The life study

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Project Title: The life study
Project Number: 4U01AG022376-07
Project web address: Follow on NIH
Organization: University Of Florida, United States, Florida, GAINESVILLE
Principal Investigators (PI): Pahor Marco, US
 
Project Description:
As life expectancy in the US continues to rise, the maintenance of independence among older Americans has emerged as a major clinical and public health priority. Efficient and reliable locomotion, or the ability to move without assistance, is a fundamental feature of human functioning. Older people who lose mobility are less likely to remain in the community, have higher rates of morbidity, mortality, and hospitalizations and experience a poorer quality of life. Several studies have shown that regular physical activity improves physical performance, but definitive evidence showing that mobility disability can be prevented is lacking. A Phase 3 randomized, controlled trial is needed to fill this evidence gap. This application is a competitive renewal for the Physical Exercise to Prevent Disability pilot study, lay title Lifestyle Interventions and Independence For Elders - LIFE pilot study. The Data Safety Monitoring Board unanimously determined that all pilot study benchmarks, including infrastructure, quality control, recruitment, adherence with the interventions, retention, safety, outcomes rates, outcomes definition refinement, and sample size estimates, were successfully achieved. We propose conducting a Phase 3, single-masked multicenter randomized controlled trial to compare a moderate-intensity physical activity program to a successful aging health education program in sedentary older persons who are at risk of disability. This trial will enable us to address the aims listed below. The primary aim is to assess the long-term effects of the proposed interventions on the primary outcome of major mobility disability, as operationalized by the inability to walk 400 m. Secondary aims focus on assessing the relative effects of the interventions on the following secondary outcomes: cognitive function; serious fall injuries; persistent mobility disability; the combined outcome of major mobility disability or death; disability in activities of daily living; and cost-effectiveness. Tertiary aims relate to assessing the relative effects of the interventions on (a) the combined outcome of mild cognitive impairment or dementia and (b) physical performance within pre-specified subgroups defined on the basis of ethnicity/race, gender and baseline physical performance; and (c) to explore time by intervention interactions on the SPPB score and 400 m walk speed endpoints. The proposed trial will provide definitive evidence regarding whether physical activity is effective and practical for preventing major mobility disability.
 
Project Terms:
There are no related terms in database.
Project Title: The life study
Project Number: 4U01AG022376-07
Project web address: Follow on NIH
Organization: University Of Florida, United States, Florida, GAINESVILLE
Principal Investigators (PI): Pahor Marco, US
 
Project Categories:
Behavioral and Social Sciences
 
Other Information:
Fiscal Year: 2003
Project Start Date: 30 September 2003
Project End Date: 30 November 2015
Project program: Research Project--Cooperative Agreements
 
Project Funding Information:
Funding Mechanism: Non-SBIR/STTR RPGs
Year Funding Organization Total Funding, $
2012 NIH - National Institute On Aging $14,571,004
Project Title: The life study
Project Number: 4U01AG022376-07
Project web address: Follow on NIH
Organization: University Of Florida, United States, Florida, GAINESVILLE
Principal Investigators (PI): Pahor Marco, US
 
Title FY Funding
Uf ecg reading center 2012 $58357
Uf field center 2012 $1496716
Uf admin coordinating center 2012 $13015931
Project Title: The life study
Project Number: 4U01AG022376-07
Project web address: Follow on NIH
Organization: University Of Florida, United States, Florida, GAINESVILLE
Principal Investigators (PI): Pahor Marco, US
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: The life study
Project Number: 4U01AG022376-07
Project web address: Follow on NIH
Organization: University Of Florida, United States, Florida, GAINESVILLE
Principal Investigators (PI): Pahor Marco, US
 
