Myocardial hypertrophy and heart failure

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Project Title: Myocardial hypertrophy and heart failure
Project Number: 5P01HL059139-07
Project web address: Follow on NIH
Organization: Univ Of Med/Dent Of Nj-Nj Medical School, United States, New Jersey, NEWARK
Principal Investigators (PI): Vatner Stephen F, US
 
Project Description:
Despite recent advances in the treatment of human heart failure, the overall impact on morbidity and mortality has been limited, and heart failure remains the pre-eminent cardiovascular health problem in the country. Limitations in our understanding can be attributed, in part, to the inability to examine basic mechanisms in appropriate animal models in which the progressive pathogenesis of hypertrophy and heart failure can be studied. Thus, the overall aim of this Program Project is to identify physiological, biochemical and molecular mechanisms which are fundamental to the progression from imposition of the abnormal load to development of compensated hypertrophy to heart failure. A secondary goal is to understand the mechanism of potential therapeutic agents within the context of the pathogenesis of hypertrophy and heartfailure, focusing on beta-adreriergic blockade therapy. The latter is central to one of the major themes of this Program Project, i.e., alterations in beta-adrenergic and G-protein signaling in hypertrophy and heart failure. To achieve these goals, we will focus primarily on the study of transgenic mice and a novel canine model of heart failure superimposed on chronic, severe cardiac hypertrophy. The organization of the Program Project includes 4 projects and 3 cores. The first Project will examine genomic and proteomic mechanisms of hypertrophy and heart failure utilizing the novel canine model of severe, chronic cardiac hypertrophy with heart failuresuperimposed. The next Project will emphasizes altered beta-adrenergic receptor signaling and signaling mechanisms involving stress-activated protein kinases in hypertrophy and heart failure. The overall goals of this projectare to elucidate cellular and molecular mechanisms, which may explain the adverse action of enhanced beta-adrenergic receptor signaling in heart failure and conversely, the salutary action of beta-adrenergic receptor blockade therapy. The next Project is designed to provide novel information on molecular mechanisms of adenylyl Cyclase regulation, also, using transgenic models. The final Project will focuses on molecular mechanisms involving Gprotein coupled receptor signaling, e.g., beta-adrenergic and angiotensin receptors in the development of hypertrophy and heart failure. This Program Project will provide significant new information on molecular mechanisms involved in mediating hypertrophy and heart failure, which will also have relevance for understanding corresponding mechanisms in myocardial ischemic disease as well.
 
Project Terms:
heart function heart failure ventricular hypertrophy pathologic process
Project Title: Myocardial hypertrophy and heart failure
Project Number: 5P01HL059139-07
Project web address: Follow on NIH
Organization: Univ Of Med/Dent Of Nj-Nj Medical School, United States, New Jersey, NEWARK
Principal Investigators (PI): Vatner Stephen F, US
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology > Cardiovascular and cerebrovascular diseases > Heart failure
 
Other Information:
Fiscal Year: 1997
Project Start Date: 15 September 1997
Project End Date: 29 February 2008
Project program: Research Program Projects
 
Project Funding Information:
Funding Mechanism: Program project and research center grants
Year Funding Organization Total Funding, $
2004 NIH - National Heart, Lung, And Blood Institute $1,597,506
Project Title: Myocardial hypertrophy and heart failure
Project Number: 5P01HL059139-07
Project web address: Follow on NIH
Organization: Univ Of Med/Dent Of Nj-Nj Medical School, United States, New Jersey, NEWARK
Principal Investigators (PI): Vatner Stephen F, US
 
Title FY Funding
There are no results for this project in database.
Project Title: Myocardial hypertrophy and heart failure
Project Number: 5P01HL059139-07
Project web address: Follow on NIH
Organization: Univ Of Med/Dent Of Nj-Nj Medical School, United States, New Jersey, NEWARK
Principal Investigators (PI): Vatner Stephen F, US
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Myocardial hypertrophy and heart failure
Project Number: 5P01HL059139-07
Project web address: Follow on NIH
Organization: Univ Of Med/Dent Of Nj-Nj Medical School, United States, New Jersey, NEWARK
Principal Investigators (PI): Vatner Stephen F, US
 
