Myocardial hypertrophy and heart failure

  • Description
  • Details
  • Subprojects
  • History
  • Relations
  • Publications
Project Title: Myocardial hypertrophy and heart failure
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 5P01HL059139-07
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project Description:
Despite recent advances in the treatment of human heart failure, the overall impact on morbidity and mortality has been limited, and heart failure remains the pre-eminent cardiovascular health problem in the country. Limitations in our understanding can be attributed, in part, to the inability to examine basic mechanisms in appropriate animal models in which the progressive pathogenesis of hypertrophy and heart failure can be studied. Thus, the overall aim of this Program Project is to identify physiological, biochemical and molecular mechanisms which are fundamental to the progression from imposition of the abnormal load to development of compensated hypertrophy to heart failure. A secondary goal is to understand the mechanism of potential therapeutic agents within the context of the pathogenesis of hypertrophy and heart failure, focusing on beta-adreriergic blockade therapy. The latter is central to one of the major themes of this Program Project, i.e., alterations in beta-adrenergic and G-protein signaling in hypertrophy and heart failure. To achieve these goals, we will focus primarily on the study of transgenic mice and a novel canine model of heart failure superimposed on chronic, severe cardiac hypertrophy. The organization of the Program Project includes 4 projects and 3 cores. The first Project will examine genomic and proteomic mechanisms of hypertrophy and heart failure utilizing the novel canine model of severe, chronic cardiac hypertrophy with heart failure superimposed. The next Project will emphasizes altered beta-adrenergic receptor signaling and signaling mechanisms involving stress-activated protein kinases in hypertrophy and heart failure. The overall goals of this projectare to elucidate cellular and molecular mechanisms, which may explain the adverse action of enhanced beta-adrenergic receptor signaling in heart failure and conversely, the salutary action of beta-adrenergic receptor blockade therapy. The next Project is designed to provide novel information on molecular mechanisms of adenylyl Cyclase regulation, also, using transgenic models. The final Project will focuses on molecular mechanisms involving Gprotein coupled receptor signaling, e.g., beta-adrenergic and angiotensin receptors in the development of hypertrophy and heart failure. This Program Project will provide significant new information on molecular mechanisms involved in mediating hypertrophy and heart failure, which will also have relevance for understanding corresponding mechanisms in myocardial ischemic disease as well.
 
Project Terms:
heart function heart failure ventricular hypertrophy pathologic process
Project Title: Myocardial hypertrophy and heart failure
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 5P01HL059139-07
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology, Aging mechanisms by anatomy > Cardiovascular and cerebrovascular diseases, Tissue level > Heart failure, Differentiated tissues > Muscle tissue
 
Other Information:
Fiscal Year: 1997
Project Start Date: 15 September 1997
Project End Date: 29 February 2008
Administering Institute Or Center: HL
 
Project Funding Information:
Total Funding: $1,597,506
Total Cost: $1,597,506
Year Funding Organization Total Funding, $
2004 NATIONAL HEART, LUNG, AND BLOOD INSTITUTE $1,597,506
Project Title: Myocardial hypertrophy and heart failure
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 5P01HL059139-07
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project_number Title Year FY Total Cost
There are no results for this project in database.
Project Title: Myocardial hypertrophy and heart failure
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 5P01HL059139-07
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project number Project title Organization FY Funding Organization FY Total Cost
5R01HL102472-02Intrinsic Vascular Smooth Muscle Cell StiffnessUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2013NATIONAL HEART
$453,532
5R01HL093481-04Adenylyl cyclase isoforms in hypertrophy and heart failureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2012NATIONAL HEART
$469,235
5R01HL106511-02Skeletal Muscle Basis for Improved Exercise Endurance in AC5 KOUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2012NATIONAL HEART
$453,345
5T32HL069752-09Integrative mechanisms in Cardiovascular DiseaseUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2012NATIONAL HEART
$209,834
5R01HL033107-27Cardiovascular Control in Normal and Disease StatesUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2011NATIONAL HEART
$670,274
1R01HL106511-01A1Skeletal Muscle Basis for Improved Exercise Endurance in AC5 KOUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2011NATIONAL HEART
$468,800
5P01AG027211-05Longevity and Stress ResistanceUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2011NATIONAL INSTITUTE ON AGING
$2,037,769
5P20HL101420-02AC5 Inhibitor Treatment for Heart FailureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2011NATIONAL HEART
$779,111
5R01HL093481-03Adenylyl cyclase isoforms in hypertrophy and heart failureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2011NATIONAL HEART
$468,924
5T32HL069752-08Integrative mechanisms in Cardiovascular DiseaseUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2011NATIONAL HEART
$170,402
5P01HL069020-10-6Molecular Mechanisms in Chronically Stunned MyocardiumUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$342,976
5P01AG027211-04Longevity and Stress ResistanceUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL INSTITUTE ON AGING
$2,054,477
1R01HL102472-01Intrinsic Vascular Smooth Muscle Cell StiffnessUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$491,296
1P20HL101420-01AC5 Inhibitor Treatment for Heart FailureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$779,111
5T32HL069752-07Integrative mechanisms in Cardiovascular DiseaseUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$271,048
5R01HL093481-02Adenylyl cyclase isoforms in hypertrophy and heart failureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$473,661
5R01HL033107-26Cardiovascular Control in Normal and Disease StatesUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$737,225
5P01AG027211-03Longevity and Stress ResistanceUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2009NATIONAL INSTITUTE ON AGING
$2,182,671
5P01HL069020-09-6Molecular Mechanisms in Chronically Stunned MyocardiumUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2009NATIONAL HEART
$335,213
5R01HL033107-25Cardiovascular Control in Normal and Disease StatesUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2009NATIONAL HEART
$752,274
Project Title: Myocardial hypertrophy and heart failure
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 5P01HL059139-07
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Myocardial hypertrophy and heart failure