Title Journal Year Country Rel
Analysis and Interpretation of Accelerometry Data in Older Adults: The LIFE Study. J Gerontol A Biol Sci Med Sci 2016 united states
Actigraphy features for predicting mobility disability in older adults. Physiol Meas 2016 england
Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial. J Am Geriatr Soc 2016 united states
Cost-effectiveness of the LIFE Physical Activity Intervention for Older Adults at Increased Risk for Mobility Disability. J Gerontol A Biol Sci Med Sci 2016 united states
Effect of structured physical activity on prevention of serious fall injuries in adults aged 70-89: randomized clinical trial (LIFE Study). BMJ 2016 england
Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study. J Am Med Dir Assoc 2016 united states
Socioeconomic differences in the benefits of structured physical activity compared with health education on the prevention of major mobility disability in older adults: the LIFE study. J Epidemiol Community Health 2016 england
Genetic Moderators of the Impact of Physical Activity on Depressive Symptoms. J Frailty Aging 2016 france
Hypertension and Its Role in Cognitive Function: Current Evidence and Challenges for the Future. Am J Hypertens 2016 united states
Effect of Structured Physical Activity on Respiratory Outcomes in Sedentary Elderly Adults with Mobility Limitations. J Am Geriatr Soc 2016 united states
Effect of a 24-Month Physical Activity Intervention vs Health Education on Cognitive Outcomes in Sedentary Older Adults: The LIFE Randomized Trial. JAMA 2015 united states
The MAT-sf: identifying risk for major mobility disability. J Gerontol A Biol Sci Med Sci 2015 united states
Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations - The LIFE Study. Exp Gerontol 2015 england
Effects of a One-Year Physical Activity Program on Serum C-Terminal Agrin Fragment (CAF) Concentrations among Mobility-Limited Older Adults. J Nutr Health Aging 2015 france
Prevalence of metabolic syndrome and its association with physical capacity, disability, and self-rated health in Lifestyle Interventions and Independence for Elders Study participants. J Am Geriatr Soc 2015 united states
Associations Between Ankle-Brachial Index and Cognitive Function: Results From the Lifestyle Interventions and Independence for Elders Trial. J Am Med Dir Assoc 2015 united states
A physical activity intervention to treat the frailty syndrome in older persons-results from the LIFE-P study. J Gerontol A Biol Sci Med Sci 2015 united states
Association of objectively measured physical activity with cardiovascular risk in mobility-limited older adults. J Am Heart Assoc 2015 england
Low-intensity walking activity is associated with better health. J Appl Gerontol 2014 united states
The effects of a long-term physical activity intervention on serum uric acid in older adults at risk for physical disability. J Aging Phys Act 2014 united states
Behavioral medicine in the 21st century: transforming the Road Less Traveled into the American Way of Life. Ann Behav Med 2014 united states
Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA 2014 united states
Respiratory impairment and dyspnea and their associations with physical inactivity and mobility in sedentary community-dwelling older persons. J Am Geriatr Soc 2014 united states
Sleep-wake disturbances in sedentary community-dwelling elderly adults with functional limitations. J Am Geriatr Soc 2014 united states
The LIFE Cognition Study: design and baseline characteristics. Clin Interv Aging 2014 new zealand
Physical activity and resting pulse rate in older adults: findings from a randomized controlled trial. Am Heart J 2014 united states
Genetic influence on exercise-induced changes in physical function among mobility-limited older adults. Physiol Genomics 2014 united states
Identification of misdiagnosed fronto-temporal dementia using APOE genotype and phenotype-genotype correlation analyses. Curr Alzheimer Res 2014 united arab emirates
The impact of sarcopenia on a physical activity intervention: the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P). J Nutr Health Aging 2014 france
Performance of a computer-based assessment of cognitive function measures in two cohorts of seniors. Int J Geriatr Psychiatry 2013 england
Using the NIH Toolbox in special populations: considerations for assessment of pediatric, geriatric, culturally diverse, non-English-speaking, and disabled individuals. Neurology 2013 united states
Lifestyle interventions and independence for elders study: recruitment and baseline characteristics. J Gerontol A Biol Sci Med Sci 2013 united states
NIH toolbox for assessment of neurological and behavioral function. Neurology 2013 united states
Emotion assessment using the NIH Toolbox. Neurology 2013 united states
Commentary: Luke and Cooper are wrong: physical activity has a crucial role in weight management and determinants of obesity. Int J Epidemiol 2013 england
Physical activity increases gains in and prevents loss of physical function: results from the lifestyle interventions and independence for elders pilot study. J Gerontol A Biol Sci Med Sci 2013 united states
Promoting physical activity for elders with compromised function: the lifestyle interventions and independence for elders (LIFE) study physical activity intervention. Clin Interv Aging 2013 new zealand
The MAT-sf: clinical relevance and validity. J Gerontol A Biol Sci Med Sci 2013 united states
