; Shen, Y T; Kudej, R K; Ghaleh-Marzban, B; Uechi, M; Asai, K; Mirsky, I; Patrick, T A; Shannon, R P; Vatner, D E 1997
Downregulation of caveolin by chronic beta-adrenergic receptor stimulation in mice. The American journal of physiology.. 1997 Dec 273 (6 Pt 1) :C1957-62 Oka, N; Asai, K; Kudej, R K; Edwards, J G; Toya, Y; Schwencke, C; Vatner, D E; Vatner, S F; Ishikawa, Y 1997
Localisation of cardiac GS alpha in transgenic mice overexpressing GS alpha. Journal of molecular and cellular cardiology.. 1997 Jun 29 (6) :1649-53 Muntz, K H; Ishikawa, Y; Wagner, T; Homcy, C J; Vatner, S F; Vatner, D E 1997
Effects of a novel inotropic agent, BAY y 5959, in conscious dogs: comparison with dobutamine and milrinone. The American journal of physiology.. 1997 Feb 272 (2 Pt 2) :H753-9 Sato, N; Uechi, M; Asai, K; Patrick, T; Kudej, R K; Vatner, S F 1997
Effects of chronic beta-adrenergic receptor stimulation in mice. Journal of molecular and cellular cardiology.. 1997 Oct 29 (10) :2735-46 Kudej, R K; Iwase, M; Uechi, M; Vatner, D E; Oka, N; Ishikawa, Y; Shannon, R P; Bishop, S P; Vatner, S F 1997
Effects of renin inhibition compared to angiotensin converting enzyme inhibition in conscious dogs with pacing-induced heart failure. Cardiovascular research.. 1997 Jun 34 (3) :464-72 Shannon, R P; Friedrich, S; Mathier, M; Knight, D R 1997
Delayed enhanced nitric oxide-mediated coronary vasodilation following brief ischemia and prolonged reperfusion in conscious dogs. Circulation research.. 1997 Jul 81 (1) :53-9 Kim, S J; Ghaleh, B; Kudej, R K; Huang, C H; Hintze, T H; Vatner, S F 1997
Voltage-dependent calcium channel promoter restores baroreflex sensitivity in conscious dogs with heart failure. Circulation.. 1998 Sep 29 98 (13) :1342-7 Uechi, M;Asai, K;Sato, N;Vatner, S F 1998
Depressed heart rate variability and arterial baroreflex in conscious transgenic mice with overexpression of cardiac Gsalpha. Circulation research.. 1998 Mar 9 82 (4) :416-23 Uechi, M;Asai, K;Osaka, M;Smith, A;Sato, N;Wagner, T E;Ishikawa, Y;Hayakawa, H;Vatner, D E;Shannon, R P;Homcy, C J;Vatner, S F 1998
Lack of desensitization and enhanced efficiency of calcium channel promoter in conscious dogs with heart failure. The American journal of physiology.. 1998 Dec 275 (6 Pt 2) :H2219-26 Asai, K;Uechi, M;Sato, N;Shen, W;Meguro, T;Mathier, M A;Shannon, R P;Vatner, S F 1998
Selective large coronary endothelial dysfunction in conscious dogs with chronic coronary pressure overload. The American journal of physiology.. 1998 Feb 274 (2 Pt 2) :H539-51 Ghaleh, B;Hittinger, L;Kim, S J;Kudej, R K;Iwase, M;Uechi, M;Berdeaux, A;Bishop, S P;Vatner, S F 1998
Overexpression of myocardial Gsalpha prevents full expression of catecholamine desensitization despite increased beta-adrenergic receptor kinase. The Journal of clinical investigation. 1998 May 1 101 (9) :1916-22 Vatner, D E;Asai, K;Iwase, M;Ishikawa, Y;Wagner, T E;Shannon, R P;Homcy, C J;Vatner, S F 1998
Ineffective perfusion-contraction matching in conscious, chronically instrumented pigs with an extended period of coronary stenosis. Circulation research.. 1998 Jun 15 82 (11) :1199-205 Kudej, R K;Ghaleh, B;Sato, N;Shen, Y T;Bishop, S P;Vatner, S F 1998