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 5P01HL059139-07
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Title Abstract Authors Year Rel
Downregulation of caveolin by chronic beta-adrenergic receptor stimulation in mice. The American journal of physiology.. 1997 Dec 273 (6 Pt 1) :C1957-62 Oka, N; Asai, K; Kudej, R K; Edwards, J G; Toya, Y; Schwencke, C; Vatner, D E; Vatner, S F; Ishikawa, Y 1997
Caveolin interaction with protein kinase C. Isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide. The Journal of biological chemistry.. 1997 Dec 26 272 (52) :33416-21 Oka, N; Yamamoto, M; Schwencke, C; Kawabe, J; Ebina, T; Ohno, S; Couet, J; Lisanti, M P; Ishikawa, Y 1997
Caveolin is an activator of insulin receptor signaling. The Journal of biological chemistry.. 1998 Oct 9 273 (41) :26962-8 Yamamoto, M;Toya, Y;Schwencke, C;Lisanti, M P;Myers Jr, M G;Ishikawa, Y 1998
Forskolin derivatives with increased selectivity for cardiac adenylyl cyclase. Journal of molecular and cellular cardiology.. 1998 Jan 30 (1) :97-108 Toya, Y;Schwencke, C;Ishikawa, Y 1998
Voltage-dependent calcium channel promoter restores baroreflex sensitivity in conscious dogs with heart failure. Circulation.. 1998 Sep 29 98 (13) :1342-7 Uechi, M;Asai, K;Sato, N;Vatner, S F 1998
Regulation of cAMP signaling by phosphorylation. Advances in second messenger and phosphoprotein research.. 1998 32 () :99-120 Ishikawa, Y 1998
Depressed heart rate variability and arterial baroreflex in conscious transgenic mice with overexpression of cardiac Gsalpha. Circulation research.. 1998 Mar 9 82 (4) :416-23 Uechi, M;Asai, K;Osaka, M;Smith, A;Sato, N;Wagner, T E;Ishikawa, Y;Hayakawa, H;Vatner, D E;Shannon, R P;Homcy, C J;Vatner, S F 1998
Lack of desensitization and enhanced efficiency of calcium channel promoter in conscious dogs with heart failure. The American journal of physiology.. 1998 Dec 275 (6 Pt 2) :H2219-26 Asai, K;Uechi, M;Sato, N;Shen, W;Meguro, T;Mathier, M A;Shannon, R P;Vatner, S F 1998
Selective large coronary endothelial dysfunction in conscious dogs with chronic coronary pressure overload. The American journal of physiology.. 1998 Feb 274 (2 Pt 2) :H539-51 Ghaleh, B;Hittinger, L;Kim, S J;Kudej, R K;Iwase, M;Uechi, M;Berdeaux, A;Bishop, S P;Vatner, S F 1998
Overexpression of myocardial Gsalpha prevents full expression of catecholamine desensitization despite increased beta-adrenergic receptor kinase. The Journal of clinical investigation. 1998 May 1 101 (9) :1916-22 Vatner, D E;Asai, K;Iwase, M;Ishikawa, Y;Wagner, T E;Shannon, R P;Homcy, C J;Vatner, S F 1998
Ineffective perfusion-contraction matching in conscious, chronically instrumented pigs with an extended period of coronary stenosis. Circulation research.. 1998 Jun 15 82 (11) :1199-205 Kudej, R K;Ghaleh, B;Sato, N;Shen, Y T;Bishop, S P;Vatner, S F 1998
Cyclosporine attenuates pressure-overload hypertrophy in mice while enhancing susceptibility to decompensation and heart failure. Circulation research.. 1999 Apr 2 84 (6) :735-40 Meguro, T;Hong, C;Asai, K;Takagi, G;McKinsey, T A;Olson, E N;Vatner, S F 1999
An alpha-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes. The American journal of physiology.. 1999 May 276 (5 Pt 2) :H1780-7 Kim, S J;Iizuka, K;Kelly, R A;Geng, Y J;Bishop, S P;Yang, G;Kudej, A;McConnell, B K;Seidman, C E;Seidman, J G;Vatner, S F 1999
High efficiency gene transfer by multiple transfection protocol. The Histochemical journal.. 1999 Apr 31 (4) :241-3 Yamamoto, M;Okumura, S;Schwencke, C;Sadoshima, J;Ishikawa, Y 1999
Progressive loss of myocardial ATP due to a loss of total purines during the development of heart failure in dogs: a compensatory role for the parallel loss of creatine. Circulation.. 1999 Nov 16 100 (20) :2113-8 Shen, W;Asai, K;Uechi, M;Mathier, M A;Shannon, R P;Vatner, S F;Ingwall, J S 1999
Caveolin is an inhibitor of platelet-derived growth factor receptor signaling. Experimental cell research.. 1999 Mar 15 247 (2) :380-8 Yamamoto, M;Toya, Y;Jensen, R A;Ishikawa, Y 1999
Beta-adrenergic receptor-G protein-adenylyl cyclase signal transduction in the failing heart. The American journal of cardiology.. 1999 Jun 17 83 (12A) :80H-85H Vatner, D E;Asai, K;Iwase, M;Ishikawa, Y;Shannon, R P;Homcy, C J;Vatner, S F 1999
Downregulation of caveolin expression by cAMP signal. Life sciences.. 1999 64 (15) :1349-57 Yamamoto, M;Okumura, S;Oka, N;Schwencke, C;Ishikawa, Y 1999
Mechanisms of desensitization to a PDE inhibitor (milrinone) in conscious dogs with heart failure. The American journal of physiology.. 1999 May 276 (5 Pt 2) :H1699-705 Sato, N;Asai, K;Okumura, S;Takagi, G;Shannon, R P;Fujita-Yamaguchi, Y;Ishikawa, Y;Vatner, S F;Vatner, D E 1999
An adenosine agonist and preconditioning shift the distribution of myocardial blood flow in conscious pigs. The American journal of physiology.. 1999 Feb 276 (2 Pt 2) :H368-75 Huang, C H;Kim, S J;Ghaleh, B;Kudej, R K;Shen, Y T;Bishop, S P;Vatner, S F 1999
Reduced subendocardial ryanodine receptors and consequent effects on cardiac function in conscious dogs with left ventricular hypertrophy. Circulation research.. 1999 May 14 84 (9) :999-1006 Hittinger, L;Ghaleh, B;Chen, J;Edwards, J G;Kudej, R K;Iwase, M;Kim, S J;Vatner, S F;Vatner, D E 1999
Apoptosis of cardiac myocytes in Gsalpha transgenic mice. Circulation research.. 1999 Jan 8-22 84 (1) :34-42 Geng, Y J;Ishikawa, Y;Vatner, D E;Wagner, T E;Bishop, S P;Vatner, S F;Homcy, C J 1999
Enhanced cAMP-induced nitric oxide-dependent coronary dilation during myocardial stunning in conscious pigs. American journal of physiology. Heart and circulatory physiology.. 2000 Dec 279 (6) :H2967-74 Kudej, R K; Zhang, X P; Ghaleh, B; Huang, C H; Jackson, J B; Kudej, A B; Sato, N; Sato, S; Vatner, D E; Hintze, T H; Vatner, S F 2000
Peripheral vascular endothelial dysfunction and apoptosis in old monkeys. Arteriosclerosis, thrombosis, and vascular biology.. 2000 Jun 20 (6) :1493-9 Asai, K; Kudej, R K; Shen, Y T; Yang, G P; Takagi, G; Kudej, A B; Geng, Y J; Sato, N; Nazareno, J B; Vatner, D E; Natividad, F; Bishop, S P; Vatner, S F 2000
Determinants of the cardiomyopathic phenotype in chimeric mice overexpressing cardiac Gsalpha. Circulation research.. 2000 Apr 14 86 (7) :802-6 Vatner, D E; Yang, G P; Geng, Y J; Asai, K; Yun, J S; Wagner, T E; Ishikawa, Y; Bishop, S P; Homcy, C J; Vatner, S F 2000
Nitric oxide, an important regulator of perfusion-contraction matching in conscious pigs. American journal of physiology. Heart and circulatory physiology.. 2000 Jul 279 (1) :H451-6 Kudej, R K; Kim, S J; Shen, Y T; Jackson, J B; Kudej, A B; Yang, G P; Bishop, S P; Vatner, S F 2000
Cyclosporine reduces left ventricular mass with chronic aortic banding in mice, which could be due to apoptosis and fibrosis. Journal of molecular and cellular cardiology.. 2001 Aug 33 (8) :1505-14 Yang, G; Meguro, T; Hong, C; Asai, K; Takagi, G; Karoor, V L; Sadoshima, J; Vatner, D E; Bishop, S P; Vatner, S F 2001
Beta-adrenergic cardiac hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart. Journal of molecular and cellular cardiology.. 2001 Mar 33 (3) :561-73 Morisco, C; Zebrowski, D C; Vatner, D E; Vatner, S F; Sadoshima, J 2001