Resilience to obesity among socioeconomically disadvantaged women: the READI study. Int J Obes (Lond) 2012 england
Total and abdominal adiposity are associated with inflammation in older adults using a factor analysis approach. J Gerontol A Biol Sci Med Sci 2012 united states
Effects of a 12-month physical activity intervention on prevalence of metabolic syndrome in elderly men and women. J Gerontol A Biol Sci Med Sci 2012 united states
Angiotensin-converting enzyme inhibitor use by older adults is associated with greater functional responses to exercise. J Am Geriatr Soc 2012 united states
Muscle strength and BMI as predictors of major mobility disability in the Lifestyle Interventions and Independence for Elders pilot (LIFE-P). J Gerontol A Biol Sci Med Sci 2011 united states
Effect of phosphodiesterase type 5 inhibition on microvascular coronary dysfunction in women: a Women's Ischemia Syndrome Evaluation (WISE) ancillary study. Clin Cardiol 2011 united states
Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc 2011 united states
The Lifestyle Interventions and Independence for Elders Study: design and methods. J Gerontol A Biol Sci Med Sci 2011 united states
Consideration of insurance reimbursement for physical activity and exercise programs for patients with diabetes. JAMA 2011 united states
Syndrome X and microvascular coronary dysfunction. Circulation 2011 united states
In women with symptoms of cardiac ischemia, nonobstructive coronary arteries, and microvascular dysfunction, angiotensin-converting enzyme inhibition is associated with improved microvascular function: A double-blind randomized study from the National Heart, Lung and Blood Institute Women's Ischemia Syndrome Evaluation (WISE). Am Heart J 2011 united states
What causes myocardial infarction in women without obstructive coronary artery disease? Circulation 2011 united states
Maximizing the potential of an aging population. JAMA 2010 united states
Effects of exercise on mobility in obese and nonobese older adults. Obesity (Silver Spring) 2010 united states
Psychomotor speed and functional brain MRI 2 years after completing a physical activity treatment. J Gerontol A Biol Sci Med Sci 2010 united states
Evaluation of the late life disability instrument in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study. Health Qual Life Outcomes 2010 england
Relationship between physical functioning and physical activity in the lifestyle interventions and independence for elders pilot. J Am Geriatr Soc 2010 united states
Long-term physical activity and inflammatory biomarkers in older adults. Med Sci Sports Exerc 2010 united states
Interruption of physical activity because of illness in the Lifestyle Interventions and Independence for Elders Pilot trial. J Aging Phys Act 2010 united states
What is a meaningful change in physical performance? Findings from a clinical trial in older adults (the LIFE-P study). J Nutr Health Aging 2009 france
Stopping to rest during a 400-meter walk and incident mobility disability in older persons with functional limitations. J Am Geriatr Soc 2009 united states
Changes in cognitive function in a randomized trial of physical activity: results of the lifestyle interventions and independence for elders pilot study. J Gerontol A Biol Sci Med Sci 2009 united states
A cost analysis of a physical activity intervention for older adults. J Phys Act Health 2009 united states
The Lifestyle Interventions and Independence for Elders Pilot (LIFE-P): 2-year follow-up. J Gerontol A Biol Sci Med Sci 2009 united states
Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc 2008 united states
Physical activity in prefrail older adults: confidence and satisfaction related to physical function. J Gerontol B Psychol Sci Soc Sci 2008 united states
Use of accelerometry to measure physical activity in older adults at risk for mobility disability. J Aging Phys Act 2008 united states
Self-reported napping and duration and quality of sleep in the lifestyle interventions and independence for elders pilot study. J Am Geriatr Soc 2008 united states
Effects of physical activity on strength and skeletal muscle fat infiltration in older adults: a randomized controlled trial. J Appl Physiol (1985) 2008 united states
Maximal fitness testing in sedentary elderly at substantial risk of disability: LIFE-P study experience. J Aging Phys Act 2008 united states
Activity adherence and physical function in older adults with functional limitations. Med Sci Sports Exerc 2007 united states
Designing clinical trials of interventions for mobility disability: results from the lifestyle interventions and independence for elders pilot (LIFE-P) trial. J Gerontol A Biol Sci Med Sci 2007 united states
Lifestyle Interventions and Independence for Elders pilot study: recruitment and baseline characteristics. J Am Geriatr Soc 2007 united states
Predictors of adherence to physical activity in the Lifestyle Interventions and Independence for Elders pilot study (LIFE-P). Clin Interv Aging 2007 new zealand
Health-related quality of life in older adults at risk for disability. Am J Prev Med 2007 netherlands
Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study. J Gerontol A Biol Sci Med Sci 2006 united states
How much and what type of physical activity is enough? What physicians should tell their patients. Arch Intern Med 2005 united states
The lifestyle interventions and independence for elders (LIFE) pilot study: design and methods. Contemp Clin Trials 2005 united states