National health and alcohol study (nesarc-iii)

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Project Title: National health and alcohol study (nesarc-iii)
Project Number: 275200900007C-15-0-1
Project web address: Follow on NIH
Organization: Westat, Inc., United States, Maryland, ROCKVILLE
Principal Investigators (PI): Maklan David M, US
 
Project Description:
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) seeks to expand research applying genetic epidemiologic methods to studies of alcohol and other substance use disorders (AUD/SUD; alcohol or drug abuse and dependence). Previous studies using twin, adoption, and family approaches indicate that genetic factors substantially contribute to the vulnerability to AUD/SUD. Shared environmental factors have also been shown to strongly influence risk; however, the influence of genetic factors appears to increase with age. Significant advances also have been made in our understanding of the onset and progression of AUD/SUD and in defining a disinhibited phenotype. Building on these findings, new studies are needed to apply genetic epidemiology approaches to advance our understanding in a variety of areas, integrate as well as differentiate genetic and environmental factors in the onset and maintenance of AUD/SUD; broaden and refine phenotypic definitions of AUD/SUD; guide the translation of etiologic findings to prevention, treatment, and gene identification, and meet the methodologic challenges of the field. A variety of research approaches have established that AUD/SUD are heritable complex disorders, and that family history of AUD/SUD is probably the most potent risk factor for these disorders. Heritability estimates have been high, and shared environmental effects appear to be strong. Genetic epidemiologic studies have highlighted the nature of AUD/SUD as a developmental disorder, particularly as part of a general vulnerability to problem behavior associated with disinhibition. A surprising degree of non-specificity has been found in regard to choice of substance and gender; that is, many risk factors appear to operate similarly in the vulnerability to abuse and dependence for a variety of drugs in men and women. Increasingly sophisticated approaches have also been applied to understand the high prevalence of psychiatric comorbidity with AUD/SUD. Important findings are emerging on the roles of gene-environment correlation and gene-environment interaction in elucidating the development of substance and alcohol use and AUD/SUD. The purpose of this project is to conduct a cross-sectional, nationally representative survey of the U.S. general population, 18 years or older, that will collect phenotypic information (questionnaire) on alcohol and drug use and disorders, co-occurring psychiatric disorders, and medical disorders related to AUD/SUD as well as background information and risk factors for the aforementioned disorders. DNA will also be collected.
 
Project Terms:
adoption age alcohol abuse alcohol consumption alcohol or other drugs use alcohol use disorder alcohols applied genetics area comorbidity complex contractor dependence development developmental disease/disorder diagnosis diagnostic disability disease disinhibition dna drug abuse drug use disorder environment environmental risk factor epidemiologic methods epidemiologic studies family family history of gender gene environment interaction general population genes genetic genetic epidemiology health heritability high prevalence interview maintenance major depressive disorder measures medical meetings men mental disorders national institute on alcohol abuse and alcoholism nature panic disorder pharmaceutical preparations phenotype prevention preventive intervention problem behavior qualifying questionnaires reporting research respondent risk risk factors role saliva schedule social specific qualifier value structure substance use disorder surveys testing training translations twin multiple birth validation studies woman alcoholism behavioral and social science brain disorders clinical research drug abuse (nida only) genetic testing genetics mental health substance abuse
Project Title: National health and alcohol study (nesarc-iii)
Project Number: 275200900007C-15-0-1
Project web address: Follow on NIH
Organization: Westat, Inc., United States, Maryland, ROCKVILLE
Principal Investigators (PI): Maklan David M, US
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology
 
Other Information:
Fiscal Year: 2009
Project Start Date: 1 June 2009
Project End Date: 30 November 2013
 
Project Funding Information:
Funding Mechanism: Non SBIR/STTR Contracts
Year Funding Organization Total Funding, $
2013 NIH - National Institute On Alcohol Abuse And Alcoholism $11,237,538
Project Title: National health and alcohol study (nesarc-iii)
Project Number: 275200900007C-15-0-1
Project web address: Follow on NIH
Organization: Westat, Inc., United States, Maryland, ROCKVILLE
Principal Investigators (PI): Maklan David M, US
 
Title FY Funding
There are no results for this project in database.
Project Title: National health and alcohol study (nesarc-iii)
Project Number: 275200900007C-15-0-1
Project web address: Follow on NIH
Organization: Westat, Inc., United States, Maryland, ROCKVILLE
Principal Investigators (PI): Maklan David M, US
 
Project Title Organization FY Funding
National Health And Alcohol Study (Nesarc-Iii)Westat, Inc.2013$11,237,538
National Epidemiological Survey On Alcohol And Related Conditions (Nesarc-Iii)Westat, Inc.2012$13,487,600
Project Title: National health and alcohol study (nesarc-iii)
Project Number: 275200900007C-15-0-1
Project web address: Follow on NIH
Organization: Westat, Inc., United States, Maryland, ROCKVILLE
Principal Investigators (PI): Maklan David M, US
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: National health and alcohol study (nesarc-iii)
Project Number: 275200900007C-15-0-1
Project web address: Follow on NIH
Organization: Westat, Inc., United States, Maryland, ROCKVILLE
Principal Investigators (PI): Maklan David M, US
 
Title Journal Year Country Rel