Cyclosporine attenuates pressure-overload hypertrophy in mice while enhancing susceptibility to decompensation and heart failure. Circulation research.. 1999 Apr 2 84 (6) :735-40 Meguro, T;Hong, C;Asai, K;Takagi, G;McKinsey, T A;Olson, E N;Vatner, S F 1999
An alpha-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes. The American journal of physiology.. 1999 May 276 (5 Pt 2) :H1780-7 Kim, S J;Iizuka, K;Kelly, R A;Geng, Y J;Bishop, S P;Yang, G;Kudej, A;McConnell, B K;Seidman, C E;Seidman, J G;Vatner, S F 1999
Progressive loss of myocardial ATP due to a loss of total purines during the development of heart failure in dogs: a compensatory role for the parallel loss of creatine. Circulation.. 1999 Nov 16 100 (20) :2113-8 Shen, W;Asai, K;Uechi, M;Mathier, M A;Shannon, R P;Vatner, S F;Ingwall, J S 1999
Mechanisms of desensitization to a PDE inhibitor (milrinone) in conscious dogs with heart failure. The American journal of physiology.. 1999 May 276 (5 Pt 2) :H1699-705 Sato, N;Asai, K;Okumura, S;Takagi, G;Shannon, R P;Fujita-Yamaguchi, Y;Ishikawa, Y;Vatner, S F;Vatner, D E 1999
An adenosine agonist and preconditioning shift the distribution of myocardial blood flow in conscious pigs. The American journal of physiology.. 1999 Feb 276 (2 Pt 2) :H368-75 Huang, C H;Kim, S J;Ghaleh, B;Kudej, R K;Shen, Y T;Bishop, S P;Vatner, S F 1999
Reduced subendocardial ryanodine receptors and consequent effects on cardiac function in conscious dogs with left ventricular hypertrophy. Circulation research.. 1999 May 14 84 (9) :999-1006 Hittinger, L;Ghaleh, B;Chen, J;Edwards, J G;Kudej, R K;Iwase, M;Kim, S J;Vatner, S F;Vatner, D E 1999
Apoptosis of cardiac myocytes in Gsalpha transgenic mice. Circulation research.. 1999 Jan 8-22 84 (1) :34-42 Geng, Y J;Ishikawa, Y;Vatner, D E;Wagner, T E;Bishop, S P;Vatner, S F;Homcy, C J 1999
Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5. Heart failure reviews. 2010 Sep 15 (5) :495-512 Ho, David;Yan, Lin;Iwatsubo, Kousaku;Vatner, Dorothy E;Vatner, Stephen F 2010
Novel mechanisms for caspase inhibition protecting cardiac function with chronic pressure overload. Basic research in cardiology. 2013 Jan 108 (1) :324 Park, Misun;Vatner, Stephen F;Yan, Lin;Gao, Shumin;Yoon, Seunghun;Lee, Grace Jung Ah;Xie, Lai-Hua;Kitsis, Richard N;Vatner, Dorothy E 2013
Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway. Circulation. 2013 Apr 23 127 (16) :1692-701 Lai, Lo;Yan, Lin;Gao, Shumin;Hu, Che-Lin;Ge, Hui;Davidow, Amy;Park, Misun;Bravo, Claudio;Iwatsubo, Kousaku;Ishikawa, Yoshihiro;Auwerx, Johan;Sinclair, David A;Vatner, Stephen F;Vatner, Dorothy E 2013
Metabolomic analysis of two different models of delayed preconditioning. Journal of molecular and cellular cardiology. 2013 Feb 55 () :19-26 Bravo, Claudio;Kudej, Raymond K;Yuan, Chujun;Yoon, Seonghun;Ge, Hui;Park, Ji Yeon;Tian, Bin;Stanley, William C;Vatner, Stephen F;Vatner, Dorothy E;Yan, Lin 2013
Adenylyl cyclase type 5 in cardiac disease, metabolism, and aging. American journal of physiology. Heart and circulatory physiology. 2013 Jul 1 305 (1) :H1-8 Vatner, Stephen F;Park, Misun;Yan, Lin;Lee, Grace J;Lai, Lo;Iwatsubo, Kousaku;Ishikawa, Yoshihiro;Pessin, Jeffrey;Vatner, Dorothy E 2013
Myocardial ischemic protection in natural mammalian hibernation. Basic research in cardiology. 2015 Mar 110 (2) :9 Yan, Lin; Kudej, Raymond K; Vatner, Dorothy E; Vatner, Stephen F 2015