Paradoxically enhanced endothelin-B receptor-mediated vasoconstriction in conscious old monkeys. Circulation.. 2001 May 15 103 (19) :2382-6 Asai, K; Kudej, R K; Takagi, G; Kudej, A B; Natividad, F; Shen, Y T; Vatner, D E; Vatner, S F 2001
A novel mechanism for myocardial stunning involving impaired Ca(2+) handling. Circulation research.. 2001 Oct 26 89 (9) :831-7 Kim, S J; Kudej, R K; Yatani, A; Kim, Y K; Takagi, G; Honda, R; Colantonio, D A; Van Eyk, J E; Vatner, D E; Rasmusson, R L; Vatner, S F 2001
Gene program for cardiac cell survival induced by transient ischemia in conscious pigs. Proceedings of the National Academy of Sciences of the United States of America.. 2001 Jul 31 98 (16) :9336-41 Depre, C; Tomlinson, J E; Kudej, R K; Gaussin, V; Thompson, E; Kim, S J; Vatner, D E; Topper, J N; Vatner, S F 2001
The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy. The Journal of clinical investigation.. 2002 Jul 110 (2) :271-9 Sadoshima, Junichi; Montagne, Olivier; Wang, Qian; Yang, Guiping; Warden, Jill; Liu, Jing; Takagi, Gen; Karoor, Vijaya; Hong, Chull; Johnson, Gary L; Vatner, Dorothy E; Vatner, Stephen F 2002
H11 kinase is a novel mediator of myocardial hypertrophy in vivo. Circulation research.. 2002 Nov 29 91 (11) :1007-14 Depre, Christophe; Hase, Makoto; Gaussin, Vinciane; Zajac, Anna; Wang, Li; Hittinger, Luc; Ghaleh, Bijan; Yu, Xianzhong; Kudej, Raymond K; Wagner, Thomas; Sadoshima, Junichi; Vatner, Stephen F 2002
Altered excitation-contraction coupling in myocytes from remodeled myocardium after chronic myocardial infarction. Journal of molecular and cellular cardiology.. 2002 Jan 34 (1) :63-73 Kim, Young-Kwon; Kim, Song-Jung; Kramer, Christopher M; Yatani, Atsuko; Takagi, Gen; Mankad, Sunil; Szigeti, Gyula P; Singh, Deepak; Bishop, Sanford P; Shannon, Richard P; Vatner, Dorothy E; Vatner, Stephen F 2002
Mitochondrial preference for short chain fatty acid oxidation during coronary artery constriction. Circulation.. 2002 Jan 22 105 (3) :367-72 Lewandowski, E Douglas; Kudej, Raymond K; White, Lawrence T; O'Donnell, J Michael; Vatner, Stephen F 2002
Brief increase in carbohydrate oxidation after reperfusion reverses myocardial stunning in conscious pigs. Circulation. 2002 Nov 26 106 (22) :2836-41 Kudej, Raymond K; White, Lawrence T; Kudej, Amelia B; Vatner, Stephen F; Lewandowski, E Douglas 2002
Enhanced iNOS function in myocytes one day after brief ischemic episode. American journal of physiology. Heart and circulatory physiology.. 2002 Feb 282 (2) :H423-8 Kim, Song-Jung; Kim, Young-Kwon; Takagi, Gen; Huang, Cheng-Hsiung; Geng, Yong-Jian; Vatner, Stephen F 2002
Accelerated cardiomyopathy in mice with overexpression of cardiac G(s)alpha and a missense mutation in the alpha-myosin heavy chain. Circulation.. 2002 Feb 5 105 (5) :614-20 Hardt, Stefan E; Geng, Yong-Jian; Montagne, Olivier; Asai, Kuniya; Hong, Chull; Yang, Gui Ping; Bishop, Sanford P; Kim, Song-Jung; Vatner, Dorothy E; Seidman, Christine E; Seidman, J G; Homcy, Charles J; Vatner, Stephen F 2002
Isoform-specific regulation of adenylyl cyclase: a potential target in future pharmacotherapy. Expert opinion on therapeutic targets.. 2003 Jun 7 (3) :441-51 Iwatsubo, Kousaku; Tsunematsu, Takashi; Ishikawa, Yoshihiro 2003
Ischemic preconditioning prevents ischemia-induced beta-adrenergic receptor sequestration. Journal of molecular and cellular cardiology.. 2003 Aug 35 (8) :923-9 Iwatsubo, Kousaku; Toya, Yoshiyuki; Fujita, Takayuki; Ebina, Toshiaki; Schwencke, Carsten; Minamisawa, Susumu; Umemura, Satoshi; Ishikawa, Yoshihiro 2003
Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy. Circulation.. 2003 Dec 9 108 (23) :2926-33 Gaussin, Vinciane; Tomlinson, James E; Depre, Christophe; Engelhardt, Stefan; Antos, Christopher L; Takagi, Gen; Hein, Lutz; Topper, James N; Liggett, Stephen B; Olson, Eric N; Lohse, Martin J; Vatner, Stephen F; Vatner, Dorothy E 2003
Nitric oxide-dependent vasodilation maintains blood flow in true hibernating myocardium. Journal of molecular and cellular cardiology.. 2003 Aug 35 (8) :931-5 Kudej, Raymond K; Vatner, Stephen F 2003
Neurally-mediated increase in calcineurin activity regulates cardiac contractile function in absence of hypertrophy. Cardiovascular research.. 2003 Sep 1 59 (3) :649-57 Li, Joan; Yatani, Atsuko; Kim, Song-Jung; Takagi, Gen; Irie, Keiichi; Zhang, Qizhi; Karoor, Vijaya; Hong, Chull; Yang, Guiping; Sadoshima, Junichi; Depre, Christophe; Vatner, Dorothy E; West, Malcolm J; Vatner, Stephen F 2003
Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to beta-adrenergic receptor stimulation. Circulation research.. 2003 Jul 11 93 (1) :12-22 Tomita, Hideharu; Nazmy, Michael; Kajimoto, Katsuya; Yehia, Ghassan; Molina, Carlos A; Sadoshima, Junichi 2003
Gender differences on the effects of aging on cardiac and peripheral adrenergic stimulation in old conscious monkeys. American journal of physiology. Heart and circulatory physiology.. 2003 Aug 285 (2) :H527-34 Takagi, Gen; Asai, Kuniya; Vatner, Stephen F; Kudej, Raymond K; Rossi, Franco; Peppas, Athanasios; Takagi, Ikuyo; Resuello, Ranillo R G; Natividad, Filipinas; Shen, You-Tang; Vatner, Dorothy E 2003
Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. The Journal of clinical investigation.. 2003 May 111 (10) :1463-74 Yamamoto, Shimako; Yang, Guiping; Zablocki, Daniela; Liu, Jing; Hong, Chull; Kim, Song-Jung; Soler, Sandra; Odashima, Mari; Thaisz, Jill; Yehia, Ghassan; Molina, Carlos A; Yatani, Atsuko; Vatner, Dorothy E; Vatner, Stephen F; Sadoshima, Junichi 2003
Novel mechanisms mediating stunned myocardium. Heart failure reviews.. 2003 Apr 8 (2) :143-53 Kim, Song-Jung; Depre, Christophe; Vatner, Stephen F 2003
Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus. American journal of physiology. Heart and circulatory physiology.. 2003 Apr 284 (4) :H1043-7 Morisco, Carmine; Sadoshima, Junichi; Trimarco, Bruno; Arora, Rohit; Vatner, Dorothy E; Vatner, Stephen F 2003
Cardiac nerves affect myocardial stunning through reactive oxygen and nitric oxide mechanisms. Circulation research.. 2003 Oct 31 93 (9) :866-73 Huang, Cheng-Hsiung; Vatner, Stephen F; Peppas, Athanasios P; Yang, Guiping; Kudej, Raymond K 2003
Characterization of pDJA1, a cardiac-specific chaperone found by genomic profiling of the post-ischemic swine heart. Cardiovascular research.. 2003 Apr 1 58 (1) :126-35 Depre, Christophe; Wang, Li; Tomlinson, James E; Gaussin, Vinciane; Abdellatif, Maha; Topper, James N; Vatner, Stephen F 2003
Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload. Proceedings of the National Academy of Sciences of the United States of America.. 2003 Aug 19 100 (17) :9986-90 Okumura, Satoshi; Takagi, Gen; Kawabe, Jun-ichi; Yang, Guiping; Lee, Ming-Chih; Hong, Chull; Liu, Jing; Vatner, Dorothy E; Sadoshima, Junichi; Vatner, Stephen F; Ishikawa, Yoshihiro 2003
Mesenteric lymph from rats with thermal injury prolongs the action potential and increases Ca2+ transient in rat ventricular myocytes. Shock (Augusta, Ga.). 2003 Nov 20 (5) :458-64 Yatani, Atsuko; Xu, Da-Zhong; Kim, Song-Jung; Vatner, Stephen F; Deitch, Edwin A 2003
Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy. Journal of cardiovascular pharmacology. 2003 Dec 42 Suppl 1 () :S27-32 Ikoma, Eiko; Tsunematsu, Takashi; Nakazawa, Ichirou; Shiwa, Tadashi; Hibi, Kiyoshi; Ebina, Toshiaki; Mochida, Yasuyuki; Toya, Yoshiyuki; Hori, Hideaki; Uchino, Kazuaki; Minamisawa, Susumu; Kimura, Kazuo; Umemura, Satoshi; Ishikawa, Yoshihiro 2003
Nicotinic acetylcholine receptor alpha 7 regulates cAMP signal within lipid rafts. American journal of physiology. Cell physiology.. 2003 Sep 285 (3) :C567-74 Oshikawa, Jin; Toya, Yoshiyuki; Fujita, Takayuki; Egawa, Masato; Kawabe, Junichi; Umemura, Satoshi; Ishikawa, Yoshihiro 2003
Motor dysfunction in type 5 adenylyl cyclase-null mice. The Journal of biological chemistry.. 2003 May 9 278 (19) :16936-40 Iwamoto, Tamio; Okumura, Satoshi; Iwatsubo, Kousaku; Kawabe, Jun-Ichi; Ohtsu, Koji; Sakai, Ikuko; Hashimoto, Yoko; Izumitani, Aki; Sango, Kazunori; Ajiki, Kyoko; Toya, Yoshiyuki; Umemura, Satoshi; Goshima, Yoshio; Arai, Nobutaka; Vatner, Stephen F; Ishikawa, Yoshihiro 2003
Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt. The Journal of biological chemistry.. 2003 Nov 28 278 (48) :47622-8 Kim, Young-Kwon; Kim, Song-Jung; Yatani, Atsuko; Huang, Yanhong; Castelli, Germana; Vatner, Dorothy E; Liu, Jing; Zhang, Qizhi; Diaz, Gissela; Zieba, Renata; Thaisz, Jill; Drusco, Alessandra; Croce, Carlo; Sadoshima, Junichi; Condorelli, Gianluigi; Vatner, Stephen F 2003
Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy. The Journal of clinical investigation.. 2003 Nov 112 (9) :1395-406 Yamamoto, Mitsutaka; Yang, Guiping; Hong, Chull; Liu, Jing; Holle, Eric; Yu, Xianzhong; Wagner, Thomas; Vatner, Stephen F; Sadoshima, Junichi 2003
Persistent stunning induces myocardial hibernation and protection: flow/function and metabolic mechanisms. Circulation research.. 2003 Jun 13 92 (11) :1233-9 Kim, Song-Jung; Peppas, Athanasios; Hong, Suk-Keun; Yang, Guiping; Huang, Yanhong; Diaz, Gissela; Sadoshima, Junichi; Vatner, Dorothy E; Vatner, Stephen F 2003
Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation. Circulation research.. 2003 Aug 22 93 (4) :364-71 Okumura, Satoshi; Kawabe, Jun-ichi; Yatani, Atsuko; Takagi, Gen; Lee, Ming-Chih; Hong, Chull; Liu, Jing; Takagi, Ikuyo; Sadoshima, Junichi; Vatner, Dorothy E; Vatner, Stephen F; Ishikawa, Yoshihiro 2003
Rapid upregulation of CTGF in cardiac myocytes by hypertrophic stimuli: implication for cardiac fibrosis and hypertrophy. Journal of molecular and cellular cardiology.. 2004 Aug 37 (2) :477-81 Matsui, Yutaka; Sadoshima, Junichi 2004
Negative regulators of cardiac hypertrophy. Cardiovascular research.. 2004 Aug 15 63 (3) :500-9 Hardt, Stefan E; Sadoshima, Junichi 2004
Phosphorylation of eukaryotic translation initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy. Circulation research.. 2004 Apr 16 94 (7) :926-35 Hardt, Stefan E; Tomita, Hideharu; Katus, Hugo A; Sadoshima, Junichi 2004
Gender-specific proteomic alterations in glycolytic and mitochondrial pathways in aging monkey hearts. Journal of molecular and cellular cardiology.. 2004 Nov 37 (5) :921-9 Yan, L; Ge, H; Li, H; Lieber, S C; Natividad, F; Resuello, R R G; Kim, S-J; Akeju, S; Sun, A; Loo, K; Peppas, A P; Rossi, F; Lewandowski, E D; Thomas, A P; Vatner, S F; Vatner, D E 2004
Program of cell survival underlying human and experimental hibernating myocardium. Circulation research.. 2004 Aug 20 95 (4) :433-40 Depre, Christophe; Kim, Song-Jung; John, Anna S; Huang, Yanhong; Rimoldi, Ornella E; Pepper, John R; Dreyfus, Gilles D; Gaussin, Vinciane; Pennell, Dudley J; Vatner, Dorothy E; Camici, Paolo G; Vatner, Stephen F 2004
Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure. Journal of molecular and cellular cardiology.. 2004 Feb 36 (2) :305-12 Karoor, Vijaya; Vatner, Stephen F; Takagi, Gen; Yang, Guiping; Thaisz, Jill; Sadoshima, Junichi; Vatner, Dorothy E 2004
Computer model of action potential of mouse ventricular myocytes. American journal of physiology. Heart and circulatory physiology.. 2004 Sep 287 (3) :H1378-403 Bondarenko, Vladimir E; Szigeti, Gyula P; Bett, Glenna C L; Kim, Song-Jung; Rasmusson, Randall L 2004
Insights into cardioprotection obtained from study of cellular Ca2+ handling in myocardium of true hibernating mammals. American journal of physiology. Heart and circulatory physiology.. 2004 Jun 286 (6) :H2219-28 Yatani, Atsuko; Kim, Song-Jung; Kudej, Raymond K; Wang, Qian; Depre, Christophe; Irie, Keiichi; Kranias, Evangelia G; Vatner, Stephen F; Vatner, Dorothy E 2004
Aging increases stiffness of cardiac myocytes measured by atomic force microscopy nanoindentation. American journal of physiology. Heart and circulatory physiology.. 2004 Aug 287 (2) :H645-51 Lieber, Samuel C; Aubry, Nadine; Pain, Jayashree; Diaz, Gissela; Kim, Song-Jung; Vatner, Stephen F 2004
Limited transfer of cytosolic NADH into mitochondria at high cardiac workload. American journal of physiology. Heart and circulatory physiology.. 2004 Jun 286 (6) :H2237-42 O'Donnell, J Michael; Kudej, Raymond K; LaNoue, Kathyrn F; Vatner, Stephen F; Lewandowski, E Douglas 2004
Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Circulation research.. 2004 Nov 12 95 (10) :971-80 Alcendor, Ralph R; Kirshenbaum, Lorrie A; Imai, Shin-ichiro; Vatner, Stephen F; Sadoshima, Junichi 2004
Strain-dependent beta-adrenergic receptor function influences myocardial responses to isoproterenol stimulation in mice. American journal of physiology. Heart and circulatory physiology.. 2005 Jul 289 (1) :H30-6 Faulx, Michael D; Ernsberger, Paul; Vatner, Dorothy; Hoffman, Robert D; Lewis, William; Strachan, Ryan; Hoit, Brian D 2005
PKC-{epsilon}-dependent survival signals in diabetic hearts. American journal of physiology. Heart and circulatory physiology.. 2005 Oct 289 (4) :H1343-50 Malhotra, Ashwani; Begley, Rebecca; Kang, Barinder P S; Rana, Irmindra; Liu, Jing; Yang, Guiping; Mochly-Rosen, Daria; Meggs, Leonard G 2005
Paradoxical cellular Ca2+ signaling in severe but compensated canine left ventricular hypertrophy. Circulation research.. 2005 Sep 2 97 (5) :457-64 Song, Long-Sheng; Pi, Yeqing; Kim, Song-Jung; Yatani, Atsuko; Guatimosim, Silvia; Kudej, Raymond K; Zhang, Qingxiu; Cheng, Heping; Hittinger, Luc; Ghaleh, Bijan; Vatner, Dorothy E; Lederer, W Jonathan; Vatner, Stephen F 2005
Autophagy in chronically ischemic myocardium. Proceedings of the National Academy of Sciences of the United States of America.. 2005 Sep 27 102 (39) :13807-12 Yan, Lin; Vatner, Dorothy E; Kim, Song-Jung; Ge, Hui; Masurekar, Malthi; Massover, William H; Yang, Guiping; Matsui, Yutaka; Sadoshima, Junichi; Vatner, Stephen F 2005
Preconditioning effects of PKCdelta. Journal of molecular and cellular cardiology.. 2005 Oct 39 (4) :719-21 Hirotani, Shinichi; Sadoshima, Junichi 2005
H11 has dose-dependent and dual hypertrophic and proapoptotic functions in cardiac myocytes. The Biochemical journal.. 2005 Jun 1 388 (Pt 2) :475-83 Hase, Makoto; Depre, Christophe; Vatner, Stephen F; Sadoshima, Junichi 2005
Mechanisms of cell survival in myocardial hibernation. Trends in cardiovascular medicine.. 2005 Apr 15 (3) :101-10 Depre, Christophe; Vatner, Stephen F 2005
FGF induces hypertrophy and angiogenesis in hibernating myocardium. Circulation research.. 2005 Apr 15 96 (7) :705-7 Vatner, Stephen F 2005
Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice. The Journal of clinical investigation.. 2005 Nov 115 (11) :3045-56 Zhai, Peiyong; Yamamoto, Mitsutaka; Galeotti, Jonathan; Liu, Jing; Masurekar, Malthi; Thaisz, Jill; Irie, Keiichi; Holle, Eric; Yu, Xianzhong; Kupershmidt, Sabina; Roden, Dan M; Wagner, Thomas; Yatani, Atsuko; Vatner, Dorothy E; Vatner, Stephen F; Sadoshima, Junichi 2005
Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus. Circulation research.. 2005 Aug 5 97 (3) :219-26 Gaussin, Vinciane; Morley, Gregory E; Cox, Luk; Zwijsen, An; Vance, Kendra M; Emile, Lorin; Tian, Yimin; Liu, Jing; Hong, Chull; Myers, Dina; Conway, Simon J; Depre, Christophe; Mishina, Yuji; Behringer, Richard R; Hanks, Mark C; Schneider, Michael D; Huylebroeck, Danny; Fishman, Glenn I; Burch, John B E; Vatner, Stephen F 2005
Redox regulation of growth and death in cardiac myocytes. Antioxidants & redox signaling. 2006 Sep-Oct 8 (9-10) :1621-4 Sadoshima, Junichi 2006
Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus. The Journal of clinical investigation. 2006 Nov 116 (11) :3026-34 Yokoyama, Utako; Minamisawa, Susumu; Quan, Hong; Ghatak, Shibnath; Akaike, Toru; Segi-Nishida, Eri; Iwasaki, Shiho; Iwamoto, Mari; Misra, Suniti; Tamura, Kouichi; Hori, Hideaki; Yokota, Shumpei; Toole, Bryan P; Sugimoto, Yukihiko; Ishikawa, Yoshihiro 2006
Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity. Journal of molecular and cellular cardiology.. 2006 May 40 (5) :605-18 Zebrowski, David C; Alcendor, Ralph R; Kirshenbaum, Lorrie A; Sadoshima, Junichi 2006
Global changes in gene expression during cardiac hypertrophy: a new direction of cardiac signaling research. Journal of molecular and cellular cardiology.. 2006 Aug 41 (2) :219-22 Usui, Soichiro; Yeh, Ijen; Tian, Bin; Sadoshima, Junichi 2006
Thioredoxin and ventricular remodeling. Journal of molecular and cellular cardiology. 2006 Nov 41 (5) :762-73 Ago, Tetsuro; Sadoshima, Junichi 2006
Thioredoxin1 upregulates mitochondrial proteins related to oxidative phosphorylation and TCA cycle in the heart. Antioxidants & redox signaling. 2006 Sep-Oct 8 (9-10) :1635-50 Ago, Tetsuro; Yeh, Ijen; Yamamoto, Mitsutaka; Schinke-Braun, Martina; Brown, Jeffrey A; Tian, Bin; Sadoshima, Junichi 2006
Overexpressed cardiac Gsalpha in rabbits. Journal of molecular and cellular cardiology.. 2006 Jul 41 (1) :44-50 Nishizawa, Takao; Vatner, Stephen F; Hong, Chull; Shen, You-Tang; Hardt, Stefan E; Robbins, Jeffrey; Ishikawa, Yoshihiro; Sadoshima, Junichi; Vatner, Dorothy E 2006
Autophagy: a novel protective mechanism in chronic ischemia. Cell cycle (Georgetown, Tex.). 2006 Jun 5 (11) :1175-7 Yan, Lin; Sadoshima, Junichi; Vatner, Dorothy E; Vatner, Stephen F 2006
An angiotensin II type 1 receptor mutant lacking epidermal growth factor receptor transactivation does not induce angiotensin II-mediated cardiac hypertrophy. Circulation research.. 2006 Sep 1 99 (5) :528-36 Zhai, Peiyong; Galeotti, Jonathan; Liu, Jing; Holle, Eric; Yu, Xianzhong; Wagner, Thomas; Sadoshima, Junichi 2006
Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition. Journal of molecular and cellular cardiology. 2006 Oct 41 (4) :680-8 Liu, Jing; Sadoshima, Junichi; Zhai, Peiyong; Hong, Chull; Yang, Guiping; Chen, Wei; Yan, Lin; Wang, Yibin; Vatner, Stephen F; Vatner, Dorothy E 2006
Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy. Circulation. 2006 Oct 24 114 (17) :1821-8 Depre, Christophe; Wang, Qian; Yan, Lin; Hedhli, Nadia; Peter, Pallavi; Chen, Li; Hong, Chull; Hittinger, Luc; Ghaleh, Bijan; Sadoshima, Junichi; Vatner, Dorothy E; Vatner, Stephen F; Madura, Kiran 2006
Obligatory role of cardiac nerves and alpha1-adrenergic receptors for the second window of ischemic preconditioning in conscious pigs. Circulation research. 2006 Nov 24 99 (11) :1270-6 Kudej, Raymond K; Shen, You-Tang; Peppas, Athanasios P; Huang, Cheng-Hsiung; Chen, Wei; Yan, Lin; Vatner, Dorothy E; Vatner, Stephen F 2006
Down regulation of the L-type Ca2+ channel, GRK2, and phosphorylated phospholamban: protective mechanisms for the denervated failing heart. Journal of molecular and cellular cardiology.. 2006 May 40 (5) :619-28 Yatani, A; Shen, Y-T; Yan, L; Chen, W; Kim, S-J; Sano, K; Irie, K; Vatner, S F; Vatner, D E 2006
Thioredoxin1 as a negative regulator of cardiac hypertrophy. Antioxidants & redox signaling. 2007 Jun 9 (6) :679-87 Ago, Tetsuro; Sadoshima, Junichi 2007
Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circulation research. 2007 Mar 30 100 (6) :914-22 Matsui, Yutaka; Takagi, Hiromitsu; Qu, Xueping; Abdellatif, Maha; Sakoda, Hideyuki; Asano, Tomoichiro; Levine, Beth; Sadoshima, Junichi 2007
Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. Circulation research. 2007 May 11 100 (9) :1344-52 Odashima, Mari; Usui, Soichiro; Takagi, Hiromitsu; Hong, Chull; Liu, Jing; Yokota, Mitsuhiro; Sadoshima, Junichi 2007
Inhibition of glycogen synthase kinase 3beta during heart failure is protective. Circulation research. 2007 Nov 26 101 (11) :1164-74 Hirotani, Shinichi; Zhai, Peiyong; Tomita, Hideharu; Galeotti, Jonathan; Marquez, Juan Pablo; Gao, Shumin; Hong, Chull; Yatani, Atsuko; Avila, Jesus; Sadoshima, Junichi 2007
AMPK mediates autophagy during myocardial ischemia in vivo. Autophagy. 2007 Jul-Aug 3 (4) :405-7 Takagi, Hiromitsu; Matsui, Yutaka; Hirotani, Shinichi; Sakoda, Hideyuki; Asano, Tomoichiro; Sadoshima, Junichi 2007
cAMP-mediated regulation of CYP enzymes and its application in chemotherapy. Drug metabolism letters. 2007 Aug 1 (3) :176-8 Ishikawa, Yoshihiro; Suzuki, Sayaka; Otsu, Koji; Ulucan, Coskun; Iwatsubo, Kousaku; Eguchi, Haruki 2007
The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart. Antioxidants & redox signaling. 2007 Sep 9 (9) :1373-81 Takagi, Hiromitsu; Matsui, Yutaka; Sadoshima, Junichi 2007
Dopamine induces apoptosis in young, but not in neonatal, neurons via Ca2+-dependent signal. American journal of physiology. Cell physiology. 2007 Nov 293 (5) :C1498-508 Iwatsubo, Kousaku; Suzuki, Sayaka; Li, Chanxia; Tsunematsu, Takashi; Nakamura, Fumi; Okumura, Satoshi; Sato, Motohiko; Minamisawa, Susumu; Toya, Yoshiyuki; Umemura, Satoshi; Ishikawa, Yoshihiro 2007
Cardioprotection in stunned and hibernating myocardium. Heart failure reviews. 2007 Dec 12 (3-4) :307-17 Depre, Christophe; Vatner, Stephen F 2007
Increased apoptosis and myocyte enlargement with decreased cardiac mass; distinctive features of the aging male, but not female, monkey heart. Journal of molecular and cellular cardiology. 2007 Oct 43 (4) :487-91 Zhang, Xiao-Ping; Vatner, Stephen F; Shen, You-Tang; Rossi, Franco; Tian, Yimin; Peppas, Athanasios; Resuello, Ranillo R G; Natividad, Filipinas F; Vatner, Dorothy E 2007
Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress. Circulation. 2007 Oct 16 116 (16) :1776-83 Okumura, Satoshi; Vatner, Dorothy E; Kurotani, Reiko; Bai, Yunzhe; Gao, Shumin; Yuan, Zengrong; Iwatsubo, Kousaku; Ulucan, Coskun; Kawabe, Jun-ichi; Ghosh, Kaushik; Vatner, Stephen F; Ishikawa, Yoshihiro 2007
Functional adenylyl cyclase inhibition in murine cardiomyocytes by 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-[gamma-thio]triphosphate. The Journal of pharmacology and experimental therapeutics. 2007 May 321 (2) :608-15 Rottlaender, Dennis; Matthes, Jan; Vatner, Stephen F; Seifert, Roland; Herzig, Stefan 2007
Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases. The Journal of biological chemistry. 2007 Nov 9 282 (45) :33181-91 Zhai, Peiyong; Gao, Shumin; Holle, Eric; Yu, Xianzhong; Yatani, Atsuko; Wagner, Thomas; Sadoshima, Junichi 2007
Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy. American journal of physiology. Heart and circulatory physiology. 2007 Sep 293 (3) :H1662-72 Ulucan, Coskun; Wang, Xu; Baljinnyam, Erdene; Bai, Yunzhe; Okumura, Satoshi; Sato, Motohiko; Minamisawa, Susumu; Hirotani, Shinichi; Ishikawa, Yoshihiro 2007
Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell. 2007 Jul 27 130 (2) :247-58 Yan, Lin; Vatner, Dorothy E; O'Connor, J Patrick; Ivessa, Andreas; Ge, Hui; Chen, Wei; Hirotani, Shinichi; Ishikawa, Yoshihiro; Sadoshima, Junichi; Vatner, Stephen F 2007
Sirt1 regulates aging and resistance to oxidative stress in the heart. Circulation research. 2007 May 25 100 (10) :1512-21 Alcendor, Ralph R; Gao, Shumin; Zhai, Peiyong; Zablocki, Daniela; Holle, Eric; Yu, Xianzhong; Tian, Bin; Wagner, Thomas; Vatner, Stephen F; Sadoshima, Junichi 2007
Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor. Circulation. 2007 Nov 27 116 (22) :2535-43 Stroud, Dina Myers; Gaussin, Vinciane; Burch, John B E; Yu, Cindy; Mishina, Yuji; Schneider, Michael D; Fishman, Glenn I; Morley, Gregory E 2007
Altered autonomic control in conscious transgenic rabbits with overexpressed cardiac Gsalpha. American journal of physiology. Heart and circulatory physiology. 2007 Feb 292 (2) :H971-5 Nishizawa, Takao; Shen, You-Tang; Rossi, Franco; Hong, Chull; Robbins, Jeffrey; Ishikawa, Yoshihiro; Sadoshima, Junichi; Vatner, Dorothy E; Vatner, Stephen F 2007
Sex-specific regulation of gene expression in the aging monkey aorta. Physiological genomics. 2007 Apr 24 29 (2) :169-80 Qiu, Hongyu; Tian, Bin; Resuello, Ranilo G; Natividad, Filipinas F; Peppas, Athanasios; Shen, You-Tang; Vatner, Dorothy E; Vatner, Stephen F; Depre, Christophe 2007
Sex differences in myocardial infarction and rupture. Journal of molecular and cellular cardiology. 2007 Nov 43 (5) :532-4 Qiu, Hongyu; Depre, Christophe; Vatner, Stephen F; Vatner, Dorothy E 2007
Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor. The Journal of clinical investigation. 2007 May 117 (5) :1335-43 Peter, Pallavi S; Brady, Jennifer E; Yan, Lin; Chen, Wei; Engelhardt, Stefan; Wang, Yibin; Sadoshima, Junichi; Vatner, Stephen F; Vatner, Dorothy E 2007
Mechanism of gender-specific differences in aortic stiffness with aging in nonhuman primates. Circulation. 2007 Aug 7 116 (6) :669-76 Qiu, Hongyu; Depre, Christophe; Ghosh, Kaushik; Resuello, Ranillo G; Natividad, Filipinas F; Rossi, Franco; Peppas, Athanasios; Shen, You-Tang; Vatner, Dorothy E; Vatner, Stephen F 2007
Cardiac dysfunction in aging conscious rats: altered cardiac cytoskeletal proteins as a potential mechanism. American journal of physiology. Heart and circulatory physiology. 2008 Aug 295 (2) :H860-6 Lieber, Samuel C; Qiu, Hongyu; Chen, Li; Shen, You-Tang; Hong, Chull; Hunter, William C; Aubry, Nadine; Vatner, Stephen F; Vatner, Dorothy E 2008
Overexpression of Gsalpha compensates for myocyte loss in diabetic cardiomyopathy. Canadian journal of physiology and pharmacology. 2008 Mar 86 (3) :122-30 Malhotra, Ashwani; Kang, Barinder P S; Vashistha, Himanshu; Yadav, Virender S; Meggs, Leonard G 2008
Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. Autophagy. 2008 May 16 4 (4) :409-15 Matsui, Yutaka; Kyoi, Shiori; Takagi, Hiromitsu; Hsu, Chiao-Po; Hariharan, Nirmala; Ago, Tetsuro; Vatner, Stephen F; Sadoshima, Junichi 2008
A cAMP pathway underlying reward prediction in associative learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Oct 29 28 (44) :11401-8 Kheirbek, Mazen A; Beeler, Jeff A; Ishikawa, Yoshihiro; Zhuang, Xiaoxi 2008
Cardiac myosin light chain kinase: a new player in the regulation of myosin light chain in the heart. Circulation research. 2008 Mar 14 102 (5) :516-8 Ishikawa, Yoshihiro;Kurotani, Reiko 2008
Characterization of a novel cardiac isoform of the cell cycle-related kinase that is regulated during heart failure. The Journal of biological chemistry. 2008 Aug 8 283 (32) :22157-65 Qiu, Hongyu; Dai, Huacheng; Jain, Komal; Shah, Rina; Hong, Chull; Pain, Jayashree; Tian, Bin; Vatner, Dorothy E; Vatner, Stephen F; Depre, Christophe 2008
Lats2 is a negative regulator of myocyte size in the heart. Circulation research. 2008 Nov 21 103 (11) :1309-18 Matsui, Yutaka; Nakano, Noritsugu; Shao, Dan; Gao, Shumin; Luo, Wenting; Hong, Chull; Zhai, Peiyong; Holle, Eric; Yu, Xianzhong; Yabuta, Norikazu; Tao, Wufan; Wagner, Thomas; Nojima, Hiroshi; Sadoshima, Junichi 2008
Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning. Circulation. 2008 Nov 4 118 (19) :1961-9 Shen, You-Tang; Depre, Christophe; Yan, Lin; Park, Ji Yeon; Tian, Bin; Jain, Komal; Chen, Li; Zhang, Yan; Kudej, Raymond K; Zhao, Xin; Sadoshima, Junichi; Vatner, Dorothy E; Vatner, Stephen F 2008
Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload. Proceedings of the National Academy of Sciences of the United States of America. 2008 Dec 30 105 (52) :20900-5 Matsuda, Takahisa; Zhai, Peiyong; Maejima, Yasuhiro; Hong, Chull; Gao, Shumin; Tian, Bin; Goto, Kazumichi; Takagi, Hiromitsu; Tamamori-Adachi, Mimi; Kitajima, Shigetaka; Sadoshima, Junichi 2008
Overcoming an energy crisis?: an adaptive role of glycogen synthase kinase-3 inhibition in ischemia/reperfusion. Circulation research. 2008 Oct 24 103 (9) :910-3 Zhai, Peiyong; Sadoshima, Junichi 2008
Therapeutic targets for heart failure: beyond beta-adrenergic and renin-angiotensin system blockade. Recent patents on cardiovascular drug discovery. 2008 Jan 3 (1) :37-44 Iwatsubo, Kousaku;Ishikawa, Yoshihiro 2008
A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell. 2008 Jun 13 133 (6) :978-93 Ago, Tetsuro; Liu, Tong; Zhai, Peiyong; Chen, Wei; Li, Hong; Molkentin, Jeffery D; Vatner, Stephen F; Sadoshima, Junichi 2008
Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes. Cardiovascular research. 2008 Apr 1 78 (1) :36-44 Morisco, Carmine; Marrone, Chiara; Galeotti, Jonathan; Shao, Dan; Vatner, Dorothy E; Vatner, Stephen F; Sadoshima, Junichi 2008
Sirt1 protects the heart from aging and stress. Biological chemistry. 2008 Mar 389 (3) :221-31 Hsu, Chiao-Po; Odewale, Ibrahim; Alcendor, Ralph R; Sadoshima, Junichi 2008
Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload. American journal of physiology. Heart and circulatory physiology. 2008 Oct 295 (4) :H1385-93 Hedhli, Nadia; Lizano, Paulo; Hong, Chull; Fritzky, Luke F; Dhar, Sunil K; Liu, Huasheng; Tian, Yimin; Gao, Shumin; Madura, Kiran; Vatner, Stephen F; Depre, Christophe 2008
The role of redox modulation of class II histone deacetylases in mediating pathological cardiac hypertrophy. Journal of molecular medicine (Berlin, Germany). 2009 Aug 87 (8) :785-91 Oka, Shin-ichi; Ago, Tetsuro; Kitazono, Takanari; Zablocki, Daniela; Sadoshima, Junichi 2009
Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes. Circulation research. 2009 Aug 28 105 (5) :481-91 Hsu, Chiao-Po; Oka, Shinichi; Shao, Dan; Hariharan, Nirmala; Sadoshima, Junichi 2009
Adenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Sep 30 29 (39) :12115-24 Kheirbek, Mazen A; Britt, Jon P; Beeler, Jeff A; Ishikawa, Yoshihiro; McGehee, Daniel S; Zhuang, Xiaoxi 2009
Adenylyl cyclase type 5 protein expression during cardiac development and stress. American journal of physiology. Heart and circulatory physiology. 2009 Nov 297 (5) :H1776-82 Hu, Che-Lin; Chandra, Rachna; Ge, Hui; Pain, Jayashree; Yan, Lin; Babu, Gopal; Depre, Christophe; Iwatsubo, Kousaku; Ishikawa, Yoshihiro; Sadoshima, Junichi; Vatner, Stephen F; Vatner, Dorothy E 2009
Epac increases melanoma cell migration by a heparan sulfate-related mechanism. American journal of physiology. Cell physiology. 2009 Oct 297 (4) :C802-13 Baljinnyam, Erdene;Iwatsubo, Kousaku;Kurotani, Reiko;Wang, Xu;Ulucan, Coskun;Iwatsubo, Mizuka;Lagunoff, David;Ishikawa, Yoshihiro 2009
Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload. American journal of physiology. Heart and circulatory physiology. 2009 Nov 297 (5) :H1814-9 Gelpi, Ricardo J; Gao, Shumin; Zhai, Peiyong; Yan, Lin; Hong, Chull; Danridge, Lauren M A; Ge, Hui; Maejima, Yasahiro; Donato, Martin; Yokota, Mitsuhiro; Molkentin, Jeffery D; Vatner, Dorothy E; Vatner, Stephen F; Sadoshima, Junichi 2009
Distinct roles of glycogen synthase kinase (GSK)-3alpha and GSK-3beta in mediating cardiomyocyte differentiation in murine bone marrow-derived mesenchymal stem cells. The Journal of biological chemistry. 2009 Dec 25 284 (52) :36647-58 Cho, Jaeyeaon; Rameshwar, Pranela; Sadoshima, Junichi 2009
Optimizing cell-based therapy for cardiac regeneration. Circulation. 2009 Sep 8 120 (10) :831-4 Del Re, Dominic P; Sadoshima, Junichi 2009
Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress. Circulation journal : official journal of the Japanese Circulation Society. 2009 Feb 73 (2) :195-200 Vatner, Stephen F; Yan, Lin; Ishikawa, Yoshihiro; Vatner, Dorothy E; Sadoshima, Junichi 2009
Cytochrome c oxidase III as a mechanism for apoptosis in heart failure following myocardial infarction. American journal of physiology. Cell physiology. 2009 Oct 297 (4) :C928-34 Wu, Changgong; Yan, Lin; Depre, Christophe; Dhar, Sunil K; Shen, You-Tang; Sadoshima, Junichi; Vatner, Stephen F; Vatner, Dorothy E 2009
Apoptosis predominates in nonmyocytes in heart failure. American journal of physiology. Heart and circulatory physiology. 2009 Aug 297 (2) :H785-91 Park, Misun; Shen, You-Tang; Gaussin, Vinciane; Heyndrickx, Guy R; Bartunek, Jozef; Resuello, Ranillo R G; Natividad, Filipinas F; Kitsis, Richard N; Vatner, Dorothy E; Vatner, Stephen F 2009
Nicotinamide phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes. Autophagy. 2009 Nov 5 (8) :1229-31 Hsu, Chiao-Po; Hariharan, Nirmala; Alcendor, Ralph R; Oka, Shinichi; Sadoshima, Junichi 2009
Molecular mechanisms mediating preconditioning following chronic ischemia differ from those in classical second window. American journal of physiology. Heart and circulatory physiology. 2010 Sep 299 (3) :H752-62 Depre, Christophe;Park, Ji Yeon;Shen, You-Tang;Zhao, Xin;Qiu, Hongyu;Yan, Lin;Tian, Bin;Vatner, Stephen F;Vatner, Dorothy E 2010
Short communication: the cardiac myosin binding protein C Arg502Trp mutation: a common cause of hypertrophic cardiomyopathy. Circulation research. 2010 May 14 106 (9) :1549-52 Saltzman, Adam J;Mancini-DiNardo, Debora;Li, Chumei;Chung, Wendy K;Ho, Carolyn Y;Hurst, Stephanie;Wynn, Julia;Care, Melanie;Hamilton, Robert M;Seidman, Gregor W;Gorham, Joshua;McDonough, Barbara;Sparks, Elizabeth;Seidman, J G;Seidman, Christine E;Rehm, Heidi L 2010
Activation of PKN mediates survival of cardiac myocytes in the heart during ischemia/reperfusion. Circulation research. 2010 Sep 3 107 (5) :642-9 Takagi, Hiromitsu;Hsu, Chiao-Po;Kajimoto, Katsuya;Shao, Dan;Yang, Yanfei;Maejima, Yasuhiro;Zhai, Peiyong;Yehia, Ghassan;Yamada, Chikaomi;Zablocki, Daniela;Sadoshima, Junichi 2010
Progressive loss of creatine maintains a near normal DeltaG approximately (ATP) in transgenic mouse hearts with cardiomyopathy caused by overexpressing Gsalpha. Journal of molecular and cellular cardiology. 2010 Apr 48 (4) :591-9 Shen, Weiqun;Vatner, Dorothy E;Vatner, Stephen F;Ingwall, Joanne S 2010
Effects of cardiac overexpression of type 6 adenylyl cyclase affects on the response to chronic pressure overload. American journal of physiology. Heart and circulatory physiology. 2010 Sep 299 (3) :H707-12 Guellich, Aziz;Gao, Shumin;Hong, Chull;Yan, Lin;Wagner, Thomas E;Dhar, Sunil K;Ghaleh, Bijan;Hittinger, Luc;Iwatsubo, Kosaku;Ishikawa, Yoshihiro;Vatner, Stephen F;Vatner, Dorothy E 2010
Nifedipine inhibits cardiac hypertrophy and left ventricular dysfunction in response to pressure overload. Journal of cardiovascular translational research. 2010 Aug 3 (4) :304-13 Ago, Tetsuro;Yang, Yanfei;Zhai, Peiyong;Sadoshima, Junichi 2010
Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation. 2010 Nov 23 122 (21) :2170-82 Hsu, Chiao-Po;Zhai, Peiyong;Yamamoto, Takanobu;Maejima, Yasuhiro;Matsushima, Shouji;Hariharan, Nirmala;Shao, Dan;Takagi, Hiromitsu;Oka, Shinichi;Sadoshima, Junichi 2010
Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circulation research. 2010 Apr 16 106 (7) :1253-64 Ago, Tetsuro;Kuroda, Junya;Pain, Jayashree;Fu, Cexiong;Li, Hong;Sadoshima, Junichi 2010
Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice. The Journal of clinical investigation. 2010 Oct 120 (10) :3555-67 Del Re, Dominic P;Matsuda, Takahisa;Zhai, Peiyong;Gao, Shumin;Clark, Geoffrey J;Van Der Weyden, Louise;Sadoshima, Junichi 2010
Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5. Heart failure reviews. 2010 Sep 15 (5) :495-512 Ho, David;Yan, Lin;Iwatsubo, Kousaku;Vatner, Dorothy E;Vatner, Stephen F 2010
Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circulation research. 2010 Dec 10 107 (12) :1470-82 Hariharan, Nirmala;Maejima, Yasuhiro;Nakae, Jun;Paik, Jihye;Depinho, Ronald A;Sadoshima, Junichi 2010
New insights into the molecular phenotype of eccentric hypertrophy. Journal of molecular and cellular cardiology. 2010 Aug 49 (2) :153-6 Sciarretta, Sebastiano;Sadoshima, Junichi 2010
NADPH oxidase and cardiac failure. Journal of cardiovascular translational research. 2010 Aug 3 (4) :314-20 Kuroda, Junya;Sadoshima, Junichi 2010
NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proceedings of the National Academy of Sciences of the United States of America. 2010 Aug 31 107 (35) :15565-70 Kuroda, Junya;Ago, Tetsuro;Matsushima, Shouji;Zhai, Peiyong;Schneider, Michael D;Sadoshima, Junichi 2010
Design of a miniature tissue culture system to culture mouse heart valves. Annals of biomedical engineering. 2010 Mar 38 (3) :674-82 Lieber, Samuel C;Kruithof, Boudewijn P T;Aubry, Nadine;Vatner, Stephen F;Gaussin, Vinciane 2010
A molecular dissociation between cued and contextual appetitive learning. Learning &memory (Cold Spring Harbor, N.Y.). 2010 Mar 17 (3) :148-54 Kheirbek, Mazen A;Beeler, Jeff A;Chi, Wanhao;Ishikawa, Yoshihiro;Zhuang, Xiaoxi 2010
The NADPH oxidase Nox4 and aging in the heart. Aging. 2010 Dec 2 (12) :1012-6 Ago, Tetsuro;Matsushima, Shouji;Kuroda, Junya;Zablocki, Daniela;Kitazono, Takanari;Sadoshima, Junichi 2010