Title Journal Year Country Rel
Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. PLoS One 2014 united states
Interacting with thioredoxin-1--disease or no disease? Antioxid Redox Signal 2013 united states
Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart. PLoS One 2013 united states
Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1? and upregulation of peroxisome proliferator-activated receptor-?. Circ Res 2013 united states
Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. J Biol Chem 2013 united states
Angiotensin II and oxidative stress in the failing heart. Antioxid Redox Signal 2013 united states
Truncations of titin causing dilated cardiomyopathy. N Engl J Med 2012 united states
Regulation of cell survival and death by pyridine nucleotides. Circ Res 2012 united states
Enhancing the potential of cardiac progenitor cells: pushing forward with Pim-1. Circ Res 2012 united states
Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase. Am J Physiol Heart Circ Physiol 2012 united states
Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome. Circulation 2012 united states
Overview of pyridine nucleotides review series. Circ Res 2012 united states
Protection of the heart against ischemia/reperfusion by silent information regulator 1. Trends Cardiovasc Med 2011 united states
Oxidative stress stimulates autophagic flux during ischemia/reperfusion. Antioxid Redox Signal 2011 united states
Regulation of myocardial growth and death by NADPH oxidase. J Mol Cell Cardiol 2011 england
Endogenous muscle atrophy F-box mediates pressure overload-induced cardiac hypertrophy through regulation of nuclear factor-kappaB. Circ Res 2011 united states
Comparative analysis of mRNA isoform expression in cardiac hypertrophy and development reveals multiple post-transcriptional regulatory modules. PLoS One 2011 united states
Differential roles of GSK-3ýý during myocardial ischemia and ischemia/reperfusion. Circ Res 2011 united states
Regulation of longevity by regulator of G-protein signaling protein, Loco. Aging Cell 2011 england
Sirt3 targets mPTP and prevents aging in the heart. Aging (Albany NY) 2011 united states
Hypotonic swelling-induced activation of PKN1 mediates cell survival in cardiac myocytes. Am J Physiol Heart Circ Physiol 2011 united states
Second window of preconditioning normalizes palmitate use for oxidation and improves function during low-flow ischaemia. Cardiovasc Res 2011 england
Is Raf1 a nexus for cardiac hypertrophic signaling in human disease? J Mol Cell Cardiol 2011 england
Myocardial injection with GSK-3β-overexpressing bone marrow-derived mesenchymal stem cells attenuates cardiac dysfunction after myocardial infarction. Circ Res 2011 united states
Prevention of ventricular arrhythmia and calcium dysregulation in a catecholaminergic polymorphic ventricular tachycardia mouse model carrying calsequestrin-2 mutation. J Cardiovasc Electrophysiol 2011 united states
Application of recombinant thioredoxin1 for treatment of heart disease. J Mol Cell Cardiol 2011 england
Thioredoxin 1 negatively regulates angiotensin II-induced cardiac hypertrophy through upregulation of miR-98/let-7. Circ Res 2011 united states
Arterial Pressure Monitoring in Mice. Curr Protoc Mouse Biol 2011
Heart Rate and Electrocardiography Monitoring in Mice. Curr Protoc Mouse Biol 2011
Echocardiography in Mice. Curr Protoc Mouse Biol 2011
Is autophagy in response to ischemia and reperfusion protective or detrimental for the heart? Pediatr Cardiol 2011 united states
Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circ Res 2010 united states
Molecular mechanisms mediating preconditioning following chronic ischemia differ from those in classical second window. Am J Physiol Heart Circ Physiol 2010 united states
Nifedipine inhibits cardiac hypertrophy and left ventricular dysfunction in response to pressure overload. J Cardiovasc Transl Res 2010 united states
NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proc Natl Acad Sci U S A 2010 united states
Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice. J Clin Invest 2010 united states
Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5. Heart Fail Rev 2010 united states
Design of a miniature tissue culture system to culture mouse heart valves. Ann Biomed Eng 2010 united states
Progressive loss of creatine maintains a near normal DeltaG approximately (ATP) in transgenic mouse hearts with cardiomyopathy caused by overexpressing Gsalpha. J Mol Cell Cardiol 2010 england
Effects of cardiac overexpression of type 6 adenylyl cyclase affects on the response to chronic pressure overload. Am J Physiol Heart Circ Physiol 2010 united states
NADPH oxidase and cardiac failure. J Cardiovasc Transl Res 2010 united states
Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation 2010 united states
Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circ Res 2010 united states
New insights into the molecular phenotype of eccentric hypertrophy. J Mol Cell Cardiol 2010 england
A molecular dissociation between cued and contextual appetitive learning. Learn Mem 2010 united states
The NADPH oxidase Nox4 and aging in the heart. Aging (Albany NY) 2010 united states
Short communication: the cardiac myosin binding protein C Arg502Trp mutation: a common cause of hypertrophic cardiomyopathy. Circ Res 2010 united states
Activation of PKN mediates survival of cardiac myocytes in the heart during ischemia/reperfusion. Circ Res 2010 united states
Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress. Circ J 2009 japan
