Molecular analysis of tumors for treatment selection in clinical trials- phase ii

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Project Title: Molecular analysis of tumors for treatment selection in clinical trials- phase ii
Project Number: 261201500003I-0-26100012-1
Project web address: Follow on NIH
Organization: Leidos Biomedical Research, Inc., United States, Maryland, FREDERICK
Principal Investigators (PI): Phillips Rohan Joyann, US
 
Project Description:
The National Cancer Institute (NCI) is continuing to pursue clinical trials concepts that incorporate genomics into the evolving national strategy for precision medicine. Recent advances in knowledge of the molecular abnormalities in tumors that either drive proliferation or promote survival have led to the development of many therapeutic agents that target those abnormalities. Studies will screen for molecular features that may predict response to a targeted agent with a specific mechanism of action. In some cases, the study designs will use an umbrella protocol whereby a single entry point for molecular screening will then distribute patients to multiple, single-arm phase 2/3 trials. One example of the trials in the series, MATCH, was open for patient enrollment in July 2015. Other trials will use enrichment designs where the particular molecular characteristic is an eligibility criterion and the therapy is limited to such patients.
 
Project Terms:
arm base biological assay biopsy biopsy specimen blood blood specimen cancer imaging case study characteristics clinical data clinical trials data design development diagnostic dna dna sequence early therapeutic-clinical trials network eligibility determination enrollment exome experience facilities and administrative costs fine needle aspiration biopsy fluorescent in situ hybridization future genetic genomics image interventional radiology knowledge laboratories malignant neoplasms metabolomics methylome molecular molecular abnormality molecular analysis molecular profiling mutation national cancer institute new therapeutic target next generation sequencing partial response pathologic patients pharmaceutical preparations phase ii clinical trials phase ii/iii trial precision medicine protocols documentation quality control relapse research research design residual state resources response rna sequences sampling screening selection for treatments series shipping ships specimen testing therapeutic agents tissues transcriptome sequencing tube tumor validation variant cancer clinical research clinical trials and supportive activities genetics human genome
Project Title: Molecular analysis of tumors for treatment selection in clinical trials- phase ii
Project Number: 261201500003I-0-26100012-1
Project web address: Follow on NIH
Organization: Leidos Biomedical Research, Inc., United States, Maryland, FREDERICK
Principal Investigators (PI): Phillips Rohan Joyann, US
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology > Cancer & related diseases > Malignant neoplasms (including in situ)
 
Other Information:
Fiscal Year: 2015
Project Start Date: 26 September 2015
Project End Date: 25 September 2020
 
Project Funding Information:
Funding Mechanism: Non SBIR/STTR Contracts
Year Funding Organization Total Funding, $
2015 NIH - National Cancer Institute $19,125,511
Project Title: Molecular analysis of tumors for treatment selection in clinical trials- phase ii
Project Number: 261201500003I-0-26100012-1
Project web address: Follow on NIH
Organization: Leidos Biomedical Research, Inc., United States, Maryland, FREDERICK
Principal Investigators (PI): Phillips Rohan Joyann, US
 
Title FY Funding
There are no results for this project in database.
Project Title: Molecular analysis of tumors for treatment selection in clinical trials- phase ii
Project Number: 261201500003I-0-26100012-1
Project web address: Follow on NIH
Organization: Leidos Biomedical Research, Inc., United States, Maryland, FREDERICK
Principal Investigators (PI): Phillips Rohan Joyann, US
 
Project Title Organization FY Funding
Molecular Analysis Of Tumors For Treatment Selection In Clinical Trials- Phase IiLeidos Biomedical Research, Inc.2015$19,125,511
Project Title: Molecular analysis of tumors for treatment selection in clinical trials- phase ii
Project Number: 261201500003I-0-26100012-1
Project web address: Follow on NIH
Organization: Leidos Biomedical Research, Inc., United States, Maryland, FREDERICK
Principal Investigators (PI): Phillips Rohan Joyann, US
 
Project number Project title Principal investigator
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Project Title: Molecular analysis of tumors for treatment selection in clinical trials- phase ii
Project Number: 261201500003I-0-26100012-1
Project web address: Follow on NIH
Organization: Leidos Biomedical Research, Inc., United States, Maryland, FREDERICK
Principal Investigators (PI): Phillips Rohan Joyann, US
 
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