Endogenous muscle atrophy F-box mediates pressure overload-induced cardiac hypertrophy through regulation of nuclear factor-kappaB. Circulation research. 2011 Jul 8 109 (2) :161-71 Usui, Soichiro; Maejima, Yasuhiro; Pain, Jayashree; Hong, Chull; Cho, Jaeyeaon; Park, Ji Yeon; Zablocki, Daniela; Tian, Bin; Glass, David J; Sadoshima, Junichi 2011
Prevention of ventricular arrhythmia and calcium dysregulation in a catecholaminergic polymorphic ventricular tachycardia mouse model carrying calsequestrin-2 mutation. Journal of cardiovascular electrophysiology. 2011 Mar 22 (3) :316-24 Alcalai, Ronny; Wakimoto, Hiroko; Arad, Michael; Planer, David; Konno, Tetsuo; Wang, Libin; Seidman, Jon G; Seidman, Christine E; Berul, Charles I 2011
Arterial Pressure Monitoring in Mice. Current protocols in mouse biology. 2011 1 () :105-122 Zhao, Xin; Ho, David; Gao, Shumin; Hong, Chull; Vatner, Dorothy E; Vatner, Stephen F 2011
Oxidative stress stimulates autophagic flux during ischemia/reperfusion. Antioxidants & redox signaling. 2011 Jun 14 (11) :2179-90 Hariharan, Nirmala; Zhai, Peiyong; Sadoshima, Junichi 2011
Myocardial injection with GSK-3ýý-overexpressing bone marrow-derived mesenchymal stem cells attenuates cardiac dysfunction after myocardial infarction. Circulation research. 2011 Feb 18 108 (4) :478-89 Cho, Jaeyeaon; Zhai, Peiyong; Maejima, Yasuhiro; Sadoshima, Junichi 2011
Differential roles of GSK-3ýý during myocardial ischemia and ischemia/reperfusion. Circulation research. 2011 Aug 19 109 (5) :502-11 Zhai, Peiyong; Sciarretta, Sebastiano; Galeotti, Jonathan; Volpe, Massimo; Sadoshima, Junichi 2011
Application of recombinant thioredoxin1 for treatment of heart disease. Journal of molecular and cellular cardiology. 2011 Oct 51 (4) :570-3 Matsushima, Shouji; Zablocki, Daniela; Sadoshima, Junichi 2011
Comparative analysis of mRNA isoform expression in cardiac hypertrophy and development reveals multiple post-transcriptional regulatory modules. PloS one. 2011 6 (7) :e22391 Park, Ji Yeon; Li, Wencheng; Zheng, Dinghai; Zhai, Peiyong; Zhao, Yun; Matsuda, Takahisa; Vatner, Stephen F; Sadoshima, Junichi; Tian, Bin 2011
Heart Rate and Electrocardiography Monitoring in Mice. Current protocols in mouse biology. 2011 Mar 1 1 () :123-139 Ho, David; Zhao, Xin; Gao, Shumin; Hong, Chull; Vatner, Dorothy E; Vatner, Stephen F 2011
Thioredoxin 1 negatively regulates angiotensin II-induced cardiac hypertrophy through upregulation of miR-98/let-7. Circulation research. 2011 Feb 4 108 (3) :305-13 Yang, Yanfei; Ago, Tetsuro; Zhai, Peiyong; Abdellatif, Maha; Sadoshima, Junichi 2011
Protection of the heart against ischemia/reperfusion by silent information regulator 1. Trends in cardiovascular medicine. 2011 Jan 21 (1) :27-32 Yamamoto, Takanobu;Sadoshima, Junichi 2011
Is Raf1 a nexus for cardiac hypertrophic signaling in human disease? Journal of molecular and cellular cardiology. 2011 Jul 51 (1) :1-3 Del Re, Dominic P; Sadoshima, Junichi 2011
Sirt3 targets mPTP and prevents aging in the heart. Aging. 2011 Jan 3 (1) :12-3 Sadoshima, Junichi 2011
Echocardiography in Mice. Current protocols in mouse biology. 2011 Mar 1 1 () :71-83 Gao, Shumin; Ho, David; Vatner, Dorothy E; Vatner, Stephen F 2011
Is autophagy in response to ischemia and reperfusion protective or detrimental for the heart? Pediatric cardiology. 2011 Mar 32 (3) :275-81 Sciarretta, Sebastiano; Hariharan, Nirmala; Monden, Yoshiya; Zablocki, Daniela; Sadoshima, Junichi 2011
Hypotonic swelling-induced activation of PKN1 mediates cell survival in cardiac myocytes. American journal of physiology. Heart and circulatory physiology. 2011 Jan 300 (1) :H191-200 Kajimoto, Katsuya; Shao, Dan; Takagi, Hiromitsu; Maceri, Gregorio; Zablocki, Daniela; Mukai, Hideyuki; Ono, Yoshitaka; Sadoshima, Junichi 2011
Regulation of myocardial growth and death by NADPH oxidase. Journal of molecular and cellular cardiology. 2011 Mar 50 (3) :408-16 Maejima, Yasuhiro; Kuroda, Junya; Matsushima, Shouji; Ago, Tetsuro; Sadoshima, Junichi 2011
Second window of preconditioning normalizes palmitate use for oxidation and improves function during low-flow ischaemia. Cardiovascular research. 2011 Dec 1 92 (3) :394-400 Kudej, Raymond K; Fasano, Mathew; Zhao, Xin; Lopaschuk, Gary D; Fischer, Susan K; Vatner, Dorothy E; Vatner, Stephen F; Lewandowski, E Douglas 2011
Overview of pyridine nucleotides review series. Circulation research. 2012 Aug 17 111 (5) :604-10 Nakamura, Michinari;Bhatnagar, Aruni;Sadoshima, Junichi 2012
Regulation of cell survival and death by pyridine nucleotides. Circulation research. 2012 Aug 17 111 (5) :611-27 Oka, Shin-Ichi;Hsu, Chiao-Po;Sadoshima, Junichi 2012
Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome. Circulation. 2012 Mar 6 125 (9) :1134-46 Sciarretta, Sebastiano;Zhai, Peiyong;Shao, Dan;Maejima, Yasuhiro;Robbins, Jeffrey;Volpe, Massimo;Condorelli, Gianluigi;Sadoshima, Junichi 2012
Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase. American journal of physiology. Heart and circulatory physiology. 2012 Jun 15 302 (12) :H2622-8 Iwatsubo, Kosaku;Bravo, Claudio;Uechi, Masami;Baljinnyam, Erdene;Nakamura, Takashi;Umemura, Masanari;Lai, Lo;Gao, Shumin;Yan, Lin;Zhao, Xin;Park, Misun;Qiu, Hongyu;Okumura, Satoshi;Iwatsubo, Mizuka;Vatner, Dorothy E;Vatner, Stephen F;Ishikawa, Yoshihiro 2012
Enhancing the potential of cardiac progenitor cells: pushing forward with Pim-1. Circulation research. 2012 Apr 27 110 (9) :1154-6 Del Re, Dominic P;Sadoshima, Junichi 2012
Interacting with Thioredoxin-1-Disease or No Disease? Antioxidants &redox signaling. 2012 Sep 24 () : Zschauer, Tim-Christian;Matsushima, Shouji;Altschmied, Joachim;Shao, Dan;Sadoshima, Junichi;Haendeler, Judith 2012
Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart. PloS one. 2013 8 (1) :e51632 Hariharan, Nirmala;Ikeda, Yoshiyuki;Hong, Chull;Alcendor, Ralph R;Usui, Soichiro;Gao, Shumin;Maejima, Yasuhiro;Sadoshima, Junichi 2013
Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1ýý and upregulation of peroxisome proliferator-activated receptor-ýý. Circulation research. 2013 Apr 12 112 (8) :1135-49 Matsushima, Shouji;Kuroda, Junya;Ago, Tetsuro;Zhai, Peiyong;Ikeda, Yoshiyuki;Oka, Shinichi;Fong, Guo-Hua;Tian, Rong;Sadoshima, Junichi 2013
Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. The Journal of biological chemistry. 2013 Feb 8 288 (6) :3977-88 Del Re, Dominic P;Yang, Yanfei;Nakano, Noritsugu;Cho, Jaeyeaon;Zhai, Peiyong;Yamamoto, Takanobu;Zhang, Nailing;Yabuta, Norikazu;Nojima, Hiroshi;Pan, Duojia;Sadoshima, Junichi 2013
Angiotensin II and Oxidative Stress in the Failing Heart. Antioxidants &redox signaling. 2012 May 3 () : Zablocki, Daniela;Sadoshima, Junichi 2012
Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nature medicine. 2013 Nov 19 (11) :1478-88 Maejima, Yasuhiro;Kyoi, Shiori;Zhai, Peiyong;Liu, Tong;Li, Hong;Ivessa, Andreas;Sciarretta, Sebastiano;Del Re, Dominic P;Zablocki, Daniela K;Hsu, Chiao-Po;Lim, Dae-Sik;Isobe, Mitsuaki;Sadoshima, Junichi 2013
Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. PloS one. 2014 9 (6) :e98972 Yamamoto, Takanobu;Byun, Jaemin;Zhai, Peiyong;Ikeda, Yoshiyuki;Oka, Shinichi;Sadoshima, Junichi 2014