Igf::ot::igf - b5999 special studies/analysis- other

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Project Title: Igf::ot::igf - b5999 special studies/analysis- other
Project Number: 268201500014C-0-0-1
Project web address: Follow on NIH
Organization: Broad Institute, Inc., United States, Massachusetts, CAMBRIDGE
Principal Investigators (PI): Wilkinson Jane, US
 
Project Description:
Trans-Omics for Precision Medicine (TOPMed) is an NHLBI-wide initiative to generate scientific resources to enhance our understanding of fundamental biological processes that underlie HLBS disorders through the integration of ?omics (e.g., genomic, proteomic, metabolomic) and phenotypic data in an effort to improve the prediction, prevention, diagnosis, and treatment of these disorders. To support the NHLBI TOPMed program, the Whole-Genome Sequencing (WGS) project will collect whole-genome sequencing data from individuals with well characterized phenotypes and existing clinical outcome data. This project aims to identify genetic markers of increased or decreased risk of disease, as well as those that help define disease subtypes. The initial phase of the WGS project has identified nearly 20,000 participants from previous NHLBI-funded studies to undergo whole-genome sequencing. This first set of participants includes individuals that have complex traits (e.g., dyslipidemia) and the following heart, lung, blood and sleep (HLBS) disorders: Atrial fibrillation, Asthma, Chronic obstructive pulmonary disease (COPD), Obesity,and Sleep apnea. The objective is to establish a novel genomic resource that is reflective of the diversity of the US population. Almost half of current study participants are of European descent, with the remainder being people of African, Hispanic and Pacific Islander ancestry. Currently, the WGS project is being conducted by nine participating research centers, four sequencing centers, an informatics research center, and a Data Coordinating Center (DCC). As the project progresses, it is anticipated that other centers will join the consortium. The National Center for Biotechnology will provide archival and bioinformatics support.
 
Project Terms:
african asthma atrial fibrillation behavioral bioinformatics biological process biotechnology blood chronic obstructive airway disease clinical clinical data communities complex data data coordinating center diagnosis disease disorder risk disorder subtype dyslipidemias ensure european funding genetic markers genetic transcription genome sequencing genomics goals health heart hispanics image improved individual informatics lung medicine metabolic metabolomics molecular national heart and blood institute novel obesity outcome pacific island americans participant pattern personalized medicine phase phenotype population population heterogeneity precision medicine precision medicine initiative prevention programs protein expression proteomics repository research resources sleep apnea syndromes sleep disorders system trait cardiovascular genetics heart disease human genome sleep research
Project Title: Igf::ot::igf - b5999 special studies/analysis- other
Project Number: 268201500014C-0-0-1
Project web address: Follow on NIH
Organization: Broad Institute, Inc., United States, Massachusetts, CAMBRIDGE
Principal Investigators (PI): Wilkinson Jane, US
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology
 
Other Information:
Fiscal Year: 2015
Project Start Date: 25 September 2015
Project End Date: 24 September 2016
 
Project Funding Information:
Funding Mechanism: Non SBIR/STTR Contracts
Year Funding Organization Total Funding, $
2015 NIH - National Heart, Lung, And Blood Institute $38,181,500
Project Title: Igf::ot::igf - b5999 special studies/analysis- other
Project Number: 268201500014C-0-0-1
Project web address: Follow on NIH
Organization: Broad Institute, Inc., United States, Massachusetts, CAMBRIDGE
Principal Investigators (PI): Wilkinson Jane, US
 
Title FY Funding
There are no results for this project in database.
Project Title: Igf::ot::igf - b5999 special studies/analysis- other
Project Number: 268201500014C-0-0-1
Project web address: Follow on NIH
Organization: Broad Institute, Inc., United States, Massachusetts, CAMBRIDGE
Principal Investigators (PI): Wilkinson Jane, US
 
Project Title Organization FY Funding
Igf::Ot::Igf - B5999 Special Studies/Analysis- OtherBroad Institute, Inc.2015$38,181,500
Project Title: Igf::ot::igf - b5999 special studies/analysis- other
Project Number: 268201500014C-0-0-1
Project web address: Follow on NIH
Organization: Broad Institute, Inc., United States, Massachusetts, CAMBRIDGE
Principal Investigators (PI): Wilkinson Jane, US
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Igf::ot::igf - b5999 special studies/analysis- other
Project Number: 268201500014C-0-0-1
Project web address: Follow on NIH
Organization: Broad Institute, Inc., United States, Massachusetts, CAMBRIDGE
Principal Investigators (PI): Wilkinson Jane, US
 
Title Journal Year Country Rel