Distinct roles of glycogen synthase kinase (GSK)-3alpha and GSK-3beta in mediating cardiomyocyte differentiation in murine bone marrow-derived mesenchymal stem cells. J Biol Chem 2009 united states
Optimizing cell-based therapy for cardiac regeneration. Circulation 2009 united states
Nicotinamide phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes. Autophagy 2009 united states
Apoptosis predominates in nonmyocytes in heart failure. Am J Physiol Heart Circ Physiol 2009 united states
Adenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning. J Neurosci 2009 united states
Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes. Circ Res 2009 united states
Adenylyl cyclase type 5 protein expression during cardiac development and stress. Am J Physiol Heart Circ Physiol 2009 united states
The role of redox modulation of class II histone deacetylases in mediating pathological cardiac hypertrophy. J Mol Med (Berl) 2009 germany
Epac increases melanoma cell migration by a heparan sulfate-related mechanism. Am J Physiol Cell Physiol 2009 united states
Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload. Am J Physiol Heart Circ Physiol 2009 united states
Cytochrome c oxidase III as a mechanism for apoptosis in heart failure following myocardial infarction. Am J Physiol Cell Physiol 2009 united states
Overexpression of Gsalpha compensates for myocyte loss in diabetic cardiomyopathy. Can J Physiol Pharmacol 2008 canada
Therapeutic targets for heart failure: beyond beta-adrenergic and renin-angiotensin system blockade. Recent Pat Cardiovasc Drug Discov 2008 united arab emirates
Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload. Am J Physiol Heart Circ Physiol 2008 united states
Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload. Proc Natl Acad Sci U S A 2008 united states
Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. Autophagy 2008 united states
Lats2 is a negative regulator of myocyte size in the heart. Circ Res 2008 united states
A cAMP pathway underlying reward prediction in associative learning. J Neurosci 2008 united states
Cardiac myosin light chain kinase: a new player in the regulation of myosin light chain in the heart. Circ Res 2008 united states
Characterization of a novel cardiac isoform of the cell cycle-related kinase that is regulated during heart failure. J Biol Chem 2008 united states
A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell 2008 united states
Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning. Circulation 2008 united states
Overcoming an energy crisis?: an adaptive role of glycogen synthase kinase-3 inhibition in ischemia/reperfusion. Circ Res 2008 united states
Cardiac dysfunction in aging conscious rats: altered cardiac cytoskeletal proteins as a potential mechanism. Am J Physiol Heart Circ Physiol 2008 united states
Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes. Cardiovasc Res 2008 netherlands
Sirt1 protects the heart from aging and stress. Biol Chem 2008 germany
Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor. J Clin Invest 2007 united states
Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell 2007 united states
Sex differences in myocardial infarction and rupture. J Mol Cell Cardiol 2007 england
Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor. Circulation 2007 united states
cAMP-mediated regulation of CYP enzymes and its application in chemotherapy. Drug Metab Lett 2007 united arab emirates
Cardioprotection in stunned and hibernating myocardium. Heart Fail Rev 2007 united states
Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. Circ Res 2007 united states
Increased apoptosis and myocyte enlargement with decreased cardiac mass; distinctive features of the aging male, but not female, monkey heart. J Mol Cell Cardiol 2007 england
Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res 2007 united states
Dopamine induces apoptosis in young, but not in neonatal, neurons via Ca2+-dependent signal. Am J Physiol Cell Physiol 2007 united states
Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases. J Biol Chem 2007 united states
Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res 2007 united states
The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart. Antioxid Redox Signal 2007 united states
Mechanism of gender-specific differences in aortic stiffness with aging in nonhuman primates. Circulation 2007 united states
Sex-specific regulation of gene expression in the aging monkey aorta. Physiol Genomics 2007 united states
Functional adenylyl cyclase inhibition in murine cardiomyocytes by 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-[gamma-thio]triphosphate. J Pharmacol Exp Ther 2007 united states
Inhibition of glycogen synthase kinase 3beta during heart failure is protective. Circ Res 2007 united states
Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress. Circulation 2007 united states
Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy. Am J Physiol Heart Circ Physiol 2007 united states
AMPK mediates autophagy during myocardial ischemia in vivo. Autophagy 2007 united states
Thioredoxin1 as a negative regulator of cardiac hypertrophy. Antioxid Redox Signal 2007 united states
Altered autonomic control in conscious transgenic rabbits with overexpressed cardiac Gsalpha. Am J Physiol Heart Circ Physiol 2007 united states
Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus. J Clin Invest 2006 united states
Thioredoxin and ventricular remodeling. J Mol Cell Cardiol 2006 england
Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy. Circulation 2006 united states