Loc: hiv prevention trials network

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Project Title: Loc: hiv prevention trials network
Project Number: 2UM1AI068619-08
Project web address: Follow on NIH
Organization: Family Health International, United States, North Carolina, RESEARCH TRIANGLE PARK
Principal Investigators (PI): El-Sadr Wafaa M, US
Cohen Myron S, US
 
Project Description:
The mission of the HIV Prevention Trials Network (HPTN) is to conduct research designed to identify the best combinations of HIV prevention interventions to prevent HIV infection in populations at the highest risk for this infection. The HPTN will be led by Drs. Wafaa EI-Sadr, Columbia University, and Myron S. Cohen, University of North Carolina at Chapel Hill, and supported by experienced operations, laboratory and statistical and data centers. The HPTN will address and support the two research Priority Areas in order to achieve the following eight Specific Aims: Specific Aims for Priority Area 1: Integrate Strategies to Prevent HIV Infection: Aim 1: To develop an integrated strategy to prevent HIV infection in young women in Southern Africa; Aim 2: To develop integrated strategies to prevent HIV infection in men who have sex with men (MSM); Sub-aim 2a: To identify an integrated strategy to prevent HIV acquisition in HIV-uninfected MSM and transgender women in the Americas; Sub-aim 2b: To identify an integrated strategy to prevent HIV transmission from HIV-infected MSM in the United States (U.S.); Aim 3: To develop an integrated strategy to prevent HIV infection in injection drug users (IDUs) in Eastern Europe and Asia; Aim 4: To implement an integrated strategy to virtually eliminate (<1%) HIV transmission in discordant couples in sub-Saharan Africa {SSA}; Aim 5: To develop methods to engage MSM in SSA in prevention research, paving the way for development of an integrated strategy to prevent HIV infection in this population Specific Aims for Priority Area 2: Pre-exposure Prophylaxis {PrEP}: Aim 6: To evaluate the efficacy of an ARV regimen containing maraviroc (MVC) for PrEP; Aim 7: To develop new agents for PrEP with favorable profiles, including long lasting agents; Aim 8: To develop pharmacostatistical models to define the role of new agents for PrEP.
 
Project Terms:
address africa south of the sahara aids prevention americas area couples data development eastern europe epidemic experience far east goals health policy health practice high risk hiv hiv infections hiv prevention trials network infection injecting drug user intervention laboratories men who have sex with men methods mission modeling myron new agents north carolina operation population prevent prevention research preventive intervention prophylactic treatment public health regimen research research design research priority role southern africa transgender transmission process united states universities woman young woman behavioral and social science clinical research clinical trials drug abuse (nida only) hiv/aids infectious diseases prevention substance abuse
Project Title: Loc: hiv prevention trials network
Project Number: 2UM1AI068619-08
Project web address: Follow on NIH
Organization: Family Health International, United States, North Carolina, RESEARCH TRIANGLE PARK
Principal Investigators (PI): El-Sadr Wafaa M, US
Cohen Myron S, US
 
Project Categories:
Behavioral and Social Sciences > Population studies
Natural Sciences
 
Other Information:
Fiscal Year: 2006
Project Start Date: 1 June 2006
Project End Date: 30 November 2020
Project program: Research Project with Complex Structure Cooperative Agreement
 
Project Funding Information:
Funding Mechanism: Non-SBIR/STTR RPGs
Year Funding Organization Total Funding, $
2014 NIH - National Institute Of Allergy And Infectious Diseases $43,787,903
Project Title: Loc: hiv prevention trials network
Project Number: 2UM1AI068619-08
Project web address: Follow on NIH
Organization: Family Health International, United States, North Carolina, RESEARCH TRIANGLE PARK
Principal Investigators (PI): El-Sadr Wafaa M, US
Cohen Myron S, US
 
Title FY Funding
There are no results for this project in database.
Project Title: Loc: hiv prevention trials network
Project Number: 2UM1AI068619-08
Project web address: Follow on NIH
Organization: Family Health International, United States, North Carolina, RESEARCH TRIANGLE PARK
Principal Investigators (PI): El-Sadr Wafaa M, US
Cohen Myron S, US
 
Project number Project title Principal investigator
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Project Title: Loc: hiv prevention trials network
Project Number: 2UM1AI068619-08
Project web address: Follow on NIH
Organization: Family Health International, United States, North Carolina, RESEARCH TRIANGLE PARK
Principal Investigators (PI): El-Sadr Wafaa M, US
Cohen Myron S, US
 
Title Journal Year Country Rel
Venues for Meeting Sex Partners and Partner HIV Risk Characteristics: HIV Prevention Trials Network (HPTN064) Women's HIV Seroincidence Study (ISIS). AIDS Behav 2016 united states
Antiretroviral Medication Adherence and Amplified HIV Transmission Risk Among Sexually Active HIV-Infected Individuals in Three Diverse International Settings. AIDS Behav 2016 united states
Brief Report: HIV Drug Resistance in Adults Failing Early Antiretroviral Treatment: Results From the HIV Prevention Trials Network 052 Trial. J Acquir Immune Defic Syndr 2016 united states
Socioecological factors influencing women's HIV risk in the United States: qualitative findings from the women's HIV SeroIncidence study (HPTN 064). BMC Public Health 2016 england
Using Cognitive Interviews to Enhance Measurement in Empirical Bioethics: Developing a Measure of the Preventive Misconception in Biomedical HIV Prevention Trials. AJOB Empir Bioeth 2016 united states
Economic Resources and HIV Preventive Behaviors Among School-Enrolled Young Women in Rural South Africa (HPTN 068). AIDS Behav 2016 united states
Transgender Women in Clinical Trials of Pre-Exposure Prophylaxis. J Acquir Immune Defic Syndr 2016 united states
HPTN 068: A Randomized Control Trial of a Conditional Cash Transfer to Reduce HIV Infection in Young Women in South Africa-Study Design and Baseline Results. AIDS Behav 2016 united states
Costs of Expanded Rapid HIV Testing in Four Emergency Departments. Public Health Rep 2016 united states
Frequency and predictors of estimated HIV transmissions and bacterial STI acquisition among HIV-positive patients in HIV care across three continents. J Int AIDS Soc 2016 switzerland
Transgender People and HIV Prevention: What We Know and What We Need to Know, a Call to Action. J Acquir Immune Defic Syndr 2016 united states
Engaging Transgender People in NIH-Funded HIV/AIDS Clinical Trials Research. J Acquir Immune Defic Syndr 2016 united states
Symptoms, Side Effects and Adherence in the iPrEx Open-Label Extension. Clin Infect Dis 2016 united states
The promise and pitfalls of long-acting injectable agents for HIV prevention. Curr Opin HIV AIDS 2016 united states
Economic, Legal, and Social Hardships Associated with HIV Risk among Black Men who have Sex with Men in Six US Cities. J Urban Health 2016 united states
Pharmacology supports on-demand PrEP. Lancet HIV 2016 netherlands
Population health and individualized care in the global AIDS response: synergy or conflict? AIDS 2016 england
Antiretroviral drug use in a cross-sectional population survey in Africa: NIMH Project Accept (HPTN 043). J Acquir Immune Defic Syndr 2016 united states
Antiretroviral Therapy for the Prevention of HIV-1 Transmission. N Engl J Med 2016 united states
Post-traumatic Stress Disorder Symptoms and Mental Health over Time among Low-Income Women at Increased Risk of HIV in the U.S. J Health Care Poor Underserved 2016 united states
Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study. Lancet HIV 2016 netherlands